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Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 50013663   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50162774
PNG
(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57|
Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)
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1n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bc1-xL (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568342
PNG
(CHEMBL4851522)
Show SMILES [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)CNc1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CCN(C2)c3c1 |r,t:10|
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1n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568326
PNG
(CHEMBL4872671)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCOc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
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30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568336
PNG
(CHEMBL4870458)
Show SMILES Cc1ccccc1-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568338
PNG
(CHEMBL4872320)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3cccc(Cl)c3)c12
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100n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568341
PNG
(CHEMBL4870837)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3ccccc3)c12
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120n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568331
PNG
(CHEMBL4875429)
Show SMILES CC(C)c1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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170n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568332
PNG
(CHEMBL4856143)
Show SMILES COc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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170n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568328
PNG
(CHEMBL4864929)
Show SMILES Cc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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170n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM23223
PNG
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)|
Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
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180n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568339
PNG
(CHEMBL4876147)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
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190n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568324
PNG
(CHEMBL4860820)
Show SMILES OC(=O)c1ccc(Cl)cc1-c1cccc2n(CCCOc3cccc4ccccc34)ccc12
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220n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568334
PNG
(CHEMBL4846508)
Show SMILES Cc1ccc(cc1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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230n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568326
PNG
(CHEMBL4872671)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCOc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
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250n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568328
PNG
(CHEMBL4864929)
Show SMILES Cc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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250n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568329
PNG
(CHEMBL4876348)
Show SMILES Cc1ccc(cc1)-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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250n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568337
PNG
(CHEMBL4872495)
Show SMILES COc1ccccc1-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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270n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568330
PNG
(CHEMBL4855114)
Show SMILES CCc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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270n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568323
PNG
(CHEMBL4878113)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCCOc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
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280n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568340
PNG
(CHEMBL4852823)
Show SMILES COc1cccc(c1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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290n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568330
PNG
(CHEMBL4855114)
Show SMILES CCc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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300n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568325
PNG
(CHEMBL4870608)
Show SMILES Cc1cccc(c1)-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
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360n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568327
PNG
(CHEMBL4868913)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCOc3cccc4ccccc34)cc(-c3cccc(Cl)c3)c12
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360n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568338
PNG
(CHEMBL4872320)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3cccc(Cl)c3)c12
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450n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM23223
PNG
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)|
Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
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460n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568324
PNG
(CHEMBL4860820)
Show SMILES OC(=O)c1ccc(Cl)cc1-c1cccc2n(CCCOc3cccc4ccccc34)ccc12
PDB

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490n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568340
PNG
(CHEMBL4852823)
Show SMILES COc1cccc(c1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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530n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568322
PNG
(CHEMBL4864735)
Show SMILES Cc1cccc(c1)-c1cn(CCCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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560n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM23223
PNG
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)|
Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
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610n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bc1-xL (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568336
PNG
(CHEMBL4870458)
Show SMILES Cc1ccccc1-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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660n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568333
PNG
(CHEMBL4859740)
Show SMILES Cc1cccc(-c2cn(CCOc3cccc4ccccc34)c3cccc(-c4ccccc4C(O)=O)c23)c1C
PDB
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710n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568334
PNG
(CHEMBL4846508)
Show SMILES Cc1ccc(cc1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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800n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568332
PNG
(CHEMBL4856143)
Show SMILES COc1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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820n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568341
PNG
(CHEMBL4870837)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3ccccc3)c12
PDB

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820n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568329
PNG
(CHEMBL4876348)
Show SMILES Cc1ccc(cc1)-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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870n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568325
PNG
(CHEMBL4870608)
Show SMILES Cc1cccc(c1)-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB
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920n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568335
PNG
(CHEMBL4865871)
Show SMILES Cc1cccc(c1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB
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960n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568339
PNG
(CHEMBL4876147)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(Cc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
PDB

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1.08E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568321
PNG
(CHEMBL4860027)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCCOc3cccc4ccccc34)ccc12
PDB
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1.19E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568337
PNG
(CHEMBL4872495)
Show SMILES COc1ccccc1-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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1.28E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568333
PNG
(CHEMBL4859740)
Show SMILES Cc1cccc(-c2cn(CCOc3cccc4ccccc34)c3cccc(-c4ccccc4C(O)=O)c23)c1C
PDB

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1.30E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50568322
PNG
(CHEMBL4864735)
Show SMILES Cc1cccc(c1)-c1cn(CCCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB
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1.33E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568331
PNG
(CHEMBL4875429)
Show SMILES CC(C)c1ccccc1-c1cn(CCOc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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1.74E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568335
PNG
(CHEMBL4865871)
Show SMILES Cc1cccc(c1)-c1cn(Cc2cccc3ccccc23)c2cccc(-c3ccccc3C(O)=O)c12
PDB

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1.80E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50568327
PNG
(CHEMBL4868913)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCOc3cccc4ccccc34)cc(-c3cccc(Cl)c3)c12
PDB
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2.30E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bc1-xL (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50568324
PNG
(CHEMBL4860820)
Show SMILES OC(=O)c1ccc(Cl)cc1-c1cccc2n(CCCOc3cccc4ccccc34)ccc12
PDB
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2.30E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bc1-xL (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568323
PNG
(CHEMBL4878113)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCCOc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
PDB

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2.55E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50568323
PNG
(CHEMBL4878113)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCCOc3cccc4ccccc34)cc(-c3cccc(c3)C(F)(F)F)c12
PDB
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3.10E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bc1-xL (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568327
PNG
(CHEMBL4868913)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCOc3cccc4ccccc34)cc(-c3cccc(Cl)c3)c12
PDB

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3.21E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
Bcl2-associated agonist of cell death


(Homo sapiens (Human))
BDBM50568321
PNG
(CHEMBL4860027)
Show SMILES OC(=O)c1ccccc1-c1cccc2n(CCCOc3cccc4ccccc34)ccc12
PDB

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4.53E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128215
BindingDB Entry DOI: 10.7270/Q2K35ZDS
More data for this
Ligand-Target Pair
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