Found 56 hits Enz. Inhib. hit(s) with all data for entry = 50000971 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266668
(CHEMBL4098545)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C192H295N61O60S/c1-15-92(8)149(184(308)220-94(10)188(312)313)251-177(301)128(76-142(201)268)240-171(295)127(75-141(200)267)238-161(285)114(43-31-64-215-192(209)210)224-170(294)126(74-140(199)266)237-160(284)113(42-30-63-214-191(207)208)223-157(281)110(39-25-27-60-194)229-186(310)151(96(12)259)253-178(302)129(77-143(202)269)239-164(288)118(58-65-314-14)228-165(289)119(66-89(2)3)232-169(293)125(72-102-81-216-108-37-23-22-36-106(102)108)236-163(287)117(54-57-139(198)265)230-183(307)148(91(6)7)250-175(299)123(68-98-32-18-16-19-33-98)235-172(296)130(78-145(271)272)241-162(286)116(53-56-138(197)264)221-153(277)93(9)219-156(280)111(40-28-61-212-189(203)204)222-158(282)112(41-29-62-213-190(205)206)226-181(305)135(86-256)247-174(298)132(80-147(275)276)242-166(290)120(67-90(4)5)231-167(291)121(70-100-44-48-104(261)49-45-100)233-159(283)109(38-24-26-59-193)225-180(304)134(85-255)246-168(292)122(71-101-46-50-105(262)51-47-101)234-173(297)131(79-146(273)274)243-182(306)136(87-257)248-187(311)152(97(13)260)252-176(300)124(69-99-34-20-17-21-35-99)244-185(309)150(95(11)258)249-144(270)83-217-155(279)115(52-55-137(196)263)227-179(303)133(84-254)245-154(278)107(195)73-103-82-211-88-218-103/h16-23,32-37,44-51,81-82,88-97,107,109-136,148-152,216,254-262H,15,24-31,38-43,52-80,83-87,193-195H2,1-14H3,(H2,196,263)(H2,197,264)(H2,198,265)(H2,199,266)(H2,200,267)(H2,201,268)(H2,202,269)(H,211,218)(H,217,279)(H,219,280)(H,220,308)(H,221,277)(H,222,282)(H,223,281)(H,224,294)(H,225,304)(H,226,305)(H,227,303)(H,228,289)(H,229,310)(H,230,307)(H,231,291)(H,232,293)(H,233,283)(H,234,297)(H,235,296)(H,236,287)(H,237,284)(H,238,285)(H,239,288)(H,240,295)(H,241,286)(H,242,290)(H,243,306)(H,244,309)(H,245,278)(H,246,292)(H,247,298)(H,248,311)(H,249,270)(H,250,299)(H,251,301)(H,252,300)(H,253,302)(H,271,272)(H,273,274)(H,275,276)(H,312,313)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214)(H4,209,210,215)/t92-,93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,148-,149-,150-,151-,152-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0210 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266677
(CHEMBL4080035)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C145H225N45O47S/c1-11-71(6)114(141(235)174-89(39-43-110(203)204)127(221)178-95(54-77-60-161-81-31-19-18-30-79(77)81)131(225)175-91(50-69(2)3)129(223)168-83(33-21-23-46-147)124(218)179-96(56-107(152)200)120(214)162-62-108(153)201)189-135(229)93(52-75-26-14-12-15-27-75)177-133(227)97(57-111(205)206)180-126(220)87(37-41-105(150)198)166-117(211)72(7)165-121(215)84(34-24-47-159-144(154)155)167-123(217)85(35-25-48-160-145(156)157)170-139(233)102(66-193)186-134(228)99(59-113(209)210)181-128(222)90(44-49-238-10)173-125(219)88(38-42-106(151)199)172-122(216)82(32-20-22-45-146)169-138(232)101(65-192)185-130(224)92(51-70(4)5)176-132(226)98(58-112(207)208)182-140(234)103(67-194)187-143(237)116(74(9)196)190-136(230)94(53-76-28-16-13-17-29-76)183-142(236)115(73(8)195)188-109(202)63-163-119(213)86(36-40-104(149)197)171-137(231)100(64-191)184-118(212)80(148)55-78-61-158-68-164-78/h12-19,26-31,60-61,68-74,80,82-103,114-116,161,191-196H,11,20-25,32-59,62-67,146-148H2,1-10H3,(H2,149,197)(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,201)(H,158,164)(H,162,214)(H,163,213)(H,165,215)(H,166,211)(H,167,217)(H,168,223)(H,169,232)(H,170,233)(H,171,231)(H,172,216)(H,173,219)(H,174,235)(H,175,225)(H,176,226)(H,177,227)(H,178,221)(H,179,218)(H,180,220)(H,181,222)(H,182,234)(H,183,236)(H,184,212)(H,185,224)(H,186,228)(H,187,237)(H,188,202)(H,189,229)(H,190,230)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H4,154,155,159)(H4,156,157,160)/t71-,72-,73+,74+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,114-,115-,116-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00820 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.000900 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266669
(CHEMBL4093458)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C185H290N56O57S/c1-15-95(10)146(177(293)218-113(52-55-142(259)260)159(275)223-120(72-101-77-202-105-40-23-22-39-103(101)105)165(281)220-115(67-91(2)3)162(278)212-107(42-25-27-58-187)156(272)224-121(74-135(190)251)152(268)205-79-136(252)203-83-140(256)238-62-31-46-130(238)174(290)232-128(88-246)173(289)229-125(85-243)153(269)207-80-137(253)209-96(11)180(296)240-64-33-48-132(240)182(298)241-65-34-49-133(241)181(297)239-63-32-47-131(239)175(291)228-124(84-242)149(191)265)236-168(284)118(70-99-35-18-16-19-36-99)222-163(279)116(68-92(4)5)219-157(273)109(44-29-60-200-184(194)195)217-176(292)145(94(8)9)235-161(277)110(45-30-61-201-185(196)197)211-155(271)108(43-28-59-199-183(192)193)214-171(287)127(87-245)231-167(283)123(76-144(263)264)225-160(276)114(56-66-299-14)216-158(274)112(50-53-134(189)250)215-154(270)106(41-24-26-57-186)213-170(286)126(86-244)230-164(280)117(69-93(6)7)221-166(282)122(75-143(261)262)226-172(288)129(89-247)233-179(295)148(98(13)249)237-169(285)119(71-100-37-20-17-21-38-100)227-178(294)147(97(12)248)234-139(255)82-206-151(267)111(51-54-141(257)258)210-138(254)81-204-150(266)104(188)73-102-78-198-90-208-102/h16-23,35-40,77-78,90-98,104,106-133,145-148,202,242-249H,15,24-34,41-76,79-89,186-188H2,1-14H3,(H2,189,250)(H2,190,251)(H2,191,265)(H,198,208)(H,203,252)(H,204,266)(H,205,268)(H,206,267)(H,207,269)(H,209,253)(H,210,254)(H,211,271)(H,212,278)(H,213,286)(H,214,287)(H,215,270)(H,216,274)(H,217,292)(H,218,293)(H,219,273)(H,220,281)(H,221,282)(H,222,279)(H,223,275)(H,224,272)(H,225,276)(H,226,288)(H,227,294)(H,228,291)(H,229,289)(H,230,280)(H,231,283)(H,232,290)(H,233,295)(H,234,255)(H,235,277)(H,236,284)(H,237,285)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H4,192,193,199)(H4,194,195,200)(H4,196,197,201)/t95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00180 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266670
(CHEMBL4065846)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C180H276N54O60S/c1-12-89(6)142(173(289)212-108(48-52-138(253)254)157(273)216-114(67-96-73-195-100-36-20-19-35-98(96)100)161(277)213-110(63-87(2)3)159(275)207-102(38-22-24-55-182)154(270)217-115(69-131(186)245)149(265)198-75-132(246)196-79-136(250)231-58-27-41-125(231)171(287)226-123(84-239)170(286)223-120(81-236)150(266)200-76-133(247)202-91(8)176(292)233-60-29-43-127(233)178(294)234-61-30-44-128(234)177(293)232-59-28-42-126(232)172(288)222-119(80-235)145(187)261)229-165(281)112(65-94-31-15-13-16-32-94)215-163(279)116(70-139(255)256)218-156(272)106(45-49-129(184)243)205-146(262)90(7)203-151(267)103(39-25-56-193-179(188)189)206-153(269)104(40-26-57-194-180(190)191)209-168(284)122(83-238)225-164(280)118(72-141(259)260)219-158(274)109(53-62-295-11)211-155(271)107(46-50-130(185)244)210-152(268)101(37-21-23-54-181)208-167(283)121(82-237)224-160(276)111(64-88(4)5)214-162(278)117(71-140(257)258)220-169(285)124(85-240)227-175(291)144(93(10)242)230-166(282)113(66-95-33-17-14-18-34-95)221-174(290)143(92(9)241)228-135(249)78-199-148(264)105(47-51-137(251)252)204-134(248)77-197-147(263)99(183)68-97-74-192-86-201-97/h13-20,31-36,73-74,86-93,99,101-128,142-144,195,235-242H,12,21-30,37-72,75-85,181-183H2,1-11H3,(H2,184,243)(H2,185,244)(H2,186,245)(H2,187,261)(H,192,201)(H,196,246)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,247)(H,203,267)(H,204,248)(H,205,262)(H,206,269)(H,207,275)(H,208,283)(H,209,284)(H,210,268)(H,211,271)(H,212,289)(H,213,277)(H,214,278)(H,215,279)(H,216,273)(H,217,270)(H,218,272)(H,219,274)(H,220,285)(H,221,290)(H,222,288)(H,223,286)(H,224,276)(H,225,280)(H,226,287)(H,227,291)(H,228,249)(H,229,281)(H,230,282)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,188,189,193)(H4,190,191,194)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0170 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266671
(CHEMBL4101203)Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C179H274N54O60S/c1-86(2)62-109(158(274)206-101(37-21-23-54-181)153(269)216-114(68-130(185)244)148(264)197-74-131(245)195-78-135(249)230-57-26-40-124(230)170(286)225-122(83-238)169(285)222-119(80-235)149(265)199-75-132(246)201-90(8)175(291)232-59-28-42-126(232)177(293)233-60-29-43-127(233)176(292)231-58-27-41-125(231)171(287)221-118(79-234)144(186)260)212-160(276)113(66-95-72-194-99-35-19-18-34-97(95)99)215-156(272)107(47-51-137(252)253)211-172(288)141(88(5)6)228-164(280)111(64-93-30-14-12-15-31-93)214-162(278)115(69-138(254)255)217-155(271)105(44-48-128(183)242)204-145(261)89(7)202-150(266)102(38-24-55-192-178(187)188)205-152(268)103(39-25-56-193-179(189)190)208-167(283)121(82-237)224-163(279)117(71-140(258)259)218-157(273)108(52-61-294-11)210-154(270)106(45-49-129(184)243)209-151(267)100(36-20-22-53-180)207-166(282)120(81-236)223-159(275)110(63-87(3)4)213-161(277)116(70-139(256)257)219-168(284)123(84-239)226-174(290)143(92(10)241)229-165(281)112(65-94-32-16-13-17-33-94)220-173(289)142(91(9)240)227-134(248)77-198-147(263)104(46-50-136(250)251)203-133(247)76-196-146(262)98(182)67-96-73-191-85-200-96/h12-19,30-35,72-73,85-92,98,100-127,141-143,194,234-241H,20-29,36-71,74-84,180-182H2,1-11H3,(H2,183,242)(H2,184,243)(H2,185,244)(H2,186,260)(H,191,200)(H,195,245)(H,196,262)(H,197,264)(H,198,263)(H,199,265)(H,201,246)(H,202,266)(H,203,247)(H,204,261)(H,205,268)(H,206,274)(H,207,282)(H,208,283)(H,209,267)(H,210,270)(H,211,288)(H,212,276)(H,213,277)(H,214,278)(H,215,272)(H,216,269)(H,217,271)(H,218,273)(H,219,284)(H,220,289)(H,221,287)(H,222,285)(H,223,275)(H,224,279)(H,225,286)(H,226,290)(H,227,248)(H,228,280)(H,229,281)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,187,188,192)(H4,189,190,193)/t89-,90-,91+,92+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,141-,142-,143-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266672
(CHEMBL4100420)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C194H305N57O60S2/c1-18-98(10)152(185(305)231-121(56-62-149(272)273)169(289)236-129(80-106-85-212-110-42-26-25-41-108(106)110)175(295)233-124(75-94(2)3)172(292)228-123(64-74-313-17)171(291)238-131(83-141(200)260)180(300)248-154(102(14)256)187(307)230-113(44-28-30-66-196)163(283)221-114(46-32-68-210-193(204)205)164(284)237-130(82-140(199)259)176(296)220-111(45-31-67-209-192(202)203)159(279)214-87-142(261)217-100(12)189(309)250-71-35-49-137(250)191(311)251-72-36-50-138(251)190(310)249-70-34-48-136(249)183(303)241-133(90-252)156(201)276)246-178(298)127(78-104-37-21-19-22-38-104)235-173(293)125(76-95(4)5)232-165(285)115(47-33-69-211-194(206)207)229-184(304)151(97(8)9)245-157(277)99(11)218-161(281)118(53-59-146(266)267)224-167(287)119(54-60-147(268)269)225-168(288)120(55-61-148(270)271)226-170(290)122(63-73-312-16)227-166(286)117(51-57-139(198)258)223-162(282)112(43-27-29-65-195)222-181(301)134(91-253)242-174(294)126(77-96(6)7)234-177(297)132(84-150(274)275)239-182(302)135(92-254)243-188(308)155(103(15)257)247-179(299)128(79-105-39-23-20-24-40-105)240-186(306)153(101(13)255)244-144(263)89-215-160(280)116(52-58-145(264)265)219-143(262)88-213-158(278)109(197)81-107-86-208-93-216-107/h19-26,37-42,85-86,93-103,109,111-138,151-155,212,252-257H,18,27-36,43-84,87-92,195-197H2,1-17H3,(H2,198,258)(H2,199,259)(H2,200,260)(H2,201,276)(H,208,216)(H,213,278)(H,214,279)(H,215,280)(H,217,261)(H,218,281)(H,219,262)(H,220,296)(H,221,283)(H,222,301)(H,223,282)(H,224,287)(H,225,288)(H,226,290)(H,227,286)(H,228,292)(H,229,304)(H,230,307)(H,231,305)(H,232,285)(H,233,295)(H,234,297)(H,235,293)(H,236,289)(H,237,284)(H,238,291)(H,239,302)(H,240,306)(H,241,303)(H,242,294)(H,243,308)(H,244,263)(H,245,277)(H,246,298)(H,247,299)(H,248,300)(H,264,265)(H,266,267)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H4,202,203,209)(H4,204,205,210)(H4,206,207,211)/t98-,99-,100-,101+,102+,103+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,151-,152-,153-,154-,155-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00120 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266673
(CHEMBL4076828)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C185H285N51O60S/c1-16-94(10)147(179(291)214-114(52-58-144(258)259)163(275)219-121(73-101-77-197-105-39-24-23-38-103(101)105)168(280)216-116(68-90(2)3)165(277)205-107(41-26-28-61-187)158(270)220-122(75-136(191)247)154(266)199-79-137(248)198-82-140(251)233-63-30-43-130(233)176(288)227-128(87-241)175(287)225-125(84-238)155(267)201-80-138(249)203-96(12)182(294)235-65-32-45-132(235)184(296)236-66-33-46-133(236)183(295)234-64-31-44-131(234)177(289)223-124(83-237)150(192)262)231-170(282)119(71-99-34-19-17-20-35-99)218-166(278)117(69-91(4)5)215-159(271)108(42-29-62-196-185(193)194)213-178(290)146(93(8)9)230-151(263)95(11)204-156(268)111(49-55-141(252)253)209-161(273)112(50-56-142(254)255)210-162(274)113(51-57-143(256)257)211-164(276)115(59-67-297-15)212-160(272)110(48-54-135(190)246)208-157(269)106(40-25-27-60-186)206-173(285)127(86-240)226-167(279)118(70-92(6)7)217-169(281)123(76-145(260)261)221-174(286)129(88-242)228-181(293)149(98(14)244)232-171(283)120(72-100-36-21-18-22-37-100)222-180(292)148(97(13)243)229-139(250)81-200-153(265)109(47-53-134(189)245)207-172(284)126(85-239)224-152(264)104(188)74-102-78-195-89-202-102/h17-24,34-39,77-78,89-98,104,106-133,146-149,197,237-244H,16,25-33,40-76,79-88,186-188H2,1-15H3,(H2,189,245)(H2,190,246)(H2,191,247)(H2,192,262)(H,195,202)(H,198,248)(H,199,266)(H,200,265)(H,201,267)(H,203,249)(H,204,268)(H,205,277)(H,206,285)(H,207,284)(H,208,269)(H,209,273)(H,210,274)(H,211,276)(H,212,272)(H,213,290)(H,214,291)(H,215,271)(H,216,280)(H,217,281)(H,218,278)(H,219,275)(H,220,270)(H,221,286)(H,222,292)(H,223,289)(H,224,264)(H,225,287)(H,226,279)(H,227,288)(H,228,293)(H,229,250)(H,230,263)(H,231,282)(H,232,283)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,193,194,196)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,149-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.000700 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266674
(CHEMBL4098061)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C181H279N55O60S/c1-12-89(6)142(174(291)213-108(48-52-138(254)255)157(274)217-114(67-96-73-197-100-36-20-19-35-98(96)100)161(278)214-110(63-87(2)3)159(276)207-102(38-22-24-55-183)154(271)218-115(69-133(188)249)149(266)199-75-134(250)198-78-137(253)233-58-27-41-126(233)172(289)228-124(84-242)171(288)225-120(80-238)150(267)201-76-135(251)203-91(8)177(294)235-60-29-43-128(235)179(296)236-61-30-44-129(236)178(295)234-59-28-42-127(234)173(290)223-119(79-237)145(189)262)231-165(282)112(65-94-31-15-13-16-32-94)216-163(280)116(70-139(256)257)219-156(273)106(46-50-131(186)247)205-146(263)90(7)204-151(268)103(39-25-56-195-180(190)191)206-153(270)104(40-26-57-196-181(192)193)209-169(286)123(83-241)227-164(281)118(72-141(260)261)220-158(275)109(53-62-297-11)212-155(272)107(47-51-132(187)248)211-152(269)101(37-21-23-54-182)208-168(285)122(82-240)226-160(277)111(64-88(4)5)215-162(279)117(71-140(258)259)221-170(287)125(85-243)229-176(293)144(93(10)245)232-166(283)113(66-95-33-17-14-18-34-95)222-175(292)143(92(9)244)230-136(252)77-200-148(265)105(45-49-130(185)246)210-167(284)121(81-239)224-147(264)99(184)68-97-74-194-86-202-97/h13-20,31-36,73-74,86-93,99,101-129,142-144,197,237-245H,12,21-30,37-72,75-85,182-184H2,1-11H3,(H2,185,246)(H2,186,247)(H2,187,248)(H2,188,249)(H2,189,262)(H,194,202)(H,198,250)(H,199,266)(H,200,265)(H,201,267)(H,203,251)(H,204,268)(H,205,263)(H,206,270)(H,207,276)(H,208,285)(H,209,286)(H,210,284)(H,211,269)(H,212,272)(H,213,291)(H,214,278)(H,215,279)(H,216,280)(H,217,274)(H,218,271)(H,219,273)(H,220,275)(H,221,287)(H,222,292)(H,223,290)(H,224,264)(H,225,288)(H,226,277)(H,227,281)(H,228,289)(H,229,293)(H,230,252)(H,231,282)(H,232,283)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,190,191,195)(H4,192,193,196)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266675
(CHEMBL4090347)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C158H245N49O53S/c1-11-77(6)124(154(258)188-95(41-45-120(223)224)138(242)192-101(57-83-63-174-87-32-19-18-31-85(83)87)142(246)189-97(53-75(2)3)140(244)182-89(34-21-23-48-160)135(239)193-102(59-116(165)219)131(235)176-65-117(220)175-67-119(222)207-51-26-37-112(207)153(257)202-110(72-212)152(256)198-106(68-208)127(166)231)205-146(250)99(55-81-27-14-12-15-28-81)191-144(248)103(60-121(225)226)194-137(241)93(39-43-114(163)217)180-128(232)78(7)179-132(236)90(35-24-49-172-157(167)168)181-134(238)91(36-25-50-173-158(169)170)184-150(254)109(71-211)201-145(249)105(62-123(229)230)195-139(243)96(46-52-261-10)187-136(240)94(40-44-115(164)218)186-133(237)88(33-20-22-47-159)183-149(253)108(70-210)200-141(245)98(54-76(4)5)190-143(247)104(61-122(227)228)196-151(255)111(73-213)203-156(260)126(80(9)215)206-147(251)100(56-82-29-16-13-17-30-82)197-155(259)125(79(8)214)204-118(221)66-177-130(234)92(38-42-113(162)216)185-148(252)107(69-209)199-129(233)86(161)58-84-64-171-74-178-84/h12-19,27-32,63-64,74-80,86,88-112,124-126,174,208-215H,11,20-26,33-62,65-73,159-161H2,1-10H3,(H2,162,216)(H2,163,217)(H2,164,218)(H2,165,219)(H2,166,231)(H,171,178)(H,175,220)(H,176,235)(H,177,234)(H,179,236)(H,180,232)(H,181,238)(H,182,244)(H,183,253)(H,184,254)(H,185,252)(H,186,237)(H,187,240)(H,188,258)(H,189,246)(H,190,247)(H,191,248)(H,192,242)(H,193,239)(H,194,241)(H,195,243)(H,196,255)(H,197,259)(H,198,256)(H,199,233)(H,200,245)(H,201,249)(H,202,257)(H,203,260)(H,204,221)(H,205,250)(H,206,251)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H4,167,168,172)(H4,169,170,173)/t77-,78-,79+,80+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,124-,125-,126-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0150 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266669
(CHEMBL4093458)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C185H290N56O57S/c1-15-95(10)146(177(293)218-113(52-55-142(259)260)159(275)223-120(72-101-77-202-105-40-23-22-39-103(101)105)165(281)220-115(67-91(2)3)162(278)212-107(42-25-27-58-187)156(272)224-121(74-135(190)251)152(268)205-79-136(252)203-83-140(256)238-62-31-46-130(238)174(290)232-128(88-246)173(289)229-125(85-243)153(269)207-80-137(253)209-96(11)180(296)240-64-33-48-132(240)182(298)241-65-34-49-133(241)181(297)239-63-32-47-131(239)175(291)228-124(84-242)149(191)265)236-168(284)118(70-99-35-18-16-19-36-99)222-163(279)116(68-92(4)5)219-157(273)109(44-29-60-200-184(194)195)217-176(292)145(94(8)9)235-161(277)110(45-30-61-201-185(196)197)211-155(271)108(43-28-59-199-183(192)193)214-171(287)127(87-245)231-167(283)123(76-144(263)264)225-160(276)114(56-66-299-14)216-158(274)112(50-53-134(189)250)215-154(270)106(41-24-26-57-186)213-170(286)126(86-244)230-164(280)117(69-93(6)7)221-166(282)122(75-143(261)262)226-172(288)129(89-247)233-179(295)148(98(13)249)237-169(285)119(71-100-37-20-17-21-38-100)227-178(294)147(97(12)248)234-139(255)82-206-151(267)111(51-54-141(257)258)210-138(254)81-204-150(266)104(188)73-102-78-198-90-208-102/h16-23,35-40,77-78,90-98,104,106-133,145-148,202,242-249H,15,24-34,41-76,79-89,186-188H2,1-14H3,(H2,189,250)(H2,190,251)(H2,191,265)(H,198,208)(H,203,252)(H,204,266)(H,205,268)(H,206,267)(H,207,269)(H,209,253)(H,210,254)(H,211,271)(H,212,278)(H,213,286)(H,214,287)(H,215,270)(H,216,274)(H,217,292)(H,218,293)(H,219,273)(H,220,281)(H,221,282)(H,222,279)(H,223,275)(H,224,272)(H,225,276)(H,226,288)(H,227,294)(H,228,291)(H,229,289)(H,230,280)(H,231,283)(H,232,290)(H,233,295)(H,234,255)(H,235,277)(H,236,284)(H,237,285)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H4,192,193,199)(H4,194,195,200)(H4,196,197,201)/t95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,145-,146-,147-,148-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266670
(CHEMBL4065846)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C180H276N54O60S/c1-12-89(6)142(173(289)212-108(48-52-138(253)254)157(273)216-114(67-96-73-195-100-36-20-19-35-98(96)100)161(277)213-110(63-87(2)3)159(275)207-102(38-22-24-55-182)154(270)217-115(69-131(186)245)149(265)198-75-132(246)196-79-136(250)231-58-27-41-125(231)171(287)226-123(84-239)170(286)223-120(81-236)150(266)200-76-133(247)202-91(8)176(292)233-60-29-43-127(233)178(294)234-61-30-44-128(234)177(293)232-59-28-42-126(232)172(288)222-119(80-235)145(187)261)229-165(281)112(65-94-31-15-13-16-32-94)215-163(279)116(70-139(255)256)218-156(272)106(45-49-129(184)243)205-146(262)90(7)203-151(267)103(39-25-56-193-179(188)189)206-153(269)104(40-26-57-194-180(190)191)209-168(284)122(83-238)225-164(280)118(72-141(259)260)219-158(274)109(53-62-295-11)211-155(271)107(46-50-130(185)244)210-152(268)101(37-21-23-54-181)208-167(283)121(82-237)224-160(276)111(64-88(4)5)214-162(278)117(71-140(257)258)220-169(285)124(85-240)227-175(291)144(93(10)242)230-166(282)113(66-95-33-17-14-18-34-95)221-174(290)143(92(9)241)228-135(249)78-199-148(264)105(47-51-137(251)252)204-134(248)77-197-147(263)99(183)68-97-74-192-86-201-97/h13-20,31-36,73-74,86-93,99,101-128,142-144,195,235-242H,12,21-30,37-72,75-85,181-183H2,1-11H3,(H2,184,243)(H2,185,244)(H2,186,245)(H2,187,261)(H,192,201)(H,196,246)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,247)(H,203,267)(H,204,248)(H,205,262)(H,206,269)(H,207,275)(H,208,283)(H,209,284)(H,210,268)(H,211,271)(H,212,289)(H,213,277)(H,214,278)(H,215,279)(H,216,273)(H,217,270)(H,218,272)(H,219,274)(H,220,285)(H,221,290)(H,222,288)(H,223,286)(H,224,276)(H,225,280)(H,226,287)(H,227,291)(H,228,249)(H,229,281)(H,230,282)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,188,189,193)(H4,190,191,194)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,142-,143-,144-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
UniChem
Similars
| MMDB
Article
PubMed
| n/a | n/a | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266671
(CHEMBL4101203)Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C179H274N54O60S/c1-86(2)62-109(158(274)206-101(37-21-23-54-181)153(269)216-114(68-130(185)244)148(264)197-74-131(245)195-78-135(249)230-57-26-40-124(230)170(286)225-122(83-238)169(285)222-119(80-235)149(265)199-75-132(246)201-90(8)175(291)232-59-28-42-126(232)177(293)233-60-29-43-127(233)176(292)231-58-27-41-125(231)171(287)221-118(79-234)144(186)260)212-160(276)113(66-95-72-194-99-35-19-18-34-97(95)99)215-156(272)107(47-51-137(252)253)211-172(288)141(88(5)6)228-164(280)111(64-93-30-14-12-15-31-93)214-162(278)115(69-138(254)255)217-155(271)105(44-48-128(183)242)204-145(261)89(7)202-150(266)102(38-24-55-192-178(187)188)205-152(268)103(39-25-56-193-179(189)190)208-167(283)121(82-237)224-163(279)117(71-140(258)259)218-157(273)108(52-61-294-11)210-154(270)106(45-49-129(184)243)209-151(267)100(36-20-22-53-180)207-166(282)120(81-236)223-159(275)110(63-87(3)4)213-161(277)116(70-139(256)257)219-168(284)123(84-239)226-174(290)143(92(10)241)229-165(281)112(65-94-32-16-13-17-33-94)220-173(289)142(91(9)240)227-134(248)77-198-147(263)104(46-50-136(250)251)203-133(247)76-196-146(262)98(182)67-96-73-191-85-200-96/h12-19,30-35,72-73,85-92,98,100-127,141-143,194,234-241H,20-29,36-71,74-84,180-182H2,1-11H3,(H2,183,242)(H2,184,243)(H2,185,244)(H2,186,260)(H,191,200)(H,195,245)(H,196,262)(H,197,264)(H,198,263)(H,199,265)(H,201,246)(H,202,266)(H,203,247)(H,204,261)(H,205,268)(H,206,274)(H,207,282)(H,208,283)(H,209,267)(H,210,270)(H,211,288)(H,212,276)(H,213,277)(H,214,278)(H,215,272)(H,216,269)(H,217,271)(H,218,273)(H,219,284)(H,220,289)(H,221,287)(H,222,285)(H,223,275)(H,224,279)(H,225,286)(H,226,290)(H,227,248)(H,228,280)(H,229,281)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,187,188,192)(H4,189,190,193)/t89-,90-,91+,92+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,141-,142-,143-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266676
(CHEMBL4074468)Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C179H275N55O59S/c1-86(2)62-109(158(274)207-101(37-21-23-54-181)153(269)217-114(68-131(186)246)148(264)198-74-132(247)196-78-136(251)231-57-26-40-124(231)170(286)226-122(83-239)169(285)223-119(80-236)149(265)200-75-133(248)202-90(8)175(291)233-59-28-42-126(233)177(293)234-60-29-43-127(234)176(292)232-58-27-41-125(232)171(287)222-118(79-235)144(187)260)213-160(276)113(66-95-72-195-99-35-19-18-34-97(95)99)216-156(272)107(46-50-130(185)245)212-172(288)141(88(5)6)229-164(280)111(64-93-30-14-12-15-31-93)215-162(278)115(69-138(254)255)218-155(271)105(44-48-128(183)243)205-145(261)89(7)203-150(266)102(38-24-55-193-178(188)189)206-152(268)103(39-25-56-194-179(190)191)209-167(283)121(82-238)225-163(279)117(71-140(258)259)219-157(273)108(52-61-294-11)211-154(270)106(45-49-129(184)244)210-151(267)100(36-20-22-53-180)208-166(282)120(81-237)224-159(275)110(63-87(3)4)214-161(277)116(70-139(256)257)220-168(284)123(84-240)227-174(290)143(92(10)242)230-165(281)112(65-94-32-16-13-17-33-94)221-173(289)142(91(9)241)228-135(250)77-199-147(263)104(47-51-137(252)253)204-134(249)76-197-146(262)98(182)67-96-73-192-85-201-96/h12-19,30-35,72-73,85-92,98,100-127,141-143,195,235-242H,20-29,36-71,74-84,180-182H2,1-11H3,(H2,183,243)(H2,184,244)(H2,185,245)(H2,186,246)(H2,187,260)(H,192,201)(H,196,247)(H,197,262)(H,198,264)(H,199,263)(H,200,265)(H,202,248)(H,203,266)(H,204,249)(H,205,261)(H,206,268)(H,207,274)(H,208,282)(H,209,283)(H,210,267)(H,211,270)(H,212,288)(H,213,276)(H,214,277)(H,215,278)(H,216,272)(H,217,269)(H,218,271)(H,219,273)(H,220,284)(H,221,289)(H,222,287)(H,223,285)(H,224,275)(H,225,279)(H,226,286)(H,227,290)(H,228,250)(H,229,280)(H,230,281)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,188,189,193)(H4,190,191,194)/t89-,90-,91+,92+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,141-,142-,143-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266672
(CHEMBL4100420)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C194H305N57O60S2/c1-18-98(10)152(185(305)231-121(56-62-149(272)273)169(289)236-129(80-106-85-212-110-42-26-25-41-108(106)110)175(295)233-124(75-94(2)3)172(292)228-123(64-74-313-17)171(291)238-131(83-141(200)260)180(300)248-154(102(14)256)187(307)230-113(44-28-30-66-196)163(283)221-114(46-32-68-210-193(204)205)164(284)237-130(82-140(199)259)176(296)220-111(45-31-67-209-192(202)203)159(279)214-87-142(261)217-100(12)189(309)250-71-35-49-137(250)191(311)251-72-36-50-138(251)190(310)249-70-34-48-136(249)183(303)241-133(90-252)156(201)276)246-178(298)127(78-104-37-21-19-22-38-104)235-173(293)125(76-95(4)5)232-165(285)115(47-33-69-211-194(206)207)229-184(304)151(97(8)9)245-157(277)99(11)218-161(281)118(53-59-146(266)267)224-167(287)119(54-60-147(268)269)225-168(288)120(55-61-148(270)271)226-170(290)122(63-73-312-16)227-166(286)117(51-57-139(198)258)223-162(282)112(43-27-29-65-195)222-181(301)134(91-253)242-174(294)126(77-96(6)7)234-177(297)132(84-150(274)275)239-182(302)135(92-254)243-188(308)155(103(15)257)247-179(299)128(79-105-39-23-20-24-40-105)240-186(306)153(101(13)255)244-144(263)89-215-160(280)116(52-58-145(264)265)219-143(262)88-213-158(278)109(197)81-107-86-208-93-216-107/h19-26,37-42,85-86,93-103,109,111-138,151-155,212,252-257H,18,27-36,43-84,87-92,195-197H2,1-17H3,(H2,198,258)(H2,199,259)(H2,200,260)(H2,201,276)(H,208,216)(H,213,278)(H,214,279)(H,215,280)(H,217,261)(H,218,281)(H,219,262)(H,220,296)(H,221,283)(H,222,301)(H,223,282)(H,224,287)(H,225,288)(H,226,290)(H,227,286)(H,228,292)(H,229,304)(H,230,307)(H,231,305)(H,232,285)(H,233,295)(H,234,297)(H,235,293)(H,236,289)(H,237,284)(H,238,291)(H,239,302)(H,240,306)(H,241,303)(H,242,294)(H,243,308)(H,244,263)(H,245,277)(H,246,298)(H,247,299)(H,248,300)(H,264,265)(H,266,267)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H4,202,203,209)(H4,204,205,210)(H4,206,207,211)/t98-,99-,100-,101+,102+,103+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,151-,152-,153-,154-,155-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266674
(CHEMBL4098061)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C181H279N55O60S/c1-12-89(6)142(174(291)213-108(48-52-138(254)255)157(274)217-114(67-96-73-197-100-36-20-19-35-98(96)100)161(278)214-110(63-87(2)3)159(276)207-102(38-22-24-55-183)154(271)218-115(69-133(188)249)149(266)199-75-134(250)198-78-137(253)233-58-27-41-126(233)172(289)228-124(84-242)171(288)225-120(80-238)150(267)201-76-135(251)203-91(8)177(294)235-60-29-43-128(235)179(296)236-61-30-44-129(236)178(295)234-59-28-42-127(234)173(290)223-119(79-237)145(189)262)231-165(282)112(65-94-31-15-13-16-32-94)216-163(280)116(70-139(256)257)219-156(273)106(46-50-131(186)247)205-146(263)90(7)204-151(268)103(39-25-56-195-180(190)191)206-153(270)104(40-26-57-196-181(192)193)209-169(286)123(83-241)227-164(281)118(72-141(260)261)220-158(275)109(53-62-297-11)212-155(272)107(47-51-132(187)248)211-152(269)101(37-21-23-54-182)208-168(285)122(82-240)226-160(277)111(64-88(4)5)215-162(279)117(71-140(258)259)221-170(287)125(85-243)229-176(293)144(93(10)245)232-166(283)113(66-95-33-17-14-18-34-95)222-175(292)143(92(9)244)230-136(252)77-200-148(265)105(45-49-130(185)246)210-167(284)121(81-239)224-147(264)99(184)68-97-74-194-86-202-97/h13-20,31-36,73-74,86-93,99,101-129,142-144,197,237-245H,12,21-30,37-72,75-85,182-184H2,1-11H3,(H2,185,246)(H2,186,247)(H2,187,248)(H2,188,249)(H2,189,262)(H,194,202)(H,198,250)(H,199,266)(H,200,265)(H,201,267)(H,203,251)(H,204,268)(H,205,263)(H,206,270)(H,207,276)(H,208,285)(H,209,286)(H,210,284)(H,211,269)(H,212,272)(H,213,291)(H,214,278)(H,215,279)(H,216,280)(H,217,274)(H,218,271)(H,219,273)(H,220,275)(H,221,287)(H,222,292)(H,223,290)(H,224,264)(H,225,288)(H,226,277)(H,227,281)(H,228,289)(H,229,293)(H,230,252)(H,231,282)(H,232,283)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,190,191,195)(H4,192,193,196)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,142-,143-,144-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266677
(CHEMBL4080035)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C145H225N45O47S/c1-11-71(6)114(141(235)174-89(39-43-110(203)204)127(221)178-95(54-77-60-161-81-31-19-18-30-79(77)81)131(225)175-91(50-69(2)3)129(223)168-83(33-21-23-46-147)124(218)179-96(56-107(152)200)120(214)162-62-108(153)201)189-135(229)93(52-75-26-14-12-15-27-75)177-133(227)97(57-111(205)206)180-126(220)87(37-41-105(150)198)166-117(211)72(7)165-121(215)84(34-24-47-159-144(154)155)167-123(217)85(35-25-48-160-145(156)157)170-139(233)102(66-193)186-134(228)99(59-113(209)210)181-128(222)90(44-49-238-10)173-125(219)88(38-42-106(151)199)172-122(216)82(32-20-22-45-146)169-138(232)101(65-192)185-130(224)92(51-70(4)5)176-132(226)98(58-112(207)208)182-140(234)103(67-194)187-143(237)116(74(9)196)190-136(230)94(53-76-28-16-13-17-29-76)183-142(236)115(73(8)195)188-109(202)63-163-119(213)86(36-40-104(149)197)171-137(231)100(64-191)184-118(212)80(148)55-78-61-158-68-164-78/h12-19,26-31,60-61,68-74,80,82-103,114-116,161,191-196H,11,20-25,32-59,62-67,146-148H2,1-10H3,(H2,149,197)(H2,150,198)(H2,151,199)(H2,152,200)(H2,153,201)(H,158,164)(H,162,214)(H,163,213)(H,165,215)(H,166,211)(H,167,217)(H,168,223)(H,169,232)(H,170,233)(H,171,231)(H,172,216)(H,173,219)(H,174,235)(H,175,225)(H,176,226)(H,177,227)(H,178,221)(H,179,218)(H,180,220)(H,181,222)(H,182,234)(H,183,236)(H,184,212)(H,185,224)(H,186,228)(H,187,237)(H,188,202)(H,189,229)(H,190,230)(H,203,204)(H,205,206)(H,207,208)(H,209,210)(H4,154,155,159)(H4,156,157,160)/t71-,72-,73+,74+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,114-,115-,116-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00190 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266675
(CHEMBL4090347)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C158H245N49O53S/c1-11-77(6)124(154(258)188-95(41-45-120(223)224)138(242)192-101(57-83-63-174-87-32-19-18-31-85(83)87)142(246)189-97(53-75(2)3)140(244)182-89(34-21-23-48-160)135(239)193-102(59-116(165)219)131(235)176-65-117(220)175-67-119(222)207-51-26-37-112(207)153(257)202-110(72-212)152(256)198-106(68-208)127(166)231)205-146(250)99(55-81-27-14-12-15-28-81)191-144(248)103(60-121(225)226)194-137(241)93(39-43-114(163)217)180-128(232)78(7)179-132(236)90(35-24-49-172-157(167)168)181-134(238)91(36-25-50-173-158(169)170)184-150(254)109(71-211)201-145(249)105(62-123(229)230)195-139(243)96(46-52-261-10)187-136(240)94(40-44-115(164)218)186-133(237)88(33-20-22-47-159)183-149(253)108(70-210)200-141(245)98(54-76(4)5)190-143(247)104(61-122(227)228)196-151(255)111(73-213)203-156(260)126(80(9)215)206-147(251)100(56-82-29-16-13-17-30-82)197-155(259)125(79(8)214)204-118(221)66-177-130(234)92(38-42-113(162)216)185-148(252)107(69-209)199-129(233)86(161)58-84-64-171-74-178-84/h12-19,27-32,63-64,74-80,86,88-112,124-126,174,208-215H,11,20-26,33-62,65-73,159-161H2,1-10H3,(H2,162,216)(H2,163,217)(H2,164,218)(H2,165,219)(H2,166,231)(H,171,178)(H,175,220)(H,176,235)(H,177,234)(H,179,236)(H,180,232)(H,181,238)(H,182,244)(H,183,253)(H,184,254)(H,185,252)(H,186,237)(H,187,240)(H,188,258)(H,189,246)(H,190,247)(H,191,248)(H,192,242)(H,193,239)(H,194,241)(H,195,243)(H,196,255)(H,197,259)(H,198,256)(H,199,233)(H,200,245)(H,201,249)(H,202,257)(H,203,260)(H,204,221)(H,205,250)(H,206,251)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H4,167,168,172)(H4,169,170,173)/t77-,78-,79+,80+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,124-,125-,126-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00890 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266678
(CHEMBL4060629)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C180H277N55O59S/c1-12-89(6)142(173(289)213-108(48-52-138(253)254)157(273)217-114(67-96-73-196-100-36-20-19-35-98(96)100)161(277)214-110(63-87(2)3)159(275)208-102(38-22-24-55-182)154(270)218-115(69-132(187)247)149(265)199-75-133(248)197-79-137(252)232-58-27-41-125(232)171(287)227-123(84-240)170(286)224-120(81-237)150(266)201-76-134(249)203-91(8)176(292)234-60-29-43-127(234)178(294)235-61-30-44-128(235)177(293)233-59-28-42-126(233)172(288)223-119(80-236)145(188)261)230-165(281)112(65-94-31-15-13-16-32-94)216-163(279)116(70-139(255)256)219-156(272)106(46-50-130(185)245)206-146(262)90(7)204-151(267)103(39-25-56-194-179(189)190)207-153(269)104(40-26-57-195-180(191)192)210-168(284)122(83-239)226-164(280)118(72-141(259)260)220-158(274)109(53-62-295-11)212-155(271)107(47-51-131(186)246)211-152(268)101(37-21-23-54-181)209-167(283)121(82-238)225-160(276)111(64-88(4)5)215-162(278)117(71-140(257)258)221-169(285)124(85-241)228-175(291)144(93(10)243)231-166(282)113(66-95-33-17-14-18-34-95)222-174(290)143(92(9)242)229-136(251)78-200-148(264)105(45-49-129(184)244)205-135(250)77-198-147(263)99(183)68-97-74-193-86-202-97/h13-20,31-36,73-74,86-93,99,101-128,142-144,196,236-243H,12,21-30,37-72,75-85,181-183H2,1-11H3,(H2,184,244)(H2,185,245)(H2,186,246)(H2,187,247)(H2,188,261)(H,193,202)(H,197,248)(H,198,263)(H,199,265)(H,200,264)(H,201,266)(H,203,249)(H,204,267)(H,205,250)(H,206,262)(H,207,269)(H,208,275)(H,209,283)(H,210,284)(H,211,268)(H,212,271)(H,213,289)(H,214,277)(H,215,278)(H,216,279)(H,217,273)(H,218,270)(H,219,272)(H,220,274)(H,221,285)(H,222,290)(H,223,288)(H,224,286)(H,225,276)(H,226,280)(H,227,287)(H,228,291)(H,229,251)(H,230,281)(H,231,282)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,189,190,194)(H4,191,192,195)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,142-,143-,144-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.32 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266687
(CHEMBL4072029)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C195H308N58O60S2/c1-18-98(10)152(186(307)232-121(56-62-149(273)274)169(290)237-129(80-106-85-214-110-42-26-25-41-108(106)110)175(296)234-124(75-94(2)3)172(293)229-123(64-74-315-17)171(292)239-131(83-143(202)264)180(301)250-154(102(14)259)188(309)231-113(44-28-30-66-197)163(284)221-114(46-32-68-212-194(206)207)164(285)238-130(82-142(201)263)176(297)220-111(45-31-67-211-193(204)205)159(280)215-87-144(265)218-100(12)190(311)252-71-35-49-138(252)192(313)253-72-36-50-139(253)191(312)251-70-34-48-137(251)184(305)242-133(89-254)156(203)277)248-178(299)127(78-104-37-21-19-22-38-104)236-173(294)125(76-95(4)5)233-165(286)115(47-33-69-213-195(208)209)230-185(306)151(97(8)9)247-157(278)99(11)219-161(282)118(53-59-146(267)268)225-167(288)119(54-60-147(269)270)226-168(289)120(55-61-148(271)272)227-170(291)122(63-73-314-16)228-166(287)117(52-58-141(200)262)224-162(283)112(43-27-29-65-196)222-182(303)135(91-256)244-174(295)126(77-96(6)7)235-177(298)132(84-150(275)276)240-183(304)136(92-257)245-189(310)155(103(15)260)249-179(300)128(79-105-39-23-20-24-40-105)241-187(308)153(101(13)258)246-145(266)88-216-160(281)116(51-57-140(199)261)223-181(302)134(90-255)243-158(279)109(198)81-107-86-210-93-217-107/h19-26,37-42,85-86,93-103,109,111-139,151-155,214,254-260H,18,27-36,43-84,87-92,196-198H2,1-17H3,(H2,199,261)(H2,200,262)(H2,201,263)(H2,202,264)(H2,203,277)(H,210,217)(H,215,280)(H,216,281)(H,218,265)(H,219,282)(H,220,297)(H,221,284)(H,222,303)(H,223,302)(H,224,283)(H,225,288)(H,226,289)(H,227,291)(H,228,287)(H,229,293)(H,230,306)(H,231,309)(H,232,307)(H,233,286)(H,234,296)(H,235,298)(H,236,294)(H,237,290)(H,238,285)(H,239,292)(H,240,304)(H,241,308)(H,242,305)(H,243,279)(H,244,295)(H,245,310)(H,246,266)(H,247,278)(H,248,299)(H,249,300)(H,250,301)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H4,204,205,211)(H4,206,207,212)(H4,208,209,213)/t98-,99-,100-,101+,102+,103+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,151-,152-,153-,154-,155-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.24 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266688
(CHEMBL4065550)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@H](C)O)[C@@H](C)CC)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C208H329N59O64S/c1-13-15-16-17-18-19-20-21-22-23-24-25-32-62-158(282)234-123(171(217)296)66-71-157(281)223-76-40-37-53-122(170(216)295)235-193(318)146(104-272)259-200(325)150-59-44-80-265(150)205(330)152-61-46-82-267(152)206(331)151-60-45-81-266(151)204(329)112(9)232-160(284)97-230-176(301)142(100-268)255-198(323)147(105-273)258-199(324)149-58-43-79-264(149)162(286)99-227-159(283)96-228-175(300)138(90-156(215)280)249-180(305)125(55-36-39-75-210)238-185(310)133(84-108(3)4)245-187(312)137(88-117-94-226-121-52-34-33-51-119(117)121)248-183(308)131(67-72-163(287)288)244-201(326)167(110(7)14-2)262-191(316)135(86-115-47-28-26-29-48-115)247-189(314)139(91-164(289)290)250-182(307)129(64-69-154(213)278)236-172(297)111(8)233-177(302)126(56-41-77-224-207(218)219)237-179(304)127(57-42-78-225-208(220)221)240-196(321)145(103-271)257-190(315)141(93-166(293)294)251-184(309)132(73-83-332-12)243-181(306)130(65-70-155(214)279)242-178(303)124(54-35-38-74-209)239-195(320)144(102-270)256-186(311)134(85-109(5)6)246-188(313)140(92-165(291)292)252-197(322)148(106-274)260-203(328)169(114(11)276)263-192(317)136(87-116-49-30-27-31-50-116)253-202(327)168(113(10)275)261-161(285)98-229-174(299)128(63-68-153(212)277)241-194(319)143(101-269)254-173(298)120(211)89-118-95-222-107-231-118/h26-31,33-34,47-52,94-95,107-114,120,122-152,167-169,226,268-276H,13-25,32,35-46,53-93,96-106,209-211H2,1-12H3,(H2,212,277)(H2,213,278)(H2,214,279)(H2,215,280)(H2,216,295)(H2,217,296)(H,222,231)(H,223,281)(H,227,283)(H,228,300)(H,229,299)(H,230,301)(H,232,284)(H,233,302)(H,234,282)(H,235,318)(H,236,297)(H,237,304)(H,238,310)(H,239,320)(H,240,321)(H,241,319)(H,242,303)(H,243,306)(H,244,326)(H,245,312)(H,246,313)(H,247,314)(H,248,308)(H,249,305)(H,250,307)(H,251,309)(H,252,322)(H,253,327)(H,254,298)(H,255,323)(H,256,311)(H,257,315)(H,258,324)(H,259,325)(H,260,328)(H,261,285)(H,262,316)(H,263,317)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H4,218,219,224)(H4,220,221,225)/t110-,111-,112-,113+,114-,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,167-,168-,169-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00620 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266689
(CHEMBL4095024)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C205H324N58O62S/c1-13-15-16-17-18-19-20-21-22-23-24-25-32-62-156(277)231-122(169(214)291)66-71-155(276)220-76-40-37-53-121(168(213)290)232-197(319)148-59-44-80-261(148)202(324)150-61-46-82-263(150)203(325)149-60-45-81-262(149)201(323)111(9)229-158(279)97-227-174(296)141(100-264)252-195(317)145(104-268)255-196(318)147-58-43-79-260(147)160(281)99-224-157(278)96-225-173(295)137(90-154(212)275)246-178(300)124(55-36-39-75-207)235-183(305)132(84-107(3)4)242-185(307)136(88-116-94-223-120-52-34-33-51-118(116)120)245-181(303)130(67-72-161(282)283)241-198(320)165(109(7)14-2)258-189(311)134(86-114-47-28-26-29-48-114)244-187(309)138(91-162(284)285)247-180(302)128(64-69-152(210)273)233-170(292)110(8)230-175(297)125(56-41-77-221-204(215)216)234-177(299)126(57-42-78-222-205(217)218)237-193(315)144(103-267)254-188(310)140(93-164(288)289)248-182(304)131(73-83-326-12)240-179(301)129(65-70-153(211)274)239-176(298)123(54-35-38-74-206)236-192(314)143(102-266)253-184(306)133(85-108(5)6)243-186(308)139(92-163(286)287)249-194(316)146(105-269)256-200(322)167(113(11)271)259-190(312)135(87-115-49-30-27-31-50-115)250-199(321)166(112(10)270)257-159(280)98-226-172(294)127(63-68-151(209)272)238-191(313)142(101-265)251-171(293)119(208)89-117-95-219-106-228-117/h26-31,33-34,47-52,94-95,106-113,119,121-150,165-167,223,264-271H,13-25,32,35-46,53-93,96-105,206-208H2,1-12H3,(H2,209,272)(H2,210,273)(H2,211,274)(H2,212,275)(H2,213,290)(H2,214,291)(H,219,228)(H,220,276)(H,224,278)(H,225,295)(H,226,294)(H,227,296)(H,229,279)(H,230,297)(H,231,277)(H,232,319)(H,233,292)(H,234,299)(H,235,305)(H,236,314)(H,237,315)(H,238,313)(H,239,298)(H,240,301)(H,241,320)(H,242,307)(H,243,308)(H,244,309)(H,245,303)(H,246,300)(H,247,302)(H,248,304)(H,249,316)(H,250,321)(H,251,293)(H,252,317)(H,253,306)(H,254,310)(H,255,318)(H,256,322)(H,257,280)(H,258,311)(H,259,312)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H4,215,216,221)(H4,217,218,222)/t109-,110-,111-,112+,113+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,165-,166-,167-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00630 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Mus musculus) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.000900 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Mus musculus) | BDBM50266690
(CHEMBL439305)Show SMILES CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O)C(O)=O Show InChI InChI=1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135(232)233)154(249)204-120(73-100-44-33-31-34-45-100)159(254)214-140(93(11)19-2)167(262)192-97(15)146(241)201-122(76-103-79-183-108-49-39-38-48-106(103)108)157(252)203-118(72-90(5)6)158(253)212-138(91(7)8)165(260)200-110(52-43-70-182-172(177)178)149(244)184-81-130(225)193-109(51-42-69-181-171(175)176)148(243)187-84-137(236)237)196-144(239)95(13)189-143(238)94(12)191-152(247)114(58-63-127(174)222)194-131(226)82-185-151(246)113(61-66-134(230)231)198-155(250)117(71-89(3)4)202-156(251)119(75-102-54-56-105(221)57-55-102)205-162(257)124(85-216)208-164(259)126(87-218)209-166(261)139(92(9)10)213-161(256)123(78-136(234)235)206-163(258)125(86-217)210-169(264)142(99(17)220)215-160(255)121(74-101-46-35-32-36-47-101)207-168(263)141(98(16)219)211-132(227)83-186-150(245)112(60-65-133(228)229)197-145(240)96(14)190-147(242)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,54-57,79-80,88-99,107,109-126,138-142,183,216-221H,18-30,37,40-43,50-53,58-78,81-87,173H2,1-17H3,(H2,174,222)(H,179,188)(H,180,223)(H,184,244)(H,185,246)(H,186,245)(H,187,243)(H,189,238)(H,190,242)(H,191,247)(H,192,262)(H,193,225)(H,194,226)(H,195,224)(H,196,239)(H,197,240)(H,198,250)(H,199,248)(H,200,260)(H,201,241)(H,202,251)(H,203,252)(H,204,249)(H,205,257)(H,206,258)(H,207,263)(H,208,259)(H,209,261)(H,210,264)(H,211,227)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,265,266)(H4,175,176,181)(H4,177,178,182)/t93-,94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116?,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00440 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Mus musculus) | BDBM50266691
(CHEMBL4086979)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C203H319N57O64/c1-12-14-15-16-17-18-19-20-21-22-23-24-31-61-154(275)228-128(201(323)324)65-70-153(274)217-74-39-36-54-121(230-177(299)126(64-69-151(209)272)236-173(295)119(52-34-37-72-204)233-189(311)141(100-264)250-181(303)130(82-106(5)6)239-183(305)136(89-161(284)285)245-191(313)144(103-267)253-197(319)165(111(11)269)256-187(309)132(84-113-48-29-26-30-49-113)246-196(318)164(110(10)268)254-157(278)95-223-169(291)124(62-67-149(207)270)235-188(310)140(99-263)248-168(290)117(206)86-115-92-216-104-225-115)176(298)243-137(90-162(286)287)185(307)251-142(101-265)190(312)234-123(56-41-76-219-203(214)215)174(296)231-122(55-40-75-218-202(212)213)172(294)227-108(8)167(289)229-125(63-68-150(208)271)178(300)244-135(88-160(282)283)184(306)240-131(83-112-46-27-25-28-47-112)186(308)255-163(107(7)13-2)195(317)237-127(66-71-159(280)281)179(301)241-133(85-114-91-220-118-51-33-32-50-116(114)118)182(304)238-129(81-105(3)4)180(302)232-120(53-35-38-73-205)175(297)242-134(87-152(210)273)170(292)222-93-155(276)221-96-158(279)257-77-42-57-145(257)193(315)252-143(102-266)192(314)249-139(98-262)171(293)224-94-156(277)226-109(9)198(320)259-79-44-59-147(259)200(322)260-80-45-60-148(260)199(321)258-78-43-58-146(258)194(316)247-138(97-261)166(211)288/h25-30,32-33,46-51,91-92,104-111,117,119-148,163-165,220,261-269H,12-24,31,34-45,52-90,93-103,204-206H2,1-11H3,(H2,207,270)(H2,208,271)(H2,209,272)(H2,210,273)(H2,211,288)(H,216,225)(H,217,274)(H,221,276)(H,222,292)(H,223,291)(H,224,293)(H,226,277)(H,227,294)(H,228,275)(H,229,289)(H,230,299)(H,231,296)(H,232,302)(H,233,311)(H,234,312)(H,235,310)(H,236,295)(H,237,317)(H,238,304)(H,239,305)(H,240,306)(H,241,301)(H,242,297)(H,243,298)(H,244,300)(H,245,313)(H,246,318)(H,247,316)(H,248,290)(H,249,314)(H,250,303)(H,251,307)(H,252,315)(H,253,319)(H,254,278)(H,255,308)(H,256,309)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,323,324)(H4,212,213,218)(H4,214,215,219)/t107-,108-,109-,110+,111+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,163-,164-,165-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00230 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50266690
(CHEMBL439305)Show SMILES CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O)C(O)=O Show InChI InChI=1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135(232)233)154(249)204-120(73-100-44-33-31-34-45-100)159(254)214-140(93(11)19-2)167(262)192-97(15)146(241)201-122(76-103-79-183-108-49-39-38-48-106(103)108)157(252)203-118(72-90(5)6)158(253)212-138(91(7)8)165(260)200-110(52-43-70-182-172(177)178)149(244)184-81-130(225)193-109(51-42-69-181-171(175)176)148(243)187-84-137(236)237)196-144(239)95(13)189-143(238)94(12)191-152(247)114(58-63-127(174)222)194-131(226)82-185-151(246)113(61-66-134(230)231)198-155(250)117(71-89(3)4)202-156(251)119(75-102-54-56-105(221)57-55-102)205-162(257)124(85-216)208-164(259)126(87-218)209-166(261)139(92(9)10)213-161(256)123(78-136(234)235)206-163(258)125(86-217)210-169(264)142(99(17)220)215-160(255)121(74-101-46-35-32-36-47-101)207-168(263)141(98(16)219)211-132(227)83-186-150(245)112(60-65-133(228)229)197-145(240)96(14)190-147(242)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,54-57,79-80,88-99,107,109-126,138-142,183,216-221H,18-30,37,40-43,50-53,58-78,81-87,173H2,1-17H3,(H2,174,222)(H,179,188)(H,180,223)(H,184,244)(H,185,246)(H,186,245)(H,187,243)(H,189,238)(H,190,242)(H,191,247)(H,192,262)(H,193,225)(H,194,226)(H,195,224)(H,196,239)(H,197,240)(H,198,250)(H,199,248)(H,200,260)(H,201,241)(H,202,251)(H,203,252)(H,204,249)(H,205,257)(H,206,258)(H,207,263)(H,208,259)(H,209,261)(H,210,264)(H,211,227)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,265,266)(H4,175,176,181)(H4,177,178,182)/t93-,94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116?,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266692
(CHEMBL4082505)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C181H278N54O61S/c1-12-89(6)142(174(291)212-108(48-52-138(254)255)157(274)216-114(67-96-73-196-100-36-20-19-35-98(96)100)161(278)213-110(63-87(2)3)159(276)206-102(38-22-24-55-183)154(271)217-115(69-132(187)247)149(266)198-75-133(248)197-78-136(251)232-58-27-41-126(232)172(289)227-124(84-241)171(288)224-120(80-237)150(267)200-76-134(249)202-91(8)177(294)234-60-29-43-128(234)179(296)235-61-30-44-129(235)178(295)233-59-28-42-127(233)173(290)222-119(79-236)145(188)262)230-165(282)112(65-94-31-15-13-16-32-94)215-163(280)116(70-139(256)257)218-156(273)106(45-49-130(185)245)204-146(263)90(7)203-151(268)103(39-25-56-194-180(189)190)205-153(270)104(40-26-57-195-181(191)192)208-169(286)123(83-240)226-164(281)118(72-141(260)261)219-158(275)109(53-62-297-11)211-155(272)107(46-50-131(186)246)210-152(269)101(37-21-23-54-182)207-168(285)122(82-239)225-160(277)111(64-88(4)5)214-162(279)117(71-140(258)259)220-170(287)125(85-242)228-176(293)144(93(10)244)231-166(283)113(66-95-33-17-14-18-34-95)221-175(292)143(92(9)243)229-135(250)77-199-148(265)105(47-51-137(252)253)209-167(284)121(81-238)223-147(264)99(184)68-97-74-193-86-201-97/h13-20,31-36,73-74,86-93,99,101-129,142-144,196,236-244H,12,21-30,37-72,75-85,182-184H2,1-11H3,(H2,185,245)(H2,186,246)(H2,187,247)(H2,188,262)(H,193,201)(H,197,248)(H,198,266)(H,199,265)(H,200,267)(H,202,249)(H,203,268)(H,204,263)(H,205,270)(H,206,276)(H,207,285)(H,208,286)(H,209,284)(H,210,269)(H,211,272)(H,212,291)(H,213,278)(H,214,279)(H,215,280)(H,216,274)(H,217,271)(H,218,273)(H,219,275)(H,220,287)(H,221,292)(H,222,290)(H,223,264)(H,224,288)(H,225,277)(H,226,281)(H,227,289)(H,228,293)(H,229,250)(H,230,282)(H,231,283)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,189,190,194)(H4,191,192,195)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,142-,143-,144-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Mus musculus) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.000500 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.00100 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266694
(CHEMBL4069307)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C175H273N55O59S/c1-14-83(7)136(170(286)198-85(9)140(185)256)227-162(278)112(65-128(184)244)214-156(272)111(64-127(183)243)215-166(282)119(77-234)223-168(284)120(78-235)224-169(285)122-41-30-55-230(122)131(247)73-194-129(245)71-195-144(260)110(63-126(182)242)213-148(264)97(38-25-27-52-177)202-153(269)105(57-81(3)4)209-155(271)109(61-91-69-193-95-36-23-22-35-93(91)95)212-151(267)103(45-49-132(248)249)208-171(287)137(84(8)15-2)228-160(276)107(59-89-31-18-16-19-32-89)211-158(274)113(66-133(250)251)216-150(266)101(43-47-124(180)240)200-141(257)86(10)199-145(261)98(39-28-53-191-174(186)187)201-147(263)99(40-29-54-192-175(188)189)204-165(281)118(76-233)222-159(275)115(68-135(254)255)217-152(268)104(50-56-290-13)207-149(265)102(44-48-125(181)241)206-146(262)96(37-24-26-51-176)203-164(280)117(75-232)221-154(270)106(58-82(5)6)210-157(273)114(67-134(252)253)218-167(283)121(79-236)225-173(289)139(88(12)238)229-161(277)108(60-90-33-20-17-21-34-90)219-172(288)138(87(11)237)226-130(246)72-196-143(259)100(42-46-123(179)239)205-163(279)116(74-231)220-142(258)94(178)62-92-70-190-80-197-92/h16-23,31-36,69-70,80-88,94,96-122,136-139,193,231-238H,14-15,24-30,37-68,71-79,176-178H2,1-13H3,(H2,179,239)(H2,180,240)(H2,181,241)(H2,182,242)(H2,183,243)(H2,184,244)(H2,185,256)(H,190,197)(H,194,245)(H,195,260)(H,196,259)(H,198,286)(H,199,261)(H,200,257)(H,201,263)(H,202,269)(H,203,280)(H,204,281)(H,205,279)(H,206,262)(H,207,265)(H,208,287)(H,209,271)(H,210,273)(H,211,274)(H,212,267)(H,213,264)(H,214,272)(H,215,282)(H,216,266)(H,217,268)(H,218,283)(H,219,288)(H,220,258)(H,221,270)(H,222,275)(H,223,284)(H,224,285)(H,225,289)(H,226,246)(H,227,278)(H,228,276)(H,229,277)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,186,187,191)(H4,188,189,192)/t83-,84-,85-,86-,87+,88+,94-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,136-,137-,138-,139-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0170 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266692
(CHEMBL4082505)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C181H278N54O61S/c1-12-89(6)142(174(291)212-108(48-52-138(254)255)157(274)216-114(67-96-73-196-100-36-20-19-35-98(96)100)161(278)213-110(63-87(2)3)159(276)206-102(38-22-24-55-183)154(271)217-115(69-132(187)247)149(266)198-75-133(248)197-78-136(251)232-58-27-41-126(232)172(289)227-124(84-241)171(288)224-120(80-237)150(267)200-76-134(249)202-91(8)177(294)234-60-29-43-128(234)179(296)235-61-30-44-129(235)178(295)233-59-28-42-127(233)173(290)222-119(79-236)145(188)262)230-165(282)112(65-94-31-15-13-16-32-94)215-163(280)116(70-139(256)257)218-156(273)106(45-49-130(185)245)204-146(263)90(7)203-151(268)103(39-25-56-194-180(189)190)205-153(270)104(40-26-57-195-181(191)192)208-169(286)123(83-240)226-164(281)118(72-141(260)261)219-158(275)109(53-62-297-11)211-155(272)107(46-50-131(186)246)210-152(269)101(37-21-23-54-182)207-168(285)122(82-239)225-160(277)111(64-88(4)5)214-162(279)117(71-140(258)259)220-170(287)125(85-242)228-176(293)144(93(10)244)231-166(283)113(66-95-33-17-14-18-34-95)221-175(292)143(92(9)243)229-135(250)77-199-148(265)105(47-51-137(252)253)209-167(284)121(81-238)223-147(264)99(184)68-97-74-193-86-201-97/h13-20,31-36,73-74,86-93,99,101-129,142-144,196,236-244H,12,21-30,37-72,75-85,182-184H2,1-11H3,(H2,185,245)(H2,186,246)(H2,187,247)(H2,188,262)(H,193,201)(H,197,248)(H,198,266)(H,199,265)(H,200,267)(H,202,249)(H,203,268)(H,204,263)(H,205,270)(H,206,276)(H,207,285)(H,208,286)(H,209,284)(H,210,269)(H,211,272)(H,212,291)(H,213,278)(H,214,279)(H,215,280)(H,216,274)(H,217,271)(H,218,273)(H,219,275)(H,220,287)(H,221,292)(H,222,290)(H,223,264)(H,224,288)(H,225,277)(H,226,281)(H,227,289)(H,228,293)(H,229,250)(H,230,282)(H,231,283)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,189,190,194)(H4,191,192,195)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0310 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266678
(CHEMBL4060629)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C180H277N55O59S/c1-12-89(6)142(173(289)213-108(48-52-138(253)254)157(273)217-114(67-96-73-196-100-36-20-19-35-98(96)100)161(277)214-110(63-87(2)3)159(275)208-102(38-22-24-55-182)154(270)218-115(69-132(187)247)149(265)199-75-133(248)197-79-137(252)232-58-27-41-125(232)171(287)227-123(84-240)170(286)224-120(81-237)150(266)201-76-134(249)203-91(8)176(292)234-60-29-43-127(234)178(294)235-61-30-44-128(235)177(293)233-59-28-42-126(233)172(288)223-119(80-236)145(188)261)230-165(281)112(65-94-31-15-13-16-32-94)216-163(279)116(70-139(255)256)219-156(272)106(46-50-130(185)245)206-146(262)90(7)204-151(267)103(39-25-56-194-179(189)190)207-153(269)104(40-26-57-195-180(191)192)210-168(284)122(83-239)226-164(280)118(72-141(259)260)220-158(274)109(53-62-295-11)212-155(271)107(47-51-131(186)246)211-152(268)101(37-21-23-54-181)209-167(283)121(82-238)225-160(276)111(64-88(4)5)215-162(278)117(71-140(257)258)221-169(285)124(85-241)228-175(291)144(93(10)243)231-166(282)113(66-95-33-17-14-18-34-95)222-174(290)143(92(9)242)229-136(251)78-200-148(264)105(45-49-129(184)244)205-135(250)77-198-147(263)99(183)68-97-74-193-86-202-97/h13-20,31-36,73-74,86-93,99,101-128,142-144,196,236-243H,12,21-30,37-72,75-85,181-183H2,1-11H3,(H2,184,244)(H2,185,245)(H2,186,246)(H2,187,247)(H2,188,261)(H,193,202)(H,197,248)(H,198,263)(H,199,265)(H,200,264)(H,201,266)(H,203,249)(H,204,267)(H,205,250)(H,206,262)(H,207,269)(H,208,275)(H,209,283)(H,210,284)(H,211,268)(H,212,271)(H,213,289)(H,214,277)(H,215,278)(H,216,279)(H,217,273)(H,218,270)(H,219,272)(H,220,274)(H,221,285)(H,222,290)(H,223,288)(H,224,286)(H,225,276)(H,226,280)(H,227,287)(H,228,291)(H,229,251)(H,230,281)(H,231,282)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,189,190,194)(H4,191,192,195)/t89-,90-,91-,92+,93+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266687
(CHEMBL4072029)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C195H308N58O60S2/c1-18-98(10)152(186(307)232-121(56-62-149(273)274)169(290)237-129(80-106-85-214-110-42-26-25-41-108(106)110)175(296)234-124(75-94(2)3)172(293)229-123(64-74-315-17)171(292)239-131(83-143(202)264)180(301)250-154(102(14)259)188(309)231-113(44-28-30-66-197)163(284)221-114(46-32-68-212-194(206)207)164(285)238-130(82-142(201)263)176(297)220-111(45-31-67-211-193(204)205)159(280)215-87-144(265)218-100(12)190(311)252-71-35-49-138(252)192(313)253-72-36-50-139(253)191(312)251-70-34-48-137(251)184(305)242-133(89-254)156(203)277)248-178(299)127(78-104-37-21-19-22-38-104)236-173(294)125(76-95(4)5)233-165(286)115(47-33-69-213-195(208)209)230-185(306)151(97(8)9)247-157(278)99(11)219-161(282)118(53-59-146(267)268)225-167(288)119(54-60-147(269)270)226-168(289)120(55-61-148(271)272)227-170(291)122(63-73-314-16)228-166(287)117(52-58-141(200)262)224-162(283)112(43-27-29-65-196)222-182(303)135(91-256)244-174(295)126(77-96(6)7)235-177(298)132(84-150(275)276)240-183(304)136(92-257)245-189(310)155(103(15)260)249-179(300)128(79-105-39-23-20-24-40-105)241-187(308)153(101(13)258)246-145(266)88-216-160(281)116(51-57-140(199)261)223-181(302)134(90-255)243-158(279)109(198)81-107-86-210-93-217-107/h19-26,37-42,85-86,93-103,109,111-139,151-155,214,254-260H,18,27-36,43-84,87-92,196-198H2,1-17H3,(H2,199,261)(H2,200,262)(H2,201,263)(H2,202,264)(H2,203,277)(H,210,217)(H,215,280)(H,216,281)(H,218,265)(H,219,282)(H,220,297)(H,221,284)(H,222,303)(H,223,302)(H,224,283)(H,225,288)(H,226,289)(H,227,291)(H,228,287)(H,229,293)(H,230,306)(H,231,309)(H,232,307)(H,233,286)(H,234,296)(H,235,298)(H,236,294)(H,237,290)(H,238,285)(H,239,292)(H,240,304)(H,241,308)(H,242,305)(H,243,279)(H,244,295)(H,245,310)(H,246,266)(H,247,278)(H,248,299)(H,249,300)(H,250,301)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H4,204,205,211)(H4,206,207,212)(H4,208,209,213)/t98-,99-,100-,101+,102+,103+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,151-,152-,153-,154-,155-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00220 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266691
(CHEMBL4086979)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C203H319N57O64/c1-12-14-15-16-17-18-19-20-21-22-23-24-31-61-154(275)228-128(201(323)324)65-70-153(274)217-74-39-36-54-121(230-177(299)126(64-69-151(209)272)236-173(295)119(52-34-37-72-204)233-189(311)141(100-264)250-181(303)130(82-106(5)6)239-183(305)136(89-161(284)285)245-191(313)144(103-267)253-197(319)165(111(11)269)256-187(309)132(84-113-48-29-26-30-49-113)246-196(318)164(110(10)268)254-157(278)95-223-169(291)124(62-67-149(207)270)235-188(310)140(99-263)248-168(290)117(206)86-115-92-216-104-225-115)176(298)243-137(90-162(286)287)185(307)251-142(101-265)190(312)234-123(56-41-76-219-203(214)215)174(296)231-122(55-40-75-218-202(212)213)172(294)227-108(8)167(289)229-125(63-68-150(208)271)178(300)244-135(88-160(282)283)184(306)240-131(83-112-46-27-25-28-47-112)186(308)255-163(107(7)13-2)195(317)237-127(66-71-159(280)281)179(301)241-133(85-114-91-220-118-51-33-32-50-116(114)118)182(304)238-129(81-105(3)4)180(302)232-120(53-35-38-73-205)175(297)242-134(87-152(210)273)170(292)222-93-155(276)221-96-158(279)257-77-42-57-145(257)193(315)252-143(102-266)192(314)249-139(98-262)171(293)224-94-156(277)226-109(9)198(320)259-79-44-59-147(259)200(322)260-80-45-60-148(260)199(321)258-78-43-58-146(258)194(316)247-138(97-261)166(211)288/h25-30,32-33,46-51,91-92,104-111,117,119-148,163-165,220,261-269H,12-24,31,34-45,52-90,93-103,204-206H2,1-11H3,(H2,207,270)(H2,208,271)(H2,209,272)(H2,210,273)(H2,211,288)(H,216,225)(H,217,274)(H,221,276)(H,222,292)(H,223,291)(H,224,293)(H,226,277)(H,227,294)(H,228,275)(H,229,289)(H,230,299)(H,231,296)(H,232,302)(H,233,311)(H,234,312)(H,235,310)(H,236,295)(H,237,317)(H,238,304)(H,239,305)(H,240,306)(H,241,301)(H,242,297)(H,243,298)(H,244,300)(H,245,313)(H,246,318)(H,247,316)(H,248,290)(H,249,314)(H,250,303)(H,251,307)(H,252,315)(H,253,319)(H,254,278)(H,255,308)(H,256,309)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,323,324)(H4,212,213,218)(H4,214,215,219)/t107-,108-,109-,110+,111+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,163-,164-,165-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00390 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266688
(CHEMBL4065550)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@H](C)O)[C@@H](C)CC)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C208H329N59O64S/c1-13-15-16-17-18-19-20-21-22-23-24-25-32-62-158(282)234-123(171(217)296)66-71-157(281)223-76-40-37-53-122(170(216)295)235-193(318)146(104-272)259-200(325)150-59-44-80-265(150)205(330)152-61-46-82-267(152)206(331)151-60-45-81-266(151)204(329)112(9)232-160(284)97-230-176(301)142(100-268)255-198(323)147(105-273)258-199(324)149-58-43-79-264(149)162(286)99-227-159(283)96-228-175(300)138(90-156(215)280)249-180(305)125(55-36-39-75-210)238-185(310)133(84-108(3)4)245-187(312)137(88-117-94-226-121-52-34-33-51-119(117)121)248-183(308)131(67-72-163(287)288)244-201(326)167(110(7)14-2)262-191(316)135(86-115-47-28-26-29-48-115)247-189(314)139(91-164(289)290)250-182(307)129(64-69-154(213)278)236-172(297)111(8)233-177(302)126(56-41-77-224-207(218)219)237-179(304)127(57-42-78-225-208(220)221)240-196(321)145(103-271)257-190(315)141(93-166(293)294)251-184(309)132(73-83-332-12)243-181(306)130(65-70-155(214)279)242-178(303)124(54-35-38-74-209)239-195(320)144(102-270)256-186(311)134(85-109(5)6)246-188(313)140(92-165(291)292)252-197(322)148(106-274)260-203(328)169(114(11)276)263-192(317)136(87-116-49-30-27-31-50-116)253-202(327)168(113(10)275)261-161(285)98-229-174(299)128(63-68-153(212)277)241-194(319)143(101-269)254-173(298)120(211)89-118-95-222-107-231-118/h26-31,33-34,47-52,94-95,107-114,120,122-152,167-169,226,268-276H,13-25,32,35-46,53-93,96-106,209-211H2,1-12H3,(H2,212,277)(H2,213,278)(H2,214,279)(H2,215,280)(H2,216,295)(H2,217,296)(H,222,231)(H,223,281)(H,227,283)(H,228,300)(H,229,299)(H,230,301)(H,232,284)(H,233,302)(H,234,282)(H,235,318)(H,236,297)(H,237,304)(H,238,310)(H,239,320)(H,240,321)(H,241,319)(H,242,303)(H,243,306)(H,244,326)(H,245,312)(H,246,313)(H,247,314)(H,248,308)(H,249,305)(H,250,307)(H,251,309)(H,252,322)(H,253,327)(H,254,298)(H,255,323)(H,256,311)(H,257,315)(H,258,324)(H,259,325)(H,260,328)(H,261,285)(H,262,316)(H,263,317)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H4,218,219,224)(H4,220,221,225)/t110-,111-,112-,113+,114-,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,167-,168-,169-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00520 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266689
(CHEMBL4095024)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C205H324N58O62S/c1-13-15-16-17-18-19-20-21-22-23-24-25-32-62-156(277)231-122(169(214)291)66-71-155(276)220-76-40-37-53-121(168(213)290)232-197(319)148-59-44-80-261(148)202(324)150-61-46-82-263(150)203(325)149-60-45-81-262(149)201(323)111(9)229-158(279)97-227-174(296)141(100-264)252-195(317)145(104-268)255-196(318)147-58-43-79-260(147)160(281)99-224-157(278)96-225-173(295)137(90-154(212)275)246-178(300)124(55-36-39-75-207)235-183(305)132(84-107(3)4)242-185(307)136(88-116-94-223-120-52-34-33-51-118(116)120)245-181(303)130(67-72-161(282)283)241-198(320)165(109(7)14-2)258-189(311)134(86-114-47-28-26-29-48-114)244-187(309)138(91-162(284)285)247-180(302)128(64-69-152(210)273)233-170(292)110(8)230-175(297)125(56-41-77-221-204(215)216)234-177(299)126(57-42-78-222-205(217)218)237-193(315)144(103-267)254-188(310)140(93-164(288)289)248-182(304)131(73-83-326-12)240-179(301)129(65-70-153(211)274)239-176(298)123(54-35-38-74-206)236-192(314)143(102-266)253-184(306)133(85-108(5)6)243-186(308)139(92-163(286)287)249-194(316)146(105-269)256-200(322)167(113(11)271)259-190(312)135(87-115-49-30-27-31-50-115)250-199(321)166(112(10)270)257-159(280)98-226-172(294)127(63-68-151(209)272)238-191(313)142(101-265)251-171(293)119(208)89-117-95-219-106-228-117/h26-31,33-34,47-52,94-95,106-113,119,121-150,165-167,223,264-271H,13-25,32,35-46,53-93,96-105,206-208H2,1-12H3,(H2,209,272)(H2,210,273)(H2,211,274)(H2,212,275)(H2,213,290)(H2,214,291)(H,219,228)(H,220,276)(H,224,278)(H,225,295)(H,226,294)(H,227,296)(H,229,279)(H,230,297)(H,231,277)(H,232,319)(H,233,292)(H,234,299)(H,235,305)(H,236,314)(H,237,315)(H,238,313)(H,239,298)(H,240,301)(H,241,320)(H,242,307)(H,243,308)(H,244,309)(H,245,303)(H,246,300)(H,247,302)(H,248,304)(H,249,316)(H,250,321)(H,251,293)(H,252,317)(H,253,306)(H,254,310)(H,255,318)(H,256,322)(H,257,280)(H,258,311)(H,259,312)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H4,215,216,221)(H4,217,218,222)/t109-,110-,111-,112+,113+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,165-,166-,167-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00580 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266668
(CHEMBL4098545)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C192H295N61O60S/c1-15-92(8)149(184(308)220-94(10)188(312)313)251-177(301)128(76-142(201)268)240-171(295)127(75-141(200)267)238-161(285)114(43-31-64-215-192(209)210)224-170(294)126(74-140(199)266)237-160(284)113(42-30-63-214-191(207)208)223-157(281)110(39-25-27-60-194)229-186(310)151(96(12)259)253-178(302)129(77-143(202)269)239-164(288)118(58-65-314-14)228-165(289)119(66-89(2)3)232-169(293)125(72-102-81-216-108-37-23-22-36-106(102)108)236-163(287)117(54-57-139(198)265)230-183(307)148(91(6)7)250-175(299)123(68-98-32-18-16-19-33-98)235-172(296)130(78-145(271)272)241-162(286)116(53-56-138(197)264)221-153(277)93(9)219-156(280)111(40-28-61-212-189(203)204)222-158(282)112(41-29-62-213-190(205)206)226-181(305)135(86-256)247-174(298)132(80-147(275)276)242-166(290)120(67-90(4)5)231-167(291)121(70-100-44-48-104(261)49-45-100)233-159(283)109(38-24-26-59-193)225-180(304)134(85-255)246-168(292)122(71-101-46-50-105(262)51-47-101)234-173(297)131(79-146(273)274)243-182(306)136(87-257)248-187(311)152(97(13)260)252-176(300)124(69-99-34-20-17-21-35-99)244-185(309)150(95(11)258)249-144(270)83-217-155(279)115(52-55-137(196)263)227-179(303)133(84-254)245-154(278)107(195)73-103-82-211-88-218-103/h16-23,32-37,44-51,81-82,88-97,107,109-136,148-152,216,254-262H,15,24-31,38-43,52-80,83-87,193-195H2,1-14H3,(H2,196,263)(H2,197,264)(H2,198,265)(H2,199,266)(H2,200,267)(H2,201,268)(H2,202,269)(H,211,218)(H,217,279)(H,219,280)(H,220,308)(H,221,277)(H,222,282)(H,223,281)(H,224,294)(H,225,304)(H,226,305)(H,227,303)(H,228,289)(H,229,310)(H,230,307)(H,231,291)(H,232,293)(H,233,283)(H,234,297)(H,235,296)(H,236,287)(H,237,284)(H,238,285)(H,239,288)(H,240,295)(H,241,286)(H,242,290)(H,243,306)(H,244,309)(H,245,278)(H,246,292)(H,247,298)(H,248,311)(H,249,270)(H,250,299)(H,251,301)(H,252,300)(H,253,302)(H,271,272)(H,273,274)(H,275,276)(H,312,313)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214)(H4,209,210,215)/t92-,93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,148-,149-,150-,151-,152-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00800 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.000400 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266690
(CHEMBL439305)Show SMILES CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O)C(O)=O Show InChI InChI=1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135(232)233)154(249)204-120(73-100-44-33-31-34-45-100)159(254)214-140(93(11)19-2)167(262)192-97(15)146(241)201-122(76-103-79-183-108-49-39-38-48-106(103)108)157(252)203-118(72-90(5)6)158(253)212-138(91(7)8)165(260)200-110(52-43-70-182-172(177)178)149(244)184-81-130(225)193-109(51-42-69-181-171(175)176)148(243)187-84-137(236)237)196-144(239)95(13)189-143(238)94(12)191-152(247)114(58-63-127(174)222)194-131(226)82-185-151(246)113(61-66-134(230)231)198-155(250)117(71-89(3)4)202-156(251)119(75-102-54-56-105(221)57-55-102)205-162(257)124(85-216)208-164(259)126(87-218)209-166(261)139(92(9)10)213-161(256)123(78-136(234)235)206-163(258)125(86-217)210-169(264)142(99(17)220)215-160(255)121(74-101-46-35-32-36-47-101)207-168(263)141(98(16)219)211-132(227)83-186-150(245)112(60-65-133(228)229)197-145(240)96(14)190-147(242)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,54-57,79-80,88-99,107,109-126,138-142,183,216-221H,18-30,37,40-43,50-53,58-78,81-87,173H2,1-17H3,(H2,174,222)(H,179,188)(H,180,223)(H,184,244)(H,185,246)(H,186,245)(H,187,243)(H,189,238)(H,190,242)(H,191,247)(H,192,262)(H,193,225)(H,194,226)(H,195,224)(H,196,239)(H,197,240)(H,198,250)(H,199,248)(H,200,260)(H,201,241)(H,202,251)(H,203,252)(H,204,249)(H,205,257)(H,206,258)(H,207,263)(H,208,259)(H,209,261)(H,210,264)(H,211,227)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,265,266)(H4,175,176,181)(H4,177,178,182)/t93-,94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116?,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >0.00100 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50266695
(CHEMBL4098991)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C189H280N54O61S/c1-90(2)65-116(163(280)216-115(56-64-305-12)162(279)224-123(73-141(195)259)173(290)238-149(95(9)251)181(298)207-81-144(262)240-60-25-38-134(240)179(296)234-132(87-249)178(295)231-128(83-245)156(273)206-79-142(260)209-94(8)185(302)242-62-27-40-136(242)187(304)243-63-28-41-137(243)186(303)241-61-26-39-135(241)180(297)229-127(82-244)152(196)269)219-167(284)122(71-102-77-204-108-34-20-19-33-106(102)108)223-161(278)114(52-55-140(194)258)217-182(299)148(92(5)6)237-171(288)120(67-98-29-15-13-16-30-98)222-168(285)124(74-145(263)264)225-160(277)113(51-54-139(193)257)211-153(270)93(7)210-157(274)110(36-23-58-202-188(197)198)212-158(275)111(37-24-59-203-189(199)200)214-176(293)131(86-248)233-170(287)126(76-147(267)268)226-164(281)117(66-91(3)4)218-165(282)118(69-100-42-46-104(254)47-43-100)220-159(276)109(35-21-22-57-190)213-175(292)130(85-247)232-166(283)119(70-101-44-48-105(255)49-45-101)221-169(286)125(75-146(265)266)227-177(294)133(88-250)235-184(301)151(97(11)253)239-172(289)121(68-99-31-17-14-18-32-99)228-183(300)150(96(10)252)236-143(261)80-205-155(272)112(50-53-138(192)256)215-174(291)129(84-246)230-154(271)107(191)72-103-78-201-89-208-103/h13-20,29-34,42-49,77-78,89-97,107,109-137,148-151,204,244-255H,21-28,35-41,50-76,79-88,190-191H2,1-12H3,(H2,192,256)(H2,193,257)(H2,194,258)(H2,195,259)(H2,196,269)(H,201,208)(H,205,272)(H,206,273)(H,207,298)(H,209,260)(H,210,274)(H,211,270)(H,212,275)(H,213,292)(H,214,293)(H,215,291)(H,216,280)(H,217,299)(H,218,282)(H,219,284)(H,220,276)(H,221,286)(H,222,285)(H,223,278)(H,224,279)(H,225,277)(H,226,281)(H,227,294)(H,228,300)(H,229,297)(H,230,271)(H,231,295)(H,232,283)(H,233,287)(H,234,296)(H,235,301)(H,236,261)(H,237,288)(H,238,290)(H,239,289)(H,263,264)(H,265,266)(H,267,268)(H4,197,198,202)(H4,199,200,203)/t93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,148-,149-,150-,151-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266695
(CHEMBL4098991)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C189H280N54O61S/c1-90(2)65-116(163(280)216-115(56-64-305-12)162(279)224-123(73-141(195)259)173(290)238-149(95(9)251)181(298)207-81-144(262)240-60-25-38-134(240)179(296)234-132(87-249)178(295)231-128(83-245)156(273)206-79-142(260)209-94(8)185(302)242-62-27-40-136(242)187(304)243-63-28-41-137(243)186(303)241-61-26-39-135(241)180(297)229-127(82-244)152(196)269)219-167(284)122(71-102-77-204-108-34-20-19-33-106(102)108)223-161(278)114(52-55-140(194)258)217-182(299)148(92(5)6)237-171(288)120(67-98-29-15-13-16-30-98)222-168(285)124(74-145(263)264)225-160(277)113(51-54-139(193)257)211-153(270)93(7)210-157(274)110(36-23-58-202-188(197)198)212-158(275)111(37-24-59-203-189(199)200)214-176(293)131(86-248)233-170(287)126(76-147(267)268)226-164(281)117(66-91(3)4)218-165(282)118(69-100-42-46-104(254)47-43-100)220-159(276)109(35-21-22-57-190)213-175(292)130(85-247)232-166(283)119(70-101-44-48-105(255)49-45-101)221-169(286)125(75-146(265)266)227-177(294)133(88-250)235-184(301)151(97(11)253)239-172(289)121(68-99-31-17-14-18-32-99)228-183(300)150(96(10)252)236-143(261)80-205-155(272)112(50-53-138(192)256)215-174(291)129(84-246)230-154(271)107(191)72-103-78-201-89-208-103/h13-20,29-34,42-49,77-78,89-97,107,109-137,148-151,204,244-255H,21-28,35-41,50-76,79-88,190-191H2,1-12H3,(H2,192,256)(H2,193,257)(H2,194,258)(H2,195,259)(H2,196,269)(H,201,208)(H,205,272)(H,206,273)(H,207,298)(H,209,260)(H,210,274)(H,211,270)(H,212,275)(H,213,292)(H,214,293)(H,215,291)(H,216,280)(H,217,299)(H,218,282)(H,219,284)(H,220,276)(H,221,286)(H,222,285)(H,223,278)(H,224,279)(H,225,277)(H,226,281)(H,227,294)(H,228,300)(H,229,297)(H,230,271)(H,231,295)(H,232,283)(H,233,287)(H,234,296)(H,235,301)(H,236,261)(H,237,288)(H,238,290)(H,239,289)(H,263,264)(H,265,266)(H,267,268)(H4,197,198,202)(H4,199,200,203)/t93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,148-,149-,150-,151-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Mus musculus) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0440 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50266693
(CHEBI:5391 | Glucagen Hypokit | Glucagon | Glucago...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00130 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50266691
(CHEMBL4086979)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O |r| Show InChI InChI=1S/C203H319N57O64/c1-12-14-15-16-17-18-19-20-21-22-23-24-31-61-154(275)228-128(201(323)324)65-70-153(274)217-74-39-36-54-121(230-177(299)126(64-69-151(209)272)236-173(295)119(52-34-37-72-204)233-189(311)141(100-264)250-181(303)130(82-106(5)6)239-183(305)136(89-161(284)285)245-191(313)144(103-267)253-197(319)165(111(11)269)256-187(309)132(84-113-48-29-26-30-49-113)246-196(318)164(110(10)268)254-157(278)95-223-169(291)124(62-67-149(207)270)235-188(310)140(99-263)248-168(290)117(206)86-115-92-216-104-225-115)176(298)243-137(90-162(286)287)185(307)251-142(101-265)190(312)234-123(56-41-76-219-203(214)215)174(296)231-122(55-40-75-218-202(212)213)172(294)227-108(8)167(289)229-125(63-68-150(208)271)178(300)244-135(88-160(282)283)184(306)240-131(83-112-46-27-25-28-47-112)186(308)255-163(107(7)13-2)195(317)237-127(66-71-159(280)281)179(301)241-133(85-114-91-220-118-51-33-32-50-116(114)118)182(304)238-129(81-105(3)4)180(302)232-120(53-35-38-73-205)175(297)242-134(87-152(210)273)170(292)222-93-155(276)221-96-158(279)257-77-42-57-145(257)193(315)252-143(102-266)192(314)249-139(98-262)171(293)224-94-156(277)226-109(9)198(320)259-79-44-59-147(259)200(322)260-80-45-60-148(260)199(321)258-78-43-58-146(258)194(316)247-138(97-261)166(211)288/h25-30,32-33,46-51,91-92,104-111,117,119-148,163-165,220,261-269H,12-24,31,34-45,52-90,93-103,204-206H2,1-11H3,(H2,207,270)(H2,208,271)(H2,209,272)(H2,210,273)(H2,211,288)(H,216,225)(H,217,274)(H,221,276)(H,222,292)(H,223,291)(H,224,293)(H,226,277)(H,227,294)(H,228,275)(H,229,289)(H,230,299)(H,231,296)(H,232,302)(H,233,311)(H,234,312)(H,235,310)(H,236,295)(H,237,317)(H,238,304)(H,239,305)(H,240,306)(H,241,301)(H,242,297)(H,243,298)(H,244,300)(H,245,313)(H,246,318)(H,247,316)(H,248,290)(H,249,314)(H,250,303)(H,251,307)(H,252,315)(H,253,319)(H,254,278)(H,255,308)(H,256,309)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,323,324)(H4,212,213,218)(H4,214,215,219)/t107-,108-,109-,110+,111+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,163-,164-,165-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50266673
(CHEMBL4076828)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C185H285N51O60S/c1-16-94(10)147(179(291)214-114(52-58-144(258)259)163(275)219-121(73-101-77-197-105-39-24-23-38-103(101)105)168(280)216-116(68-90(2)3)165(277)205-107(41-26-28-61-187)158(270)220-122(75-136(191)247)154(266)199-79-137(248)198-82-140(251)233-63-30-43-130(233)176(288)227-128(87-241)175(287)225-125(84-238)155(267)201-80-138(249)203-96(12)182(294)235-65-32-45-132(235)184(296)236-66-33-46-133(236)183(295)234-64-31-44-131(234)177(289)223-124(83-237)150(192)262)231-170(282)119(71-99-34-19-17-20-35-99)218-166(278)117(69-91(4)5)215-159(271)108(42-29-62-196-185(193)194)213-178(290)146(93(8)9)230-151(263)95(11)204-156(268)111(49-55-141(252)253)209-161(273)112(50-56-142(254)255)210-162(274)113(51-57-143(256)257)211-164(276)115(59-67-297-15)212-160(272)110(48-54-135(190)246)208-157(269)106(40-25-27-60-186)206-173(285)127(86-240)226-167(279)118(70-92(6)7)217-169(281)123(76-145(260)261)221-174(286)129(88-242)228-181(293)149(98(14)244)232-171(283)120(72-100-36-21-18-22-37-100)222-180(292)148(97(13)243)229-139(250)81-200-153(265)109(47-53-134(189)245)207-172(284)126(85-239)224-152(264)104(188)74-102-78-195-89-202-102/h17-24,34-39,77-78,89-98,104,106-133,146-149,197,237-244H,16,25-33,40-76,79-88,186-188H2,1-15H3,(H2,189,245)(H2,190,246)(H2,191,247)(H2,192,262)(H,195,202)(H,198,248)(H,199,266)(H,200,265)(H,201,267)(H,203,249)(H,204,268)(H,205,277)(H,206,285)(H,207,284)(H,208,269)(H,209,273)(H,210,274)(H,211,276)(H,212,272)(H,213,290)(H,214,291)(H,215,271)(H,216,280)(H,217,281)(H,218,278)(H,219,275)(H,220,270)(H,221,286)(H,222,292)(H,223,289)(H,224,264)(H,225,287)(H,226,279)(H,227,288)(H,228,293)(H,229,250)(H,230,263)(H,231,282)(H,232,283)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H4,193,194,196)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,149-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.12 | n/a | n/a | n/a | n/a |
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
| Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay |
J Med Chem 60: 4293-4303 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00174
BindingDB Entry DOI: 10.7270/Q27S7R7M |
More data for this
Ligand-Target Pair | |
Search and Browse
