Compile Data Set for Download or QSAR

Found 26 hits Enz. Inhib. hit(s) with all data for entry = 6636   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142416 (US8927738, 2-[2-(2-Furan-3-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccoc3)nn12 Show InChI InChI=1S/C16H16N6O/c1-10-7-17-11(2)16-20-14(21-22(10)16)4-3-13-8-18-15(19-13)12-5-6-23-9-12/h5-9H,3-4H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142410 (US8927738, 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-i...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cccs3)nc12 Show InChI InChI=1S/C17H17N5S/c1-11-5-6-12(2)22-17(11)20-15(21-22)8-7-13-10-18-16(19-13)14-4-3-9-23-14/h3-6,9-10H,7-8H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142414 (US8927738, 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-i...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C16H16N6S/c1-10-8-17-11(2)16-20-14(21-22(10)16)6-5-12-9-18-15(19-12)13-4-3-7-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142412 (US8927738, 2-[2-(2-Furan-2-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3ccco3)nc12 Show InChI InChI=1S/C17H17N5O/c1-11-5-6-12(2)22-17(11)20-15(21-22)8-7-13-10-18-16(19-13)14-4-3-9-23-14/h3-6,9-10H,7-8H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142415 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-2-yl-1H-im...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3nccs3)nn12 Show InChI InChI=1S/C15H15N7S/c1-9-7-17-10(2)14-20-12(21-22(9)14)4-3-11-8-18-13(19-11)15-16-5-6-23-15/h5-8H,3-4H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142413 (US8927738, 2-[2-(2-Furan-3-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3ccoc3)nc12 Show InChI InChI=1S/C17H17N5O/c1-11-3-4-12(2)22-17(11)20-15(21-22)6-5-14-9-18-16(19-14)13-7-8-23-10-13/h3-4,7-10H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142409 (US8927738, 2-[2-(2-Furan-2-yl-1-methyl-1H-imidazol...) Show SMILES Cc1ccc(C)n2nc(CCc3cn(C)c(n3)-c3ccco3)nc12 Show InChI InChI=1S/C18H19N5O/c1-12-6-7-13(2)23-17(12)20-16(21-23)9-8-14-11-22(3)18(19-14)15-5-4-10-24-15/h4-7,10-11H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142417 (US8927738, 2-[2-(2-Furan-2-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccco3)nn12 Show InChI InChI=1S/C16H16N6O/c1-10-8-17-11(2)16-20-14(21-22(10)16)6-5-12-9-18-15(19-12)13-4-3-7-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50397979 (CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142406 (US8927738, 2-[2-(2-Furan-2-yl-1-methyl-1H-imidazol...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3ccco3)nn12 Show InChI InChI=1S/C17H18N6O/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142411 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-2-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3nccs3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-15(10)20-13(21-22)6-5-12-9-18-14(19-12)16-17-7-8-23-16/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142404 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-5-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cncs3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-16(10)20-14(21-22)6-5-12-7-18-15(19-12)13-8-17-9-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142407 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-4-yl-1H-im...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3cscn3)nn12 Show InChI InChI=1S/C15H15N7S/c1-9-5-16-10(2)15-20-13(21-22(9)15)4-3-11-6-17-14(19-11)12-7-23-8-18-12/h5-8H,3-4H2,1-2H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142408 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-4-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cscn3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-16(10)20-14(21-22)6-5-12-7-17-15(19-12)13-8-23-9-18-13/h3-4,7-9H,5-6H2,1-2H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142418 (US8927738, 5,8-Dimethyl-2-{2-[1-methyl-2-(5-methyl...) Show SMILES Cc1ccc(o1)-c1nc(CCc2nc3c(C)ncc(C)n3n2)cn1C Show InChI InChI=1S/C18H20N6O/c1-11-9-19-13(3)17-21-16(22-24(11)17)8-6-14-10-23(4)18(20-14)15-7-5-12(2)25-15/h5,7,9-10H,6,8H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142399 (US8927738, 5,8-Dimethyl-2-[2-(2-phenyl-1H-imidazol...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H18N6/c1-12-10-19-13(2)18-22-16(23-24(12)18)9-8-15-11-20-17(21-15)14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142396 (US8927738, 8-Methoxy-5-methyl-2-[2-(2-phenyl-1H-im...) Show SMILES COc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3ccccc3)nc12 Show InChI InChI=1S/C19H19N5O/c1-13-8-10-16(25-2)19-22-17(23-24(13)19)11-9-15-12-20-18(21-15)14-6-4-3-5-7-14/h3-8,10,12H,9,11H2,1-2H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142403 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-5-yl-1H-im...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3cncs3)nn12 Show InChI InChI=1S/C15H15N7S/c1-9-5-17-10(2)15-20-13(21-22(9)15)4-3-11-6-18-14(19-11)12-7-16-8-23-12/h5-8H,3-4H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142402 (US8927738, 5,8-Dimethyl-2-[2-(1-methyl-2-thiazol-2...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3nccs3)nn12 Show InChI InChI=1S/C16H17N7S/c1-10-8-18-11(2)14-20-13(21-23(10)14)5-4-12-9-22(3)15(19-12)16-17-6-7-24-16/h6-9H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142401 (US8927738, 8-Methoxy-5-methyl-2-[2-(1-methyl-2-thi...) Show SMILES COc1ccc(C)n2nc(CCc3cn(C)c(n3)-c3cccs3)nc12 Show InChI InChI=1S/C18H19N5OS/c1-12-6-8-14(24-3)17-20-16(21-23(12)17)9-7-13-11-22(2)18(19-13)15-5-4-10-25-15/h4-6,8,10-11H,7,9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142419 (US8927738, 5,8-Dimethyl-2-[2-(1-methyl-2-thiazol-4...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cscn3)nn12 Show InChI InChI=1S/C16H17N7S/c1-10-6-17-11(2)15-20-14(21-23(10)15)5-4-12-7-22(3)16(19-12)13-8-24-9-18-13/h6-9H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142420 (US8927738, 2-{2-[2-(4-Fluoro-phenyl)-1H-imidazol-4...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccc(F)cc3)nn12 Show InChI InChI=1S/C18H17FN6/c1-11-9-20-12(2)18-23-16(24-25(11)18)8-7-15-10-21-17(22-15)13-3-5-14(19)6-4-13/h3-6,9-10H,7-8H2,1-2H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142405 (US8927738, 5,8-Dimethyl-2-[2-(1-methyl-2-thiazol-5...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cncs3)nn12 Show InChI InChI=1S/C16H17N7S/c1-10-6-18-11(2)15-20-14(21-23(10)15)5-4-12-8-22(3)16(19-12)13-7-17-9-24-13/h6-9H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142398 (US8927738, 8-Ethyl-5-methyl-2-[2-(1-methyl-2-pheny...) Show SMILES CCc1ccc(C)n2nc(CCc3cn(C)c(n3)-c3ccccc3)nc12 Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)13-12-18-14-25(3)20(22-18)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142400 (US8927738, 5,8-Dimethyl-2-[2-(1-methyl-2-phenyl-1H...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3ccccc3)nn12 Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)18-22-17(23-25(13)18)10-9-16-12-24(3)19(21-16)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142397 (US8927738, 8-Methoxy-5-methyl-2-[2-(1-methyl-2-phe...) Show SMILES COc1ccc(C)n2nc(CCc3cn(C)c(n3)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5O/c1-14-9-11-17(26-3)20-22-18(23-25(14)20)12-10-16-13-24(2)19(21-16)15-7-5-4-6-8-15/h4-9,11,13H,10,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair