Reaction Details |
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Target | Eukaryotic initiation factor 4A-I |
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Ligand | BDBM50235737 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1657826 (CHEMBL4007296) |
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IC50 | >100000±n/a nM |
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Citation | Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem25:2200-2209 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic initiation factor 4A-I |
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Name: | Eukaryotic initiation factor 4A-I |
Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
Type: | PROTEIN |
Mol. Mass.: | 46146.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864983 |
Residue: | 406 |
Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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BDBM50235737 |
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n/a |
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Name | BDBM50235737 |
Synonyms: | CHEMBL4070102 |
Type | Small organic molecule |
Emp. Form. | C12H11ClFNO2 |
Mol. Mass. | 255.673 |
SMILES | CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O |
Structure |
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