Compile Data Set for Download or QSAR

Found 64 hits of ic50 for UniProtKB: P04629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515356 ((13E,14E,22R,24S)-12-amino-24,35- difluoro-4-oxa-7...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515377 ((13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515357 ((13E,14E,22R,24S,5S)-12-amino-24,35-difluoro- 5-me...) Show SMILES C[C@H]1CNC(=O)c2c(N)nn3ccc(nc23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515375 ((13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCC(F)(F)COc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515361 ((13E,14E,22R,24S,6R)-12-amino-24, 35-difluoro-6-me...) Show SMILES C[C@@H]1COc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515360 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 6,6-dim...) Show SMILES CC1(C)CNC(=O)c2c(N)nn3ccc(nc23)N2C[C@@H](F)CC2c2cc(F)cnc2OC1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515372 ((13E,14E,22R,5S)-12-amino-35- fluoro-5-methyl-4-ox...) Show SMILES C[C@H]1CNC(=O)c2c(N)nn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2O1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647635 (T-05 | US20240025908, Example 3) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NOCCN3)c2n1)c1cc(F)cc(F)c1F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647639 (T-17 | US20240025908, Example 7) Show SMILES COc1ccc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1 |r,t:20| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647640 (T-36 | US20240025908, Example 8) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)cc(F)c1F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647642 (T-42 | US20240025908, Example 10) Show SMILES COc1ncc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1 |r,t:20| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647638 (T-12 | US20240025908, Example 6) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)ccc1OC(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647641 (T-37 | US20240025908, Example 9) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NOCCN3)c2n1)c1cc(F)ccc1OC(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515358 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 4-oxa-9...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515354 (US11098060, Example 12 | US11098060, Example 34) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515354 (US11098060, Example 12 | US11098060, Example 34) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM472735 (2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...) Show SMILES Nc1nn2ccc(nc2c1C(=O)N[C@H]1CC[C@H](O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F |r,wU:13.14,wD:24.28,16.18,(3.91,3.31,;2.44,2.83,;1.2,3.74,;-.05,2.83,;-1.56,3.15,;-2.59,2.01,;-2.11,.54,;-.6,.22,;.43,1.37,;1.97,1.37,;2.87,.12,;2.24,-1.29,;4.4,.28,;5.31,-.96,;6.84,-.8,;7.74,-2.05,;7.12,-3.46,;8.02,-4.7,;5.59,-3.62,;4.68,-2.37,;-3.14,-.6,;-2.67,-2.07,;-3.91,-2.97,;-5.16,-2.07,;-4.68,-.6,;-5.59,.64,;-4.96,2.05,;-5.87,3.3,;-5.24,4.7,;-7.4,3.13,;-8.02,1.73,;-7.12,.48,;-7.74,-.92,)| Show InChI InChI=1S/C23H26F2N6O2/c24-13-3-8-17(25)16(12-13)18-2-1-10-30(18)19-9-11-31-22(28-19)20(21(26)29-31)23(33)27-14-4-6-15(32)7-5-14/h3,8-9,11-12,14-15,18,32H,1-2,4-7,10H2,(H2,26,29)(H,27,33)/t14-,15-,18-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...				US Patent US10829492 (2020) BindingDB Entry DOI: 10.7270/Q2RB77QV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515367 (US11098060, Example 26) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515373 ((R,13E,14E)-12-amino-35-fluoro- 4-oxa-7-aza-1(5,3)...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515350 ((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515345 (US11098060, Example 1) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1C1CCCN31 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.68	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515363 (US11098060, Example 21) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.71	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515346 ((13E,14E)-12-amino-35-fluoro-4-oxa-8-aza-1 (5,3)-p...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1C1CCCN31 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.86	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515368 ((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.89	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515365 (US11098060, Example 23) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCn1cc(F)cc([C@H]2C[C@H](F)CN32)c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.39	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515352 ((R,13E,14E)-12-amino-35-fluro-4-oxa-8-aza- 1(5,3)-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ccc(F)cc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515371 ((13E,14E,22R,24S)-12-amino- 24,35-difluoro-8-aza-1...