Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 50008662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM123891 (US8754113, I-1-85 | US9169240, 24) Show SMILES NS(=O)(=O)NCc1nnc(Cc2nc3ccc(cc3s2)-c2ccccc2)o1 Show InChI InChI=1S/C17H15N5O3S2/c18-27(23,24)19-10-16-22-21-15(25-16)9-17-20-13-7-6-12(8-14(13)26-17)11-4-2-1-3-5-11/h1-8,19H,9-10H2,(H2,18,23,24)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human endothelial lipase using HDL as substrate measured after 4 hrs				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Pancreatic triacylglycerol lipase (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521231 (CHEMBL4435864) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C29H27ClN6O7S3/c30-22-14-19(6-8-21(22)29(37)36-10-12-42-13-11-36)20-7-9-23-24(15-20)44-28(33-23)26(45(38,39)17-18-4-2-1-3-5-18)27-35-34-25(43-27)16-32-46(31,40)41/h1-9,14-15,26,32H,10-13,16-17H2,(H2,31,40,41)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521235 (CHEMBL4473238) Show SMILES COCCS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O6S3/c1-30-9-10-33(26,27)18(19-25-24-17(31-19)12-22-34(21,28)29)20-23-15-8-7-14(11-16(15)32-20)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521230 (CHEMBL4546575) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C21H16N4O5S3/c1-33(28,29)17(19-25-24-16(30-19)10-15-18(26)23-21(27)32-15)20-22-13-8-7-12(9-14(13)31-20)11-5-3-2-4-6-11/h2-9,15,17H,10H2,1H3,(H,23,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521233 (CHEMBL4458141) Show SMILES CC(C)S(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O5S3/c1-12(2)32(26,27)18(19-25-24-17(30-19)11-22-33(21,28)29)20-23-15-9-8-14(10-16(15)31-20)13-6-4-3-5-7-13/h3-10,12,18,22H,11H2,1-2H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521236 (CHEMBL4589925) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C20H18F3N5O5S3/c21-20(22,23)8-9-35(29,30)17(18-28-27-16(33-18)11-25-36(24,31)32)19-26-14-7-6-13(10-15(14)34-19)12-4-2-1-3-5-12/h1-7,10,17,25H,8-9,11H2,(H2,24,31,32)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521237 (CHEMBL4468090) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H21N5O5S3/c25-37(32,33)26-14-21-28-29-23(34-21)22(36(30,31)15-16-7-3-1-4-8-16)24-27-19-12-11-18(13-20(19)35-24)17-9-5-2-6-10-17/h1-13,22,26H,14-15H2,(H2,25,32,33)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521225 (CHEMBL4440746) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(Cl)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O5S3/c25-17-8-6-15(10-18(17)26)16-7-9-19-20(11-16)37-24(29-19)22(38(32,33)13-14-4-2-1-3-5-14)23-31-30-21(36-23)12-28-39(27,34)35/h1-11,22,28H,12-13H2,(H2,27,34,35)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521224 (CHEMBL4577903) Show SMILES CN(C)C(=O)c1ccc(cc1Cl)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C27H25ClN6O6S3/c1-34(2)27(35)19-10-8-17(12-20(19)28)18-9-11-21-22(13-18)41-26(31-21)24(42(36,37)15-16-6-4-3-5-7-16)25-33-32-23(40-25)14-30-43(29,38)39/h3-13,24,30H,14-15H2,1-2H3,(H2,29,38,39)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521234 (CHEMBL4536805) Show SMILES CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C22H19N5O5S2/c1-22(20(28)24-21(29)25-22)11-16-26-27-18(32-16)17(34(2,30)31)19-23-14-9-8-13(10-15(14)33-19)12-6-4-3-5-7-12/h3-10,17H,11H2,1-2H3,(H2,24,25,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521228 (CHEMBL4563513) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H23N5O7S3/c1-41(35,36)21(23-30-29-20(38-23)13-19-22(32)28-26(34)40-19)24-27-17-7-6-16(12-18(17)39-24)14-2-4-15(5-3-14)25(33)31-8-10-37-11-9-31/h2-7,12,19,21H,8-11,13H2,1H3,(H,28,32,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521233 (CHEMBL4458141) Show SMILES CC(C)S(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O5S3/c1-12(2)32(26,27)18(19-25-24-17(30-19)11-22-33(21,28)29)20-23-15-9-8-14(10-16(15)31-20)13-6-4-3-5-7-13/h3-10,12,18,22H,11H2,1-2H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521235 (CHEMBL4473238) Show SMILES COCCS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O6S3/c1-30-9-10-33(26,27)18(19-25-24-17(31-19)12-22-34(21,28)29)20-23-15-8-7-14(11-16(15)32-20)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521226 (CHEMBL4471545) Show SMILES CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C18H17N5O5S3/c1-30(24,25)16(17-23-22-15(28-17)10-20-31(19,26)27)18-21-13-8-7-12(9-14(13)29-18)11-5-3-2-4-6-11/h2-9,16,20H,10H2,1H3,(H2,19,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521236 (CHEMBL4589925) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C20H18F3N5O5S3/c21-20(22,23)8-9-35(29,30)17(18-28-27-16(33-18)11-25-36(24,31)32)19-26-14-7-6-13(10-15(14)34-19)12-4-2-1-3-5-12/h1-7,10,17,25H,8-9,11H2,(H2,24,31,32)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521225 (CHEMBL4440746) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(Cl)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O5S3/c25-17-8-6-15(10-18(17)26)16-7-9-19-20(11-16)37-24(29-19)22(38(32,33)13-14-4-2-1-3-5-14)23-31-30-21(36-23)12-28-39(27,34)35/h1-11,22,28H,12-13H2,(H2,27,34,35)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521230 (CHEMBL4546575) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C21H16N4O5S3/c1-33(28,29)17(19-25-24-16(30-19)10-15-18(26)23-21(27)32-15)20-22-13-8-7-12(9-14(13)31-20)11-5-3-2-4-6-11/h2-9,15,17H,10H2,1H3,(H,23,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521232 (CHEMBL4567596) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1cccc(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H20ClN5O5S3/c25-18-8-4-7-16(11-18)17-9-10-19-20(12-17)36-24(28-19)22(37(31,32)14-15-5-2-1-3-6-15)23-30-29-21(35-23)13-27-38(26,33)34/h1-12,22,27H,13-14H2,(H2,26,33,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521232 (CHEMBL4567596) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1cccc(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H20ClN5O5S3/c25-18-8-4-7-16(11-18)17-9-10-19-20(12-17)36-24(28-19)22(37(31,32)14-15-5-2-1-3-6-15)23-30-29-21(35-23)13-27-38(26,33)34/h1-12,22,27H,13-14H2,(H2,26,33,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521237 (CHEMBL4468090) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H21N5O5S3/c25-37(32,33)26-14-21-28-29-23(34-21)22(36(30,31)15-16-7-3-1-4-8-16)24-27-19-12-11-18(13-20(19)35-24)17-9-5-2-6-10-17/h1-13,22,26H,14-15H2,(H2,25,32,33)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521227 (CHEMBL4473964) Show SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H24N6O7S3/c1-38-26(33)29-19-10-7-17(8-11-19)18-9-12-20-21(13-18)40-25(30-20)23(41(34,35)15-16-5-3-2-4-6-16)24-32-31-22(39-24)14-28-42(27,36)37/h2-13,23,28H,14-15H2,1H3,(H,29,33)(H2,27,36,37)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521228 (CHEMBL4563513) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H23N5O7S3/c1-41(35,36)21(23-30-29-20(38-23)13-19-22(32)28-26(34)40-19)24-27-17-7-6-16(12-18(17)39-24)14-2-4-15(5-3-14)25(33)31-8-10-37-11-9-31/h2-7,12,19,21H,8-11,13H2,1H3,(H,28,32,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<22	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521226 (CHEMBL4471545) Show SMILES CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C18H17N5O5S3/c1-30(24,25)16(17-23-22-15(28-17)10-20-31(19,26)27)18-21-13-8-7-12(9-14(13)29-18)11-5-3-2-4-6-11/h2-9,16,20H,10H2,1H3,(H2,19,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521232 (CHEMBL4567596) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1cccc(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H20ClN5O5S3/c25-18-8-4-7-16(11-18)17-9-10-19-20(12-17)36-24(28-19)22(37(31,32)14-15-5-2-1-3-6-15)23-30-29-21(35-23)13-27-38(26,33)34/h1-12,22,27H,13-14H2,(H2,26,33,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521230 (CHEMBL4546575) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C21H16N4O5S3/c1-33(28,29)17(19-25-24-16(30-19)10-15-18(26)23-21(27)32-15)20-22-13-8-7-12(9-14(13)31-20)11-5-3-2-4-6-11/h2-9,15,17H,10H2,1H3,(H,23,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521226 (CHEMBL4471545) Show SMILES CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C18H17N5O5S3/c1-30(24,25)16(17-23-22-15(28-17)10-20-31(19,26)27)18-21-13-8-7-12(9-14(13)29-18)11-5-3-2-4-6-11/h2-9,16,20H,10H2,1H3,(H2,19,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521234 (CHEMBL4536805) Show SMILES CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C22H19N5O5S2/c1-22(20(28)24-21(29)25-22)11-16-26-27-18(32-16)17(34(2,30)31)19-23-14-9-8-13(10-15(14)33-19)12-6-4-3-5-7-12/h3-10,17H,11H2,1-2H3,(H2,24,25,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521236 (CHEMBL4589925) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C20H18F3N5O5S3/c21-20(22,23)8-9-35(29,30)17(18-28-27-16(33-18)11-25-36(24,31)32)19-26-14-7-6-13(10-15(14)34-19)12-4-2-1-3-5-12/h1-7,10,17,25H,8-9,11H2,(H2,24,31,32)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521229 (CHEMBL4516251) Show SMILES CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)N2CCOCC2)S(C)(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C27H26N6O7S2/c1-27(25(35)29-26(36)30-27)14-20-31-32-22(40-20)21(42(2,37)38)23-28-18-8-7-17(13-19(18)41-23)15-3-5-16(6-4-15)24(34)33-9-11-39-12-10-33/h3-8,13,21H,9-12,14H2,1-2H3,(H2,29,30,35,36)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521229 (CHEMBL4516251) Show SMILES CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccc(cc2)C(=O)N2CCOCC2)S(C)(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C27H26N6O7S2/c1-27(25(35)29-26(36)30-27)14-20-31-32-22(40-20)21(42(2,37)38)23-28-18-8-7-17(13-19(18)41-23)15-3-5-16(6-4-15)24(34)33-9-11-39-12-10-33/h3-8,13,21H,9-12,14H2,1-2H3,(H2,29,30,35,36)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521232 (CHEMBL4567596) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1cccc(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H20ClN5O5S3/c25-18-8-4-7-16(11-18)17-9-10-19-20(12-17)36-24(28-19)22(37(31,32)14-15-5-2-1-3-6-15)23-30-29-21(35-23)13-27-38(26,33)34/h1-12,22,27H,13-14H2,(H2,26,33,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Lipoprotein lipase (Homo sapiens (Human))	BDBM24567 ((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...) Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human LPL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by sub...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521237 (CHEMBL4468090) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H21N5O5S3/c25-37(32,33)26-14-21-28-29-23(34-21)22(36(30,31)15-16-7-3-1-4-8-16)24-27-19-12-11-18(13-20(19)35-24)17-9-5-2-6-10-17/h1-13,22,26H,14-15H2,(H2,25,32,33)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521237 (CHEMBL4468090) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H21N5O5S3/c25-37(32,33)26-14-21-28-29-23(34-21)22(36(30,31)15-16-7-3-1-4-8-16)24-27-19-12-11-18(13-20(19)35-24)17-9-5-2-6-10-17/h1-13,22,26H,14-15H2,(H2,25,32,33)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521227 (CHEMBL4473964) Show SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H24N6O7S3/c1-38-26(33)29-19-10-7-17(8-11-19)18-9-12-20-21(13-18)40-25(30-20)23(41(34,35)15-16-5-3-2-4-6-16)24-32-31-22(39-24)14-28-42(27,36)37/h2-13,23,28H,14-15H2,1H3,(H,29,33)(H2,27,36,37)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521228 (CHEMBL4563513) Show SMILES CS(=O)(=O)C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H23N5O7S3/c1-41(35,36)21(23-30-29-20(38-23)13-19-22(32)28-26(34)40-19)24-27-17-7-6-16(12-18(17)39-24)14-2-4-15(5-3-14)25(33)31-8-10-37-11-9-31/h2-7,12,19,21H,8-11,13H2,1H3,(H,28,32,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521236 (CHEMBL4589925) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)CCC(F)(F)F Show InChI InChI=1S/C20H18F3N5O5S3/c21-20(22,23)8-9-35(29,30)17(18-28-27-16(33-18)11-25-36(24,31)32)19-26-14-7-6-13(10-15(14)34-19)12-4-2-1-3-5-12/h1-7,10,17,25H,8-9,11H2,(H2,24,31,32)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521225 (CHEMBL4440746) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(Cl)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O5S3/c25-17-8-6-15(10-18(17)26)16-7-9-19-20(11-16)37-24(29-19)22(38(32,33)13-14-4-2-1-3-5-14)23-31-30-21(36-23)12-28-39(27,34)35/h1-11,22,28H,12-13H2,(H2,27,34,35)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50521231 (CHEMBL4435864) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C29H27ClN6O7S3/c30-22-14-19(6-8-21(22)29(37)36-10-12-42-13-11-36)20-7-9-23-24(15-20)44-28(33-23)26(45(38,39)17-18-4-2-1-3-5-18)27-35-34-25(43-27)16-32-46(31,40)41/h1-9,14-15,26,32H,10-13,16-17H2,(H2,31,40,41)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521225 (CHEMBL4440746) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(Cl)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O5S3/c25-17-8-6-15(10-18(17)26)16-7-9-19-20(11-16)37-24(29-19)22(38(32,33)13-14-4-2-1-3-5-14)23-31-30-21(36-23)12-28-39(27,34)35/h1-11,22,28H,12-13H2,(H2,27,34,35)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521234 (CHEMBL4536805) Show SMILES CC1(Cc2nnc(o2)C(c2nc3ccc(cc3s2)-c2ccccc2)S(C)(=O)=O)NC(=O)NC1=O Show InChI InChI=1S/C22H19N5O5S2/c1-22(20(28)24-21(29)25-22)11-16-26-27-18(32-16)17(34(2,30)31)19-23-14-9-8-13(10-15(14)33-19)12-6-4-3-5-7-12/h3-10,17H,11H2,1-2H3,(H2,24,25,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521226 (CHEMBL4471545) Show SMILES CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C18H17N5O5S3/c1-30(24,25)16(17-23-22-15(28-17)10-20-31(19,26)27)18-21-13-8-7-12(9-14(13)29-18)11-5-3-2-4-6-11/h2-9,16,20H,10H2,1H3,(H2,19,26,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521227 (CHEMBL4473964) Show SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H24N6O7S3/c1-38-26(33)29-19-10-7-17(8-11-19)18-9-12-20-21(13-18)40-25(30-20)23(41(34,35)15-16-5-3-2-4-6-16)24-32-31-22(39-24)14-28-42(27,36)37/h2-13,23,28H,14-15H2,1H3,(H,29,33)(H2,27,36,37)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521227 (CHEMBL4473964) Show SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(c1nnc(CNS(N)(=O)=O)o1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H24N6O7S3/c1-38-26(33)29-19-10-7-17(8-11-19)18-9-12-20-21(13-18)40-25(30-20)23(41(34,35)15-16-5-3-2-4-6-16)24-32-31-22(39-24)14-28-42(27,36)37/h2-13,23,28H,14-15H2,1H3,(H,29,33)(H2,27,36,37)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521231 (CHEMBL4435864) Show SMILES NS(=O)(=O)NCc1nnc(o1)C(c1nc2ccc(cc2s1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C29H27ClN6O7S3/c30-22-14-19(6-8-21(22)29(37)36-10-12-42-13-11-36)20-7-9-23-24(15-20)44-28(33-23)26(45(38,39)17-18-4-2-1-3-5-18)27-35-34-25(43-27)16-32-46(31,40)41/h1-9,14-15,26,32H,10-13,16-17H2,(H2,31,40,41)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521233 (CHEMBL4458141) Show SMILES CC(C)S(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O5S3/c1-12(2)32(26,27)18(19-25-24-17(30-19)11-22-33(21,28)29)20-23-15-9-8-14(10-16(15)31-20)13-6-4-3-5-7-13/h3-10,12,18,22H,11H2,1-2H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50521235 (CHEMBL4473238) Show SMILES COCCS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C20H21N5O6S3/c1-30-9-10-33(26,27)18(19-25-24-17(31-19)12-22-34(21,28)29)20-23-15-8-7-14(11-16(15)32-20)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3,(H2,21,28,29)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...				ACS Med Chem Lett 9: 1263-1268 (2018) Article DOI: 10.1021/acsmedchemlett.8b00424 BindingDB Entry DOI: 10.7270/Q2TF01QC
					More data for this Ligand-Target Pair

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