Found 30 hits Enz. Inhib. hit(s) with all data for entry = 50011212 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50093142
(1,5-di{4-[4-amino(imino)methylaminobenzylcarbamoyl...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#8]-[#6@H]-2-[#6]-[#6]-[#6]-[#6@H](-[#6]-[#6]-[#6]-2)-[#8]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-c2ccc(cc2)\[#7]=[#6](/[#7])-[#7])cc1 Show InChI InChI=1S/C36H52N12O6/c37-31(38)43-27-11-7-25(8-12-27)23-41-33(49)45-15-19-47(20-16-45)35(51)53-29-3-1-4-30(6-2-5-29)54-36(52)48-21-17-46(18-22-48)34(50)42-24-26-9-13-28(14-10-26)44-32(39)40/h7-14,29-30H,1-6,15-24H2,(H,41,49)(H,42,50)(H4,37,38,43)(H4,39,40,44)/t29-,30+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50101018
(1,4-di{4-[4-amino(imino)methylphenylcarboxamidomet...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC1CCN(CC1)C(=O)OCc1ccc(COC(=O)N2CCC(CNC(=O)c3ccc(cc3)C(N)=N)CC2)cc1 Show InChI InChI=1S/C38H46N8O6/c39-33(40)29-5-9-31(10-6-29)35(47)43-21-25-13-17-45(18-14-25)37(49)51-23-27-1-2-28(4-3-27)24-52-38(50)46-19-15-26(16-20-46)22-44-36(48)32-11-7-30(8-12-32)34(41)42/h1-12,25-26H,13-24H2,(H3,39,40)(H3,41,42)(H,43,47)(H,44,48) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103793
(4-[(4-Carbamimidoyl-benzoylamino)-methyl]-piperidi...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C30H35N5O2/c31-28(32)25-11-13-26(14-12-25)29(36)34-21-22-16-19-35(20-17-22)30(37)33-18-15-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,22,27H,15-21H2,(H3,31,32)(H,33,37)(H,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103801
(3-[4-(3,3-Diphenyl-propylcarbamoyl)-piperazin-1-yl...)Show SMILES [#6]-[#8]-[#6](=O)-[#6](-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c1ccccc1)-c1ccccc1)-c1ccc(cc1)\[#7]=[#6](/[#7])-[#7] Show InChI InChI=1S/C31H36N6O4/c1-41-29(39)27(24-12-14-25(15-13-24)35-30(32)33)28(38)36-18-20-37(21-19-36)31(40)34-17-16-26(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-15,26-27H,16-21H2,1H3,(H,34,40)(H4,32,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103803
(4-[2-(4-Guanidino-phenyl)-3-phenethylcarbamoyl-pro...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](-[#6]-[#6](=O)-[#7]-[#6]-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C39H45N7O3/c40-38(41)44-33-18-16-32(17-19-33)35(28-36(47)42-22-20-29-10-4-1-5-11-29)37(48)45-24-26-46(27-25-45)39(49)43-23-21-34(30-12-6-2-7-13-30)31-14-8-3-9-15-31/h1-19,34-35H,20-28H2,(H,42,47)(H,43,49)(H4,40,41,44) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103816
(4-[(4-Carbamimidoyl-phenylcarbamoyl)-methyl]-piper...)Show SMILES NC(=N)c1ccc(NC(=O)CC2CCN(CC2)C(=O)NCCC(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C30H35N5O2/c31-29(32)25-11-13-26(14-12-25)34-28(36)21-22-16-19-35(20-17-22)30(37)33-18-15-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,22,27H,15-21H2,(H3,31,32)(H,33,37)(H,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103804
(1N-(3,3-diphenylpropyl)-4-[4-amino(imino)methylphe...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NCc1ccc(cc1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H30N4O2/c32-29(33)25-15-17-27(18-16-25)31(37)35-21-22-11-13-26(14-12-22)30(36)34-20-19-28(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-18,28H,19-21H2,(H3,32,33)(H,34,36)(H,35,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103812
(CHEMBL309580 | Piperazine-1,4-dicarboxylic acid 4-...)Show SMILES NC(=N)c1ccc(CNC(=O)N2CCN(CC2)C(=O)NCCC(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C29H34N6O2/c30-27(31)25-13-11-22(12-14-25)21-33-29(37)35-19-17-34(18-20-35)28(36)32-16-15-26(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,26H,15-21H2,(H3,30,31)(H,32,36)(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103815
(CHEMBL74695 | Piperazine-1,4-dicarboxylic acid (3,...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c2ccccc2)-c2ccccc2)cc1 Show InChI InChI=1S/C29H35N7O2/c30-27(31)34-25-13-11-22(12-14-25)21-33-29(38)36-19-17-35(18-20-36)28(37)32-16-15-26(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,26H,15-21H2,(H,32,37)(H,33,38)(H4,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103796
(CHEMBL76769 | Piperazine-1,4-dicarboxylic acid (4,...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-2-[#6]-[#6]C([#6]-[#6]-2)(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C32H39N7O2/c33-29(34)36-27-13-11-24(12-14-27)23-35-30(40)38-19-21-39(22-20-38)31(41)37-28-15-17-32(18-16-28,25-7-3-1-4-8-25)26-9-5-2-6-10-26/h1-14,28H,15-23H2,(H,35,40)(H,37,41)(H4,33,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 890 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103809
(CHEMBL305614 | Piperazine-1,4-dicarboxylic acid 4-...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H29N7O2/c26-23(27)30-22-9-6-18(7-10-22)16-28-24(33)31-11-13-32(14-12-31)25(34)29-17-19-5-8-20-3-1-2-4-21(20)15-19/h1-10,15H,11-14,16-17H2,(H,28,33)(H,29,34)(H4,26,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103806
(4-(4-Carbamimidoyl-benzoylamino)-piperidine-1-carb...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C29H33N5O2/c30-27(31)23-11-13-24(14-12-23)28(35)33-25-16-19-34(20-17-25)29(36)32-18-15-26(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,25-26H,15-20H2,(H3,30,31)(H,32,36)(H,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103800
(CHEMBL311936 | Piperazine-1,4-dicarboxylic acid [2...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-2-c3ccccc3-c3ccccc-23)cc1 Show InChI InChI=1S/C29H33N7O2/c30-27(31)34-21-11-9-20(10-12-21)19-33-29(38)36-17-15-35(16-18-36)28(37)32-14-13-26-24-7-3-1-5-22(24)23-6-2-4-8-25(23)26/h1-12,26H,13-19H2,(H,32,37)(H,33,38)(H4,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103802
(CHEMBL73907 | Piperazine-1,4-dicarboxylic acid 4-g...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 Show InChI InChI=1S/C35H39N7O2/c36-32(37)40-31-18-16-27(17-19-31)26-39-34(44)42-24-22-41(23-25-42)33(43)38-21-20-35(28-10-4-1-5-11-28,29-12-6-2-7-13-29)30-14-8-3-9-15-30/h1-19H,20-26H2,(H,38,43)(H,39,44)(H4,36,37,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103805
(4-[2-(4-Guanidino-phenyl)-acetyl]-piperazine-1-car...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c2ccccc2)-c2ccccc2)cc1 Show InChI InChI=1S/C29H34N6O2/c30-28(31)33-25-13-11-22(12-14-25)21-27(36)34-17-19-35(20-18-34)29(37)32-16-15-26(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,26H,15-21H2,(H,32,37)(H4,30,31,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103797
(CHEMBL77525 | Piperazine-1,4-dicarboxylic acid 4-g...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C23H31N7O2/c24-21(25)28-20-10-8-19(9-11-20)17-27-23(32)30-15-13-29(14-16-30)22(31)26-12-4-7-18-5-2-1-3-6-18/h1-3,5-6,8-11H,4,7,12-17H2,(H,26,31)(H,27,32)(H4,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103813
(CHEMBL305677 | Piperazine-1,4-dicarboxylic acid 4-...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C26H31N7O2/c27-24(28)31-22-10-8-19(9-11-22)18-30-26(35)33-16-14-32(15-17-33)25(34)29-13-12-21-6-3-5-20-4-1-2-7-23(20)21/h1-11H,12-18H2,(H,29,34)(H,30,35)(H4,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103811
(4-[(4-Carbamimidoyl-benzenesulfonylamino)-methyl]-...)Show SMILES NC(=N)c1ccc(cc1)S(=O)(=O)NCC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C29H35N5O3S/c30-28(31)25-11-13-26(14-12-25)38(36,37)33-21-22-16-19-34(20-17-22)29(35)32-18-15-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,22,27,33H,15-21H2,(H3,30,31)(H,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103789
(4-[(4-Guanidino-benzoylamino)-methyl]-piperidine-1...)Show SMILES [#7]\[#6](-[#7])=[#7]\c1ccc(cc1)-[#6](=O)-[#7]-[#6]-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C30H36N6O2/c31-29(32)35-26-13-11-25(12-14-26)28(37)34-21-22-16-19-36(20-17-22)30(38)33-18-15-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-14,22,27H,15-21H2,(H,33,38)(H,34,37)(H4,31,32,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103799
(4-[2-(4-Carbamimidoyl-benzoylamino)-ethyl]-piperid...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NCCC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C31H37N5O2/c32-29(33)26-11-13-27(14-12-26)30(37)34-19-15-23-17-21-36(22-18-23)31(38)35-20-16-28(24-7-3-1-4-8-24)25-9-5-2-6-10-25/h1-14,23,28H,15-22H2,(H3,32,33)(H,34,37)(H,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103790
(CHEMBL74360 | Piperazine-1,4-dicarboxylic acid 4-g...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C24H33N7O2/c25-22(26)29-21-11-9-20(10-12-21)18-28-24(33)31-16-14-30(15-17-31)23(32)27-13-5-4-8-19-6-2-1-3-7-19/h1-3,6-7,9-12H,4-5,8,13-18H2,(H,27,32)(H,28,33)(H4,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103814
(CHEMBL74428 | Piperazine-1,4-dicarboxylic acid ben...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7](-[#6]-[#6]-[#6]-c2ccccc2)-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C30H37N7O2/c31-28(32)34-27-15-13-25(14-16-27)22-33-29(38)35-18-20-36(21-19-35)30(39)37(23-26-10-5-2-6-11-26)17-7-12-24-8-3-1-4-9-24/h1-6,8-11,13-16H,7,12,17-23H2,(H,33,38)(H4,31,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103810
(3-[(4-Carbamimidoyl-benzoylamino)-methyl]-piperidi...)Show SMILES NC(=N)c1ccc(cc1)C(=O)NCC1CCCN(C1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C30H35N5O2/c31-28(32)25-13-15-26(16-14-25)29(36)34-20-22-8-7-19-35(21-22)30(37)33-18-17-27(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-6,9-16,22,27H,7-8,17-21H2,(H3,31,32)(H,33,37)(H,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103807
(CHEMBL74905 | Piperazine-1,4-dicarboxylic acid ben...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C21H27N7O2/c22-19(23)26-18-8-6-17(7-9-18)15-25-21(30)28-12-10-27(11-13-28)20(29)24-14-16-4-2-1-3-5-16/h1-9H,10-15H2,(H,24,29)(H,25,30)(H4,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103794
(4-[(3-Carbamimidoyl-benzoylamino)-methyl]-piperidi...)Show SMILES NC(=N)c1cccc(c1)C(=O)NCC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C30H35N5O2/c31-28(32)25-12-7-13-26(20-25)29(36)34-21-22-15-18-35(19-16-22)30(37)33-17-14-27(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,20,22,27H,14-19,21H2,(H3,31,32)(H,33,37)(H,34,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103792
(CHEMBL74482 | Piperazine-1,4-dicarboxylic acid dib...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7](-[#6]-c2ccccc2)-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C28H33N7O2/c29-26(30)32-25-13-11-22(12-14-25)19-31-27(36)33-15-17-34(18-16-33)28(37)35(20-23-7-3-1-4-8-23)21-24-9-5-2-6-10-24/h1-14H,15-21H2,(H,31,36)(H4,29,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103808
(CHEMBL76819 | Piperazine-1,4-dicarboxylic acid 4-g...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C22H29N7O2/c23-20(24)27-19-8-6-18(7-9-19)16-26-22(31)29-14-12-28(13-15-29)21(30)25-11-10-17-4-2-1-3-5-17/h1-9H,10-16H2,(H,25,30)(H,26,31)(H4,23,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103791
(4-{[(4-Carbamimidoyl-benzoyl)-methyl-amino]-methyl...)Show SMILES CN(CC1CCN(CC1)C(=O)NCCC(c1ccccc1)c1ccccc1)C(=O)c1ccc(cc1)C(N)=N Show InChI InChI=1S/C31H37N5O2/c1-35(30(37)27-14-12-26(13-15-27)29(32)33)22-23-17-20-36(21-18-23)31(38)34-19-16-28(24-8-4-2-5-9-24)25-10-6-3-7-11-25/h2-15,23,28H,16-22H2,1H3,(H3,32,33)(H,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103798
(CHEMBL305643 | Piperazine-1,4-dicarboxylic acid be...)Show SMILES [#6]-[#7](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-c1ccc(cc1)\[#7]=[#6](/[#7])-[#7] Show InChI InChI=1S/C22H29N7O2/c1-27(16-18-5-3-2-4-6-18)22(31)29-13-11-28(12-14-29)21(30)25-15-17-7-9-19(10-8-17)26-20(23)24/h2-10H,11-16H2,1H3,(H,25,30)(H4,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50103795
(CHEMBL77104 | Piperazine-1,4-dicarboxylic acid eth...)Show SMILES [#6]-[#6]-[#7]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#7]-[#6]-c1ccc(cc1)\[#7]=[#6](/[#7])-[#7] Show InChI InChI=1S/C16H25N7O2/c1-2-19-15(24)22-7-9-23(10-8-22)16(25)20-11-12-3-5-13(6-4-12)21-14(17)18/h3-6H,2,7-11H2,1H3,(H,19,24)(H,20,25)(H4,17,18,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 3.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against human tryptase enzyme |
Bioorg Med Chem Lett 11: 2325-30 (2001)
BindingDB Entry DOI: 10.7270/Q21835S6 |
More data for this
Ligand-Target Pair | |
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