Found 32 hits for monomerid = 50530315 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Casein kinase II alpha'/ beta
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t zu K£ln
Curated by ChEMBL
| Assay Description ATP competitive inhibition of recombinant human CK2alpha2 (1 to 335 residues)/CK2beta2 (1 to 193 residues) expressed in Escherichia coli BL21(DE3) us... |
J Med Chem 63: 7766-7772 (2020)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha... |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha... |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase 2
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit beta (CK2 beta)
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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PC cid PC sid PDB UniChem
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit beta (CK2 beta)
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha 3
(Homo sapiens) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysis |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assay |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50530315
(CHEMBL4520531)Show InChI InChI=1S/C20H14N2O3S/c23-18-10-15(7-8-16(18)19(24)25)21-20-22-17(11-26-20)14-6-5-12-3-1-2-4-13(12)9-14/h1-11,23H,(H,21,22)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assay relative to control |
J Med Chem 62: 1817-1836 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01765 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |