Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267892 (CHEMBL4088092) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267888 (CHEMBL4104462) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267877 (CHEMBL4103576) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 234 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267890 (CHEMBL4085646) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267878 (CHEMBL4104019) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267889 (CHEMBL4080219) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267885 (CHEMBL4066274) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267884 (CHEMBL4086096) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267887 (CHEMBL4077592) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267886 (CHEMBL4093849) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267876 (CHEMBL4080740) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267862 (CHEMBL4075745) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267875 (CHEMBL4062751) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50267891 (CHEMBL4076474) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5B SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit... | Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM165192 (4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 340 | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig | Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect... | ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM165193 (4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 390 | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig | Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect... | ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50514407 (CHEMBL4483038) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated... | J Med Chem 63: 3817-3833 (2020) Article DOI: 10.1021/acs.jmedchem.9b01183 BindingDB Entry DOI: 10.7270/Q2NZ8C0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50240455 (CHEMBL1253351) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept... | Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50514413 (CHEMBL4555061) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated... | J Med Chem 63: 3817-3833 (2020) Article DOI: 10.1021/acs.jmedchem.9b01183 BindingDB Entry DOI: 10.7270/Q2NZ8C0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50000029 (4-Methyl-8-{4-methyl-3-[3-(3-{3-[2-methyl-5-(4,6,8...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept... | Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50118228 (5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL | Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to STAT5B SH2 domain (unknown origin) pre-incubated for 1 hr before fluorescent-labelled pept... | Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM50514414 (CHEMBL4439829) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Binding affinity to MBP-tagged recombinant STAT5b-SH2 domain (unknown origin) using carboxyfluoresceine-labeled phosphotyrosine octapeptide incubated... | J Med Chem 63: 3817-3833 (2020) Article DOI: 10.1021/acs.jmedchem.9b01183 BindingDB Entry DOI: 10.7270/Q2NZ8C0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 5B (Homo sapiens (Human)) | BDBM165191 (2-Methoxy-4-(nonanamidomethyl)phenyl dihydrogen ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 9.60E+4 | n/a | 1.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig | Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect... | ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G | |||||||||||
More data for this Ligand-Target Pair |