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Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with all data for entry = 50006762   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503151
PNG
(CHEMBL4450420)
Show SMILES Cc1ncc(CNNC(=O)c2cnc(CNS(=O)(=O)c3ccc(F)c(Cl)c3)cn2)s1
Show InChI InChI=1S/C17H16ClFN6O3S2/c1-10-20-7-12(29-10)8-23-25-17(26)16-9-21-11(5-22-16)6-24-30(27,28)13-2-3-15(19)14(18)4-13/h2-5,7,9,23-24H,6,8H2,1H3,(H,25,26)
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n/an/a 7.90n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50503150
PNG
(EVT-101)
Show SMILES Cc1nccn1Cc1cc(cnn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C16H13F3N4/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19/h2-8,16H,9H2,1H3
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n/an/a 12n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503154
PNG
(CHEMBL4555447)
Show SMILES Cc1ncc(CNNC(=O)c2cnc(CNS(=O)(=O)c3ccc(F)c(F)c3)c(C)n2)s1
Show InChI InChI=1S/C18H18F2N6O3S2/c1-10-16(9-24-31(28,29)13-3-4-14(19)15(20)5-13)22-8-17(25-10)18(27)26-23-7-12-6-21-11(2)30-12/h3-6,8,23-24H,7,9H2,1-2H3,(H,26,27)
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n/an/a 27n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50083351
PNG
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Show SMILES CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
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n/an/a 110n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2B receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a 110n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503154
PNG
(CHEMBL4555447)
Show SMILES Cc1ncc(CNNC(=O)c2cnc(CNS(=O)(=O)c3ccc(F)c(F)c3)c(C)n2)s1
Show InChI InChI=1S/C18H18F2N6O3S2/c1-10-16(9-24-31(28,29)13-3-4-14(19)15(20)5-13)22-8-17(25-10)18(27)26-23-7-12-6-21-11(2)30-12/h3-6,8,23-24H,7,9H2,1-2H3,(H,26,27)
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n/an/a 143n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503151
PNG
(CHEMBL4450420)
Show SMILES Cc1ncc(CNNC(=O)c2cnc(CNS(=O)(=O)c3ccc(F)c(Cl)c3)cn2)s1
Show InChI InChI=1S/C17H16ClFN6O3S2/c1-10-20-7-12(29-10)8-23-25-17(26)16-9-21-11(5-22-16)6-24-30(27,28)13-2-3-15(19)14(18)4-13/h2-5,7,9,23-24H,6,8H2,1H3,(H,25,26)
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n/an/a 198n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a 340n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a 446n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN1/GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50503153
PNG
(CHEMBL4544421)
Show SMILES CCN(CC)C(=S)Oc1ccc(cc1)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C22H22N2O2S/c1-3-24(4-2)22(27)26-18-14-12-17(13-15-18)21(25)23-20-11-7-9-16-8-5-6-10-19(16)20/h5-15H,3-4H2,1-2H3,(H,23,25)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503149
PNG
(CHEMBL4464605)
Show SMILES OC(=O)c1cc2cc(ccc2c(Br)c1O)-c1ccccc1
Show InChI InChI=1S/C17H11BrO3/c18-15-13-7-6-11(10-4-2-1-3-5-10)8-12(13)9-14(16(15)19)17(20)21/h1-9,19H,(H,20,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50503149
PNG
(CHEMBL4464605)
Show SMILES OC(=O)c1cc2cc(ccc2c(Br)c1O)-c1ccccc1
Show InChI InChI=1S/C17H11BrO3/c18-15-13-7-6-11(10-4-2-1-3-5-10)8-12(13)9-14(16(15)19)17(20)21/h1-9,19H,(H,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50503149
PNG
(CHEMBL4464605)
Show SMILES OC(=O)c1cc2cc(ccc2c(Br)c1O)-c1ccccc1
Show InChI InChI=1S/C17H11BrO3/c18-15-13-7-6-11(10-4-2-1-3-5-10)8-12(13)9-14(16(15)19)17(20)21/h1-9,19H,(H,20,21)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50503149
PNG
(CHEMBL4464605)
Show SMILES OC(=O)c1cc2cc(ccc2c(Br)c1O)-c1ccccc1
Show InChI InChI=1S/C17H11BrO3/c18-15-13-7-6-11(10-4-2-1-3-5-10)8-12(13)9-14(16(15)19)17(20)21/h1-9,19H,(H,20,21)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50503153
PNG
(CHEMBL4544421)
Show SMILES CCN(CC)C(=S)Oc1ccc(cc1)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C22H22N2O2S/c1-3-24(4-2)22(27)26-18-14-12-17(13-15-18)21(25)23-20-11-7-9-16-8-5-6-10-19(16)20/h5-15H,3-4H2,1-2H3,(H,23,25)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50503146
PNG
(CHEMBL4447266)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50440056
PNG
(CHEMBL2333944)
Show SMILES Cc1ccc2[nH]c(=O)c(C3=NN(C(C3)c3ccc(Br)cc3)C(=O)CCC(O)=O)c(-c3ccccc3)c2c1 |t:9|
Show InChI InChI=1S/C29H24BrN3O4/c1-17-7-12-22-21(15-17)27(19-5-3-2-4-6-19)28(29(37)31-22)23-16-24(18-8-10-20(30)11-9-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50324401
PNG
((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50503146
PNG
(CHEMBL4447266)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50440056
PNG
(CHEMBL2333944)
Show SMILES Cc1ccc2[nH]c(=O)c(C3=NN(C(C3)c3ccc(Br)cc3)C(=O)CCC(O)=O)c(-c3ccccc3)c2c1 |t:9|
Show InChI InChI=1S/C29H24BrN3O4/c1-17-7-12-22-21(15-17)27(19-5-3-2-4-6-19)28(29(37)31-22)23-16-24(18-8-10-20(30)11-9-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50324401
PNG
((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50379184
PNG
(CHEMBL2010868)
Show SMILES OC(=O)c1cc2cccc(O)c2cc1O
Show InChI InChI=1S/C11H8O4/c12-9-3-1-2-6-4-8(11(14)15)10(13)5-7(6)9/h1-5,12-13H,(H,14,15)
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n/an/a 9.40E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50379184
PNG
(CHEMBL2010868)
Show SMILES OC(=O)c1cc2cccc(O)c2cc1O
Show InChI InChI=1S/C11H8O4/c12-9-3-1-2-6-4-8(11(14)15)10(13)5-7(6)9/h1-5,12-13H,(H,14,15)
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n/an/a 9.70E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2B receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2C receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50498439
PNG
(CHEMBL1179566)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@@H](CC[C@]12C)OS(O)(=O)=O |r|
Show InChI InChI=1S/C21H34O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19H,4-12H2,1-3H3,(H,23,24,25)/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50498439
PNG
(CHEMBL1179566)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@@H](CC[C@]12C)OS(O)(=O)=O |r|
Show InChI InChI=1S/C21H34O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19H,4-12H2,1-3H3,(H,23,24,25)/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50379184
PNG
(CHEMBL2010868)
Show SMILES OC(=O)c1cc2cccc(O)c2cc1O
Show InChI InChI=1S/C11H8O4/c12-9-3-1-2-6-4-8(11(14)15)10(13)5-7(6)9/h1-5,12-13H,(H,14,15)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 1.86E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2A


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN1a/GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50503146
PNG
(CHEMBL4447266)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50083351
PNG
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Show SMILES CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
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n/an/a 2.91E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2C receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2D receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50498439
PNG
(CHEMBL1179566)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@@H](CC[C@]12C)OS(O)(=O)=O |r|
Show InChI InChI=1S/C21H34O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19H,4-12H2,1-3H3,(H,23,24,25)/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50083351
PNG
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Show SMILES CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
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n/an/a 3.95E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50236939
PNG
(CHEMBL2333945)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NCc1ccc(cc1)C(=O)NNC(=O)c1ccccc1
Show InChI InChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2B receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50503145
PNG
(CHEMBL4456824)
Show SMILES OC(=O)c1ccc2cc(I)c3ccccc3c2c1
Show InChI InChI=1S/C15H9IO2/c16-14-8-9-5-6-10(15(17)18)7-13(9)11-3-1-2-4-12(11)14/h1-8H,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50503145
PNG
(CHEMBL4456824)
Show SMILES OC(=O)c1ccc2cc(I)c3ccccc3c2c1
Show InChI InChI=1S/C15H9IO2/c16-14-8-9-5-6-10(15(17)18)7-13(9)11-3-1-2-4-12(11)14/h1-8H,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50080029
PNG
(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r|
Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase


(Candida glabrata)		BDBM50498439
PNG
(CHEMBL1179566)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@@H](CC[C@]12C)OS(O)(=O)=O |r|
Show InChI InChI=1S/C21H34O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19H,4-12H2,1-3H3,(H,23,24,25)/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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n/an/a 6.20E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 6.80E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN1a/GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 6.80E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2D


(Homo sapiens (Human))		BDBM50083351
PNG
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Show SMILES CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
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n/an/a 7.59E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50503146
PNG
(CHEMBL4447266)
Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O |c:8|
Show InChI InChI=1S/C28H21Br2N3O4/c29-18-8-6-16(7-9-18)23-15-22(32-33(23)24(34)12-13-25(35)36)27-26(17-4-2-1-3-5-17)20-14-19(30)10-11-21(20)31-28(27)37/h1-11,14,23H,12-13,15H2,(H,31,37)(H,35,36)
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n/an/a 7.80E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B


(Homo sapiens (Human))		BDBM50259886
PNG
(CHEMBL2333943)
Show SMILES OC(=O)c1cc2cc(Br)ccc2oc1=O
Show InChI InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN1a/GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Homo sapiens (Human))		BDBM50503144
PNG
(CHEBI:35420 | CHEMBL1179605)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OS(O)(=O)=O |t:19|
Show InChI InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 1.12E+5n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...

J Med Chem 62: 3-23 (2019)


Article DOI: 10.1021/acs.jmedchem.7b01640
BindingDB Entry DOI: 10.7270/Q2N019RG
More data for this
Ligand-Target Pair
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