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Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with all data for entry = 50033597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347967
PNG
(CHEMBL1800386)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C49H90N18O9/c1-4-12-35(62-43(72)36(14-10-24-60-49(57)58)61-41(70)30-67(25-8-6-5-7-21-50)46(75)34(53)13-9-23-59-48(55)56)42(71)64-38(27-32-16-18-33(68)19-17-32)44(73)65-39(28-52)45(74)63-37(20-15-31(2)3)47(76)66(26-11-22-51)29-40(54)69/h16-19,31,34-39,68H,4-15,20-30,50-53H2,1-3H3,(H2,54,69)(H,61,70)(H,62,72)(H,63,74)(H,64,71)(H,65,73)(H4,55,56,59)(H4,57,58,60)/t34-,35-,36-,37-,38-,39-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347981
PNG
(CHEMBL1800388)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C47H86N18O9/c1-4-10-33(60-41(70)34(12-8-22-58-47(55)56)59-39(68)28-65(24-9-20-49)44(73)32(51)11-7-21-57-46(53)54)40(69)62-36(25-30-14-16-31(66)17-15-30)42(71)63-37(26-50)43(72)61-35(18-13-29(2)3)45(74)64(27-38(52)67)23-6-5-19-48/h14-17,29,32-37,66H,4-13,18-28,48-51H2,1-3H3,(H2,52,67)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,63,71)(H4,53,54,57)(H4,55,56,58)/t32-,33-,34-,35-,36-,37-/m0/s1
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n/an/a 128n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347969
PNG
(CHEMBL1800389)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C48H88N18O9/c1-4-11-34(61-42(71)35(13-10-23-59-48(56)57)60-40(69)29-66(25-8-6-21-50)45(74)33(52)12-9-22-58-47(54)55)41(70)63-37(26-31-15-17-32(67)18-16-31)43(72)64-38(27-51)44(73)62-36(19-14-30(2)3)46(75)65(28-39(53)68)24-7-5-20-49/h15-18,30,33-38,67H,4-14,19-29,49-52H2,1-3H3,(H2,53,68)(H,60,69)(H,61,71)(H,62,73)(H,63,70)(H,64,72)(H4,54,55,58)(H4,56,57,59)/t33-,34-,35-,36-,37-,38-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347965
PNG
(CHEMBL1800268)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C46H84N18O9/c1-4-9-32(59-40(69)33(11-6-21-57-46(54)55)58-38(67)27-64(23-8-19-48)43(72)31(50)10-5-20-56-45(52)53)39(68)61-35(24-29-13-15-30(65)16-14-29)41(70)62-36(25-49)42(71)60-34(17-12-28(2)3)44(73)63(22-7-18-47)26-37(51)66/h13-16,28,31-36,65H,4-12,17-27,47-50H2,1-3H3,(H2,51,66)(H,58,67)(H,59,69)(H,60,71)(H,61,68)(H,62,70)(H4,52,53,56)(H4,54,55,57)/t31-,32-,33-,34-,35-,36-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347966
PNG
(CHEMBL1800269)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C47H86N18O9/c1-4-10-33(60-41(70)34(12-8-22-58-47(55)56)59-39(68)28-65(23-6-5-19-48)44(73)32(51)11-7-21-57-46(53)54)40(69)62-36(25-30-14-16-31(66)17-15-30)42(71)63-37(26-50)43(72)61-35(18-13-29(2)3)45(74)64(24-9-20-49)27-38(52)67/h14-17,29,32-37,66H,4-13,18-28,48-51H2,1-3H3,(H2,52,67)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,63,71)(H4,53,54,57)(H4,55,56,58)/t32-,33-,34-,35-,36-,37-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347970
PNG
(CHEMBL1800390)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C50H92N18O9/c1-4-13-36(63-44(73)37(15-12-25-61-50(58)59)62-42(71)31-68(26-9-6-5-7-22-51)47(76)35(54)14-11-24-60-49(56)57)43(72)65-39(28-33-17-19-34(69)20-18-33)45(74)66-40(29-53)46(75)64-38(21-16-32(2)3)48(77)67(30-41(55)70)27-10-8-23-52/h17-20,32,35-40,69H,4-16,21-31,51-54H2,1-3H3,(H2,55,70)(H,62,71)(H,63,73)(H,64,75)(H,65,72)(H,66,74)(H4,56,57,60)(H4,58,59,61)/t35-,36-,37-,38-,39-,40-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347973
PNG
(CHEMBL1800402)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C50H88N18O10/c1-4-12-35-42(72)65-38(27-32-16-18-33(69)19-17-32)44(74)66-39(28-51)45(75)64-37(20-15-31(2)3)47(77)67(29-40(53)70)26-11-24-61-50(78)60-21-7-5-6-8-25-68(46(76)34(52)13-9-22-58-48(54)55)30-41(71)62-36(43(73)63-35)14-10-23-59-49(56)57/h16-19,31,34-39,69H,4-15,20-30,51-52H2,1-3H3,(H2,53,70)(H,62,71)(H,63,73)(H,64,75)(H,65,72)(H,66,74)(H4,54,55,58)(H4,56,57,59)(H2,60,61,78)/t34-,35-,36-,37-,38-,39-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347975
PNG
(CHEMBL1800566)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C49H86N18O10/c1-4-11-34-41(71)64-37(26-31-15-17-32(68)18-16-31)43(73)65-38(27-50)44(74)63-36(19-14-30(2)3)46(76)66(28-39(52)69)24-7-5-20-59-49(77)60-21-6-8-25-67(45(75)33(51)12-9-22-57-47(53)54)29-40(70)61-35(42(72)62-34)13-10-23-58-48(55)56/h15-18,30,33-38,68H,4-14,19-29,50-51H2,1-3H3,(H2,52,69)(H,61,70)(H,62,72)(H,63,74)(H,64,71)(H,65,73)(H4,53,54,57)(H4,55,56,58)(H2,59,60,77)/t33-,34-,35-,36-,37-,38-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347968
PNG
(CHEMBL1800387)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C46H84N18O9/c1-4-9-32(59-40(69)33(11-8-21-57-46(54)55)58-38(67)27-64(23-19-48)43(72)31(50)10-7-20-56-45(52)53)39(68)61-35(24-29-13-15-30(65)16-14-29)41(70)62-36(25-49)42(71)60-34(17-12-28(2)3)44(73)63(26-37(51)66)22-6-5-18-47/h13-16,28,31-36,65H,4-12,17-27,47-50H2,1-3H3,(H2,51,66)(H,58,67)(H,59,69)(H,60,71)(H,61,68)(H,62,70)(H4,52,53,56)(H4,54,55,57)/t31-,32-,33-,34-,35-,36-/m0/s1
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n/an/a 176n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347962
PNG
(CHEMBL1800266)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C46H84N18O9/c1-4-9-32(59-40(69)33(11-8-21-57-46(54)55)58-38(67)27-63(22-6-5-18-47)43(72)31(50)10-7-20-56-45(52)53)39(68)61-35(24-29-13-15-30(65)16-14-29)41(70)62-36(25-49)42(71)60-34(17-12-28(2)3)44(73)64(23-19-48)26-37(51)66/h13-16,28,31-36,65H,4-12,17-27,47-50H2,1-3H3,(H2,51,66)(H,58,67)(H,59,69)(H,60,71)(H,61,68)(H,62,70)(H4,52,53,56)(H4,54,55,57)/t31-,32-,33-,34-,35-,36-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347980
PNG
(CHEMBL1800699)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O |r|
Show InChI InChI=1S/C40H68N14O9/c1-4-7-27-34(58)52-30(20-25-10-12-26(55)13-11-25)36(60)53-31(21-41)37(61)51-29(14-9-24(2)3)38(62)54(23-32(42)56)19-18-48-40(63)47-17-6-15-45-22-33(57)49-28(35(59)50-27)8-5-16-46-39(43)44/h10-13,24,27-31,45,55H,4-9,14-23,41H2,1-3H3,(H2,42,56)(H,49,57)(H,50,59)(H,51,61)(H,52,58)(H,53,60)(H4,43,44,46)(H2,47,48,63)/t27-,28-,29-,30-,31-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347964
PNG
(CHEMBL1800259)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C45H82N18O9/c1-4-8-31(58-39(68)32(10-6-20-56-45(53)54)57-37(66)26-63(22-18-47)42(71)30(49)9-5-19-55-44(51)52)38(67)60-34(23-28-12-14-29(64)15-13-28)40(69)61-35(24-48)41(70)59-33(16-11-27(2)3)43(72)62(21-7-17-46)25-36(50)65/h12-15,27,30-35,64H,4-11,16-26,46-49H2,1-3H3,(H2,50,65)(H,57,66)(H,58,68)(H,59,70)(H,60,67)(H,61,69)(H4,51,52,55)(H4,53,54,56)/t30-,31-,32-,33-,34-,35-/m0/s1
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n/an/a 250n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347976
PNG
(CHEMBL1800567)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C51H90N18O10/c1-4-13-36-43(73)66-39(28-33-17-19-34(70)20-18-33)45(75)67-40(29-52)46(76)65-38(21-16-32(2)3)48(78)68(30-41(54)71)27-10-8-23-62-51(79)61-22-7-5-6-9-26-69(47(77)35(53)14-11-24-59-49(55)56)31-42(72)63-37(44(74)64-36)15-12-25-60-50(57)58/h17-20,32,35-40,70H,4-16,21-31,52-53H2,1-3H3,(H2,54,71)(H,63,72)(H,64,74)(H,65,76)(H,66,73)(H,67,75)(H4,55,56,59)(H4,57,58,60)(H2,61,62,79)/t35-,36-,37-,38-,39-,40-/m0/s1
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n/an/a 280n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347974
PNG
(CHEMBL1800403)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C47H82N18O10/c1-4-9-32-39(69)62-35(24-29-13-15-30(66)16-14-29)41(71)63-36(25-48)42(72)61-34(17-12-28(2)3)44(74)64(26-37(50)67)22-6-5-18-57-47(75)58-21-23-65(43(73)31(49)10-7-19-55-45(51)52)27-38(68)59-33(40(70)60-32)11-8-20-56-46(53)54/h13-16,28,31-36,66H,4-12,17-27,48-49H2,1-3H3,(H2,50,67)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,63,71)(H4,51,52,55)(H4,53,54,56)(H2,57,58,75)/t31-,32-,33-,34-,35-,36-/m0/s1
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n/an/a 282n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347977
PNG
(CHEMBL1800568)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C49H86N18O10/c1-4-11-34-41(71)64-37(26-31-15-17-32(68)18-16-31)43(73)65-38(27-50)44(74)63-36(19-14-30(2)3)46(76)66(28-39(52)69)24-8-6-5-7-20-59-49(77)60-23-25-67(45(75)33(51)12-9-21-57-47(53)54)29-40(70)61-35(42(72)62-34)13-10-22-58-48(55)56/h15-18,30,33-38,68H,4-14,19-29,50-51H2,1-3H3,(H2,52,69)(H,61,70)(H,62,72)(H,63,74)(H,64,71)(H,65,73)(H4,53,54,57)(H4,55,56,58)(H2,59,60,77)/t33-,34-,35-,36-,37-,38-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347963
PNG
(CHEMBL1800267)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C48H88N18O9/c1-4-11-34(61-42(71)35(13-10-23-59-48(56)57)60-40(69)29-65(24-8-6-5-7-20-49)45(74)33(52)12-9-22-58-47(54)55)41(70)63-37(26-31-15-17-32(67)18-16-31)43(72)64-38(27-51)44(73)62-36(19-14-30(2)3)46(75)66(25-21-50)28-39(53)68/h15-18,30,33-38,67H,4-14,19-29,49-52H2,1-3H3,(H2,53,68)(H,60,69)(H,61,71)(H,62,73)(H,63,70)(H,64,72)(H4,54,55,58)(H4,56,57,59)/t33-,34-,35-,36-,37-,38-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347978
PNG
(CHEMBL1800569)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C50H88N18O10/c1-4-12-35-42(72)65-38(27-32-16-18-33(69)19-17-32)44(74)66-39(28-51)45(75)64-37(20-15-31(2)3)47(77)67(29-40(53)70)25-8-6-5-7-21-60-50(78)61-24-11-26-68(46(76)34(52)13-9-22-58-48(54)55)30-41(71)62-36(43(73)63-35)14-10-23-59-49(56)57/h16-19,31,34-39,69H,4-15,20-30,51-52H2,1-3H3,(H2,53,70)(H,62,71)(H,63,73)(H,64,75)(H,65,72)(H,66,74)(H4,54,55,58)(H4,56,57,59)(H2,60,61,78)/t34-,35-,36-,37-,38-,39-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347961
PNG
(CHEMBL1800265)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C45H82N18O9/c1-4-8-31(58-39(68)32(10-6-20-56-45(53)54)57-37(66)26-62(21-7-17-46)42(71)30(49)9-5-19-55-44(51)52)38(67)60-34(23-28-12-14-29(64)15-13-28)40(69)61-35(24-48)41(70)59-33(16-11-27(2)3)43(72)63(22-18-47)25-36(50)65/h12-15,27,30-35,64H,4-11,16-26,46-49H2,1-3H3,(H2,50,65)(H,57,66)(H,58,68)(H,59,70)(H,60,67)(H,61,69)(H4,51,52,55)(H4,53,54,56)/t30-,31-,32-,33-,34-,35-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347979
PNG
(CHEMBL1800698)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O |r|
Show InChI InChI=1S/C39H66N14O9/c1-4-6-26-33(57)51-29(19-24-9-11-25(54)12-10-24)35(59)52-30(20-40)36(60)50-28(13-8-23(2)3)37(61)53(22-31(41)55)18-17-47-39(62)46-16-15-44-21-32(56)48-27(34(58)49-26)7-5-14-45-38(42)43/h9-12,23,26-30,44,54H,4-8,13-22,40H2,1-3H3,(H2,41,55)(H,48,56)(H,49,58)(H,50,60)(H,51,57)(H,52,59)(H4,42,43,45)(H2,46,47,62)/t26-,27-,28-,29-,30-/m0/s1
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n/an/a 390n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347972
PNG
(CHEMBL1800400)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C47H82N18O10/c1-4-9-32-39(69)62-35(24-29-13-15-30(66)16-14-29)41(71)63-36(25-48)42(72)61-34(17-12-28(2)3)44(74)64(26-37(50)67)22-7-20-57-47(75)58-21-8-23-65(43(73)31(49)10-5-18-55-45(51)52)27-38(68)59-33(40(70)60-32)11-6-19-56-46(53)54/h13-16,28,31-36,66H,4-12,17-27,48-49H2,1-3H3,(H2,50,67)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,63,71)(H4,51,52,55)(H4,53,54,56)(H2,57,58,75)/t31-,32-,33-,34-,35-,36-/m0/s1
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n/an/a 590n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347959
PNG
(CHEMBL1800260)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C39H70N16O8/c1-4-7-26(51-34(60)27(9-6-17-49-39(46)47)52-37(63)29(19-40)54-32(58)24(42)8-5-16-48-38(44)45)33(59)53-28(18-22-11-13-23(56)14-12-22)35(61)55-30(20-41)36(62)50-25(31(43)57)15-10-21(2)3/h11-14,21,24-30,56H,4-10,15-20,40-42H2,1-3H3,(H2,43,57)(H,50,62)(H,51,60)(H,52,63)(H,53,59)(H,54,58)(H,55,61)(H4,44,45,48)(H4,46,47,49)/t24-,25-,26-,27-,28-,29-,30-/m0/s1
PDB

UniProtKB/SwissProt

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n/an/a 860n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347971
PNG
(CHEMBL1800399)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C46H80N18O10/c1-4-8-31-38(68)61-34(23-28-12-14-29(65)15-13-28)40(70)62-35(24-47)41(71)60-33(16-11-27(2)3)43(73)63(25-36(49)66)21-7-19-56-46(74)57-20-22-64(42(72)30(48)9-5-17-54-44(50)51)26-37(67)58-32(39(69)59-31)10-6-18-55-45(52)53/h12-15,27,30-35,65H,4-11,16-26,47-48H2,1-3H3,(H2,49,66)(H,58,67)(H,59,69)(H,60,71)(H,61,68)(H,62,70)(H4,50,51,54)(H4,52,53,55)(H2,56,57,74)/t30-,31-,32-,33-,34-,35-/m0/s1
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n/an/a 920n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50316026
PNG
((S)-N-((6S,9S,12S,15S,18S)-1-amino-15-(aminomethyl...)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C41H71N15O8/c1-4-8-28(34(59)54-30(21-24-13-15-25(57)16-14-24)36(61)55-31(22-42)37(62)51-27(33(44)58)17-12-23(2)3)52-35(60)29(10-6-19-50-41(47)48)53-38(63)32-11-7-20-56(32)39(64)26(43)9-5-18-49-40(45)46/h13-16,23,26-32,57H,4-12,17-22,42-43H2,1-3H3,(H2,44,58)(H,51,62)(H,52,60)(H,53,63)(H,54,59)(H,55,61)(H4,45,46,49)(H4,47,48,50)/t26-,27-,28-,29-,30-,31-,32-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347958
PNG
(CHEMBL1800146)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C45H79N15O8/c1-4-10-32(39(64)59-35(24-28-16-18-29(61)19-17-28)42(67)60-36(25-46)43(68)55-31(37(48)62)20-15-26(2)3)56-40(65)33(14-9-22-54-45(51)52)57-41(66)34(23-27-11-6-5-7-12-27)58-38(63)30(47)13-8-21-53-44(49)50/h16-19,26-27,30-36,61H,4-15,20-25,46-47H2,1-3H3,(H2,48,62)(H,55,68)(H,56,65)(H,57,66)(H,58,63)(H,59,64)(H,60,67)(H4,49,50,53)(H4,51,52,54)/t30-,31-,32-,33-,34-,35-,36-/m0/s1
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PubMed
n/an/a 950n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347960
PNG
(CHEMBL1800262)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C42H76N16O8/c1-4-9-29(36(62)57-32(22-25-14-16-26(59)17-15-25)39(65)58-33(23-44)40(66)53-28(34(46)60)18-13-24(2)3)55-38(64)31(12-8-21-52-42(49)50)56-37(63)30(11-5-6-19-43)54-35(61)27(45)10-7-20-51-41(47)48/h14-17,24,27-33,59H,4-13,18-23,43-45H2,1-3H3,(H2,46,60)(H,53,66)(H,54,61)(H,55,64)(H,56,63)(H,57,62)(H,58,65)(H4,47,48,51)(H4,49,50,52)/t27-,28-,29-,30-,31-,32-,33-/m0/s1
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PubMed
n/an/a 2.15E+3n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair