Found 44 hits Enz. Inhib. hit(s) with all data for entry = 50006220 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM185975
(US9163008, 64 | US9656968, Compound 64)Show SMILES C[C@H](Nc1cc(nc(n1)-c1ccc(Oc2ccc(Cl)cc2F)cc1)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C20H17ClFN5O3/c1-10(18(23)28)25-17-9-15(19(24)29)26-20(27-17)11-2-5-13(6-3-11)30-16-7-4-12(21)8-14(16)22/h2-10H,1H3,(H2,23,28)(H2,24,29)(H,25,26,27)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50393023
(CHEMBL2152688)Show SMILES CS(=O)(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C24H22FN5O4S/c1-35(32,33)30-22(13-18-14-26-15-27-18)24(31)29-23-4-2-3-21(28-23)16-5-9-19(10-6-16)34-20-11-7-17(25)8-12-20/h2-12,14-15,22,30H,13H2,1H3,(H,26,27)(H,28,29,31)/t22-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497932
(CHEMBL3341989)Show SMILES NC(=O)c1cnc(nc1[C@@H](O)CO)-c1ccc(Oc2cc(F)cc(Cl)c2)cc1 |r| Show InChI InChI=1S/C19H15ClFN3O4/c20-11-5-12(21)7-14(6-11)28-13-3-1-10(2-4-13)19-23-8-15(18(22)27)17(24-19)16(26)9-25/h1-8,16,25-26H,9H2,(H2,22,27)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM190561
(US9181185, 19 | US9624194, Compound 19)Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1 Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 347 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM236497
(US9388137, 1)Show SMILES Cc1cc(cc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NCC[N+]1(C)CCCCC1 Show InChI InChI=1S/C27H30FN3O2/c1-20-18-22(27(32)29-14-17-31(2)15-4-3-5-16-31)19-26(30-20)21-6-10-24(11-7-21)33-25-12-8-23(28)9-13-25/h6-13,18-19H,3-5,14-17H2,1-2H3/p+1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 6.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50169425
(CHEMBL3341983 | US9481677, 44)Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-17-13(5-10)20(25)28-33-17)32-18-7-15(24)19(8-14(18)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM275868
(US10071957, Example 87)Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM258159
(US9493448, 61 | US9845313, Example 61)Show SMILES CCc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1 |r| Show InChI InChI=1S/C21H24FN5O3S/c1-3-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50024245
(CHEMBL3325524)Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCC[C@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145227
(US8952169, 6 | US9771376, Example 6)Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:13:14:17:21.20.19,23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497931
(CHEMBL3341986)Show SMILES C[C@H](c1ccccc1C1(F)CNC1)n1c2cc(F)c(cc2oc1=O)S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C21H18F2N4O4S2/c1-12(13-4-2-3-5-14(13)21(23)10-24-11-21)27-16-8-15(22)18(9-17(16)31-20(27)28)33(29,30)26-19-25-6-7-32-19/h2-9,12,24H,10-11H2,1H3,(H,25,26)/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM154456
(US9012443, 521)Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncns1)-c1cccc(F)c1 Show InChI InChI=1S/C23H15ClFN5O3S2/c1-33-21-10-17(13-3-2-4-14(25)7-13)19(24)9-18(21)22-16-6-5-15(8-20(16)26-11-27-22)35(31,32)30-23-28-12-29-34-23/h2-12H,1H3,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM162249
(US9051311, 6)Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNCC1)-c1cccc2CN(CCc12)S(=O)(=O)Nc1ncns1 |t:11| Show InChI InChI=1S/C23H22F3N5O2S2/c24-23(25,26)17-4-5-20(21(12-17)15-6-9-27-10-7-15)19-3-1-2-16-13-31(11-8-18(16)19)35(32,33)30-22-28-14-29-34-22/h1-6,12,14,27H,7-11,13H2,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497937
(CHEMBL3341976)Show SMILES CCOc1ncccc1-c1cc(ccc1Oc1ccc(Cl)c(c1)C(F)(F)F)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C22H18ClF3N2O5S/c1-3-32-21-15(5-4-10-27-21)16-11-13(20(29)28-34(2,30)31)6-9-19(16)33-14-7-8-18(23)17(12-14)22(24,25)26/h4-12H,3H2,1-2H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by whole-cell patch-clamp technique |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM170190
(US9079902, 21)Show SMILES Cn1cc(-c2ccc(cc2-c2cn[nH]c2)C(F)(F)F)c2ccc(cc12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H15F3N6O2S2/c1-30-10-18(15-4-2-13(21(22,23)24)6-17(15)12-8-26-27-9-12)16-5-3-14(7-19(16)30)34(31,32)29-20-25-11-28-33-20/h2-11H,1H3,(H,26,27)(H,25,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM231255
(US9346798, 2)Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Cl)c1 Show InChI InChI=1S/C17H12ClF3N4O3S2/c18-12-7-10(17(19,20)21)1-3-13(12)25-5-6-28-15-8-11(2-4-14(15)25)30(26,27)24-16-22-9-23-29-16/h1-4,7-9H,5-6H2,(H,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497932
(CHEMBL3341989)Show SMILES NC(=O)c1cnc(nc1[C@@H](O)CO)-c1ccc(Oc2cc(F)cc(Cl)c2)cc1 |r| Show InChI InChI=1S/C19H15ClFN3O4/c20-11-5-12(21)7-14(6-11)28-13-3-1-10(2-4-13)19-23-8-15(18(22)27)17(24-19)16(26)9-25/h1-8,16,25-26H,9H2,(H2,22,27)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50497939
(CHEMBL3341974)Show SMILES CC(C)CC[C@H](N)c1nc2cc(ccc2[nH]1)C(C)(C)C |r| Show InChI InChI=1S/C17H27N3/c1-11(2)6-8-13(18)16-19-14-9-7-12(17(3,4)5)10-15(14)20-16/h7,9-11,13H,6,8,18H2,1-5H3,(H,19,20)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1 .8 expressed in HEK cells by PatchXpress electrophysiological assay |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497930
(CHEMBL3341978)Show SMILES CC1(COc2ccc(cn2)-n2nc(C3CC3)c3cc(ccc23)C(=O)NS(C)(=O)=O)CC1 Show InChI InChI=1S/C22H24N4O4S/c1-22(9-10-22)13-30-19-8-6-16(12-23-19)26-18-7-5-15(21(27)25-31(2,28)29)11-17(18)20(24-26)14-3-4-14/h5-8,11-12,14H,3-4,9-10,13H2,1-2H3,(H,25,27) | PDB
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by whole-cell patch-clamp technique |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM264714
((R)-1-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-...)Show SMILES OC[C@@H](O)C(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C20H16FNO4/c21-14-6-10-16(11-7-14)26-15-8-4-13(5-9-15)17-2-1-3-18(22-17)20(25)19(24)12-23/h1-11,19,23-24H,12H2/t19-/m1/s1 | PDB
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| n/a | n/a | 133 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50393023
(CHEMBL2152688)Show SMILES CS(=O)(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1 |r| Show InChI InChI=1S/C24H22FN5O4S/c1-35(32,33)30-22(13-18-14-26-15-27-18)24(31)29-23-4-2-3-21(28-23)16-5-9-19(10-6-16)34-20-11-7-17(25)8-12-20/h2-12,14-15,22,30H,13H2,1H3,(H,26,27)(H,28,29,31)/t22-/m0/s1 | PDB
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| Article
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM185975
(US9163008, 64 | US9656968, Compound 64)Show SMILES C[C@H](Nc1cc(nc(n1)-c1ccc(Oc2ccc(Cl)cc2F)cc1)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C20H17ClFN5O3/c1-10(18(23)28)25-17-9-15(19(24)29)26-20(27-17)11-2-5-13(6-3-11)30-16-7-4-12(21)8-14(16)22/h2-10H,1H3,(H2,23,28)(H2,24,29)(H,25,26,27)/t10-/m0/s1 | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 10 subunit alpha
(Homo sapiens (Human)) | BDBM50497928
(CHEMBL3341975)Show SMILES NC1(Cc2nc(c[nH]2)-c2ccc(OC(F)(F)F)cc2)CCCOC1 Show InChI InChI=1S/C16H18F3N3O2/c17-16(18,19)24-12-4-2-11(3-5-12)13-9-21-14(22-13)8-15(20)6-1-7-23-10-15/h2-5,9H,1,6-8,10,20H2,(H,21,22) | PDB
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| Article
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1 .8 expressed in HEK cells by PatchXpress electrophysiological assay |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50393029
(CHEMBL2152694)Show SMILES CN(C)c1ccc(C(=O)NC2CC22CCN(CC2)c2ccccc2)c2ccccc12 Show InChI InChI=1S/C26H29N3O/c1-28(2)23-13-12-22(20-10-6-7-11-21(20)23)25(30)27-24-18-26(24)14-16-29(17-15-26)19-8-4-3-5-9-19/h3-13,24H,14-18H2,1-2H3,(H,27,30) | PDB
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| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497929
(CHEMBL3341977)Show SMILES CC(C)Oc1ncc(OCc2cc(F)c(cc2F)C(=O)NS(=O)(=O)N(C)C)cc1Cl Show InChI InChI=1S/C18H20ClF2N3O5S/c1-10(2)29-18-14(19)6-12(8-22-18)28-9-11-5-16(21)13(7-15(11)20)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25) | PDB
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| Article
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| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by whole-cell patch-clamp technique |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM190561
(US9181185, 19 | US9624194, Compound 19)Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1 Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m0/s1 | PDB
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| Article
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| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497934
(CHEMBL3341996)Show SMILES CC(C)COc1ccc(C)cc1-c1cccc(c1)[C@H]1CC[C@]2(CCN(C)C2=O)N1 |r| Show InChI InChI=1S/C25H32N2O2/c1-17(2)16-29-23-9-8-18(3)14-21(23)19-6-5-7-20(15-19)22-10-11-25(26-22)12-13-27(4)24(25)28/h5-9,14-15,17,22,26H,10-13,16H2,1-4H3/t22-,25-/m1/s1 | PDB
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| Article
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| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as half-maximal voltage for steady state inactivation by QPatch method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497933
(CHEMBL3341995)Show InChI InChI=1S/C20H18Cl2N4O/c1-13-18(12-23-11-10-14-6-2-4-8-16(14)21)26-20(27-13)24-19(25-26)15-7-3-5-9-17(15)22/h2-9,23H,10-12H2,1H3 | PDB
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| Article
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| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497926
(CHEMBL3341994)Show SMILES CCCCCN1C(COCC1=O)c1cncc(c1)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C21H23F3N2O3/c1-2-3-4-9-26-19(13-28-14-20(26)27)17-10-16(11-25-12-17)15-5-7-18(8-6-15)29-21(22,23)24/h5-8,10-12,19H,2-4,9,13-14H2,1H3 | PDB
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| PC cid
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| Article
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| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM236497
(US9388137, 1)Show SMILES Cc1cc(cc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NCC[N+]1(C)CCCCC1 Show InChI InChI=1S/C27H30FN3O2/c1-20-18-22(27(32)29-14-17-31(2)15-4-3-5-16-31)19-26(30-20)21-6-10-24(11-7-21)33-25-12-8-23(28)9-13-25/h6-13,18-19H,3-5,14-17H2,1-2H3/p+1 | PDB
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| Article
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| n/a | n/a | 872 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50169425
(CHEMBL3341983 | US9481677, 44)Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-17-13(5-10)20(25)28-33-17)32-18-7-15(24)19(8-14(18)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29) | PDB
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CHEMBL
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PC cid
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| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM145227
(US8952169, 6 | US9771376, Example 6)Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:13:14:17:21.20.19,23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23) | PDB
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| PC cid
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| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497940
(CHEMBL3341993)Show SMILES FC(F)(F)c1cc(Oc2ccc(cc2)C(=O)NCC2CCCCN2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H20F6N2O2/c22-20(23,24)14-9-15(21(25,26)27)11-18(10-14)31-17-6-4-13(5-7-17)19(30)29-12-16-3-1-2-8-28-16/h4-7,9-11,16,28H,1-3,8,12H2,(H,29,30) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM275868
(US10071957, Example 87)Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) by PatchXpress method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497927
(CHEMBL3341997)Show SMILES CN1CC[C@@]2(CC[C@@H](N2)c2nc(C)cc(n2)-c2ccc(cc2)C(F)(F)F)C1=O |r| Show InChI InChI=1S/C20H21F3N4O/c1-12-11-16(13-3-5-14(6-4-13)20(21,22)23)25-17(24-12)15-7-8-19(26-15)9-10-27(2)18(19)28/h3-6,11,15,26H,7-10H2,1-2H3/t15-,19+/m1/s1 | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as half-maximal voltage for steady state inactivation by QPatch method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497936
(CHEMBL3342001)Show SMILES CCOC1CC(OC2(CCN(CC2)C(=O)c2ccc(OC(C)C)c(C)c2)C1)c1scnc1C Show InChI InChI=1S/C26H36N2O4S/c1-6-30-21-14-23(24-19(5)27-16-33-24)32-26(15-21)9-11-28(12-10-26)25(29)20-7-8-22(18(4)13-20)31-17(2)3/h7-8,13,16-17,21,23H,6,9-12,14-15H2,1-5H3 | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497935
(CHEMBL3341999)Show SMILES COc1cc(ccc1OC(C)C)C(=O)N1CCC2(CC1)N(C)CCn1c(ccc21)C(F)(F)F Show InChI InChI=1S/C24H30F3N3O3/c1-16(2)33-18-6-5-17(15-19(18)32-4)22(31)29-11-9-23(10-12-29)20-7-8-21(24(25,26)27)30(20)14-13-28(23)3/h5-8,15-16H,9-14H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497941
(CHEMBL3342000)Show SMILES COc1cc(ccc1OC(C)C)C(=O)N1CCC2(CC1)CN(CC(F)F)CC(O2)c1ccccn1 Show InChI InChI=1S/C26H33F2N3O4/c1-18(2)34-21-8-7-19(14-22(21)33-3)25(32)31-12-9-26(10-13-31)17-30(16-24(27)28)15-23(35-26)20-6-4-5-11-29-20/h4-8,11,14,18,23-24H,9-10,12-13,15-17H2,1-3H3 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK cells by patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50497938
(CHEMBL3341998)Show SMILES CN1CC[C@@]2(CC[C@@H](N2)c2cc(ccn2)-c2cccc(OC(F)(F)F)c2)C1=O |r| Show InChI InChI=1S/C20H20F3N3O2/c1-26-10-8-19(18(26)27)7-5-16(25-19)17-12-14(6-9-24-17)13-3-2-4-15(11-13)28-20(21,22)23/h2-4,6,9,11-12,16,25H,5,7-8,10H2,1H3/t16-,19+/m1/s1 | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as half-maximal voltage for steady state inactivation by QPatch method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM154456
(US9012443, 521)Show SMILES COc1cc(c(Cl)cc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1ncns1)-c1cccc(F)c1 Show InChI InChI=1S/C23H15ClFN5O3S2/c1-33-21-10-17(13-3-2-4-14(25)7-13)19(24)9-18(21)22-16-6-5-15(8-20(16)26-11-27-22)35(31,32)30-23-28-12-29-34-23/h2-12H,1H3,(H,28,29,30) | PDB
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| PC cid
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Similars
| Article
PubMed
| n/a | n/a | 4.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells by IonWorks patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM162249
(US9051311, 6)Show SMILES FC(F)(F)c1ccc(c(c1)C1=CCNCC1)-c1cccc2CN(CCc12)S(=O)(=O)Nc1ncns1 |t:11| Show InChI InChI=1S/C23H22F3N5O2S2/c24-23(25,26)17-4-5-20(21(12-17)15-6-9-27-10-7-15)19-3-1-2-16-13-31(11-8-18(16)19)35(32,33)30-22-28-14-29-34-22/h1-6,12,14,27H,7-11,13H2,(H,28,29,30) | PDB
KEGG
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| PC cid
PC sid
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Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells by IonWorks patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50024245
(CHEMBL3325524)Show SMILES Fc1cc(c(F)cc1OC[C@@H]1CNCC[C@H]1c1ccc(Cl)cc1)S(=O)(=O)Nc1ncns1 |r| Show InChI InChI=1S/C20H19ClF2N4O3S2/c21-14-3-1-12(2-4-14)15-5-6-24-9-13(15)10-30-18-7-17(23)19(8-16(18)22)32(28,29)27-20-25-11-26-31-20/h1-4,7-8,11,13,15,24H,5-6,9-10H2,(H,25,26,27)/t13-,15-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM231255
(US9346798, 2)Show SMILES FC(F)(F)c1ccc(N2CCOc3cc(ccc23)S(=O)(=O)Nc2ncns2)c(Cl)c1 Show InChI InChI=1S/C17H12ClF3N4O3S2/c18-12-7-10(17(19,20)21)1-3-13(12)25-5-6-28-15-8-11(2-4-14(15)25)30(26,27)24-16-22-9-23-29-16/h1-4,7-9H,5-6H2,(H,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells by IonWorks patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM170190
(US9079902, 21)Show SMILES Cn1cc(-c2ccc(cc2-c2cn[nH]c2)C(F)(F)F)c2ccc(cc12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C21H15F3N6O2S2/c1-30-10-18(15-4-2-13(21(22,23)24)6-17(15)12-8-26-27-9-12)16-5-3-14(7-19(16)30)34(31,32)29-20-25-11-28-33-20/h2-11H,1H3,(H,26,27)(H,25,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells by IonWorks patch-clamp method |
Bioorg Med Chem Lett 24: 3690-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.038
BindingDB Entry DOI: 10.7270/Q2KS6VJM |
More data for this
Ligand-Target Pair | |
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