Found 27 hits Enz. Inhib. hit(s) with all data for entry = 50031702 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human SERT expressed in human JAR cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM30130
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human SERT expressed in human JAR cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50005536
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 22.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human SERT expressed in human JAR cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50317592
((-)-R-1-(1-(3-chlorophenyl)-2-(4-methylpiperazin-1...)Show SMILES CN1CCN(C[C@@H](c2cccc(Cl)c2)C2(N)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H30ClN3/c1-22-10-12-23(13-11-22)15-18(16-6-5-7-17(20)14-16)19(21)8-3-2-4-9-19/h5-7,14,18H,2-4,8-13,15,21H2,1H3/t18-/m0/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317589
((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317589
((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317595
(1-(1-(5-chlorothiophen-3-yl)-2-(piperazin-1-yl)eth...)Show InChI InChI=1S/C16H25ClN2OS/c17-15-10-13(12-21-15)14(11-19-8-6-18-7-9-19)16(20)4-2-1-3-5-16/h10,12,14,18,20H,1-9,11H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50317589
((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317593
(1-(1-(2,5-dichlorothiophen-3-yl)-2-(piperazin-1-yl...)Show InChI InChI=1S/C16H24Cl2N2OS/c17-14-10-12(15(18)22-14)13(11-20-8-6-19-7-9-20)16(21)4-2-1-3-5-16/h10,13,19,21H,1-9,11H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317596
(1-(1-(benzo[b]thiophen-3-yl)-2-(piperazin-1-yl)eth...)Show InChI InChI=1S/C20H28N2OS/c23-20(8-4-1-5-9-20)18(14-22-12-10-21-11-13-22)17-15-24-19-7-3-2-6-16(17)19/h2-3,6-7,15,18,21,23H,1,4-5,8-14H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 255 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50317589
((+)-S-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 389 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| n/a | n/a | 535 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317597
(1-(1-(benzo[b]thiophen-2-yl)-2-(piperazin-1-yl)eth...)Show InChI InChI=1S/C20H28N2OS/c23-20(8-4-1-5-9-20)17(15-22-12-10-21-11-13-22)19-14-16-6-2-3-7-18(16)24-19/h2-3,6-7,14,17,21,23H,1,4-5,8-13,15H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317592
((-)-R-1-(1-(3-chlorophenyl)-2-(4-methylpiperazin-1...)Show SMILES CN1CCN(C[C@@H](c2cccc(Cl)c2)C2(N)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H30ClN3/c1-22-10-12-23(13-11-22)15-18(16-6-5-7-17(20)14-16)19(21)8-3-2-4-9-19/h5-7,14,18H,2-4,8-13,15,21H2,1H3/t18-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 576 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317594
(1-(1-(2-chlorothiophen-3-yl)-2-(piperazin-1-yl)eth...)Show InChI InChI=1S/C16H25ClN2OS/c17-15-13(4-11-21-15)14(12-19-9-7-18-8-10-19)16(20)5-2-1-3-6-16/h4,11,14,18,20H,1-3,5-10,12H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM84745
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human SERT expressed in human JAR cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50317590
((-)-R-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m0/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| DrugBank Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50317590
((-)-R-1-(1-(5-chlorothiophen-3-yl)-2-(4-methylpipe...)Show SMILES CN1CCN(C[C@@H](c2csc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C17H27ClN2OS/c1-19-7-9-20(10-8-19)12-15(14-11-16(18)22-13-14)17(21)5-3-2-4-6-17/h11,13,15,21H,2-10,12H2,1H3/t15-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of human NET transfected in MDCK-Net6 cells |
Bioorg Med Chem Lett 20: 2809-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.059 BindingDB Entry DOI: 10.7270/Q2028RQV |
More data for this Ligand-Target Pair | |