Compile Data Set for Download or QSAR

Found 108 hits Enz. Inhib. hit(s) with all data for entry = 10064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511610 (US11059801, Compound dBET18) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCN1CCN(CC1)C(=O)CCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.57	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM50544938 (CHEMBL4094346 | US11059801, Compound dBET1) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	3.09	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511611 (US11059801, Compound dBET19) Show SMILES Cc1nnc2[C@H](CC(=O)NCCCCNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(CC#N)sc3-n12)c1ccc(Cl)cc1 |r,c:41| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.62	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511608 (US11059801, Compound dBET16) Show SMILES COc1cc(ccc1Nc1ccc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.84	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511621 (US11059801, Compound dBET29) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCOc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.05	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511609 (US11059801, Compound dBET17) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(cc1)C#N |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511627 (US11059801, Compound dBET35) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)CNc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511594 (US11059801, Compound dBET2) Show SMILES CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NCCCCNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2N(C)C1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511616 (US11059801, Compound dBET24) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCOCCOCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511595 (US11059801, Compound dBET3) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511605 (US11059801, Compound dBET13) Show SMILES Cc1noc(C)c1-c1ccc(cc1)-c1nc2cnccn2c1NCC(=O)NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511610 (US11059801, Compound dBET18) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCN1CCN(CC1)C(=O)CCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511664 (US11059801, Compound D-31) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2c1cccc2NCc1ccco1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511606 (US11059801, Compound dBET14) Show SMILES Cc1noc(C)c1-c1ccc(cc1)-c1nc2cnccn2c1NCC(=O)NCCCOCCOCCOCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511602 (US11059801, Compound dBET10) Show SMILES CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NCCCOCCOCCOCCCNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2N(C)C1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511629 (US11059801, Compound dBET37) Show SMILES Cc1nnc2[C@H](CC(=O)NCCCCCC(=O)NCc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:41| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511598 (US11059801, Compound dBET6) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511601 (US11059801, Compound dBET9) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCOCCOCCOCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511601 (US11059801, Compound dBET9) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCOCCOCCOCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511663 (US11059801, Compound D-30) Show SMILES CC(C)(C)OC(=O)NCCNc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511620 (US11059801, Compound dBET28) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCOc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM50544938 (CHEMBL4094346 | US11059801, Compound dBET1) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511665 (US11059801, Compound D-32) Show SMILES ClCC(=O)Nc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511604 (US11059801, Compound dBET12) Show SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)NCCCOCCOCCOCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511634 (US11059801, Compound dBET43) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCC(=O)Nc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511603 (US11059801, Compound dBET11) Show SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511652 (US11059801, Compound D-18) Show SMILES CC(C)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511622 (US11059801, Compound dBET30) Show SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(sc3-n3c(C)nnc23)C(=O)NCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c2ccc(Cl)cc2)CC1 |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511623 (US11059801, Compound dBET31) Show SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(sc3-n3c(C)nnc23)C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c2ccc(Cl)cc2)CC1 |r,c:13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511615 (US11059801, Compound dBET23) Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCCCCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc(Cl)cc1 |r,c:6| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	26.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511633 (US11059801, Compound dBET42) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCC(=O)Nc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511614 (US11059801, Compound dBET22) Show SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc(Cl)cc1 |r,c:6| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511638 (US11059801, Compound D-1 | US11059801, Compound D-...) Show SMILES Oc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	28.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511635 (US11059801, Compound dBET44) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCC(=O)Nc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511607 (US11059801, Compound dBET15) Show SMILES Cc1nnc2[C@H](CC(=O)NCCCCCCNC(=O)c3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:41| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511630 (US11059801, Compound dBET38) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCOCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511595 (US11059801, Compound dBET3) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511597 (US11059801, Compound dBET5) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511600 (US11059801, Compound dBET8) Show SMILES CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NCCCCCCCCNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2N(C)C1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511613 (US11059801, Compound dBET21) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCOc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511661 (US11059801, Compound D-28) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(NCc3ccco3)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511607 (US11059801, Compound dBET15) Show SMILES Cc1nnc2[C@H](CC(=O)NCCCCCCNC(=O)c3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:41| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511619 (US11059801, Compound dBET27) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCOCCOc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511609 (US11059801, Compound dBET17) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(cc1)C#N |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511658 (US11059801, Compound D-25) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(NCc3ccccc3)ccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	58.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511632 (US11059801, Compound dBET41) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCc1ccc(CNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511650 (US11059801, Compound D-16) Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2c1cccc2NCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	71.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511628 (US11059801, Compound dBET36) Show SMILES Cc1nnc2[C@H](CC(=O)NCCCCNC(=O)Cc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:40| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511602 (US11059801, Compound dBET10) Show SMILES CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NCCCOCCOCCOCCCNC(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2N(C)C1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
					More data for this Ligand-Target Pair

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