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCCc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.43	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647652 (US20240025908, Example 20) Show SMILES COc1c(F)cc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1 |r,t:21| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647653 (US20240025908, Example 21) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)ccc1OC(F)(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647654 (US20240025908, Example 22) Show SMILES CCOc1ncc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NOCCN3)c2n1 |r,t:21| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647655 (US20240025908, Example 23) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)cnc1OCC(F)(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647657 (US20240025908, Example 25) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NC(=O)C(C)(C)N3)c2n1)c1cc(F)cnc1OC(F)(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647658 (US20240025908, Example 26) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NOCCN3)c2n1)c1cc(F)ccc1OC(F)(F)F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647636 (T-07 | US20240025908, Example 4) Show SMILES C[C@@H](Nc1ccn2ncc(C3=NOCC(C)(C)N3)c2n1)c1cc(F)cc(F)c1F |r,t:10| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647634 (T-02 | US20240025908, Example 2) Show SMILES C[C@@H](Nc1ccn2ncc(NC3=NC(C)(C)CO3)c2n1)c1cc(F)cc(F)c1F |r,t:11| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM647633 (T-01 | US20240025908, Example 1) Show SMILES COc1ccc(F)cc1[C@@H](C)Nc1ccn2ncc(NC3=NC(C)(C)CO3)c2n1 |r,t:21| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515370 ((13E,14E,22R,24S,6S)-12-amino- 24,35-difluoro-6-me...) Show SMILES C[C@H]1CCc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515349 ((R,13E,14E)-12-amino-4-oxa-8-aza-1(5,3)- pyrazolo[...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncccc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.61	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515351 ((13E,14E,22R,24R)-12-amino-35fluoro-24- hydroxy-4-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncc(F)cc1[C@H]1C[C@@H](O)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.74	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515359 ((13E,14E,22R,24S)-12-amino-24,35-difluoro- 8-methy...) Show SMILES CN1CCCOc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C1=O)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.07	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515376 ((13E,14E,22R,24R)-12-amino-35- fluoro-24-hydroxy-4...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1C[C@@H](O)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM472762 (2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...) Show SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H17F3N6O/c1-23-18(28)15-16(22)25-27-5-4-14(24-17(15)27)26-8-10(20)7-13(26)11-6-9(19)2-3-12(11)21/h2-6,10,13H,7-8H2,1H3,(H2,22,25)(H,23,28)/t10-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...				US Patent US10829492 (2020) BindingDB Entry DOI: 10.7270/Q2RB77QV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM472759 (2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...) Show SMILES NC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H15F3N6O/c18-8-1-2-11(20)10(5-8)12-6-9(19)7-25(12)13-3-4-26-17(23-13)14(16(22)27)15(21)24-26/h1-5,9,12H,6-7H2,(H2,21,24)(H2,22,27)/t9-,12+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...				US Patent US10829492 (2020) BindingDB Entry DOI: 10.7270/Q2RB77QV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515348 ((R,13E,14E)-12-amino-4-oxa-7-aza-1(5,3)- pyrazolo[...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ncccc1[C@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515364 (US11098060, Example 22) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCn1cc(F)cc([C@H]2CCCN32)c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515369 ((13E,14E,22R,6R)-12-amino-35- fluoro-6-methyl-7-az...) Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3nc(N)c(C(=O)N1)c3n2 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515355 ((13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1C1C[C@@H](F)CN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515362 (US11098060, Example 20) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@@H]1CCCN31 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515366 ((13E,14E)-12-amino-35-fluoro-31,32-dihydro-7- aza-...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCn1cc(F)cc(C2CCCN32)c1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human))	BDBM515347 ((13E,14E)-12-amino-4-oxa-8-aza-1(5,3)- pyrazolo[1,...) Show SMILES Nc1nn2ccc3nc2c1C(=O)NCCCCc1cccc(n1)C1CCCN31 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...				Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK
					More data for this Ligand-Target Pair

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