Found 829 hits of ic50 for UniProtKB: P22460 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235240
(CHEMBL4065169)Show SMILES CS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H21FN4O2S/c1-32(30,31)29-22-8-2-7-21(28-22)24(17-9-11-20(25)12-10-17)23(18-5-3-13-26-15-18)19-6-4-14-27-16-19/h2-16,23-24H,1H3,(H,28,29)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235240
(CHEMBL4065169)Show SMILES CS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H21FN4O2S/c1-32(30,31)29-22-8-2-7-21(28-22)24(17-9-11-20(25)12-10-17)23(18-5-3-13-26-15-18)19-6-4-14-27-16-19/h2-16,23-24H,1H3,(H,28,29)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology method |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235250
(CHEMBL4104525)Show SMILES O[C@H](C(c1cccnc1)c1cccnc1)c1cccnc1-c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C23H17Cl2N3O/c24-18-10-17(11-19(25)12-18)22-20(6-3-9-28-22)23(29)21(15-4-1-7-26-13-15)16-5-2-8-27-14-16/h1-14,21,23,29H/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 mediated ultra-rapid delayed rectifier current Ikur in human atrial myocytes by voltage-patch clamp electrophysiology method |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50301472
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)Show SMILES CC1=Nc2ccnn2C(C1c1nc2cc(F)ccc2n1C)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C21H16Cl2FN5/c1-11-19(21-27-16-10-13(24)4-6-17(16)28(21)2)20(29-18(26-11)7-8-25-29)12-3-5-14(22)15(23)9-12/h3-10,19-20H,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 19: 5469-73 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.083
BindingDB Entry DOI: 10.7270/Q24M94M6 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50194360
((E)-thyl-1-methyl-6,7-dihydro-1H-indol-4(5H)-one O...)Show SMILES CCc1c(CC)n(C)c2CCCC(=NOC(=O)Nc3ccccc3)c12 |w:13.13| Show InChI InChI=1S/C20H25N3O2/c1-4-15-17(5-2)23(3)18-13-9-12-16(19(15)18)22-25-20(24)21-14-10-7-6-8-11-14/h6-8,10-11H,4-5,9,12-13H2,1-3H3,(H,21,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay |
Bioorg Med Chem Lett 16: 5855-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.059
BindingDB Entry DOI: 10.7270/Q2057FJJ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50022107
(CHEMBL3298226)Show InChI InChI=1S/C20H22N2O/c1-20(2,16-9-5-4-6-10-16)14-22-19-18-15(12-13-21-19)8-7-11-17(18)23-3/h4-13H,14H2,1-3H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current |
Bioorg Med Chem Lett 24: 3018-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.035
BindingDB Entry DOI: 10.7270/Q2HH6MNP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50022108
(CHEMBL3298228)Show InChI InChI=1S/C19H21N3O2/c1-19(2,13-8-5-4-6-9-13)12-20-17-16-14(21-18(23)22-17)10-7-11-15(16)24-3/h4-11H,12H2,1-3H3,(H2,20,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current |
Bioorg Med Chem Lett 24: 3018-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.035
BindingDB Entry DOI: 10.7270/Q2HH6MNP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235255
(CHEMBL4085436)Show InChI InChI=1S/C23H18ClN3/c24-22-10-2-1-9-20(22)23-17(6-5-13-27-23)14-21(18-7-3-11-25-15-18)19-8-4-12-26-16-19/h1-13,15-16,21H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120918
(CHEMBL3356073)Show InChI InChI=1S/C18H20N2OS/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50022109
(CHEMBL3298224)Show InChI InChI=1S/C19H22N2S/c1-4-14-9-8-12-16-17(14)18(21-22-16)20-13-19(2,3)15-10-6-5-7-11-15/h5-12H,4,13H2,1-3H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current |
Bioorg Med Chem Lett 24: 3018-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.035
BindingDB Entry DOI: 10.7270/Q2HH6MNP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235259
(CHEMBL4105245)Show InChI InChI=1S/C23H17Cl2N3/c24-21-10-2-1-8-19(21)22-16(6-4-12-27-22)14-20(17-7-3-11-26-15-17)18-9-5-13-28-23(18)25/h1-13,15,20H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120913
(CHEMBL3622361)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)NC(=O)OCC(F)(F)F)c1ccccc1)=NS2(=O)=O |r,wU:14.18,11.11,c:34,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.72,5.28,;2.75,4.13,;1.18,7.89,;1.66,9.35,;2.87,9.6,;.63,10.5,;1.12,11.97,;.09,13.12,;.48,14.29,;-.73,14.04,;-1.11,12.87,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C24H26F3N3O5S/c1-34-18-8-5-9-19-20(18)21(30-36(19,32)33)28-14-23(16-6-3-2-4-7-16)12-10-17(11-13-23)29-22(31)35-15-24(25,26)27/h2-9,17H,10-15H2,1H3,(H,28,30)(H,29,31)/t17-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235250
(CHEMBL4104525)Show SMILES O[C@H](C(c1cccnc1)c1cccnc1)c1cccnc1-c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C23H17Cl2N3O/c24-18-10-17(11-19(25)12-18)22-20(6-3-9-28-22)23(29)21(15-4-1-7-26-13-15)16-5-2-8-27-14-16/h1-14,21,23,29H/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235275
(CHEMBL4062996)Show InChI InChI=1S/C23H18ClN3/c24-21-9-1-5-17(13-21)23-18(6-4-12-27-23)14-22(19-7-2-10-25-15-19)20-8-3-11-26-16-20/h1-13,15-16,22H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Tested for irreversible inhibitory activity against AdoMet-DC (S-adenosyl-methionine decarboxylase-) isolated from Escherichia coli |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50315563
(CHEMBL1088844 | {[(1S,2S,5R)-5-methyl-2-(propan-2-...)Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay |
Bioorg Med Chem Lett 20: 2493-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.005
BindingDB Entry DOI: 10.7270/Q2T153SV |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50301473
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)Show SMILES COCC1=Nc2ccnn2C(C1c1nc2cc(F)ccc2n1C)c1ccc(Cl)c(Cl)c1 |t:3| Show InChI InChI=1S/C22H18Cl2FN5O/c1-29-18-6-4-13(25)10-16(18)28-22(29)20-17(11-31-2)27-19-7-8-26-30(19)21(20)12-3-5-14(23)15(24)9-12/h3-10,20-21H,11H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 19: 5469-73 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.083
BindingDB Entry DOI: 10.7270/Q24M94M6 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120899
(CHEMBL3622355)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)OC(=O)Nc1ccc(cc1)N(C)C)c1ccccc1)=NS2(=O)=O |r,wU:14.18,11.11,c:39,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.72,5.28,;2.75,4.13,;1.18,7.89,;1.66,9.35,;2.87,9.6,;.63,10.5,;1.12,11.97,;.09,13.12,;.58,14.58,;2.09,14.89,;3.11,13.74,;2.63,12.28,;2.58,16.35,;3.78,16.6,;1.76,17.27,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C30H34N4O5S/c1-34(2)23-14-12-22(13-15-23)32-29(35)39-24-16-18-30(19-17-24,21-8-5-4-6-9-21)20-31-28-27-25(38-3)10-7-11-26(27)40(36,37)33-28/h4-15,24H,16-20H2,1-3H3,(H,31,33)(H,32,35)/t24-,30- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120908
(CHEMBL3623054)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)n1cnnn1)c1ccccc1)=NS2(=O)=O |r,wU:14.18,11.11,c:31,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.72,5.28,;2.75,4.13,;1.17,7.89,;1.52,9.38,;.19,10.15,;-.96,9.13,;-.34,7.72,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C22H24N6O3S/c1-31-18-8-5-9-19-20(18)21(25-32(19,29)30)23-14-22(16-6-3-2-4-7-16)12-10-17(11-13-22)28-15-24-26-27-28/h2-9,15,17H,10-14H2,1H3,(H,23,25)/t17-,22- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50099581
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r| Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 17: 3271-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235253
(CHEMBL4075394)Show SMILES FC(F)(F)Oc1cccc(c1)-c1ncccc1CC(c1cccnc1)c1cccnc1 Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)31-21-9-1-5-17(13-21)23-18(6-4-12-30-23)14-22(19-7-2-10-28-15-19)20-8-3-11-29-16-20/h1-13,15-16,22H,14H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120917
(CHEMBL3356074)Show SMILES COc1cccc2C(=O)N=C(NCC(C)(C)c3ccccc3)c12 |t:9| Show InChI InChI=1S/C19H20N2O2/c1-19(2,13-8-5-4-6-9-13)12-20-17-16-14(18(22)21-17)10-7-11-15(16)23-3/h4-11H,12H2,1-3H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120904
(CHEMBL3622346)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@H](O)CC1)c1ccccc1)=NS2(=O)=O |r,wU:14.15,11.11,c:26,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.38,7.66,;1.72,5.28,;2.75,4.13,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C21H24N2O4S/c1-27-17-8-5-9-18-19(17)20(23-28(18,25)26)22-14-21(12-10-16(24)11-13-21)15-6-3-2-4-7-15/h2-9,16,24H,10-14H2,1H3,(H,22,23)/t16-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50194539
(4-(3-(2-fluorophenyl)propanamido)-N,N-diisopropyl-...)Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)CCc1ccccc1F)c1ccccc1)c1cccnc1 Show InChI InChI=1S/C30H36FN3O2/c1-21(2)34(22(3)4)30(36)29(25-14-10-18-32-19-25)26(23-11-6-5-7-12-23)20-33-28(35)17-16-24-13-8-9-15-27(24)31/h5-15,18-19,21-22,26,29H,16-17,20H2,1-4H3,(H,33,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 |
Bioorg Med Chem Lett 16: 5897-901 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50430217
(CHEMBL2331989)Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCCC1)c1ccc(Cl)c(Cl)c1 |r,t:1| Show InChI InChI=1S/C20H20Cl2N6/c1-12-18(20-23-11-25-27(20)14-4-2-3-5-14)19(28-17(26-12)8-9-24-28)13-6-7-15(21)16(22)10-13/h6-11,14,18-19H,2-5H2,1H3/t18?,19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as... |
Bioorg Med Chem Lett 23: 1743-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.064
BindingDB Entry DOI: 10.7270/Q2QN685H |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50534219
(CHEMBL4521294)Show SMILES C(Nc1nc(nc2cccc(-c3ccccc3)c12)-c1ccncc1)c1ccccn1 Show InChI InChI=1S/C25H19N5/c1-2-7-18(8-3-1)21-10-6-11-22-23(21)25(28-17-20-9-4-5-14-27-20)30-24(29-22)19-12-15-26-16-13-19/h1-16H,17H2,(H,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 transfected in mouse LTK cells |
ACS Med Chem Lett 7: 831-4 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00117
BindingDB Entry DOI: 10.7270/Q2MK6HDX |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235254
(CHEMBL4095750)Show InChI InChI=1S/C24H21N3O/c1-28-22-10-2-6-18(14-22)24-19(7-5-13-27-24)15-23(20-8-3-11-25-16-20)21-9-4-12-26-17-21/h2-14,16-17,23H,15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50022110
(CHEMBL3298140)Show InChI InChI=1S/C18H20N2O2/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50022110
(CHEMBL3298140)Show InChI InChI=1S/C18H20N2O2/c1-18(2,13-8-5-4-6-9-13)12-19-17-16-14(21-3)10-7-11-15(16)22-20-17/h4-11H,12H2,1-3H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 expressed in mouse L929 cells assessed as inhibition of current |
Bioorg Med Chem Lett 24: 3018-22 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.035
BindingDB Entry DOI: 10.7270/Q2HH6MNP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50239227
(CHEMBL4094440 | US10214511, Example 7 | US10676460...)Show SMILES NS(=O)(=O)c1cncc(c1)-c1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1 Show InChI InChI=1S/C25H20N6O2S/c26-34(32,33)20-13-18(14-27-16-20)24-30-22-11-6-10-21(17-7-2-1-3-8-17)23(22)25(31-24)29-15-19-9-4-5-12-28-19/h1-14,16H,15H2,(H2,26,32,33)(H,29,30,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Kv1.5 expressed in mouse L929 cells by patch clamp assay |
J Med Chem 60: 3795-3803 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01889
BindingDB Entry DOI: 10.7270/Q24J0H85 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50376745
(CHEMBL260684)Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CCCc2ccc(cc12)N(Cc1cccc(C)n1)C(=O)CCc1ccccc1 Show InChI InChI=1S/C34H37N3O3S/c1-3-26-15-20-31(21-16-26)41(39,40)36-33-14-8-12-28-18-19-30(23-32(28)33)37(24-29-13-7-9-25(2)35-29)34(38)22-17-27-10-5-4-6-11-27/h4-7,9-11,13,15-16,18-21,23,33,36H,3,8,12,14,17,22,24H2,1-2H3/t33-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t... |
Bioorg Med Chem Lett 18: 2714-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.026
BindingDB Entry DOI: 10.7270/Q2QC04DZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120907
(CHEMBL3623053)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)Nc1ncccn1)c1ccccc1)=NS2(=O)=O |r,wU:14.18,11.11,c:33,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.72,5.28,;2.75,4.13,;1.18,7.89,;1.66,9.35,;.64,10.51,;1.12,11.97,;2.63,12.28,;3.65,11.13,;3.17,9.66,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C25H27N5O3S/c1-33-20-9-5-10-21-22(20)23(30-34(21,31)32)28-17-25(18-7-3-2-4-8-18)13-11-19(12-14-25)29-24-26-15-6-16-27-24/h2-10,15-16,19H,11-14,17H2,1H3,(H,28,30)(H,26,27,29)/t19-,25- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50430216
(CHEMBL2331990)Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCC1)c1ccc(Cl)c(Cl)c1 |r,t:1| Show InChI InChI=1S/C19H18Cl2N6/c1-11-17(19-22-10-24-26(19)13-3-2-4-13)18(27-16(25-11)7-8-23-27)12-5-6-14(20)15(21)9-12/h5-10,13,17-18H,2-4H2,1H3/t17?,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as... |
Bioorg Med Chem Lett 23: 1743-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.064
BindingDB Entry DOI: 10.7270/Q2QN685H |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50301471
(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-propyl-1H-ben...)Show SMILES CCCn1c(nc2cc(F)ccc12)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:32| Show InChI InChI=1S/C23H20Cl2FN5/c1-3-10-30-19-7-5-15(26)12-18(19)29-23(30)21-13(2)28-20-8-9-27-31(20)22(21)14-4-6-16(24)17(25)11-14/h4-9,11-12,21-22H,3,10H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 19: 5469-73 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.083
BindingDB Entry DOI: 10.7270/Q24M94M6 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50099581
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r| Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t... |
Bioorg Med Chem Lett 18: 2714-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.026
BindingDB Entry DOI: 10.7270/Q2QC04DZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50306906
(((R)-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCC[C@H]1c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |r,t:1| Show InChI InChI=1S/C24H21Cl2FN4O/c1-14-22(24(32)30-12-2-3-20(30)15-4-7-17(27)8-5-15)23(31-21(29-14)10-11-28-31)16-6-9-18(25)19(26)13-16/h4-11,13,20,22-23H,2-3,12H2,1H3/t20-,22?,23+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 20: 1436-9 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50534225
(CHEMBL4450487)Show InChI InChI=1S/C21H15N5/c22-13-19-25-18-11-6-10-17(15-7-2-1-3-8-15)20(18)21(26-19)24-14-16-9-4-5-12-23-16/h1-12H,14H2,(H,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 transfected in mouse LTK cells |
ACS Med Chem Lett 7: 831-4 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00117
BindingDB Entry DOI: 10.7270/Q2MK6HDX |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50534218
(CHEMBL4532101)Show SMILES C(Nc1nc(nc2cccc(-c3ccccc3)c12)-c1cncs1)c1ccccn1 Show InChI InChI=1S/C23H17N5S/c1-2-7-16(8-3-1)18-10-6-11-19-21(18)23(26-13-17-9-4-5-12-25-17)28-22(27-19)20-14-24-15-29-20/h1-12,14-15H,13H2,(H,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 transfected in mouse LTK cells |
ACS Med Chem Lett 7: 831-4 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00117
BindingDB Entry DOI: 10.7270/Q2MK6HDX |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120916
(CHEMBL3623052)Show SMILES CCN(CC)S(=O)(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1 |r,wU:9.8,12.12,t:15,(.3,12.89,;1.12,11.97,;.63,10.5,;-.87,10.19,;-1.69,11.11,;1.66,9.35,;2.87,9.6,;2.48,8.44,;1.18,7.89,;2.2,6.74,;3.71,7.06,;4.74,5.91,;4.23,4.48,;3.75,3.01,;2.24,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.02,3.09,;-2.09,3.71,;.3,.77,;2.75,4.13,;1.72,5.28,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,)| Show InChI InChI=1S/C25H34N4O5S2/c1-4-29(5-2)36(32,33)27-20-14-16-25(17-15-20,19-10-7-6-8-11-19)18-26-24-23-21(34-3)12-9-13-22(23)35(30,31)28-24/h6-13,20,27H,4-5,14-18H2,1-3H3,(H,26,28)/t20-,25- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120903
(CHEMBL3622360)Show SMILES COc1cccc2c1C(NC[C@@]1(CC[C@@H](CC1)NC(=O)OC(C)C)c1ccccc1)=NS2(=O)=O |r,wU:14.18,11.11,c:32,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.72,5.28,;2.75,4.13,;1.18,7.89,;1.66,9.35,;2.87,9.6,;.63,10.5,;1.12,11.97,;.3,12.89,;2.32,12.22,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)| Show InChI InChI=1S/C25H31N3O5S/c1-17(2)33-24(29)27-19-12-14-25(15-13-19,18-8-5-4-6-9-18)16-26-23-22-20(32-3)10-7-11-21(22)34(30,31)28-23/h4-11,17,19H,12-16H2,1-3H3,(H,26,28)(H,27,29)/t19-,25- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120901
(CHEMBL3622358)Show SMILES CCOC(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1 |r,wU:6.5,9.9,t:12,(.3,12.89,;1.12,11.97,;.63,10.5,;1.66,9.35,;2.87,9.6,;1.18,7.89,;2.2,6.74,;3.71,7.06,;4.74,5.91,;4.23,4.48,;3.75,3.01,;2.24,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.02,3.09,;-2.09,3.71,;.3,.77,;2.75,4.13,;1.72,5.28,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,)| Show InChI InChI=1S/C24H29N3O5S/c1-3-32-23(28)26-18-12-14-24(15-13-18,17-8-5-4-6-9-17)16-25-22-21-19(31-2)10-7-11-20(21)33(29,30)27-22/h4-11,18H,3,12-16H2,1-2H3,(H,25,27)(H,26,28)/t18-,24- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50235260
(CHEMBL4088894)Show SMILES Nc1cccc(n1)C(Cc1cccnc1-c1cccc(c1)C(F)(F)F)c1cccnc1 Show InChI InChI=1S/C24H19F3N4/c25-24(26,27)19-8-1-5-16(13-19)23-17(6-4-12-30-23)14-20(18-7-3-11-29-15-18)21-9-2-10-22(28)31-21/h1-13,15,20H,14H2,(H2,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 (unknown origin) |
Bioorg Med Chem Lett 27: 1062-1069 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.054
BindingDB Entry DOI: 10.7270/Q2DV1N5F |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50301469
(6-(5-chloro-1-ethyl-1H-benzo[d]imidazol-2-yl)-7-(3...)Show SMILES CCn1c(nc2cc(Cl)ccc12)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:31| Show InChI InChI=1S/C22H18Cl3N5/c1-3-29-18-7-5-14(23)11-17(18)28-22(29)20-12(2)27-19-8-9-26-30(19)21(20)13-4-6-15(24)16(25)10-13/h4-11,20-21H,3H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 19: 5469-73 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.083
BindingDB Entry DOI: 10.7270/Q24M94M6 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50211550
((3S,4R)-4-(N-butyl-4-ethylphenylsulfonamido)-3-hyd...)Show SMILES CCCCN([C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1)S(=O)(=O)c1ccc(CC)cc1 Show InChI InChI=1S/C32H40N2O5S/c1-5-7-21-34(40(37,38)26-16-13-23(6-2)14-17-26)29-27-22-25(15-18-28(27)39-32(3,4)30(29)35)31(36)33-20-19-24-11-9-8-10-12-24/h8-18,22,29-30,35H,5-7,19-21H2,1-4H3,(H,33,36)/t29-,30+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells |
Bioorg Med Chem Lett 17: 3271-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50430219
(CHEMBL2331987)Show SMILES CC1=Nc2ccnn2[C@@H](C1c1ncnn1C1CCCCC1)c1ccc(Cl)c(Cl)c1 |r,t:1| Show InChI InChI=1S/C21H22Cl2N6/c1-13-19(21-24-12-26-28(21)15-5-3-2-4-6-15)20(29-18(27-13)9-10-25-29)14-7-8-16(22)17(23)11-14/h7-12,15,19-20H,2-6H2,1H3/t19?,20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Antagonist activity at human Kv1.5 expressed in mouse L929 cells assessed as inhibition of delayed rectifier repolarization current by patch clamp as... |
Bioorg Med Chem Lett 23: 1743-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.01.064
BindingDB Entry DOI: 10.7270/Q2QN685H |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50211535
(CHEMBL387993 | N-((3S,4R)-6-((S)-2-((2,6-dimethylp...)Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30+,31-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells assessed as blockade of ultra rapidly activating potassium current by volatge clamp t... |
Bioorg Med Chem Lett 18: 2714-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.026
BindingDB Entry DOI: 10.7270/Q2QC04DZ |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50239231
(CHEMBL4099807)Show SMILES C(Nc1nc(nc2cccc(-c3ccccc3)c12)-c1cccnc1)c1ccccn1 Show InChI InChI=1S/C25H19N5/c1-2-8-18(9-3-1)21-12-6-13-22-23(21)25(28-17-20-11-4-5-15-27-20)30-24(29-22)19-10-7-14-26-16-19/h1-16H,17H2,(H,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Kv1.5 expressed in mouse L929 cells by patch clamp assay |
J Med Chem 60: 3795-3803 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01889
BindingDB Entry DOI: 10.7270/Q24J0H85 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50120914
(CHEMBL3622362)Show SMILES CCS(=O)(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1 |r,wU:6.5,9.9,t:12,(1.02,11.67,;.63,10.5,;1.66,9.35,;2.87,9.6,;2.48,8.44,;1.18,7.89,;2.2,6.74,;3.71,7.06,;4.74,5.91,;4.23,4.48,;3.75,3.01,;2.24,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.02,3.09,;-2.09,3.71,;.3,.77,;2.75,4.13,;1.72,5.28,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,)| Show InChI InChI=1S/C23H29N3O5S2/c1-3-32(27,28)25-18-12-14-23(15-13-18,17-8-5-4-6-9-17)16-24-22-21-19(31-2)10-7-11-20(21)33(29,30)26-22/h4-11,18,25H,3,12-16H2,1-2H3,(H,24,26)/t18-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude |
Bioorg Med Chem Lett 25: 4983-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50239231
(CHEMBL4099807)Show SMILES C(Nc1nc(nc2cccc(-c3ccccc3)c12)-c1cccnc1)c1ccccn1 Show InChI InChI=1S/C25H19N5/c1-2-8-18(9-3-1)21-12-6-13-22-23(21)25(28-17-20-11-4-5-15-27-20)30-24(29-22)19-10-7-14-26-16-19/h1-16H,17H2,(H,28,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 transfected in mouse LTK cells |
ACS Med Chem Lett 7: 831-4 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00117
BindingDB Entry DOI: 10.7270/Q2MK6HDX |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50199068
(3-cyano-N-(2-hydroxyethyl)-6-methoxy-4-phenylisoqu...)Show SMILES COc1ccc2c(nc(C#N)c(-c3ccccc3)c2c1)C(=O)NCCO Show InChI InChI=1S/C20H17N3O3/c1-26-14-7-8-15-16(11-14)18(13-5-3-2-4-6-13)17(12-21)23-19(15)20(25)22-9-10-24/h2-8,11,24H,9-10H2,1H3,(H,22,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human Kv1.5 channel expressed in CHO cell membrane by HT clamp assay |
J Med Chem 49: 6954-7 (2006)
Article DOI: 10.1021/jm060927v
BindingDB Entry DOI: 10.7270/Q2ST7PG7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50523773
(CHEMBL4475999)Show SMILES CCCN(CCC)[C@@H]([C@H](N(CCC)C[C@H](O)CO)c1ccccn1)c1ccccn1 |r| Show InChI InChI=1S/C24H38N4O2/c1-4-15-27(16-5-2)23(21-11-7-9-13-25-21)24(22-12-8-10-14-26-22)28(17-6-3)18-20(30)19-29/h7-14,20,23-24,29-30H,4-6,15-19H2,1-3H3/t20-,23+,24+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Kv1.5 in human atrial myocytes assessed as blockade of Ikur current |
Bioorg Med Chem Lett 29: 1241-1245 (2019)
Article DOI: 10.1016/j.bmcl.2019.03.006
BindingDB Entry DOI: 10.7270/Q2J67MCP |
More data for this
Ligand-Target Pair | |
Search and Browse
