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Compile Data Set for Download or QSAR

Found 5 hits of ki for UniProtKB: P67870   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase II subunit alpha'/beta


(Homo sapiens (Human))
BDBM50335638
PNG
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
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0.220n/an/an/an/an/an/an/an/a



Cylene Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CK2alpha/CK2beta using RRRDDDSDDD peptide as substrate by radiometric assay


Bioorg Med Chem Lett 22: 45-8 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.087
BindingDB Entry DOI: 10.7270/Q24Q7XV4
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Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase II subunit alpha'/beta


(Homo sapiens (Human))
BDBM50530315
PNG
(CHEMBL4520531)
Show SMILES OC(=O)c1ccc(Nc2nc(cs2)-c2ccc3ccccc3c2)cc1O
Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25)
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86n/an/an/an/an/an/an/an/a



Universit£t zu K£ln

Curated by ChEMBL


Assay Description
ATP competitive inhibition of recombinant human CK2alpha2 (1 to 335 residues)/CK2beta2 (1 to 193 residues) expressed in Escherichia coli BL21(DE3) us...


J Med Chem 63: 7766-7772 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00587
BindingDB Entry DOI: 10.7270/Q24M9834
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase II subunit alpha'/beta


(Homo sapiens (Human))
BDBM50540033
PNG
(CHEMBL4635554)
Show SMILES OC(=O)c1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C16H11ClN2O3S/c17-10-3-1-9(2-4-10)13-8-23-16(19-13)18-11-5-6-12(15(21)22)14(20)7-11/h1-8,20H,(H,18,19)(H,21,22)
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206n/an/an/an/an/an/an/an/a



Universit£t zu K£ln

Curated by ChEMBL


Assay Description
ATP competitive inhibition of recombinant human CK2alpha2 (1 to 335 residues)/CK2beta2 (1 to 193 residues) expressed in Escherichia coli BL21(DE3) us...


J Med Chem 63: 7766-7772 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00587
BindingDB Entry DOI: 10.7270/Q24M9834
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase II subunit alpha/beta


(Homo sapiens (Human)-Rattus norvegicus (Rat))
BDBM50156369
PNG
(CHEMBL227370)
Show SMILES FC(F)(F)c1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Show InChI InChI=1S/C8HBr4F3N2/c9-1-2(10)4(12)6-5(3(1)11)16-7(17-6)8(13,14)15/h(H,16,17)
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600n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Rattus norvegicus (rat) liver cytosolic CK2


Citation and Details

Article DOI: 10.1007/s00044-010-9533-9
BindingDB Entry DOI: 10.7270/Q2C2509N
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'/beta


(Homo sapiens (Human))
BDBM50540034
PNG
(CHEMBL4647986)
Show SMILES OC(=O)c1cccc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C15H11N3O2S/c19-14(20)10-4-3-5-11(8-10)17-15-18-13(9-21-15)12-6-1-2-7-16-12/h1-9H,(H,17,18)(H,19,20)
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1.47E+3n/an/an/an/an/an/an/an/a



Universit£t zu K£ln

Curated by ChEMBL


Assay Description
ATP competitive inhibition of recombinant human CK2alpha2 (1 to 335 residues)/CK2beta2 (1 to 193 residues) expressed in Escherichia coli BL21(DE3) us...


J Med Chem 63: 7766-7772 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00587
BindingDB Entry DOI: 10.7270/Q24M9834
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)