Compile Data Set for Download or QSAR

Found 466 hits Enz. Inhib. hit(s) with all data for entry = 1619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332765 (US10196390, Compound I-1) Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2ccccc2Cl)cc1 Show InChI InChI=1S/C22H19ClN4O3/c1-2-30-18(28)11-13-7-9-14(10-8-13)25-21-19-17(12-24-22(19)29)26-20(27-21)15-5-3-4-6-16(15)23/h3-10H,2,11-12H2,1H3,(H,24,29)(H,25,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332766 (US10196390, Compound I-2) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C20H14F2N4O3/c21-12-2-1-3-13(22)16(12)18-25-14-9-23-20(29)17(14)19(26-18)24-11-6-4-10(5-7-11)8-15(27)28/h1-7H,8-9H2,(H,23,29)(H,27,28)(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332767 (US10196390, Compound I-3) Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C22H18F2N4O3/c1-2-31-17(29)10-12-6-8-13(9-7-12)26-21-19-16(11-25-22(19)30)27-20(28-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332768 (US10196390, Compound I-4) Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)cc1 Show InChI InChI=1S/C22H18ClFN4O3/c1-2-31-17(29)10-12-6-8-13(9-7-12)26-21-19-16(11-25-22(19)30)27-20(28-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332769 (US10196390, Compound I-5) Show SMILES CCOC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(Cl)cccc2Cl)cc1 Show InChI InChI=1S/C22H18Cl2N4O3/c1-2-31-17(29)10-12-6-8-13(9-7-12)26-21-19-16(11-25-22(19)30)27-20(28-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332770 (US10196390, Compound I-6) Show SMILES Clc1cccc(Cl)c1-c1nc2CNC(=O)c2c(Nc2ccc(COC=O)cc2)n1 Show InChI InChI=1S/C20H14Cl2N4O3/c21-13-2-1-3-14(22)16(13)18-25-15-8-23-20(28)17(15)19(26-18)24-12-6-4-11(5-7-12)9-29-10-27/h1-7,10H,8-9H2,(H,23,28)(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332773 (US10196390, Compound I-9) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(Cl)cc(cc2Cl)C#N)cc1 Show InChI InChI=1S/C21H13Cl2N5O3/c22-13-5-11(8-24)6-14(23)17(13)19-27-15-9-25-21(31)18(15)20(28-19)26-12-3-1-10(2-4-12)7-16(29)30/h1-6H,7,9H2,(H,25,31)(H,29,30)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332774 (US10196390, Compound I-10) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2Cl)cc1 Show InChI InChI=1S/C20H14ClFN4O3/c21-12-2-1-3-13(22)16(12)18-25-14-9-23-20(29)17(14)19(26-18)24-11-6-4-10(5-7-11)8-15(27)28/h1-7H,8-9H2,(H,23,29)(H,27,28)(H,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332775 (US10196390, Compound I-11) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CCNCC3)cc2)n1 Show InChI InChI=1S/C25H24F2N6O2/c26-17-2-1-3-18(27)21(17)23-32-19-13-29-25(35)22(19)24(33-23)31-15-6-4-14(5-7-15)12-20(34)30-16-8-10-28-11-9-16/h1-7,16,28H,8-13H2,(H,29,35)(H,30,34)(H,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332776 (US10196390, Compound I-12) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CNC3)cc2)n1 Show InChI InChI=1S/C23H20F2N6O2/c24-15-2-1-3-16(25)19(15)21-30-17-11-27-23(33)20(17)22(31-21)29-13-6-4-12(5-7-13)8-18(32)28-14-9-26-10-14/h1-7,14,26H,8-11H2,(H,27,33)(H,28,32)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332777 (US10196390, Compound I-13) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NCC3CCNCC3)cc2)n1 Show InChI InChI=1S/C26H26F2N6O2/c27-18-2-1-3-19(28)22(18)24-33-20-14-31-26(36)23(20)25(34-24)32-17-6-4-15(5-7-17)12-21(35)30-13-16-8-10-29-11-9-16/h1-7,16,29H,8-14H2,(H,30,35)(H,31,36)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332778 (US10196390, Compound I-14) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CC4(CNC4)C3)cc2)n1 Show InChI InChI=1S/C26H24F2N6O2/c27-17-2-1-3-18(28)21(17)23-33-19-11-30-25(36)22(19)24(34-23)32-15-6-4-14(5-7-15)8-20(35)31-16-9-26(10-16)12-29-13-26/h1-7,16,29H,8-13H2,(H,30,36)(H,31,35)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332779 (US10196390, Compound I-15) Show SMILES OC[C@H]1CCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C25H23F2N5O3/c26-17-4-1-5-18(27)21(17)23-30-19-12-28-25(35)22(19)24(31-23)29-15-8-6-14(7-9-15)11-20(34)32-10-2-3-16(32)13-33/h1,4-9,16,33H,2-3,10-13H2,(H,28,35)(H,29,30,31)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332780 (US10196390, Compound I-16) Show SMILES OC[C@@H]1CCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C25H23F2N5O3/c26-17-4-1-5-18(27)21(17)23-30-19-12-28-25(35)22(19)24(31-23)29-15-8-6-14(7-9-15)11-20(34)32-10-2-3-16(32)13-33/h1,4-9,16,33H,2-3,10-13H2,(H,28,35)(H,29,30,31)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332785 (US10196390, Compound I-21) Show SMILES Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C19H14F2N4O/c1-10-5-7-11(8-6-10)23-18-16-14(9-22-19(16)26)24-17(25-18)15-12(20)3-2-4-13(15)21/h2-8H,9H2,1H3,(H,22,26)(H,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332786 (US10196390, Compound I-22) Show SMILES CN(C1CCNCC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C26H26F2N6O2/c1-34(17-9-11-29-12-10-17)21(35)13-15-5-7-16(8-6-15)31-25-23-20(14-30-26(23)36)32-24(33-25)22-18(27)3-2-4-19(22)28/h2-8,17,29H,9-14H2,1H3,(H,30,36)(H,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332788 (US10196390, Compound I-61) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCCNC3)cc2)n1 |r| Show InChI InChI=1S/C25H24F2N6O2/c26-17-4-1-5-18(27)21(17)23-32-19-13-29-25(35)22(19)24(33-23)31-15-8-6-14(7-9-15)11-20(34)30-16-3-2-10-28-12-16/h1,4-9,16,28H,2-3,10-13H2,(H,29,35)(H,30,34)(H,31,32,33)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332789 (US10196390, Compound I-62) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CC4(COC4)C3)cc2)n1 Show InChI InChI=1S/C25H21F2N5O3/c26-16-2-1-3-17(27)20(16)22-30-18-9-28-24(34)21(18)23(31-22)29-15-6-4-14(5-7-15)8-19(33)32-10-25(11-32)12-35-13-25/h1-7H,8-13H2,(H,28,34)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332790 (US10196390, Compound I-63) Show SMILES C[C@H](CO)NC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C23H21F2N5O3/c1-12(11-31)27-18(32)9-13-5-7-14(8-6-13)28-22-20-17(10-26-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,33)(H,27,32)(H,28,29,30)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332791 (US10196390, Compound I-64) Show SMILES C[C@H]1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C25H23F2N5O3/c1-14-13-35-10-9-32(14)20(33)11-15-5-7-16(8-6-15)29-24-22-19(12-28-25(22)34)30-23(31-24)21-17(26)3-2-4-18(21)27/h2-8,14H,9-13H2,1H3,(H,28,34)(H,29,30,31)/t14-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332792 (US10196390, Compound I-65) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NC3CCOCC3)cc2)n1 Show InChI InChI=1S/C25H23F2N5O3/c26-17-2-1-3-18(27)21(17)23-31-19-13-28-25(34)22(19)24(32-23)30-15-6-4-14(5-7-15)12-20(33)29-16-8-10-35-11-9-16/h1-7,16H,8-13H2,(H,28,34)(H,29,33)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332793 (US10196390, Compound I-66) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CCOCC3)cc2)n1 Show InChI InChI=1S/C24H21F2N5O3/c25-16-2-1-3-17(26)20(16)22-29-18-13-27-24(33)21(18)23(30-22)28-15-6-4-14(5-7-15)12-19(32)31-8-10-34-11-9-31/h1-7H,8-13H2,(H,27,33)(H,28,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332794 (US10196390, Compound I-67) Show SMILES CN1CCN(CC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C25H24F2N6O2/c1-32-9-11-33(12-10-32)20(34)13-15-5-7-16(8-6-15)29-24-22-19(14-28-25(22)35)30-23(31-24)21-17(26)3-2-4-18(21)27/h2-8H,9-14H2,1H3,(H,28,35)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332799 (US10196390, Compound I-72) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)NCC3CNC3)cc2)n1 Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-29-24(34)21(18)23(32-22)30-15-6-4-13(5-7-15)8-19(33)28-11-14-9-27-10-14/h1-7,14,27H,8-12H2,(H,28,33)(H,29,34)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332800 (US10196390, Compound I-73 | US10196390, Compound I...) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCNC3)cc2)n1 |r| Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-28-24(34)21(18)23(32-22)30-14-6-4-13(5-7-14)10-19(33)29-15-8-9-27-11-15/h1-7,15,27H,8-12H2,(H,28,34)(H,29,33)(H,30,31,32)/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332801 (US10196390, Compound I-74) Show SMILES C[C@@H](CO)NC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C23H21F2N5O3/c1-12(11-31)27-18(32)9-13-5-7-14(8-6-13)28-22-20-17(10-26-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,33)(H,27,32)(H,28,29,30)/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332802 (US10196390, Compound I-75) Show SMILES C[C@H](O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C23H21F2N5O3/c1-12(31)10-26-18(32)9-13-5-7-14(8-6-13)28-22-20-17(11-27-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,32)(H,27,33)(H,28,29,30)/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332803 (US10196390, Compound I-76) Show SMILES CC(C)(O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C24H23F2N5O3/c1-24(2,34)12-28-18(32)10-13-6-8-14(9-7-13)29-22-20-17(11-27-23(20)33)30-21(31-22)19-15(25)4-3-5-16(19)26/h3-9,34H,10-12H2,1-2H3,(H,27,33)(H,28,32)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332804 (US10196390, Compound I-77) Show SMILES C[C@@H](O)CNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C23H21F2N5O3/c1-12(31)10-26-18(32)9-13-5-7-14(8-6-13)28-22-20-17(11-27-23(20)33)29-21(30-22)19-15(24)3-2-4-16(19)25/h2-8,12,31H,9-11H2,1H3,(H,26,32)(H,27,33)(H,28,29,30)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332805 (US10196390, Compound I-78) Show SMILES FC(F)CN1CCN(CC1)C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C26H24F4N6O2/c27-17-2-1-3-18(28)22(17)24-33-19-13-31-26(38)23(19)25(34-24)32-16-6-4-15(5-7-16)12-21(37)36-10-8-35(9-11-36)14-20(29)30/h1-7,20H,8-14H2,(H,31,38)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332806 (US10196390, Compound I-79) Show SMILES OCCNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C22H19F2N5O3/c23-14-2-1-3-15(24)18(14)20-28-16-11-26-22(32)19(16)21(29-20)27-13-6-4-12(5-7-13)10-17(31)25-8-9-30/h1-7,30H,8-11H2,(H,25,31)(H,26,32)(H,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332807 (US10196390, Compound I-80) Show SMILES CCNC(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C22H19F2N5O2/c1-2-25-17(30)10-12-6-8-13(9-7-12)27-21-19-16(11-26-22(19)31)28-20(29-21)18-14(23)4-3-5-15(18)24/h3-9H,2,10-11H2,1H3,(H,25,30)(H,26,31)(H,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332800 (US10196390, Compound I-73 | US10196390, Compound I...) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N[C@@H]3CCNC3)cc2)n1 |r| Show InChI InChI=1S/C24H22F2N6O2/c25-16-2-1-3-17(26)20(16)22-31-18-12-28-24(34)21(18)23(32-22)30-14-6-4-13(5-7-14)10-19(33)29-15-8-9-27-11-15/h1-7,15,27H,8-12H2,(H,28,34)(H,29,33)(H,30,31,32)/t15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332812 (US10196390, Compound I-84) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(CC(=O)N3CCS(=O)(=O)CC3)cc2)n1 Show InChI InChI=1S/C24H21F2N5O4S/c25-16-2-1-3-17(26)20(16)22-29-18-13-27-24(33)21(18)23(30-22)28-15-6-4-14(5-7-15)12-19(32)31-8-10-36(34,35)11-9-31/h1-7H,8-13H2,(H,27,33)(H,28,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332814 (US10196390, Compound I-86) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCNC2=O)n1 |r| Show InChI InChI=1S/C22H17F2N5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332815 (US10196390, Compound I-87) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@@H]2CCNC2=O)n1 |r| Show InChI InChI=1S/C22H17F2N5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332817 (US10196390, Compound I-91) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)[C@H]2CCNC2=O)c2C(=O)NCc2n1 |r| Show InChI InChI=1S/C22H17F2N5O2/c23-13-2-1-3-14(24)19(13)15-8-16(20-17(28-15)10-27-22(20)31)29-18-5-4-11(9-26-18)12-6-7-25-21(12)30/h1-5,8-9,12H,6-7,10H2,(H,25,30)(H,27,31)(H,26,28,29)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332818 (US10196390, Compound I-92) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)[C@@H]2CCNC2=O)c2C(=O)NCc2n1 |r| Show InChI InChI=1S/C22H17F2N5O2/c23-13-2-1-3-14(24)19(13)15-8-16(20-17(28-15)10-27-22(20)31)29-18-5-4-11(9-26-18)12-6-7-25-21(12)30/h1-5,8-9,12H,6-7,10H2,(H,25,30)(H,27,31)(H,26,28,29)/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332819 (US10196390, Compound I-109) Show SMILES CC(C)(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C22H18F2N4O3/c1-22(2,21(30)31)11-6-8-12(9-7-11)26-19-17-15(10-25-20(17)29)27-18(28-19)16-13(23)4-3-5-14(16)24/h3-9H,10H2,1-2H3,(H,25,29)(H,30,31)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332820 (US10196390, Compound I-110) Show SMILES COc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C19H14F2N4O2/c1-27-11-7-5-10(6-8-11)23-18-16-14(9-22-19(16)26)24-17(25-18)15-12(20)3-2-4-13(15)21/h2-8H,9H2,1H3,(H,22,26)(H,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332822 (US10196390, Compound I-112) Show SMILES OC(=O)[C@@H]1COCCN1C(=O)Cc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 |r| Show InChI InChI=1S/C25H21F2N5O5/c26-15-2-1-3-16(27)20(15)22-30-17-11-28-24(34)21(17)23(31-22)29-14-6-4-13(5-7-14)10-19(33)32-8-9-37-12-18(32)25(35)36/h1-7,18H,8-12H2,(H,28,34)(H,35,36)(H,29,30,31)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332823 (US10196390, Compound I-113) Show SMILES Fc1cccc(Cl)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCNC2=O)n1 Show InChI InChI=1S/C22H17ClFN5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332824 (US10196390, Compound I-114) Show SMILES Fc1cccc(Cl)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCNC2=O)n1 |r| Show InChI InChI=1S/C22H17ClFN5O2/c23-14-2-1-3-15(24)17(14)19-28-16-10-26-22(31)18(16)20(29-19)27-12-6-4-11(5-7-12)13-8-9-25-21(13)30/h1-7,13H,8-10H2,(H,25,30)(H,26,31)(H,27,28,29)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332826 (US10196390, Compound I-116) Show SMILES COCCC1(CCNC1=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C25H23F2N5O3/c1-35-12-10-25(9-11-28-24(25)34)14-5-7-15(8-6-14)30-22-20-18(13-29-23(20)33)31-21(32-22)19-16(26)3-2-4-17(19)27/h2-8H,9-13H2,1H3,(H,28,34)(H,29,33)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332827 (US10196390, Compound I-117) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCN(C3CCC3)C2=O)n1 Show InChI InChI=1S/C26H23F2N5O2/c27-18-5-2-6-19(28)21(18)23-31-20-13-29-25(34)22(20)24(32-23)30-15-9-7-14(8-10-15)17-11-12-33(26(17)35)16-3-1-4-16/h2,5-10,16-17H,1,3-4,11-13H2,(H,29,34)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332828 (US10196390, Compound I-118) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCN(C3CCC3)C2=O)n1 |r| Show InChI InChI=1S/C26H23F2N5O2/c27-18-5-2-6-19(28)21(18)23-31-20-13-29-25(34)22(20)24(32-23)30-15-9-7-14(8-10-15)17-11-12-33(26(17)35)16-3-1-4-16/h2,5-10,16-17H,1,3-4,11-13H2,(H,29,34)(H,30,31,32)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332829 (US10196390, Compound I-119) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@@H]2CCN(C3CCC3)C2=O)n1 |r| Show InChI InChI=1S/C26H23F2N5O2/c27-18-5-2-6-19(28)21(18)23-31-20-13-29-25(34)22(20)24(32-23)30-15-9-7-14(8-10-15)17-11-12-33(26(17)35)16-3-1-4-16/h2,5-10,16-17H,1,3-4,11-13H2,(H,29,34)(H,30,31,32)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332830 (US10196390, Compound I-120) Show SMILES CCNC(=O)C(C)(C)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C24H23F2N5O2/c1-4-27-23(33)24(2,3)13-8-10-14(11-9-13)29-21-19-17(12-28-22(19)32)30-20(31-21)18-15(25)6-5-7-16(18)26/h5-11H,4,12H2,1-3H3,(H,27,33)(H,28,32)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332831 (US10196390, Compound I-121) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C2CCN(CCN3CCOCC3)C2=O)n1 Show InChI InChI=1S/C28H28F2N6O3/c29-20-2-1-3-21(30)23(20)25-33-22-16-31-27(37)24(22)26(34-25)32-18-6-4-17(5-7-18)19-8-9-36(28(19)38)11-10-35-12-14-39-15-13-35/h1-7,19H,8-16H2,(H,31,37)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332832 (US10196390, Compound I-122) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)[C@H]2CCN(CCN3CCOCC3)C2=O)n1 |r| Show InChI InChI=1S/C28H28F2N6O3/c29-20-2-1-3-21(30)23(20)25-33-22-16-31-27(37)24(22)26(34-25)32-18-6-4-17(5-7-18)19-8-9-36(28(19)38)11-10-35-12-14-39-15-13-35/h1-7,19H,8-16H2,(H,31,37)(H,32,33,34)/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using microfluidics tech...				US Patent US10196390 (2019) BindingDB Entry DOI: 10.7270/Q22809Q4
					More data for this Ligand-Target Pair

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