Compile Data Set for Download or QSAR

Found 34 hits Enz. Inhib. hit(s) with all data for entry = 50049179   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description ATP competitive inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) using 1.5 ug/ml ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235741 (CHEMBL4099717) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12ClNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Ability to displace radioligand [3H]spiperone from human dopamine D3 receptor transfected chinese hamster ovary cell membranes.				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235795 (CHEMBL4089069) Show SMILES CC(C)c1cc(F)c2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235740 (CHEMBL4061441) Show SMILES CC(C)c1ccc2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)8-4-3-7-5-9(12(15)16)14-11(7)10(8)13/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-II (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235794 (CHEMBL4067856) Show SMILES CC(C)c1ccc2c(F)c([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)7-3-4-8-9(5-7)14-11(10(8)13)12(15)16/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]naltrindole as radioligand				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235739 (CHEMBL4079731) Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H13NO2/c1-7(2)8-3-4-9-6-11(12(14)15)13-10(9)5-8/h3-7,13H,1-2H3,(H,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition towards glutamate racemase from Lactobacillus fermenti was determined and expressed as KI				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235796 (CHEMBL4081704) Show SMILES CC(C)c1cc2[nH]c(cc2cc1F)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)8-5-10-7(3-9(8)13)4-11(14-10)12(15)16/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235792 (CHEMBL4101109) Show SMILES CC(C)c1ccc2cc([nH]c2c1)-c1nnn[nH]1 Show InChI InChI=1S/C12H13N5/c1-7(2)8-3-4-9-6-11(13-10(9)5-8)12-14-16-17-15-12/h3-7,13H,1-2H3,(H,14,15,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235797 (CHEMBL4089574) Show SMILES CC(C)c1ccc2cc([nH]c2c1Cl)C(O)=O Show InChI InChI=1S/C12H12ClNO2/c1-6(2)8-4-3-7-5-9(12(15)16)14-11(7)10(8)13/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-II (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235789 (CHEMBL4075940) Show SMILES CC(C)c1cccc2cc([nH]c12)C(O)=O Show InChI InChI=1S/C12H13NO2/c1-7(2)9-5-3-4-8-6-10(12(14)15)13-11(8)9/h3-7,13H,1-2H3,(H,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235742 (CHEMBL4082138) Show SMILES CCc1ccc2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C11H11NO2/c1-2-7-3-4-8-6-10(11(13)14)12-9(8)5-7/h3-6,12H,2H2,1H3,(H,13,14)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Ability to displace radioligand [3H]N-0437 from human dopamine D2 receptor transfected chinese hamster ovary cell membranes.				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50305666 (6-methyl-1H-indole-2-carboxylic acid | CHEMBL59600...) Show SMILES Cc1ccc2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C10H9NO2/c1-6-2-3-7-5-9(10(12)13)11-8(7)4-6/h2-5,11H,1H3,(H,12,13)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Ability to displace radioligand [3H]N-0437 from human dopamine D2 receptor transfected chinese hamster ovary cell membranes.				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235793 (CHEMBL4074367) Show SMILES CC(C)c1ccc2cc(C(O)=O)n(C)c2c1 Show InChI InChI=1S/C13H15NO2/c1-8(2)9-4-5-10-7-12(13(15)16)14(3)11(10)6-9/h4-8H,1-3H3,(H,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50235740 (CHEMBL4061441) Show SMILES CC(C)c1ccc2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H12FNO2/c1-6(2)8-4-3-7-5-9(12(15)16)14-11(7)10(8)13/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235743 (CHEMBL23134) Show SMILES OC(=O)c1cc2ccc(Cl)cc2[nH]1 Show InChI InChI=1S/C9H6ClNO2/c10-6-2-1-5-3-8(9(12)13)11-7(5)4-6/h1-4,11H,(H,12,13)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235744 (CHEMBL4071613) Show SMILES CC(C)c1ccc2[nH]c(cc2c1)C(O)=O Show InChI InChI=1S/C12H13NO2/c1-7(2)8-3-4-10-9(5-8)6-11(13-10)12(14)15/h3-7,13H,1-2H3,(H,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50235741 (CHEMBL4099717) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H12ClNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Ability to displace radioligand [3H]spiperone from human dopamine D3 receptor transfected chinese hamster ovary cell membranes.				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235790 (CHEMBL4062984) Show SMILES COC(=O)c1cc2ccc(cc2[nH]1)C(C)C Show InChI InChI=1S/C13H15NO2/c1-8(2)9-4-5-10-7-12(13(15)16-3)14-11(10)6-9/h4-8,14H,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligand				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235791 (CHEMBL4084655) Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(N)=O Show InChI InChI=1S/C12H14N2O/c1-7(2)8-3-4-9-6-11(12(13)15)14-10(9)5-8/h3-7,14H,1-2H3,(H2,13,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligand				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235739 (CHEMBL4079731) Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(O)=O Show InChI InChI=1S/C12H13NO2/c1-7(2)8-3-4-9-6-11(12(14)15)13-10(9)5-8/h3-7,13H,1-2H3,(H,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by isothermal titration ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair