Compile Data Set for Download or QSAR

Found 56 hits Enz. Inhib. hit(s) with all data for entry = 50031369   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50312096 (CHEMBL1080481 | N-(3-(3-chlorobenzamido)phenyl)-2-...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C21H17ClN2O3/c1-27-19-11-3-2-10-18(19)21(26)24-17-9-5-8-16(13-17)23-20(25)14-6-4-7-15(22)12-14/h2-13H,1H3,(H,23,25)(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	301	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]3-methoxy-5-(2-pyridinylethynyl) pyridine from mGluR5				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50312096 (CHEMBL1080481 | N-(3-(3-chlorobenzamido)phenyl)-2-...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C21H17ClN2O3/c1-27-19-11-3-2-10-18(19)21(26)24-17-9-5-8-16(13-17)23-20(25)14-6-4-7-15(22)12-14/h2-13H,1H3,(H,23,25)(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGluR5				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312148 (3-(1,3-dioxoisoindolin-2-yl)-N-(2-hydroxyphenyl)be...) Show SMILES Oc1ccccc1NC(=O)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C21H14N2O4/c24-18-11-4-3-10-17(18)22-19(25)13-6-5-7-14(12-13)23-20(26)15-8-1-2-9-16(15)21(23)27/h1-12,24H,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312149 (CHEMBL1081892 | N-(3-(1H-benzo[d]imidazol-2-yl)-4-...) Show SMILES Clc1ccc(NC(=O)c2ccc(Br)o2)cc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C18H11BrClN3O2/c19-16-8-7-15(25-16)18(24)21-10-5-6-12(20)11(9-10)17-22-13-3-1-2-4-14(13)23-17/h1-9H,(H,21,24)(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312096 (CHEMBL1080481 | N-(3-(3-chlorobenzamido)phenyl)-2-...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C21H17ClN2O3/c1-27-19-11-3-2-10-18(19)21(26)24-17-9-5-8-16(13-17)23-20(25)14-6-4-7-15(22)12-14/h2-13H,1H3,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312144 (3-(1,3-dioxoisoindolin-2-yl)-N-(2-fluorophenyl)ben...) Show SMILES Fc1ccccc1NC(=O)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C21H13FN2O3/c22-17-10-3-4-11-18(17)23-19(25)13-6-5-7-14(12-13)24-20(26)15-8-1-2-9-16(15)21(24)27/h1-12H,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312143 (3-(1,3-dioxoisoindolin-2-yl)-N-(pyridin-2-yl)benza...) Show SMILES O=C(Nc1ccccn1)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C20H13N3O3/c24-18(22-17-10-3-4-11-21-17)13-6-5-7-14(12-13)23-19(25)15-8-1-2-9-16(15)20(23)26/h1-12H,(H,21,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312105 (2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1 Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312141 (CHEMBL1079740 | N-(2-chlorophenyl)-3-(1,3-dioxoiso...) Show SMILES Clc1cccc(NC(=O)c2cccc(c2)N2C(=O)c3ccccc3C2=O)c1 Show InChI InChI=1S/C21H13ClN2O3/c22-14-6-4-7-15(12-14)23-19(25)13-5-3-8-16(11-13)24-20(26)17-9-1-2-10-18(17)21(24)27/h1-12H,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312104 (CHEMBL1081367 | N-(3-(3-cyanobenzamido)phenyl)-2-m...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(c2)C#N)c1 Show InChI InChI=1S/C22H17N3O3/c1-28-20-11-3-2-10-19(20)22(27)25-18-9-5-8-17(13-18)24-21(26)16-7-4-6-15(12-16)14-23/h2-13H,1H3,(H,24,26)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312134 (3-chloro-N-(3-(cyclopropanecarboxamido)phenyl)benz...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C17H15ClN2O2/c18-13-4-1-3-12(9-13)17(22)20-15-6-2-5-14(10-15)19-16(21)11-7-8-11/h1-6,9-11H,7-8H2,(H,19,21)(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312118 (2-chloro-N-(3-(3-chlorobenzamido)phenyl)benzamide ...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2Cl)c1 Show InChI InChI=1S/C20H14Cl2N2O2/c21-14-6-3-5-13(11-14)19(25)23-15-7-4-8-16(12-15)24-20(26)17-9-1-2-10-18(17)22/h1-12H,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312139 (CHEMBL1080451 | N-(3,5-dimethoxyphenyl)-3-(1,3-dio...) Show SMILES COc1cc(NC(=O)c2cccc(c2)N2C(=O)c3ccccc3C2=O)cc(OC)c1 Show InChI InChI=1S/C23H18N2O5/c1-29-17-11-15(12-18(13-17)30-2)24-21(26)14-6-5-7-16(10-14)25-22(27)19-8-3-4-9-20(19)23(25)28/h3-13H,1-2H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312127 (CHEMBL1082168 | N-(3-(3-chlorobenzamido)phenyl)fur...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C18H13ClN2O3/c19-13-5-1-4-12(10-13)17(22)20-14-6-2-7-15(11-14)21-18(23)16-8-3-9-24-16/h1-11H,(H,20,22)(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312133 (3-chloro-N-(3-(cyclobutanecarboxamido)phenyl)benza...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C2CCC2)c1 Show InChI InChI=1S/C18H17ClN2O2/c19-14-7-2-6-13(10-14)18(23)21-16-9-3-8-15(11-16)20-17(22)12-4-1-5-12/h2-3,6-12H,1,4-5H2,(H,20,22)(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312135 (3-chloro-N-(3-isobutyramidophenyl)benzamide | CHEM...) Show SMILES CC(C)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C17H17ClN2O2/c1-11(2)16(21)19-14-7-4-8-15(10-14)20-17(22)12-5-3-6-13(18)9-12/h3-11H,1-2H3,(H,19,21)(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312101 (CHEMBL1076408 | N-(3-(3-fluorobenzamido)phenyl)-2-...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(F)c2)c1 Show InChI InChI=1S/C21H17FN2O3/c1-27-19-11-3-2-10-18(19)21(26)24-17-9-5-8-16(13-17)23-20(25)14-6-4-7-15(22)12-14/h2-13H,1H3,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312138 (3-(1,3-dioxoisoindolin-2-yl)-N-(3-hydroxyphenyl)be...) Show SMILES Oc1cccc(NC(=O)c2cccc(c2)N2C(=O)c3ccccc3C2=O)c1 Show InChI InChI=1S/C21H14N2O4/c24-16-8-4-6-14(12-16)22-19(25)13-5-3-7-15(11-13)23-20(26)17-9-1-2-10-18(17)21(23)27/h1-12,24H,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.79E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312136 (CHEMBL1080810 | N-(3-acetamidophenyl)-3-chlorobenz...) Show SMILES CC(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C15H13ClN2O2/c1-10(19)17-13-6-3-7-14(9-13)18-15(20)11-4-2-5-12(16)8-11/h2-9H,1H3,(H,17,19)(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312103 (2-methoxy-N-(3-(3-(trifluoromethyl)benzamido)pheny...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 Show InChI InChI=1S/C22H17F3N2O3/c1-30-19-11-3-2-10-18(19)21(29)27-17-9-5-8-16(13-17)26-20(28)14-6-4-7-15(12-14)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312123 (3-chloro-N-(3-(4-fluorobenzamido)phenyl)benzamide ...) Show SMILES Fc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C20H14ClFN2O2/c21-15-4-1-3-14(11-15)20(26)24-18-6-2-5-17(12-18)23-19(25)13-7-9-16(22)10-8-13/h1-12H,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312124 (3-chloro-N-(3-(3-(trifluoromethyl)benzamido)phenyl...) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C21H14ClF3N2O2/c22-16-7-2-5-14(11-16)20(29)27-18-9-3-8-17(12-18)26-19(28)13-4-1-6-15(10-13)21(23,24)25/h1-12H,(H,26,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312125 (3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...) Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312126 (CHEMBL1088463 | N-(3-(3-chlorobenzamido)phenyl)ben...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc3OCOc3c2)c1 Show InChI InChI=1S/C21H15ClN2O4/c22-15-4-1-3-13(9-15)20(25)23-16-5-2-6-17(11-16)24-21(26)14-7-8-18-19(10-14)28-12-27-18/h1-11H,12H2,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312128 (3-chloro-N-(3-(2-phenylacetamido)phenyl)benzamide ...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)Cc2ccccc2)c1 Show InChI InChI=1S/C21H17ClN2O2/c22-17-9-4-8-16(13-17)21(26)24-19-11-5-10-18(14-19)23-20(25)12-15-6-2-1-3-7-15/h1-11,13-14H,12H2,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312129 (3-chloro-N-(3-(2-phenylcyclopropanecarboxamido)phe...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C2CC2c2ccccc2)c1 Show InChI InChI=1S/C23H19ClN2O2/c24-17-9-4-8-16(12-17)22(27)25-18-10-5-11-19(13-18)26-23(28)21-14-20(21)15-6-2-1-3-7-15/h1-13,20-21H,14H2,(H,25,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312130 (Adamantane-1-carboxylic acid [3-(3-chloro-benzoyla...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24,16:18:21:25.23.24| Show InChI InChI=1S/C24H25ClN2O2/c25-19-4-1-3-18(10-19)22(28)26-20-5-2-6-21(11-20)27-23(29)24-12-15-7-16(13-24)9-17(8-15)14-24/h1-6,10-11,15-17H,7-9,12-14H2,(H,26,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312131 (3-chloro-N-(3-(cyclohexanecarboxamido)phenyl)benza...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C2CCCCC2)c1 Show InChI InChI=1S/C20H21ClN2O2/c21-16-9-4-8-15(12-16)20(25)23-18-11-5-10-17(13-18)22-19(24)14-6-2-1-3-7-14/h4-5,8-14H,1-3,6-7H2,(H,22,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312132 (3-chloro-N-(3-(cyclopentanecarboxamido)phenyl)benz...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)C2CCCC2)c1 Show InChI InChI=1S/C19H19ClN2O2/c20-15-8-3-7-14(11-15)19(24)22-17-10-4-9-16(12-17)21-18(23)13-5-1-2-6-13/h3-4,7-13H,1-2,5-6H2,(H,21,23)(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312137 (3-chloro-N-(3-(2-methoxyacetamido)phenyl)benzamide...) Show SMILES COCC(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C16H15ClN2O3/c1-22-10-15(20)18-13-6-3-7-14(9-13)19-16(21)11-4-2-5-12(17)8-11/h2-9H,10H2,1H3,(H,18,20)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312140 (3-(1,3-dioxoisoindolin-2-yl)-N-(2-methoxyphenyl)be...) Show SMILES COc1ccccc1NC(=O)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C22H16N2O4/c1-28-19-12-5-4-11-18(19)23-20(25)14-7-6-8-15(13-14)24-21(26)16-9-2-3-10-17(16)22(24)27/h2-13H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312142 (3-(1,3-dioxoisoindolin-2-yl)-N-(pyridin-3-yl)benza...) Show SMILES O=C(Nc1cccnc1)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C20H13N3O3/c24-18(22-14-6-4-10-21-12-14)13-5-3-7-15(11-13)23-19(25)16-8-1-2-9-17(16)20(23)26/h1-12H,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312145 (3-(1,3-dioxoisoindolin-2-yl)-N-(4-fluorophenyl)ben...) Show SMILES Fc1ccc(NC(=O)c2cccc(c2)N2C(=O)c3ccccc3C2=O)cc1 Show InChI InChI=1S/C21H13FN2O3/c22-14-8-10-15(11-9-14)23-19(25)13-4-3-5-16(12-13)24-20(26)17-6-1-2-7-18(17)21(24)27/h1-12H,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312146 (CHEMBL1075707 | N-cyclopropyl-3-(1,3-dioxoisoindol...) Show SMILES O=C(NC1CC1)c1cccc(c1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C18H14N2O3/c21-16(19-12-8-9-12)11-4-3-5-13(10-11)20-17(22)14-6-1-2-7-15(14)18(20)23/h1-7,10,12H,8-9H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312147 (CHEMBL1081053 | N-(bicyclo[2.2.1]heptan-2-yl)-3-(1...) Show SMILES O=C(NC1CC2CCC1C2)c1cccc(c1)N1C(=O)c2ccccc2C1=O |TLB:2:3:7.6:9| Show InChI InChI=1S/C22H20N2O3/c25-20(23-19-11-13-8-9-14(19)10-13)15-4-3-5-16(12-15)24-21(26)17-6-1-2-7-18(17)22(24)27/h1-7,12-14,19H,8-11H2,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312122 (3-chloro-N-(3-(3-fluorobenzamido)phenyl)benzamide ...) Show SMILES Fc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C20H14ClFN2O2/c21-15-6-1-4-13(10-15)19(25)23-17-8-3-9-18(12-17)24-20(26)14-5-2-7-16(22)11-14/h1-12H,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312121 (3,4-dichloro-N-(3-(3-chlorobenzamido)phenyl)benzam...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccc(Cl)c(Cl)c2)c1 Show InChI InChI=1S/C20H13Cl3N2O2/c21-14-4-1-3-12(9-14)19(26)24-15-5-2-6-16(11-15)25-20(27)13-7-8-17(22)18(23)10-13/h1-11H,(H,24,26)(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312120 (3-chloro-N-(3-(4-chlorobenzamido)phenyl)benzamide ...) Show SMILES Clc1ccc(cc1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C20H14Cl2N2O2/c21-15-9-7-13(8-10-15)19(25)23-17-5-2-6-18(12-17)24-20(26)14-3-1-4-16(22)11-14/h1-12H,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312119 (CHEMBL1088448 | N,N'-(1,3-phenylene)bis(3-chlorobe...) Show SMILES Clc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C20H14Cl2N2O2/c21-15-6-1-4-13(10-15)19(25)23-17-8-3-9-18(12-17)24-20(26)14-5-2-7-16(22)11-14/h1-12H,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312117 (2-methoxy-N-(3-(2-methoxyacetamido)phenyl)benzamid...) Show SMILES COCC(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1 Show InChI InChI=1S/C17H18N2O4/c1-22-11-16(20)18-12-6-5-7-13(10-12)19-17(21)14-8-3-4-9-15(14)23-2/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312116 (CHEMBL1088173 | N-(3-acetamidophenyl)-2-methoxyben...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(C)=O)c1 Show InChI InChI=1S/C16H16N2O3/c1-11(19)17-12-6-5-7-13(10-12)18-16(20)14-8-3-4-9-15(14)21-2/h3-10H,1-2H3,(H,17,19)(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312115 (CHEMBL1086879 | N-(3-isobutyramidophenyl)-2-methox...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C(C)C)c1 Show InChI InChI=1S/C18H20N2O3/c1-12(2)17(21)19-13-7-6-8-14(11-13)20-18(22)15-9-4-5-10-16(15)23-3/h4-12H,1-3H3,(H,19,21)(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312114 (CHEMBL1086753 | N-(3-(cyclopropanecarboxamido)phen...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C18H18N2O3/c1-23-16-8-3-2-7-15(16)18(22)20-14-6-4-5-13(11-14)19-17(21)12-9-10-12/h2-8,11-12H,9-10H2,1H3,(H,19,21)(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312113 (CHEMBL1086752 | N-(3-(cyclobutanecarboxamido)pheny...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C2CCC2)c1 Show InChI InChI=1S/C19H20N2O3/c1-24-17-11-3-2-10-16(17)19(23)21-15-9-5-8-14(12-15)20-18(22)13-6-4-7-13/h2-3,5,8-13H,4,6-7H2,1H3,(H,20,22)(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312112 (CHEMBL1086751 | N-(3-(cyclopentanecarboxamido)phen...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C2CCCC2)c1 Show InChI InChI=1S/C20H22N2O3/c1-25-18-12-5-4-11-17(18)20(24)22-16-10-6-9-15(13-16)21-19(23)14-7-2-3-8-14/h4-6,9-14H,2-3,7-8H2,1H3,(H,21,23)(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312111 (CHEMBL1086750 | N-(3-(cyclohexanecarboxamido)pheny...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C2CCCCC2)c1 Show InChI InChI=1S/C21H24N2O3/c1-26-19-13-6-5-12-18(19)21(25)23-17-11-7-10-16(14-17)22-20(24)15-8-3-2-4-9-15/h5-7,10-15H,2-4,8-9H2,1H3,(H,22,24)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312110 (Adamantane-1-carboxylic acid [3-(2-methoxy-benzoyl...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |TLB:17:19:22.21.26:24,THB:20:21:24:28.19.27,20:19:22.21.26:24,27:19:22:26.25.24,27:25:22:28.20.19,17:19:22:26.25.24| Show InChI InChI=1S/C25H28N2O3/c1-30-22-8-3-2-7-21(22)23(28)26-19-5-4-6-20(12-19)27-24(29)25-13-16-9-17(14-25)11-18(10-16)15-25/h2-8,12,16-18H,9-11,13-15H2,1H3,(H,26,28)(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312109 (2-methoxy-N-(3-(2-phenylcyclopropanecarboxamido)ph...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)C2CC2c2ccccc2)c1 Show InChI InChI=1S/C24H22N2O3/c1-29-22-13-6-5-12-19(22)23(27)25-17-10-7-11-18(14-17)26-24(28)21-15-20(21)16-8-3-2-4-9-16/h2-14,20-21H,15H2,1H3,(H,25,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312108 (2-methoxy-N-(3-(2-phenylacetamido)phenyl)benzamide...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)Cc2ccccc2)c1 Show InChI InChI=1S/C22H20N2O3/c1-27-20-13-6-5-12-19(20)22(26)24-18-11-7-10-17(15-18)23-21(25)14-16-8-3-2-4-9-16/h2-13,15H,14H2,1H3,(H,23,25)(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50312107 (CHEMBL1087769 | N-(3-(2-methoxybenzamido)phenyl)fu...) Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C19H16N2O4/c1-24-16-9-3-2-8-15(16)18(22)20-13-6-4-7-14(12-13)21-19(23)17-10-5-11-25-17/h2-12H,1H3,(H,20,22)(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK293A cells assessed as inhibition of glutamate-induced calcium flux				Bioorg Med Chem Lett 19: 6502-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.059 BindingDB Entry DOI: 10.7270/Q2JD4WZJ
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 56 total )  |  Next  |  Last  >>

Jump to: