Compile Data Set for Download or QSAR

Found 145 hits Enz. Inhib. hit(s) with all data for entry = 7828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221340 (US9303023, 39) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(Cl)c4)cn3)c2c1 Show InChI InChI=1S/C24H20ClN5O3/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221360 (US9303023, 56) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-17(10-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)9-8-18-12-26-22-7-6-20(32-2)11-21(18)22/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221328 (US9303023, 27) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4)cn3)c2c1 Show InChI InChI=1S/C24H21N5O3/c1-31-19-7-8-21-20(11-19)17(12-25-21)9-10-29-14-18(13-27-29)28-24(30)22-23(32-15-26-22)16-5-3-2-4-6-16/h2-8,11-15,25H,9-10H2,1H3,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221381 (US9303023, 78) Show SMILES COc1ccc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1 Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-18(12-16)22-21(25-15-33-22)24(31)27-19-13-26-30(14-19)11-10-29-9-8-17-6-7-20(32-2)28-23(17)29/h3-9,12-15H,10-11H2,1-2H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221327 (US9303023, 26) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(F)c4)cn3)c2c1 Show InChI InChI=1S/C24H20FN5O3/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221368 (US9303023, 64) Show SMILES COc1ccc2ncn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-17(10-16)23-22(26-15-33-23)24(31)28-18-12-27-30(13-18)9-8-29-14-25-20-7-6-19(32-2)11-21(20)29/h3-7,10-15H,8-9H2,1-2H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221330 (US9303023, 29) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4F)cn3)c2c1 Show InChI InChI=1S/C24H20FN5O3/c1-32-17-6-7-21-19(10-17)15(11-26-21)8-9-30-13-16(12-28-30)29-24(31)22-23(33-14-27-22)18-4-2-3-5-20(18)25/h2-7,10-14,26H,8-9H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221386 (US9303023, 83) Show SMILES COc1cc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C26H25N5O4/c1-17-5-4-6-18(11-17)25-24(27-16-35-25)26(32)29-19-14-28-31(15-19)10-9-30-8-7-21-22(30)12-20(33-2)13-23(21)34-3/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221408 (US9303023, 105) Show SMILES COc1ccc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C25H23N5O3/c1-17-4-3-5-19(12-17)24-23(26-16-33-24)25(31)28-20-14-27-30(15-20)11-10-29-9-8-18-6-7-21(32-2)13-22(18)29/h3-9,12-16H,10-11H2,1-2H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221338 (US9303023, 37) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(OC(F)(F)F)c4)cn3)c2c1 Show InChI InChI=1S/C25H20F3N5O4/c1-35-18-5-6-21-20(10-18)16(11-29-21)7-8-33-13-17(12-31-33)32-24(34)22-23(36-14-30-22)15-3-2-4-19(9-15)37-25(26,27)28/h2-6,9-14,29H,7-8H2,1H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221367 (US9303023, 63) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1 Show InChI InChI=1S/C24H22N6O3/c1-15-4-3-5-16(10-15)23-22(26-14-33-23)24(31)28-18-12-27-30(13-18)9-8-17-11-25-19-6-7-20(32-2)29-21(17)19/h3-7,10-14,25H,8-9H2,1-2H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221339 (US9303023, 38) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(c4)C(F)(F)F)cn3)c2c1 Show InChI InChI=1S/C25H20F3N5O3/c1-35-19-5-6-21-20(10-19)16(11-29-21)7-8-33-13-18(12-31-33)32-24(34)22-23(36-14-30-22)15-3-2-4-17(9-15)25(26,27)28/h2-6,9-14,29H,7-8H2,1H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221348 (US9303023, 144) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cc(C)no4)cn3)c2c1 Show InChI InChI=1S/C22H20N6O4/c1-13-7-19(32-27-13)21-20(24-12-31-21)22(29)26-15-10-25-28(11-15)6-5-14-9-23-18-4-3-16(30-2)8-17(14)18/h3-4,7-12,23H,5-6H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221413 (US9303023, 110) Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(24-13-33-20)21(30)26-16-11-25-29(12-16)8-7-23-22-27-17(31-2)10-18(28-22)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221344 (US9303023, 43) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4cccc(Cl)c4)cn3)c2c1 Show InChI InChI=1S/C24H20ClN5O2S/c1-32-19-5-6-21-20(10-19)16(11-26-21)7-8-30-13-18(12-28-30)29-24(31)22-23(33-14-27-22)15-3-2-4-17(25)9-15/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221365 (US9303023, 61) Show SMILES COc1ccc2n(C)cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-17-5-4-6-18(11-17)25-24(27-16-34-25)26(32)29-20-13-28-31(15-20)10-9-19-14-30(2)23-8-7-21(33-3)12-22(19)23/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221332 (US9303023, 31) Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4ccc(C)c(C)c4)cn3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-17-5-6-20(11-18(17)2)26-25(28-16-36-26)27(33)30-21-14-29-32(15-21)10-9-31-8-7-19-12-23(34-3)24(35-4)13-22(19)31/h5-8,11-16H,9-10H2,1-4H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221356 (US9303023, 52) Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(F)c3)cn2)n1 Show InChI InChI=1S/C21H20FN7O4/c1-31-16-9-17(32-2)28-21(27-16)23-6-7-29-11-15(10-25-29)26-20(30)18-19(33-12-24-18)13-4-3-5-14(22)8-13/h3-5,8-12H,6-7H2,1-2H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221435 (US9303023, 132) Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C22H22N6O5/c1-14-5-4-6-15(9-14)20-19(23-13-33-20)21(29)25-16-11-24-28(12-16)7-8-32-22-26-17(30-2)10-18(27-22)31-3/h4-6,9-13H,7-8H2,1-3H3,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221347 (US9303023, 66) Show SMILES COc1ccc2[nH]cc(CCn3cnc(NC(=O)c4ncoc4-c4cccc(C)c4)c3)c2c1 Show InChI InChI=1S/C25H23N5O3/c1-16-4-3-5-17(10-16)24-23(28-15-33-24)25(31)29-22-13-30(14-27-22)9-8-18-12-26-21-7-6-19(32-2)11-20(18)21/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221313 (US9303023, 12) Show SMILES COc1cc2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2cc1OC Show InChI InChI=1S/C26H25N5O4/c1-17-5-4-6-19(11-17)25-24(27-16-35-25)26(32)29-20-14-28-31(15-20)10-9-30-8-7-18-12-22(33-2)23(34-3)13-21(18)30/h4-8,11-16H,9-10H2,1-3H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221370 (US9303023, 67) Show SMILES COc1cc(OC)nc(CCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C23H24N6O4/c1-15-6-4-7-16(10-15)22-21(24-14-33-22)23(30)26-17-12-25-29(13-17)9-5-8-18-27-19(31-2)11-20(28-18)32-3/h4,6-7,10-14H,5,8-9H2,1-3H3,(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221404 (US9303023, 101) Show SMILES COc1cc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2cn1 Show InChI InChI=1S/C24H22N6O3/c1-16-4-3-5-17(10-16)23-22(26-15-33-23)24(31)28-19-13-27-30(14-19)9-8-29-7-6-18-12-25-21(32-2)11-20(18)29/h3-7,10-15H,8-9H2,1-2H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221310 (US9303023, 9) Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3ccccc3)cn2)n1 Show InChI InChI=1S/C21H20N6O5/c1-29-16-10-17(30-2)26-21(25-16)31-9-8-27-12-15(11-23-27)24-20(28)18-19(32-13-22-18)14-6-4-3-5-7-14/h3-7,10-13H,8-9H2,1-2H3,(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221432 (US9303023, 129) Show SMILES COc1cc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)nc(OC)n1 Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(24-13-33-20)21(30)26-16-11-25-29(12-16)8-7-23-17-10-18(31-2)28-22(27-17)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221331 (US9303023, 30) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C25H23N5O2S/c1-16-4-3-5-17(10-16)24-23(27-15-33-24)25(31)29-19-13-28-30(14-19)9-8-18-12-26-22-7-6-20(32-2)11-21(18)22/h3-7,10-15,26H,8-9H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221329 (US9303023, 28) Show SMILES COc1ccc(cc1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(OC)cc23)c1 Show InChI InChI=1S/C25H23N5O4/c1-32-19-5-3-16(4-6-19)24-23(27-15-34-24)25(31)29-18-13-28-30(14-18)10-9-17-12-26-22-8-7-20(33-2)11-21(17)22/h3-8,11-15,26H,9-10H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221411 (US9303023, 108) Show SMILES COc1cc2n(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)ccc2cc1Cl Show InChI InChI=1S/C25H22ClN5O3/c1-16-4-3-5-18(10-16)24-23(27-15-34-24)25(32)29-19-13-28-31(14-19)9-8-30-7-6-17-11-20(26)22(33-2)12-21(17)30/h3-7,10-15H,8-9H2,1-2H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221357 (US9303023, 53) Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccccc3F)cn2)n1 Show InChI InChI=1S/C21H20FN7O4/c1-31-16-9-17(32-2)28-21(27-16)23-7-8-29-11-13(10-25-29)26-20(30)18-19(33-12-24-18)14-5-3-4-6-15(14)22/h3-6,9-12H,7-8H2,1-2H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221434 (US9303023, 131) Show SMILES COc1ccnc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C22H23N7O3/c1-15-5-3-6-16(11-15)20-19(25-14-32-20)21(30)27-17-12-26-29(13-17)10-4-8-23-22-24-9-7-18(28-22)31-2/h3,5-7,9,11-14H,4,8,10H2,1-2H3,(H,27,30)(H,23,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221445 (US9303023, 142) Show SMILES COc1ccc2ccn(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-7-8-22(33-2)14-23(19)30/h3,5-9,12-17H,4,10-11H2,1-2H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221353 (US9303023, 49) Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccc(C)c(C)c3)cn2)n1 Show InChI InChI=1S/C23H25N7O4/c1-14-5-6-16(9-15(14)2)21-20(25-13-34-21)22(31)27-17-11-26-30(12-17)8-7-24-23-28-18(32-3)10-19(29-23)33-4/h5-6,9-13H,7-8H2,1-4H3,(H,27,31)(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221325 (US9303023, 24) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccc(C)c(C)c4)cn3)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-16-4-5-18(10-17(16)2)25-24(28-15-34-25)26(32)30-20-13-29-31(14-20)9-8-19-12-27-23-7-6-21(33-3)11-22(19)23/h4-7,10-15,27H,8-9H2,1-3H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221311 (US9303023, 10) Show SMILES COc1cc(OC)nc(OCCn2cc(NC(=O)c3ncoc3-c3cccc(F)c3)cn2)n1 Show InChI InChI=1S/C21H19FN6O5/c1-30-16-9-17(31-2)27-21(26-16)32-7-6-28-11-15(10-24-28)25-20(29)18-19(33-12-23-18)13-4-3-5-14(22)8-13/h3-5,8-12H,6-7H2,1-2H3,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221349 (US9303023, 145) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccon4)cn3)c2c1 Show InChI InChI=1S/C21H18N6O4/c1-29-15-2-3-17-16(8-15)13(9-22-17)4-6-27-11-14(10-24-27)25-21(28)19-20(30-12-23-19)18-5-7-31-26-18/h2-3,5,7-12,22H,4,6H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221433 (US9303023, 130) Show SMILES COc1cc(OC)nc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C23H25N7O4/c1-15-6-4-7-16(10-15)21-20(25-14-34-21)22(31)27-17-12-26-30(13-17)9-5-8-24-23-28-18(32-2)11-19(29-23)33-3/h4,6-7,10-14H,5,8-9H2,1-3H3,(H,27,31)(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221405 (US9303023, 102) Show SMILES COc1cc2ncn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2cc1OC Show InChI InChI=1S/C25H24N6O4/c1-16-5-4-6-17(9-16)24-23(27-15-35-24)25(32)29-18-12-28-31(13-18)8-7-30-14-26-19-10-21(33-2)22(34-3)11-20(19)30/h4-6,9-15H,7-8H2,1-3H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221395 (US9303023, 92) Show SMILES COc1cc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1 Show InChI InChI=1S/C25H24N6O4/c1-16-5-4-6-17(11-16)23-22(26-15-35-23)25(32)28-18-13-27-31(14-18)10-9-30-8-7-19-20(33-2)12-21(34-3)29-24(19)30/h4-8,11-15H,9-10H2,1-3H3,(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221343 (US9303023, 42) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4ccccc4)cn3)c2c1 Show InChI InChI=1S/C24H21N5O2S/c1-31-19-7-8-21-20(11-19)17(12-25-21)9-10-29-14-18(13-27-29)28-24(30)22-23(32-15-26-22)16-5-3-2-4-6-16/h2-8,11-15,25H,9-10H2,1H3,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221379 (US9303023, 76) Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2cnc3ccccc23)c1 Show InChI InChI=1S/C23H20N6O2/c1-16-5-4-6-17(11-16)22-21(25-15-31-22)23(30)27-18-12-26-29(13-18)10-9-28-14-24-19-7-2-3-8-20(19)28/h2-8,11-15H,9-10H2,1H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221377 (US9303023, 74) Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ccc(F)cc23)c1 Show InChI InChI=1S/C24H20FN5O2/c1-16-3-2-4-18(11-16)23-22(26-15-32-23)24(31)28-20-13-27-30(14-20)10-9-29-8-7-17-5-6-19(25)12-21(17)29/h2-8,11-15H,9-10H2,1H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221341 (US9303023, 40) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cccc(c4)-c4ccccc4)cn3)c2c1 Show InChI InChI=1S/C30H25N5O3/c1-37-25-10-11-27-26(15-25)23(16-31-27)12-13-35-18-24(17-33-35)34-30(36)28-29(38-19-32-28)22-9-5-8-21(14-22)20-6-3-2-4-7-20/h2-11,14-19,31H,12-13H2,1H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221430 (US9303023, 127) Show SMILES COc1cc(OC)nc(NCCn2cnc(NC(=O)c3ncoc3-c3cccc(C)c3)c2)n1 Show InChI InChI=1S/C22H23N7O4/c1-14-5-4-6-15(9-14)20-19(25-13-33-20)21(30)26-16-11-29(12-24-16)8-7-23-22-27-17(31-2)10-18(28-22)32-3/h4-6,9-13H,7-8H2,1-3H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221423 (US9303023, 120) Show SMILES COc1ccnc(NCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C21H21N7O3/c1-14-4-3-5-15(10-14)19-18(24-13-31-19)20(29)26-16-11-25-28(12-16)9-8-23-21-22-7-6-17(27-21)30-2/h3-7,10-13H,8-9H2,1-2H3,(H,26,29)(H,22,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221409 (US9303023, 106) Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3cc(Cl)c(Cl)cc23)c1 Show InChI InChI=1S/C24H19Cl2N5O2/c1-15-3-2-4-17(9-15)23-22(27-14-33-23)24(32)29-18-12-28-31(13-18)8-7-30-6-5-16-10-19(25)20(26)11-21(16)30/h2-6,9-14H,7-8H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221371 (US9303023, 68) Show SMILES CCOc1cc(OC)nc(CCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C24H26N6O4/c1-4-33-21-12-20(32-3)28-19(29-21)9-6-10-30-14-18(13-26-30)27-24(31)22-23(34-15-25-22)17-8-5-7-16(2)11-17/h5,7-8,11-15H,4,6,9-10H2,1-3H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221375 (US9303023, 72) Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCn2ccc3ccccc23)c1 Show InChI InChI=1S/C24H21N5O2/c1-17-5-4-7-19(13-17)23-22(25-16-31-23)24(30)27-20-14-26-29(15-20)12-11-28-10-9-18-6-2-3-8-21(18)28/h2-10,13-16H,11-12H2,1H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221383 (US9303023, 80) Show SMILES COc1nc(OC)c2ccn(CCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2n1 Show InChI InChI=1S/C24H23N7O4/c1-15-5-4-6-16(11-15)20-19(25-14-35-20)22(32)27-17-12-26-31(13-17)10-9-30-8-7-18-21(30)28-24(34-3)29-23(18)33-2/h4-8,11-14H,9-10H2,1-3H3,(H,27,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221366 (US9303023, 62) Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(F)cc23)c1 Show InChI InChI=1S/C24H20FN5O2/c1-15-3-2-4-16(9-15)23-22(27-14-32-23)24(31)29-19-12-28-30(13-19)8-7-17-11-26-21-6-5-18(25)10-20(17)21/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221359 (US9303023, 55) Show SMILES COc1ccc(cc1)-c1ocnc1C(=O)Nc1cnn(CCNc2nc(OC)cc(OC)n2)c1 Show InChI InChI=1S/C22H23N7O5/c1-31-16-6-4-14(5-7-16)20-19(24-13-34-20)21(30)26-15-11-25-29(12-15)9-8-23-22-27-17(32-2)10-18(28-22)33-3/h4-7,10-13H,8-9H2,1-3H3,(H,26,30)(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair

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