Found 62 hits Enz. Inhib. hit(s) with all data for entry = 50016892 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174908
(CHEMBL427367 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES [O-][N+](=O)c1ccc2n(Cc3ccccc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C27H27N5O4/c33-32(34)22-7-8-24-23(15-22)27(29-31(24)17-19-4-2-1-3-5-19)28-21-10-12-30(13-11-21)16-20-6-9-25-26(14-20)36-18-35-25/h1-9,14-15,21H,10-13,16-18H2,(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174921
(CHEMBL196973 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C20H21N5O4/c26-25(27)15-2-3-17-16(10-15)20(23-22-17)21-14-5-7-24(8-6-14)11-13-1-4-18-19(9-13)29-12-28-18/h1-4,9-10,14H,5-8,11-12H2,(H2,21,22,23) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174920
(CHEMBL199025 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3ccncc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-20-2-3-23-22(14-20)26(30-32(23)16-18-5-9-28-10-6-18)29-21-7-11-31(12-8-21)15-19-1-4-24-25(13-19)34-17-33-24/h1-6,9-10,13-14,21H,7-8,11-12,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174919
(CHEMBL371222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES COc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N4O3/c1-26-16-3-4-18-17(11-16)21(24-23-18)22-15-6-8-25(9-7-15)12-14-2-5-19-20(10-14)28-13-27-19/h2-5,10-11,15H,6-9,12-13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174913
(CHEMBL197232 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-19-5-6-23-22(14-19)26(30-32(23)16-21-3-1-2-10-28-21)29-20-8-11-31(12-9-20)15-18-4-7-24-25(13-18)34-17-33-24/h1-7,10,13-14,20H,8-9,11-12,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174895
((1-benzo{1,3}dioxol-5-ylmethyl-piperidin-4-yl)(5-c...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C20H21ClN4O2/c21-14-2-3-17-16(10-14)20(24-23-17)22-15-5-7-25(8-6-15)11-13-1-4-18-19(9-13)27-12-26-18/h1-4,9-10,15H,5-8,11-12H2,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174893
(CHEMBL197497 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3cccnc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-20-4-5-23-22(13-20)26(30-32(23)16-19-2-1-9-28-14-19)29-21-7-10-31(11-8-21)15-18-3-6-24-25(12-18)34-17-33-24/h1-6,9,12-14,21H,7-8,10-11,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174916
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1 Show InChI InChI=1S/C29H28ClN5/c30-24-10-11-28-27(18-24)29(33-35(28)20-26-7-3-4-14-31-26)32-25-12-15-34(16-13-25)19-21-8-9-22-5-1-2-6-23(22)17-21/h1-11,14,17-18,25H,12-13,15-16,19-20H2,(H,32,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174911
(1-(3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)CN1CCOCC1 Show InChI InChI=1S/C26H30ClN5O4/c27-19-2-3-22-21(14-19)26(29-32(22)25(33)16-31-9-11-34-12-10-31)28-20-5-7-30(8-6-20)15-18-1-4-23-24(13-18)36-17-35-23/h1-4,13-14,20H,5-12,15-17H2,(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174906
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cccnc1 Show InChI InChI=1S/C26H24ClN5O3/c27-19-4-5-22-21(13-19)25(30-32(22)26(33)18-2-1-9-28-14-18)29-20-7-10-31(11-8-20)15-17-3-6-23-24(12-17)35-16-34-23/h1-6,9,12-14,20H,7-8,10-11,15-16H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174899
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cscn1 Show InChI InChI=1S/C24H22ClN5O3S/c25-16-2-3-20-18(10-16)23(28-30(20)24(31)19-12-34-13-26-19)27-17-5-7-29(8-6-17)11-15-1-4-21-22(9-15)33-14-32-21/h1-4,9-10,12-13,17H,5-8,11,14H2,(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174892
(CHEMBL381013 | N-(1-((2,3-dihydrobenzo[b][1,4]diox...)Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H23N5O4/c27-26(28)16-2-3-18-17(12-16)21(24-23-18)22-15-5-7-25(8-6-15)13-14-1-4-19-20(11-14)30-10-9-29-19/h1-4,11-12,15H,5-10,13H2,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174915
(CHEMBL199222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES COc1ccc2n(C)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C22H26N4O3/c1-25-19-5-4-17(27-2)12-18(19)22(24-25)23-16-7-9-26(10-8-16)13-15-3-6-20-21(11-15)29-14-28-20/h3-6,11-12,16H,7-10,13-14H2,1-2H3,(H,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174904
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)C1CC1 Show InChI InChI=1S/C24H25ClN4O3/c25-17-4-5-20-19(12-17)23(27-29(20)24(30)16-2-3-16)26-18-7-9-28(10-8-18)13-15-1-6-21-22(11-15)32-14-31-21/h1,4-6,11-12,16,18H,2-3,7-10,13-14H2,(H,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174901
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1 Show InChI InChI=1S/C23H23ClN4/c24-19-7-8-22-21(14-19)23(27-26-22)25-20-9-11-28(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H2,25,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174897
(CHEMBL370576 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3ccccc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C27H27ClN4O2/c28-21-7-8-24-23(15-21)27(30-32(24)17-19-4-2-1-3-5-19)29-22-10-12-31(13-11-22)16-20-6-9-25-26(14-20)34-18-33-25/h1-9,14-15,22H,10-13,16-18H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174914
(CHEMBL197395 | N-(1-(benzo[c][1,2,5]thiadiazol-5-y...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5nsnc5c4)CC3)c2c1 Show InChI InChI=1S/C19H19ClN6S/c20-13-2-4-16-15(10-13)19(23-22-16)21-14-5-7-26(8-6-14)11-12-1-3-17-18(9-12)25-27-24-17/h1-4,9-10,14H,5-8,11H2,(H2,21,22,23) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174912
(CHEMBL198789 | N-(1-((1H-indazol-6-yl)methyl)piper...)Show SMILES COc1ccc2[nH]nc(NC3CCN(Cc4ccc5c[nH]nc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N6O/c1-28-17-4-5-19-18(11-17)21(26-25-19)23-16-6-8-27(9-7-16)13-14-2-3-15-12-22-24-20(15)10-14/h2-5,10-12,16H,6-9,13H2,1H3,(H,22,24)(H2,23,25,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174909
(CHEMBL370361 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)-c1ccccc1 Show InChI InChI=1S/C26H25ClN4O2/c27-19-7-8-23-22(15-19)26(29-31(23)21-4-2-1-3-5-21)28-20-10-12-30(13-11-20)16-18-6-9-24-25(14-18)33-17-32-24/h1-9,14-15,20H,10-13,16-17H2,(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174919
(CHEMBL371222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES COc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N4O3/c1-26-16-3-4-18-17(11-16)21(24-23-18)22-15-6-8-25(9-7-15)12-14-2-5-19-20(10-14)28-13-27-19/h2-5,10-11,15H,6-9,12-13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174905
(5-chloro-N-(1-((2,3-dihydrobenzo[b][1,4]dioxin-6-y...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H23ClN4O2/c22-15-2-3-18-17(12-15)21(25-24-18)23-16-5-7-26(8-6-16)13-14-1-4-19-20(11-14)28-10-9-27-19/h1-4,11-12,16H,5-10,13H2,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174921
(CHEMBL196973 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C20H21N5O4/c26-25(27)15-2-3-17-16(10-15)20(23-22-17)21-14-5-7-24(8-6-14)11-13-1-4-18-19(9-13)29-12-28-18/h1-4,9-10,14H,5-8,11-12H2,(H2,21,22,23) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174894
(CHEMBL197283 | N-(1-(3,4-dimethylbenzyl)piperidin-...)Show SMILES Cc1ccc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)cc1C Show InChI InChI=1S/C21H25ClN4/c1-14-3-4-16(11-15(14)2)13-26-9-7-18(8-10-26)23-21-19-12-17(22)5-6-20(19)24-25-21/h3-6,11-12,18H,7-10,13H2,1-2H3,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174896
(CHEMBL196972 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Cc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N4O2/c1-14-2-4-18-17(10-14)21(24-23-18)22-16-6-8-25(9-7-16)12-15-3-5-19-20(11-15)27-13-26-19/h2-5,10-11,16H,6-9,12-13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174900
(CHEMBL197281 | N-(1-(3-methoxybenzyl)piperidin-4-y...)Show SMILES COc1cccc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)c1 Show InChI InChI=1S/C20H23ClN4O/c1-26-17-4-2-3-14(11-17)13-25-9-7-16(8-10-25)22-20-18-12-15(21)5-6-19(18)23-24-20/h2-6,11-12,16H,7-10,13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174915
(CHEMBL199222 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES COc1ccc2n(C)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C22H26N4O3/c1-25-19-5-4-17(27-2)12-18(19)22(24-25)23-16-7-9-26(10-8-16)13-15-3-6-20-21(11-15)29-14-28-20/h3-6,11-12,16H,7-10,13-14H2,1-2H3,(H,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174903
(CHEMBL370360 | N-(1-(4-chlorobenzyl)piperidin-4-yl...)Show SMILES Clc1ccc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)cc1 Show InChI InChI=1S/C19H20Cl2N4/c20-14-3-1-13(2-4-14)12-25-9-7-16(8-10-25)22-19-17-11-15(21)5-6-18(17)23-24-19/h1-6,11,16H,7-10,12H2,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174910
(3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)Show SMILES N#Cc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H21N5O2/c22-11-14-1-3-18-17(9-14)21(25-24-18)23-16-5-7-26(8-6-16)12-15-2-4-19-20(10-15)28-13-27-19/h1-4,9-10,16H,5-8,12-13H2,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174898
(CHEMBL197058 | N-(1-(2-fluoro-4-methoxybenzyl)pipe...)Show SMILES COc1ccc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)c(F)c1 Show InChI InChI=1S/C20H22ClFN4O/c1-27-16-4-2-13(18(22)11-16)12-26-8-6-15(7-9-26)23-20-17-10-14(21)3-5-19(17)24-25-20/h2-5,10-11,15H,6-9,12H2,1H3,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174895
((1-benzo{1,3}dioxol-5-ylmethyl-piperidin-4-yl)(5-c...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C20H21ClN4O2/c21-14-2-3-17-16(10-14)20(24-23-17)22-15-5-7-25(8-6-15)11-13-1-4-18-19(9-13)27-12-26-18/h1-4,9-10,15H,5-8,11-12H2,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174917
(5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)...)Show SMILES COc1cc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)cc2OCOc12 Show InChI InChI=1S/C21H23ClN4O3/c1-27-18-8-13(9-19-20(18)29-12-28-19)11-26-6-4-15(5-7-26)23-21-16-10-14(22)2-3-17(16)24-25-21/h2-3,8-10,15H,4-7,11-12H2,1H3,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174893
(CHEMBL197497 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3cccnc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-20-4-5-23-22(13-20)26(30-32(23)16-19-2-1-9-28-14-19)29-21-7-10-31(11-8-21)15-18-3-6-24-25(12-18)34-17-33-24/h1-6,9,12-14,21H,7-8,10-11,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174891
(CHEMBL198692 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES COc1cccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c12 Show InChI InChI=1S/C21H24N4O3/c1-26-18-4-2-3-16-20(18)21(24-23-16)22-15-7-9-25(10-8-15)12-14-5-6-17-19(11-14)28-13-27-17/h2-6,11,15H,7-10,12-13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174908
(CHEMBL427367 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES [O-][N+](=O)c1ccc2n(Cc3ccccc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C27H27N5O4/c33-32(34)22-7-8-24-23(15-22)27(29-31(24)17-19-4-2-1-3-5-19)28-21-10-12-30(13-11-21)16-20-6-9-25-26(14-20)36-18-35-25/h1-9,14-15,21H,10-13,16-18H2,(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174912
(CHEMBL198789 | N-(1-((1H-indazol-6-yl)methyl)piper...)Show SMILES COc1ccc2[nH]nc(NC3CCN(Cc4ccc5c[nH]nc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N6O/c1-28-17-4-5-19-18(11-17)21(26-25-19)23-16-6-8-27(9-7-16)13-14-2-3-15-12-22-24-20(15)10-14/h2-5,10-12,16H,6-9,13H2,1H3,(H,22,24)(H2,23,25,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174907
(CHEMBL197023 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES C(N1CCC(CC1)Nc1[nH]nc2ccccc12)c1ccc2OCOc2c1 Show InChI InChI=1S/C20H22N4O2/c1-2-4-17-16(3-1)20(23-22-17)21-15-7-9-24(10-8-15)12-14-5-6-18-19(11-14)26-13-25-18/h1-6,11,15H,7-10,12-13H2,(H2,21,22,23) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174892
(CHEMBL381013 | N-(1-((2,3-dihydrobenzo[b][1,4]diox...)Show SMILES [O-][N+](=O)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H23N5O4/c27-26(28)16-2-3-18-17(12-16)21(24-23-18)22-15-5-7-25(8-6-15)13-14-1-4-19-20(11-14)30-10-9-29-19/h1-4,11-12,15H,5-10,13H2,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174913
(CHEMBL197232 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-19-5-6-23-22(14-19)26(30-32(23)16-21-3-1-2-10-28-21)29-20-8-11-31(12-9-20)15-18-4-7-24-25(13-18)34-17-33-24/h1-7,10,13-14,20H,8-9,11-12,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174920
(CHEMBL199025 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Clc1ccc2n(Cc3ccncc3)nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C26H26ClN5O2/c27-20-2-3-23-22(14-20)26(30-32(23)16-18-5-9-28-10-6-18)29-21-7-11-31(12-8-21)15-19-1-4-24-25(13-19)34-17-33-24/h1-6,9-10,13-14,21H,7-8,11-12,15-17H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174916
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2n(Cc3ccccn3)nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1 Show InChI InChI=1S/C29H28ClN5/c30-24-10-11-28-27(18-24)29(33-35(28)20-26-7-3-4-14-31-26)32-25-12-15-34(16-13-25)19-21-8-9-22-5-1-2-6-23(22)17-21/h1-11,14,17-18,25H,12-13,15-16,19-20H2,(H,32,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174918
(CHEMBL197485 | N-(1-benzylpiperidin-4-yl)-5-chloro...)Show InChI InChI=1S/C19H21ClN4/c20-15-6-7-18-17(12-15)19(23-22-18)21-16-8-10-24(11-9-16)13-14-4-2-1-3-5-14/h1-7,12,16H,8-11,13H2,(H2,21,22,23) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174906
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cccnc1 Show InChI InChI=1S/C26H24ClN5O3/c27-19-4-5-22-21(13-19)25(30-32(22)26(33)18-2-1-9-28-14-18)29-20-7-10-31(11-8-20)15-17-3-6-23-24(12-17)35-16-34-23/h1-6,9,12-14,20H,7-8,10-11,15-16H2,(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174896
(CHEMBL196972 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES Cc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H24N4O2/c1-14-2-4-18-17(10-14)21(24-23-18)22-16-6-8-25(9-7-16)12-15-3-5-19-20(11-15)27-13-26-19/h2-5,10-11,16H,6-9,12-13H2,1H3,(H2,22,23,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174911
(1-(3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)CN1CCOCC1 Show InChI InChI=1S/C26H30ClN5O4/c27-19-2-3-22-21(14-19)26(29-32(22)25(33)16-31-9-11-34-12-10-31)28-20-5-7-30(8-6-20)15-18-1-4-23-24(13-18)36-17-35-23/h1-4,13-14,20H,5-12,15-17H2,(H,28,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174894
(CHEMBL197283 | N-(1-(3,4-dimethylbenzyl)piperidin-...)Show SMILES Cc1ccc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)cc1C Show InChI InChI=1S/C21H25ClN4/c1-14-3-4-16(11-15(14)2)13-26-9-7-18(8-10-26)23-21-19-12-17(22)5-6-20(19)24-25-21/h3-6,11-12,18H,7-10,13H2,1-2H3,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174901
(5-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1 Show InChI InChI=1S/C23H23ClN4/c24-19-7-8-22-21(14-19)23(27-26-22)25-20-9-11-28(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H2,25,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174905
(5-chloro-N-(1-((2,3-dihydrobenzo[b][1,4]dioxin-6-y...)Show SMILES Clc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H23ClN4O2/c22-15-2-3-18-17(12-15)21(25-24-18)23-16-5-7-26(8-6-16)13-14-1-4-19-20(11-14)28-10-9-27-19/h1-4,11-12,16H,5-10,13H2,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174902
(CHEMBL383150 | N-(1-(benzo[d][1,3]dioxol-5-ylmethy...)Show SMILES FC(F)(F)c1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H21F3N4O2/c22-21(23,24)14-2-3-17-16(10-14)20(27-26-17)25-15-5-7-28(8-6-15)11-13-1-4-18-19(9-13)30-12-29-18/h1-4,9-10,15H,5-8,11-12H2,(H2,25,26,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174899
((3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-...)Show SMILES Clc1ccc2n(nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1)C(=O)c1cscn1 Show InChI InChI=1S/C24H22ClN5O3S/c25-16-2-3-20-18(10-16)23(28-30(20)24(31)19-12-34-13-26-19)27-17-5-7-29(8-6-17)11-15-1-4-21-22(9-15)33-14-32-21/h1-4,9-10,12-13,17H,5-8,11,14H2,(H,27,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50174910
(3-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)Show SMILES N#Cc1ccc2[nH]nc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C21H21N5O2/c22-11-14-1-3-18-17(9-14)21(25-24-18)23-16-5-7-26(8-6-16)12-15-2-4-19-20(10-15)28-13-27-19/h1-4,9-10,16H,5-8,12-13H2,(H2,23,24,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cells |
Bioorg Med Chem Lett 15: 5293-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.08.049
BindingDB Entry DOI: 10.7270/Q2GQ6X9P |
More data for this
Ligand-Target Pair | |
Search and Browse
