Compile Data Set for Download or QSAR

Found 270 hits of ic50 data for polymerid = 703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576088 (N-(1-(4-chlorobenzyl)-2- methyl-6-(6-methyl-7-oxo-...) Show SMILES CCS(=O)(=O)Nc1cc(cc2n(Cc3ccc(Cl)cc3)c(C)nc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576114 (N-(3-(2,4-difluorobenzyl)-2- methyl-5-(6-methyl-7-...) Show SMILES CCS(=O)(=O)Nc1cc(nc2n(Cc3ccc(F)cc3F)c(C)nc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576107 (N-(3-(2,4-difluorobenzyl)-5- (6-methyl-7-oxo-6,7-d...) Show SMILES CCS(=O)(=O)Nc1cc(nc2n(Cc3ccc(F)cc3F)cnc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576112 (N-(3-(3,5-difluorobenzyl)-5- (6-methyl-7-oxo-6,7-d...) Show SMILES CCS(=O)(=O)Nc1cc(nc2n(Cc3cc(F)cc(F)c3)cnc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576106 (N-(5-(6-methyl-7-oxo-6,7- dihydro-1H-pyrrolo[2,3-c...) Show SMILES CCS(=O)(=O)Nc1cc(nc2n(Cc3ccc(cc3)C(F)(F)F)cnc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM223492 (US10407441, Compound JQ8 | US10925881, Name (S)-JQ...) Show SMILES Cc1nnc2[C@H](CC(=O)NCCc3cnc[nH]3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:18| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.19	n/a	n/a	n/a	n/a	n/a	n/a
Tensha Therapeutics, Inc. US Patent					Assay Description The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curve				US Patent US10925881 (2021) BindingDB Entry DOI: 10.7270/Q2JS9TJ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM223493 (US10407441, Compound JQ13 | US10925881, Name (S)-J...) Show SMILES CN1CCN(CCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)CC1 |r,c:12| Show InChI InChI=1S/C26H32ClN7OS/c1-16-17(2)36-26-23(16)24(19-5-7-20(27)8-6-19)29-21(25-31-30-18(3)34(25)26)15-22(35)28-9-10-33-13-11-32(4)12-14-33/h5-8,21H,9-15H2,1-4H3,(H,28,35)/t21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.49	n/a	n/a	n/a	n/a	n/a	n/a
Tensha Therapeutics, Inc. US Patent					Assay Description The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curve				US Patent US10925881 (2021) BindingDB Entry DOI: 10.7270/Q2JS9TJ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM223491 (US10407441, Compound JQ6 | US10925881, Name (S)-JQ...) Show SMILES Cc1nnc2[C@H](CC(=O)N\N=C\c3ncc[nH]3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:18| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.48	n/a	n/a	n/a	n/a	n/a	n/a
Tensha Therapeutics, Inc. US Patent					Assay Description The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curve				US Patent US10925881 (2021) BindingDB Entry DOI: 10.7270/Q2JS9TJ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576047 (4-(1-(3-chlorobenzyl)-2- methyl-1H-imidazo[4,5-b] ...) Show SMILES Cc1nc2ncc(cc2n1Cc1cccc(Cl)c1)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576066 (4-(1-(1-(4-chlorophenyl)ethyl)- 2-methyl-1H-imidaz...) Show SMILES CC(c1ccc(Cl)cc1)n1c(C)nc2ncc(nc12)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576063 (4-(1-(4-chlorobenzyl)-2-methyl- 1H-imidazo[4,5-b]p...) Show SMILES Cc1nc2ncc(nc2n1Cc1ccc(Cl)cc1)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576043 (4-(1-(4-chlorobenzyl)-2-methyl- 1H-imidazo[4,5-b]p...) Show SMILES Cc1nc2ncc(cc2n1Cc1ccc(Cl)cc1)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576085 (Compound 38 (4-(1-(2,6-dichlorobenzyl)-2-methyl-1H...) Show SMILES Cc1cc2ncc(cc2n1Cc1c(Cl)cccc1Cl)-c1cn(C)c(=O)c2n(ccc12)S(=O)(=O)c1ccc(C)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576049 (4-(1-benzyl-2-methyl-1H- imidazo[4,5-b]pyridin-6-y...) Show SMILES Cc1nc2ncc(cc2n1Cc1ccccc1)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576064 (6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl...) Show SMILES Cc1nc2ncc(nc2n1Cc1ccc(cc1)C(F)(F)F)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576044 (4-(1-(4-methoxybenzyl)-2- methyl-1H-imidazo[4,5-b]...) Show SMILES COc1ccc(Cn2c(C)nc3ncc(cc23)-c2cn(C)c(=O)c3[nH]ccc23)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576087 (Compound 40 (4-(1-((4-chlorophenyl)sulfonyl)-1H-py...) Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc2c(cn(C)c(=O)c12)-c1ccc2ccn(c2n1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576045 (6-methyl-4-(2-methyl-1-(4- methylthio)benzyl)-1H-i...) Show SMILES CSc1ccc(Cn2c(C)nc3ncc(cc23)-c2cn(C)c(=O)c3[nH]ccc23)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576065 (4-(1-(4-methoxybenzyl)-2- methyl-1H-imidazo[4,5-b]...) Show SMILES COc1ccc(Cn2c(C)nc3ncc(nc23)-c2cn(C)c(=O)c3[nH]ccc23)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576046 (6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl...) Show SMILES Cc1nc2ncc(cc2n1Cc1ccc(cc1)C(F)(F)F)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576083 (Compound 36 (4-(1-(2,6-dichlorobenzyl)-1H-pyrrolo[...) Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc2c(cn(C)c(=O)c12)-c1cnc2ccn(Cc3c(Cl)cccc3Cl)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM550507 (US11306105, Compound 300) Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(CNS(=O)(=O)c3ccccc3)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:6| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Tensha Therapeutics, Inc. US Patent					Assay Description The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curve				US Patent US10925881 (2021) BindingDB Entry DOI: 10.7270/Q2JS9TJ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576086 (Compound 39 (4-(1-(4-chlorobenzyl)-1H-pyrazolo[4,3...) Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc2c(cn(C)c(=O)c12)-c1cnc2cnn(Cc3ccc(Cl)cc3)c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552047 (US11312726, Compound 18) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3CNCc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552046 (US11312726, Compound 17) Show SMILES CC(=O)N1Cc2ccc(NC(=O)C[C@@H]3N=C(c4c(C)c(C)sc4-n4c(C)nnc34)c3ccc(Cl)cc3)cc2C1 |r,c:14| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM483491 (US10925881, Name (S)-JQ35) Show SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)CC1 |r,c:13| Show InChI InChI=1S/C27H34ClN7OS/c1-17-18(2)37-27-24(17)25(20-6-8-21(28)9-7-20)30-22(26-32-31-19(3)35(26)27)16-23(36)29-10-5-11-34-14-12-33(4)13-15-34/h6-9,22H,5,10-16H2,1-4H3,(H,29,36)/t22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	24.3	n/a	n/a	n/a	n/a	n/a	n/a
Tensha Therapeutics, Inc. US Patent					Assay Description The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curve				US Patent US10925881 (2021) BindingDB Entry DOI: 10.7270/Q2JS9TJ1
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM562619 (US11406645, Compound 504) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCC(F)F)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...				J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM562599 (US11406645, Compound 502) Show SMILES C[C@@H](O)CNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:9| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM562623 (US11406645, Compound 505) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCC(F)F)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM205429 ( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...) Show SMILES Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM205429 ( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...) Show SMILES Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM550490 (US11306105, Compound 106) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCO)c1nnc(C)n-21)c1ccc(cc1)C#N |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM562570 (US11406645, Compound 501) Show SMILES C[C@H](O)CNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:9| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552060 (US11312726, Compound 31) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3OCCOCCOCCOc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM550493 (US11306105, Compound 109) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCC(F)F)c1nnc(C)n-21)c1ccc(cc1)C#N |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576051 (6-methyl-4-(2-methyl-1H- imidazo[4,5-b]pyridin-6-y...) Show SMILES Cc1nc2ncc(cc2[nH]1)-c1cn(C)c(=O)c2[nH]ccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552041 (US11312726, Compound 12) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3C(=O)NC4(CC4)c3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM562610 (US11406645, Compound 503) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCC(C)(C)O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were dil...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W75
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM576082 (Compound 35 (4-(3-(1-(2,6-dichloro-3-fluorophenyl)...) Show SMILES CC(c1c(C)[nH]c2ncc(cc12)-c1cn(C)c(=O)c2[nH]ccc12)c1c(Cl)ccc(F)c1Cl Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2F192ZS
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM550496 (US11306105, Compound 200) Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(CC#N)sc2-n2c(C)nnc12)c1ccc(Cl)cc1 |r,c:6| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552031 (US11312726, Compound 2) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3C(=O)NCc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552038 (US11312726, Compound 9) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3NC(=O)C4(CC4)c3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552040 (US11312726, Compound 11) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3CS(=O)(=O)Cc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552048 (US11312726, Compound 19) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3CN(Cc3c1)S(C)(=O)=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552042 (US11312726, Compound 13) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)Nc1ccc3CS(=O)Cc3c1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM550487 (US11306105, Compound 103) Show SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(cc2)C#N)CC1 |r,c:13| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Acetyl-Histone Binding Assay. Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElme...				Citation and Details BindingDB Entry DOI: 10.7270/Q20K2CS3
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [44-167] (Homo sapiens (Human))	BDBM552037 (US11312726, Compound 8) Show SMILES Cc1nnc2[C@H](CC(=O)Nc3n[nH]c(=O)c4ccccc34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:23| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The experiment plate was a plate that contained a gradient concentration of the compound and a corresponding DMSO solution and was prepared with ECHO...				Citation and Details BindingDB Entry DOI: 10.7270/Q2ST7T12
					More data for this Ligand-Target Pair

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