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Compile Data Set for Download or QSAR

Found 90 hits Enz. Inhib. hit(s) with all data for entry = 50014847   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580332
PNG
(CHEMBL5081575)
Show SMILES CC(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0800n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580332
PNG
(CHEMBL5081575)
Show SMILES CC(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580346
PNG
(CHEMBL5074750)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(cc2s1)C(=O)N[C@@H](C(C)C)C(N)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.380n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580343
PNG
(CHEMBL5086585)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580347
PNG
(CHEMBL5091091)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)N(C)CCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580331
PNG
(CHEMBL5083517)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580333
PNG
(CHEMBL5081508)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580338
PNG
(CHEMBL5077855)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580334
PNG
(CHEMBL5081335)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580339
PNG
(CHEMBL5084226)
Show SMILES CC(C)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580344
PNG
(CHEMBL5075134)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580342
PNG
(CHEMBL5088958)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580340
PNG
(CHEMBL5078472)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580331
PNG
(CHEMBL5083517)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580335
PNG
(CHEMBL5092327)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(N[C@@H](C(C)C)C(N)=O)cc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580342
PNG
(CHEMBL5088958)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580337
PNG
(CHEMBL5081090)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580343
PNG
(CHEMBL5086585)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580345
PNG
(CHEMBL5081851)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580337
PNG
(CHEMBL5081090)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580341
PNG
(CHEMBL5091578)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580339
PNG
(CHEMBL5084226)
Show SMILES CC(C)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580334
PNG
(CHEMBL5081335)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580338
PNG
(CHEMBL5077855)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580340
PNG
(CHEMBL5078472)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580333
PNG
(CHEMBL5081508)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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n/an/a 11n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580335
PNG
(CHEMBL5092327)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(N[C@@H](C(C)C)C(N)=O)cc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580347
PNG
(CHEMBL5091091)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)N(C)CCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580344
PNG
(CHEMBL5075134)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580330
PNG
(CHEMBL5075263)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580346
PNG
(CHEMBL5074750)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(cc2s1)C(=O)N[C@@H](C(C)C)C(N)=O |r|
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TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580341
PNG
(CHEMBL5091578)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580330
PNG
(CHEMBL5075263)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens (Human))
BDBM50580346
PNG
(CHEMBL5074750)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(cc2s1)C(=O)N[C@@H](C(C)C)C(N)=O |r|
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TBA

Assay Description
Inhibition of recombinant human HGFA serine protease domain using Boc-QLR-AMC as substrate preincubated for 30 mins followed by substrate addition by...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50580335
PNG
(CHEMBL5092327)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(N[C@@H](C(C)C)C(N)=O)cc2s1)NC(C)=O |r|
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate addition by c...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Suppressor of tumorigenicity 14 protein


(Homo sapiens (Human))
BDBM50580336
PNG
(CHEMBL5091873)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human N-terminal met-His6-tagged matriptase catalytic domain (Gly596 to Val855 residues) expressed in Escherichia coli usin...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580345
PNG
(CHEMBL5081851)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580335
PNG
(CHEMBL5092327)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(N[C@@H](C(C)C)C(N)=O)cc2s1)NC(C)=O |r|
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n/an/a 118n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Serine protease hepsin


(Homo sapiens (Human))
BDBM50580336
PNG
(CHEMBL5091873)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580332
PNG
(CHEMBL5081575)
Show SMILES CC(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580347
PNG
(CHEMBL5091091)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)N(C)CCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580331
PNG
(CHEMBL5083517)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580346
PNG
(CHEMBL5074750)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(cc2s1)C(=O)N[C@@H](C(C)C)C(N)=O |r|
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TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50580344
PNG
(CHEMBL5075134)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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n/an/a 1.09E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate addition by c...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580330
PNG
(CHEMBL5075263)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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n/an/a 1.16E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580336
PNG
(CHEMBL5091873)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1)NC(C)=O |r|
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n/an/a 1.36E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580343
PNG
(CHEMBL5086585)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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n/an/a 1.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580339
PNG
(CHEMBL5084226)
Show SMILES CC(C)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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n/an/a 1.51E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580344
PNG
(CHEMBL5075134)
Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
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n/an/a 1.53E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50580334
PNG
(CHEMBL5081335)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCCC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1)NC(C)=O |r|
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n/an/a 1.71E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant C-terminal 10His-tagged human coagulation factor 10a (Leu24 to Lys488 residues) expressed in baculovirus infected Sf9 insec...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01671
BindingDB Entry DOI: 10.7270/Q2BZ69XG
More data for this
Ligand-Target Pair
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