BDBM50235737 CHEMBL4070102

SMILES: CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O

InChI Key: InChIKey=SOSKBOZUXWZYFU-UHFFFAOYSA-N

Data: 1 KI  6 IC50  2 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50235737   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description ATP competitive inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) using 1.5 ug/ml ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by isothermal titration ...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 1...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-II (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
ATP-dependent RNA helicase DHX29 (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 inse...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
Eukaryotic initiation factor 4A-I (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia c...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair