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Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with all data for entry = 50010735   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098163
PNG
(5-Methylsulfanyl-4-[2-(4-phenoxy-phenylamino)-thia...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Oc3ccccc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C21H18N4OS3/c1-27-20-16(11-18(29-20)19(22)23)17-12-28-21(25-17)24-13-7-9-15(10-8-13)26-14-5-3-2-4-6-14/h2-12H,1H3,(H3,22,23)(H,24,25)
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 60n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098169
PNG
(5-Methylsulfanyl-4-[2-(4-phenylamino-phenylamino)-...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Nc3ccccc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C21H19N5S3/c1-27-20-16(11-18(29-20)19(22)23)17-12-28-21(26-17)25-15-9-7-14(8-10-15)24-13-5-3-2-4-6-13/h2-12,24H,1H3,(H3,22,23)(H,25,26)
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 70n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098144
PNG
(5-Methyl-4-[2-(4-phenoxy-phenylamino)-thiazol-4-yl...)
Show SMILES Cc1sc(cc1-c1csc(Nc2ccc(Oc3ccccc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C21H18N4OS2/c1-13-17(11-19(28-13)20(22)23)18-12-27-21(25-18)24-14-7-9-16(10-8-14)26-15-5-3-2-4-6-15/h2-12H,1H3,(H3,22,23)(H,24,25)
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 80n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098141
PNG
(4-{2-[4-(4-Chloro-phenoxy)-phenylamino]-thiazol-4-...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C21H17ClN4OS3/c1-28-20-16(10-18(30-20)19(23)24)17-11-29-21(26-17)25-13-4-8-15(9-5-13)27-14-6-2-12(22)3-7-14/h2-11H,1H3,(H3,23,24)(H,25,26)
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 110n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098127
PNG
(4-[2-(4-Cyclohexyl-phenylamino)-thiazol-4-yl]-5-me...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(cc2)C2CCCCC2)n1)C(N)=N
Show InChI InChI=1S/C21H24N4S3/c1-26-20-16(11-18(28-20)19(22)23)17-12-27-21(25-17)24-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h7-13H,2-6H2,1H3,(H3,22,23)(H,24,25)
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 110n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098139
PNG
(5-Methylsulfanyl-4-[2-(3,4,5-trimethoxy-phenylamin...)
Show SMILES COc1cc(Nc2nc(cs2)-c2cc(sc2SC)C(N)=N)cc(OC)c1OC
Show InChI InChI=1S/C18H20N4O3S3/c1-23-12-5-9(6-13(24-2)15(12)25-3)21-18-22-11(8-27-18)10-7-14(16(19)20)28-17(10)26-4/h5-8H,1-4H3,(H3,19,20)(H,21,22)
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 160n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098132
PNG
(5-Methyl-4-(2-phenylamino-thiazol-4-yl)-thiophene-...)
Show SMILES Cc1sc(cc1-c1csc(Nc2ccccc2)n1)C(N)=N
Show InChI InChI=1S/C15H14N4S2/c1-9-11(7-13(21-9)14(16)17)12-8-20-15(19-12)18-10-5-3-2-4-6-10/h2-8H,1H3,(H3,16,17)(H,18,19)
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 170n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098147
PNG
(4-[2-(4-Benzyloxy-phenylamino)-thiazol-4-yl]-5-met...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(OCc3ccccc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C22H20N4OS3/c1-28-21-17(11-19(30-21)20(23)24)18-13-29-22(26-18)25-15-7-9-16(10-8-15)27-12-14-5-3-2-4-6-14/h2-11,13H,12H2,1H3,(H3,23,24)(H,25,26)
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 180n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098131
PNG
(5-Methylsulfanyl-4-[2-(4-phenylazo-phenylamino)-th...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(cc2)\N=N\c2ccccc2)n1)C(N)=N
Show InChI InChI=1S/C21H18N6S3/c1-28-20-16(11-18(30-20)19(22)23)17-12-29-21(25-17)24-13-7-9-15(10-8-13)27-26-14-5-3-2-4-6-14/h2-12H,1H3,(H3,22,23)(H,24,25)/b27-26+
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 180n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098133
PNG
(4-[2-(4-Benzyl-phenylamino)-thiazol-4-yl]-5-methyl...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Cc3ccccc3)cc2)n1)C(N)=N
Show InChI InChI=1S/C22H20N4S3/c1-27-21-17(12-19(29-21)20(23)24)18-13-28-22(26-18)25-16-9-7-15(8-10-16)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H3,23,24)(H,25,26)
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 180n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098166
PNG
(5-Methylsulfanyl-4-(2-phenylamino-thiazol-4-yl)-th...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccccc2)n1)C(N)=N
Show InChI InChI=1S/C15H14N4S3/c1-20-14-10(7-12(22-14)13(16)17)11-8-21-15(19-11)18-9-5-3-2-4-6-9/h2-8H,1H3,(H3,16,17)(H,18,19)
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 200n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098149
PNG
(4-[2-(2-Fluoro-phenylamino)-thiazol-4-yl]-5-methyl...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccccc2F)n1)C(N)=N
Show InChI InChI=1S/C15H13FN4S3/c1-21-14-8(6-12(23-14)13(17)18)11-7-22-15(20-11)19-10-5-3-2-4-9(10)16/h2-7H,1H3,(H3,17,18)(H,19,20)
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 240n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098164
PNG
(4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-5-methy...)
Show SMILES COc1ccc(Nc2nc(cs2)-c2cc(sc2SC)C(N)=N)cc1
Show InChI InChI=1S/C16H16N4OS3/c1-21-10-5-3-9(4-6-10)19-16-20-12(8-23-16)11-7-13(14(17)18)24-15(11)22-2/h3-8H,1-2H3,(H3,17,18)(H,19,20)
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 280n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098151
PNG
(4-[2-(2-Bromo-phenylamino)-thiazol-4-yl]-5-methyls...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccccc2Br)n1)C(N)=N
Show InChI InChI=1S/C15H13BrN4S3/c1-21-14-8(6-12(23-14)13(17)18)11-7-22-15(20-11)19-10-5-3-2-4-9(10)16/h2-7H,1H3,(H3,17,18)(H,19,20)
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 280n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098150
PNG
(4-[2-(4-Chloro-2-methyl-phenylamino)-thiazol-4-yl]...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Cl)cc2C)n1)C(N)=N
Show InChI InChI=1S/C16H15ClN4S3/c1-8-5-9(17)3-4-11(8)20-16-21-12(7-23-16)10-6-13(14(18)19)24-15(10)22-2/h3-7H,1-2H3,(H3,18,19)(H,20,21)
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 280n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098142
PNG
(4-[2-(3-Methoxy-phenylamino)-thiazol-4-yl]-5-methy...)
Show SMILES COc1cccc(Nc2nc(cs2)-c2cc(sc2SC)C(N)=N)c1
Show InChI InChI=1S/C16H16N4OS3/c1-21-10-5-3-4-9(6-10)19-16-20-12(8-23-16)11-7-13(14(17)18)24-15(11)22-2/h3-8H,1-2H3,(H3,17,18)(H,19,20)
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 280n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098158
PNG
(4-[2-(2,3-Dimethyl-phenylamino)-thiazol-4-yl]-5-me...)
Show SMILES CSc1sc(cc1-c1csc(Nc2cccc(C)c2C)n1)C(N)=N
Show InChI InChI=1S/C17H18N4S3/c1-9-5-4-6-12(10(9)2)20-17-21-13(8-23-17)11-7-14(15(18)19)24-16(11)22-3/h4-8H,1-3H3,(H3,18,19)(H,20,21)
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 280n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098140
PNG
(4-[2-(4-Dimethylamino-phenylamino)-thiazol-4-yl]-5...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(cc2)N(C)C)n1)C(N)=N
Show InChI InChI=1S/C17H19N5S3/c1-22(2)11-6-4-10(5-7-11)20-17-21-13(9-24-17)12-8-14(15(18)19)25-16(12)23-3/h4-9H,1-3H3,(H3,18,19)(H,20,21)
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 310n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098137
PNG
(2-amidino-4-iodobenzothiophene | 4-Iodo-benzo[b]th...)
Show SMILES NC(=N)c1cc2c(I)cccc2s1
Show InChI InChI=1S/C9H7IN2S/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12/h1-4H,(H3,11,12)
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 320n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098143
PNG
(5-Methylsulfanyl-4-[2-(3-phenyl-propylamino)-thiaz...)
Show SMILES CSc1sc(cc1-c1csc(NCCCc2ccccc2)n1)C(N)=N
Show InChI InChI=1S/C18H20N4S3/c1-23-17-13(10-15(25-17)16(19)20)14-11-24-18(22-14)21-9-5-8-12-6-3-2-4-7-12/h2-4,6-7,10-11H,5,8-9H2,1H3,(H3,19,20)(H,21,22)
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 350n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098152
PNG
(5-Methylsulfanyl-4-{2-[4-(piperidine-1-sulfonyl)-p...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(cc2)S(=O)(=O)N2CCCCC2)n1)C(N)=N
Show InChI InChI=1S/C20H23N5O2S4/c1-28-19-15(11-17(30-19)18(21)22)16-12-29-20(24-16)23-13-5-7-14(8-6-13)31(26,27)25-9-3-2-4-10-25/h5-8,11-12H,2-4,9-10H2,1H3,(H3,21,22)(H,23,24)
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 400n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098138
PNG
(4-[2-(2-Bromo-4-methyl-phenylamino)-thiazol-4-yl]-...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(C)cc2Br)n1)C(N)=N
Show InChI InChI=1S/C16H15BrN4S3/c1-8-3-4-11(10(17)5-8)20-16-21-12(7-23-16)9-6-13(14(18)19)24-15(9)22-2/h3-7H,1-2H3,(H3,18,19)(H,20,21)
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 430n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098162
PNG
(4-[2-(3-Chloro-2-methyl-phenylamino)-thiazol-4-yl]...)
Show SMILES CSc1sc(cc1-c1csc(Nc2cccc(Cl)c2C)n1)C(N)=N
Show InChI InChI=1S/C16H15ClN4S3/c1-8-10(17)4-3-5-11(8)20-16-21-12(7-23-16)9-6-13(14(18)19)24-15(9)22-2/h3-7H,1-2H3,(H3,18,19)(H,20,21)
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 440n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098153
PNG
(4-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-thiazol...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1nc(cs1)-c1cc(sc1SC)C(N)=N
Show InChI InChI=1S/C20H23N5OS3/c1-26-14-5-3-13(4-6-14)24-7-9-25(10-8-24)20-23-16(12-28-20)15-11-17(18(21)22)29-19(15)27-2/h3-6,11-12H,7-10H2,1-2H3,(H3,21,22)
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 480n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098156
PNG
(5-Methylsulfanyl-4-[2-(naphthalen-1-ylamino)-thiaz...)
Show SMILES CSc1sc(cc1-c1csc(Nc2cccc3ccccc23)n1)C(N)=N
Show InChI InChI=1S/C19H16N4S3/c1-24-18-13(9-16(26-18)17(20)21)15-10-25-19(23-15)22-14-8-4-6-11-5-2-3-7-12(11)14/h2-10H,1H3,(H3,20,21)(H,22,23)
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 500n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098145
PNG
(4-[2-(Benzo[1,3]dioxol-5-ylamino)-thiazol-4-yl]-5-...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc3OCOc3c2)n1)C(N)=N
Show InChI InChI=1S/C16H14N4O2S3/c1-23-15-9(5-13(25-15)14(17)18)10-6-24-16(20-10)19-8-2-3-11-12(4-8)22-7-21-11/h2-6H,7H2,1H3,(H3,17,18)(H,19,20)
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 520n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098155
PNG
(4-[2-(4-Methyl-benzylamino)-thiazol-4-yl]-5-methyl...)
Show SMILES CSc1sc(cc1-c1csc(NCc2ccc(C)cc2)n1)C(N)=N
Show InChI InChI=1S/C17H18N4S3/c1-10-3-5-11(6-4-10)8-20-17-21-13(9-23-17)12-7-14(15(18)19)24-16(12)22-2/h3-7,9H,8H2,1-2H3,(H3,18,19)(H,20,21)
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 640n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098148
PNG
(4-[2-(2,5-Dimethoxy-phenylamino)-thiazol-4-yl]-5-m...)
Show SMILES COc1ccc(OC)c(Nc2nc(cs2)-c2cc(sc2SC)C(N)=N)c1
Show InChI InChI=1S/C17H18N4O2S3/c1-22-9-4-5-13(23-2)11(6-9)20-17-21-12(8-25-17)10-7-14(15(18)19)26-16(10)24-3/h4-8H,1-3H3,(H3,18,19)(H,20,21)
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 660n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098128
PNG
(4-[2-(2-Isopropyl-phenylamino)-thiazol-4-yl]-5-met...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccccc2C(C)C)n1)C(N)=N
Show InChI InChI=1S/C18H20N4S3/c1-10(2)11-6-4-5-7-13(11)21-18-22-14(9-24-18)12-8-15(16(19)20)25-17(12)23-3/h4-10H,1-3H3,(H3,19,20)(H,21,22)
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 700n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098160
PNG
(5-Methylsulfanyl-4-{2-[4-(5-trifluoromethyl-pyridi...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)n1)C(N)=N
Show InChI InChI=1S/C21H16F3N5OS3/c1-31-19-14(8-16(33-19)18(25)26)15-10-32-20(29-15)28-12-3-5-13(6-4-12)30-17-7-2-11(9-27-17)21(22,23)24/h2-10H,1H3,(H3,25,26)(H,28,29)
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 910n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098129
PNG
(2-{3-[4-(5-Carbamimidoyl-2-methylsulfanyl-thiophen...)
Show SMILES CSc1sc(cc1-c1csc(Nc2cccc(OCC(N)=O)c2)n1)C(N)=N
Show InChI InChI=1S/C17H17N5O2S3/c1-25-16-11(6-13(27-16)15(19)20)12-8-26-17(22-12)21-9-3-2-4-10(5-9)24-7-14(18)23/h2-6,8H,7H2,1H3,(H2,18,23)(H3,19,20)(H,21,22)
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 1.02E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098136
PNG
(5-Methylsulfanyl-4-[2-(2,4,5-trimethyl-phenylamino...)
Show SMILES CSc1sc(cc1-c1csc(Nc2cc(C)c(C)cc2C)n1)C(N)=N
Show InChI InChI=1S/C18H20N4S3/c1-9-5-11(3)13(6-10(9)2)21-18-22-14(8-24-18)12-7-15(16(19)20)25-17(12)23-4/h5-8H,1-4H3,(H3,19,20)(H,21,22)
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 1.10E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098135
PNG
(5-Methyl-4-[2-(3,4,5-trimethoxy-phenylamino)-thiaz...)
Show SMILES COc1cc(Nc2nc(cs2)-c2cc(sc2C)C(N)=N)cc(OC)c1OC
Show InChI InChI=1S/C18H20N4O3S2/c1-9-11(7-15(27-9)17(19)20)12-8-26-18(22-12)21-10-5-13(23-2)16(25-4)14(6-10)24-3/h5-8H,1-4H3,(H3,19,20)(H,21,22)
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 1.11E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098146
PNG
(4-[2-(Benzhydryl-amino)-thiazol-4-yl]-5-methylsulf...)
Show SMILES CSc1sc(cc1-c1csc(NC(c2ccccc2)c2ccccc2)n1)C(N)=N
Show InChI InChI=1S/C22H20N4S3/c1-27-21-16(12-18(29-21)20(23)24)17-13-28-22(25-17)26-19(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-13,19H,1H3,(H3,23,24)(H,25,26)
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 1.18E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098154
PNG
(5-Methylsulfanyl-4-[2-(2-morpholin-4-yl-ethylamino...)
Show SMILES CSc1sc(cc1-c1csc(NCCN2CCOCC2)n1)C(N)=N
Show InChI InChI=1S/C15H21N5OS3/c1-22-14-10(8-12(24-14)13(16)17)11-9-23-15(19-11)18-2-3-20-4-6-21-7-5-20/h8-9H,2-7H2,1H3,(H3,16,17)(H,18,19)
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 1.40E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098165
PNG
(4-[2-(2-Chloro-phenylamino)-thiazol-4-yl]-5-methyl...)
Show SMILES CSc1sc(cc1-c1csc(Nc2ccccc2Cl)n1)C(N)=N
Show InChI InChI=1S/C15H13ClN4S3/c1-21-14-8(6-12(23-14)13(17)18)11-7-22-15(20-11)19-10-5-3-2-4-9(10)16/h2-7H,1H3,(H3,17,18)(H,19,20)
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 1.46E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098168
PNG
(4-[2-(2,6-Dichloro-phenylamino)-thiazol-4-yl]-5-me...)
Show SMILES CSc1sc(cc1-c1csc(Nc2c(Cl)cccc2Cl)n1)C(N)=N
Show InChI InChI=1S/C15H12Cl2N4S3/c1-22-14-7(5-11(24-14)13(18)19)10-6-23-15(20-10)21-12-8(16)3-2-4-9(12)17/h2-6H,1H3,(H3,18,19)(H,20,21)
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 1.50E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098130
PNG
(5-Methylsulfanyl-4-[2-(2-piperidin-1-yl-ethylamino...)
Show SMILES CSc1sc(cc1-c1csc(NCCN2CCCCC2)n1)C(N)=N
Show InChI InChI=1S/C16H23N5S3/c1-22-15-11(9-13(24-15)14(17)18)12-10-23-16(20-12)19-5-8-21-6-3-2-4-7-21/h9-10H,2-8H2,1H3,(H3,17,18)(H,19,20)
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 1.60E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098159
PNG
(4-(2-Amino-thiazol-4-yl)-5-methyl-thiophene-2-carb...)
Show SMILES Cc1sc(cc1-c1csc(N)n1)C(N)=N
Show InChI InChI=1S/C9H10N4S2/c1-4-5(2-7(15-4)8(10)11)6-3-14-9(12)13-6/h2-3H,1H3,(H3,10,11)(H2,12,13)
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 1.62E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098157
PNG
(4-{2-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-thiazol...)
Show SMILES COc1cccc(c1)N1CCN(CC1)c1nc(cs1)-c1cc(sc1SC)C(N)=N
Show InChI InChI=1S/C20H23N5OS3/c1-26-14-5-3-4-13(10-14)24-6-8-25(9-7-24)20-23-16(12-28-20)15-11-17(18(21)22)29-19(15)27-2/h3-5,10-12H,6-9H2,1-2H3,(H3,21,22)
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 1.84E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098161
PNG
(4-{2-[4-(2-Fluoro-phenyl)-piperazin-1-yl]-thiazol-...)
Show SMILES CSc1sc(cc1-c1csc(n1)N1CCN(CC1)c1ccccc1F)C(N)=N
Show InChI InChI=1S/C19H20FN5S3/c1-26-18-12(10-16(28-18)17(21)22)14-11-27-19(23-14)25-8-6-24(7-9-25)15-5-3-2-4-13(15)20/h2-5,10-11H,6-9H2,1H3,(H3,21,22)
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 3.06E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098134
PNG
(4-(2-Amino-thiazol-4-yl)-5-methylsulfanyl-thiophen...)
Show SMILES CSc1sc(cc1-c1csc(N)n1)C(N)=N
Show InChI InChI=1S/C9H10N4S3/c1-14-8-4(2-6(16-8)7(10)11)5-3-15-9(12)13-5/h2-3H,1H3,(H3,10,11)(H2,12,13)
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 3.90E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50098167
PNG
(5-Mercaptomethyl-thiophene-2-carboxamidine | CHEMB...)
Show SMILES NC(=N)c1ccc(CS)s1
Show InChI InChI=1S/C6H8N2S2/c7-6(8)5-2-1-4(3-9)10-5/h1-2,9H,3H2,(H3,7,8)
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 6.00E+3n/an/an/an/an/an/an/an/a



3-Dimensional Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Urokinase-type plasminogen activator (microPa)

Bioorg Med Chem Lett 11: 915-8 (2001)


BindingDB Entry DOI: 10.7270/Q2J67G5B
More data for this
Ligand-Target Pair