Compile Data Set for Download or QSAR

Found 41 hits Enz. Inhib. hit(s) with all data for entry = 6698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM148179 (US8962616, 7) Show SMILES CC1N=CC(=N1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:2,4,13| Show InChI InChI=1S/C17H18F2N4OS/c1-9-21-6-14(22-9)15-4-10-7-25-16(20)23-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,9-10,15H,4,7-8H2,1H3,(H2,20,23)/t9?,10?,15-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50012648 (CHEMBL3261057) Show SMILES Cc1cc(on1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:13| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-4-15(24-22-9)14-5-10-7-25-16(20)21-17(10,8-23-14)12-3-2-11(18)6-13(12)19/h2-4,6,10,14H,5,7-8H2,1H3,(H2,20,21)/t10?,14-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148176 (US8962616, 22 | US8962616, 4) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F |r,c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148176 (US8962616, 22 | US8962616, 4) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F |r,c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148186 (US8962616, 15) Show SMILES Cc1nc(oc1C)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-10(2)25-16(22-9)15-5-11-7-26-17(21)23-18(11,8-24-15)13-4-3-12(19)6-14(13)20/h3-4,6,11,15H,5,7-8H2,1-2H3,(H2,21,23)/t11?,15-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148192 (US8962616, 23) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncc(F)cn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H15F3N4OS/c18-10-1-2-12(13(20)4-10)17-8-25-14(15-22-5-11(19)6-23-15)3-9(17)7-26-16(21)24-17/h1-2,4-6,9,14H,3,7-8H2,(H2,21,24)/t9-,14+,17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148174 (US8962616, 2) Show SMILES Cn1ccc(n1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:13| Show InChI InChI=1S/C17H18F2N4OS/c1-23-5-4-14(22-23)15-6-10-8-25-16(20)21-17(10,9-24-15)12-3-2-11(18)7-13(12)19/h2-5,7,10,15H,6,8-9H2,1H3,(H2,20,21)/t10-,15+,17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148179 (US8962616, 7) Show SMILES CC1N=CC(=N1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:2,4,13| Show InChI InChI=1S/C17H18F2N4OS/c1-9-21-6-14(22-9)15-4-10-7-25-16(20)23-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,9-10,15H,4,7-8H2,1H3,(H2,20,23)/t9?,10?,15-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	185	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148178 (US8962616, 6) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncco1)c1ccc(F)cc1F |c:4| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-12-7-14(15-21-4-5-23-15)24-8-17(12,22-16(20)25-9)11-3-2-10(18)6-13(11)19/h2-6,9,12,14H,7-8H2,1H3,(H2,20,22)/t9-,12+,14-,17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148185 (US8962616, 13) Show SMILES Cc1noc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C16H16F2N4O2S/c1-8-20-14(24-22-8)13-4-9-6-25-15(19)21-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,21)/t9?,13-,16+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	208	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148180 (US8962616, 8) Show SMILES Cc1csc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C17H17F2N3OS2/c1-9-6-24-15(21-9)14-4-10-7-25-16(20)22-17(10,8-23-14)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,14H,4,7-8H2,1H3,(H2,20,22)/t10?,14-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148176 (US8962616, 22 | US8962616, 4) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F |r,c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	273	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148172 (US8962616, 17) Show SMILES Cc1nnc(o1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C16H16F2N4O2S/c1-8-21-22-14(24-8)13-4-9-6-25-15(19)20-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,20)/t9?,13-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148182 (US8962616, 11) Show SMILES Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-21-14(6-23-9)15-4-10-7-25-16(20)22-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,15H,4,7-8H2,1H3,(H2,20,22)/t10?,15-,17+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148187 (US8962616, 18) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ccncn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H16F2N4OS/c18-11-1-2-12(13(19)6-11)17-8-24-15(14-3-4-21-9-22-14)5-10(17)7-25-16(20)23-17/h1-4,6,9-10,15H,5,7-8H2,(H2,20,23)/t10-,15+,17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148185 (US8962616, 13) Show SMILES Cc1noc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C16H16F2N4O2S/c1-8-20-14(24-22-8)13-4-9-6-25-15(19)21-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,21)/t9?,13-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	439	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148188 (US8962616, 19) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ccn(n1)C1CC1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C19H20F2N4OS/c20-12-1-4-14(15(21)8-12)19-10-26-17(7-11(19)9-27-18(22)23-19)16-5-6-25(24-16)13-2-3-13/h1,4-6,8,11,13,17H,2-3,7,9-10H2,(H2,22,23)/t11-,17+,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	444	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148189 (US8962616, 20) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1nc(co1)C(F)(F)F)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H14F5N3O2S/c18-9-1-2-10(11(19)4-9)16-7-27-12(3-8(16)6-28-15(23)25-16)14-24-13(5-26-14)17(20,21)22/h1-2,4-5,8,12H,3,6-7H2,(H2,23,25)/t8-,12+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	467	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148177 (US8962616, 5) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncc(C)o1)c1ccc(F)cc1F |c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-22-16(25-9)15-6-13-10(2)26-17(21)23-18(13,8-24-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	473	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148173 (US8962616, 1) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncco1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C16H15F2N3O2S/c17-10-1-2-11(12(18)6-10)16-8-23-13(14-20-3-4-22-14)5-9(16)7-24-15(19)21-16/h1-4,6,9,13H,5,7-8H2,(H2,19,21)/t9-,13+,16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	511	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148181 (US8962616, 9) Show SMILES Cc1nccc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H18F2N4OS/c1-10-22-5-4-15(23-10)16-6-11-8-26-17(21)24-18(11,9-25-16)13-3-2-12(19)7-14(13)20/h2-5,7,11,16H,6,8-9H2,1H3,(H2,21,24)/t11?,16-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	583	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148173 (US8962616, 1) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncco1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C16H15F2N3O2S/c17-10-1-2-11(12(18)6-10)16-8-23-13(14-20-3-4-22-14)5-9(16)7-24-15(19)21-16/h1-4,6,9,13H,5,7-8H2,(H2,19,21)/t9-,13+,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	619	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148189 (US8962616, 20) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1nc(co1)C(F)(F)F)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H14F5N3O2S/c18-9-1-2-10(11(19)4-9)16-7-27-12(3-8(16)6-28-15(23)25-16)14-24-13(5-26-14)17(20,21)22/h1-2,4-5,8,12H,3,6-7H2,(H2,23,25)/t8-,12+,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	629	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148193 (US8962616, 24) Show SMILES Cc1cnc(nc1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:14| Show InChI InChI=1S/C18H18F2N4OS/c1-10-6-22-16(23-7-10)15-4-11-8-26-17(21)24-18(11,9-25-15)13-3-2-12(19)5-14(13)20/h2-3,5-7,11,15H,4,8-9H2,1H3,(H2,21,24)/t11-,15+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	688	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148187 (US8962616, 18) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ccncn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H16F2N4OS/c18-11-1-2-12(13(19)6-11)17-8-24-15(14-3-4-21-9-22-14)5-10(17)7-25-16(20)23-17/h1-4,6,9-10,15H,5,7-8H2,(H2,20,23)/t10-,15+,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	695	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148190 (US8962616, 21) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncccn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H16F2N4OS/c18-11-2-3-12(13(19)7-11)17-9-24-14(15-21-4-1-5-22-15)6-10(17)8-25-16(20)23-17/h1-5,7,10,14H,6,8-9H2,(H2,20,23)/t10-,14+,17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	983	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148193 (US8962616, 24) Show SMILES Cc1cnc(nc1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:14| Show InChI InChI=1S/C18H18F2N4OS/c1-10-6-22-16(23-7-10)15-4-11-8-26-17(21)24-18(11,9-25-15)13-3-2-12(19)5-14(13)20/h2-3,5-7,11,15H,4,8-9H2,1H3,(H2,21,24)/t11-,15+,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148177 (US8962616, 5) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncc(C)o1)c1ccc(F)cc1F |c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-22-16(25-9)15-6-13-10(2)26-17(21)23-18(13,8-24-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148176 (US8962616, 22 | US8962616, 4) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1nc(C)co1)c1ccc(F)cc1F |r,c:4| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-7-24-16(22-9)15-6-13-10(2)26-17(21)23-18(13,8-25-15)12-4-3-11(19)5-14(12)20/h3-5,7,10,13,15H,6,8H2,1-2H3,(H2,21,23)/t10-,13+,15-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148183 (US8962616, 12) Show SMILES Cc1ccnc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H18F2N4OS/c1-10-4-5-22-16(23-10)15-6-11-8-26-17(21)24-18(11,9-25-15)13-3-2-12(19)7-14(13)20/h2-5,7,11,15H,6,8-9H2,1H3,(H2,21,24)/t11?,15-,18+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148182 (US8962616, 11) Show SMILES Cc1nc(co1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-21-14(6-23-9)15-4-10-7-25-16(20)22-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,15H,4,7-8H2,1H3,(H2,20,22)/t10?,15-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148184 (US8962616, 14) Show SMILES NC1=N[C@]2(CO[C@H](CC2CS1)c1nnco1)c1ccc(F)cc1F |t:1| Show InChI InChI=1S/C15H14F2N4O2S/c16-9-1-2-10(11(17)4-9)15-6-22-12(13-21-19-7-23-13)3-8(15)5-24-14(18)20-15/h1-2,4,7-8,12H,3,5-6H2,(H2,18,20)/t8?,12-,15+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148178 (US8962616, 6) Show SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncco1)c1ccc(F)cc1F |c:4| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-12-7-14(15-21-4-5-23-15)24-8-17(12,22-16(20)25-9)11-3-2-10(18)6-13(11)19/h2-6,9,12,14H,7-8H2,1H3,(H2,20,22)/t9-,12+,14-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.37E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148186 (US8962616, 15) Show SMILES Cc1nc(oc1C)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-10(2)25-16(22-9)15-5-11-7-26-17(21)23-18(11,8-24-15)13-4-3-12(19)6-14(13)20/h3-4,6,11,15H,5,7-8H2,1-2H3,(H2,21,23)/t11?,15-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148190 (US8962616, 21) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncccn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H16F2N4OS/c18-11-2-3-12(13(19)7-11)17-9-24-14(15-21-4-1-5-22-15)6-10(17)8-25-16(20)23-17/h1-5,7,10,14H,6,8-9H2,(H2,20,23)/t10-,14+,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM50012648 (CHEMBL3261057) Show SMILES Cc1cc(on1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:13| Show InChI InChI=1S/C17H17F2N3O2S/c1-9-4-15(24-22-9)14-5-10-7-25-16(20)21-17(10,8-23-14)12-3-2-11(18)6-13(12)19/h2-4,6,10,14H,5,7-8H2,1H3,(H2,20,21)/t10?,14-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.55E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148174 (US8962616, 2) Show SMILES Cn1ccc(n1)[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:13| Show InChI InChI=1S/C17H18F2N4OS/c1-23-5-4-14(22-23)15-6-10-8-25-16(20)21-17(10,9-24-15)12-3-2-11(18)7-13(12)19/h2-5,7,10,15H,6,8-9H2,1H3,(H2,20,21)/t10-,15+,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.74E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148172 (US8962616, 17) Show SMILES Cc1nnc(o1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C16H16F2N4O2S/c1-8-21-22-14(24-8)13-4-9-6-25-15(19)20-16(9,7-23-13)11-3-2-10(17)5-12(11)18/h2-3,5,9,13H,4,6-7H2,1H3,(H2,19,20)/t9?,13-,16+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.56E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM148175 (US8962616, 3) Show SMILES Cn1cccc1[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |r,c:13| Show InChI InChI=1S/C18H19F2N3OS/c1-23-6-2-3-15(23)16-7-11-9-25-17(21)22-18(11,10-24-16)13-5-4-12(19)8-14(13)20/h2-6,8,11,16H,7,9-10H2,1H3,(H2,21,22)/t11-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148180 (US8962616, 8) Show SMILES Cc1csc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:13| Show InChI InChI=1S/C17H17F2N3OS2/c1-9-6-24-15(21-9)14-4-10-7-25-16(20)22-17(10,8-23-14)12-3-2-11(18)5-13(12)19/h2-3,5-6,10,14H,4,7-8H2,1H3,(H2,20,22)/t10?,14-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.72E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM148181 (US8962616, 9) Show SMILES Cc1nccc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H18F2N4OS/c1-10-22-5-4-15(23-10)16-6-11-8-26-17(21)24-18(11,9-25-16)13-3-2-12(19)7-14(13)20/h2-5,7,11,16H,6,8-9H2,1H3,(H2,21,24)/t11?,16-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
					More data for this Ligand-Target Pair