BDBM65456 19171-19-8::4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione::Actimid::CC-4047::Pomalyst::US9694015, 6.2::pomalidomide

SMILES: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI Key: InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N

Data: 1 KI  11 IC50

PDB links: 6 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 65456   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay				J Med Chem 62: 6615-6629 (2019) Article DOI: 10.1021/acs.jmedchem.9b00454
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
CRBN-DDB1 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.0	n/a
Celgene Corporation					Assay Description The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...				J Med Chem 61: 535-542 (2017) Article DOI: 10.1021/acs.jmedchem.6b01921 BindingDB Entry DOI: 10.7270/Q2PC30HG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Interleukin-6 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase cytosolic (Leishmania mexicana)	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
hIL-1beta (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
Granulocyte-macrophage colony-stimulating factor (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
Mediator of DNA damage checkpoint protein 1 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
C-C motif chemokine 3 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
C-C motif chemokine 4 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	DrugBank US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	37
Celgene Corporation US Patent					Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...				US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN
					More data for this Ligand-Target Pair
PD-1/PD-L1 (Homo sapiens-Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem		n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	2.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
CRBN-DDB1 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair				3D Structure (crystal)
CRBN-DDB1 (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	8.0	70
Celgene					Assay Description Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM65456 (19171-19-8 | 4-amino-2-(2,6-dioxopiperidin-3-yl)is...) Show SMILES Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 Show InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene					Assay Description To measure compound binding to endogenous CRBN.				Leukemia 26: 2326-35 (2012) Article DOI: 10.1038/leu.2012.119 BindingDB Entry DOI: 10.7270/Q26971RH
					More data for this Ligand-Target Pair				3D Structure (crystal)