Found 12 hits Enz. Inhib. hit(s) with all data for entry = 50026704 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM50242173
((2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4...)Show SMILES O[C@H]1[C@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccccc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O |r| Show InChI InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL
MCE
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| Article
PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM7460
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | PDB
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CHEMBL
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MCE
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PC cid
PC sid
PDB
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Patents
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| Article
PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM50009001
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H | PDB
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CHEMBL
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| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM7460
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | PDB
MMDB
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KEGG
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| Article
PubMed
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM7462
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H | PDB
MMDB
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KEGG
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CHEMBL
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PC cid
PC sid
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Patents
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| Article
PubMed
| n/a | n/a | 1.32E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50273195
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S...)Show SMILES C[C@@H]1OC(OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26?,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM26660
(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)Show InChI InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H | PDB
MMDB
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CHEMBL
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM7462
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H | PDB
UniProtKB/SwissProt
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PC sid
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| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM26660
(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | 3,7-dihy...)Show InChI InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H | PDB
UniProtKB/SwissProt
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CHEMBL
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50009001
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
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| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
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| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM50273195
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S...)Show SMILES C[C@@H]1OC(OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26?,27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50242173
((2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4...)Show SMILES O[C@H]1[C@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccccc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O |r| Show InChI InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1 | PDB
MMDB
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KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
MCE
KEGG
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PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recerca Biomèdica de Barcelona
Curated by ChEMBL
| Assay Description
Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem 16: 7516-24 (2008)
Article DOI: 10.1016/j.bmc.2008.04.067
BindingDB Entry DOI: 10.7270/Q2ZC82NG |
More data for this
Ligand-Target Pair | |
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