Compile Data Set for Download or QSAR

Found 192 hits Enz. Inhib. hit(s) with all data for entry = 2262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM359614 (N-[(1-Aminoisoquinolin-6-yl)methyl]-({4-[(4-methyl...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C28H26N6O/c1-19-13-33-34(17-19)18-21-4-2-20(3-5-21)10-23-12-25(16-30-14-23)28(35)32-15-22-6-7-26-24(11-22)8-9-31-27(26)29/h2-9,11-14,16-17H,10,15,18H2,1H3,(H2,29,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.86	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359712 (N-{[4-(Aminomethyl)-2,6-dimethylphenyl]methyl}-5-(...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C28H31N5O/c1-19-13-32-33(17-19)18-23-6-4-22(5-7-23)10-25-11-26(15-30-14-25)28(34)31-16-27-20(2)8-24(12-29)9-21(27)3/h4-9,11,13-15,17H,10,12,16,18,29H2,1-3H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.47	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359711 (N-{[4-(Aminomethyl)-2-methylphenyl]methyl}-5-({4-[...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3ccc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C27H29N5O/c1-19-13-31-32(17-19)18-22-5-3-21(4-6-22)10-24-11-26(15-29-14-24)27(33)30-16-25-8-7-23(12-28)9-20(25)2/h3-9,11,13-15,17H,10,12,16,18,28H2,1-2H3,(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.4	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359648 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({3-methoxy-...) Show SMILES COc1cc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)ccc1Cn1cc(C)cn1 Show InChI InChI=1S/C29H28N6O2/c1-19-13-34-35(17-19)18-24-5-3-20(12-27(24)37-2)9-22-11-25(16-31-14-22)29(36)33-15-21-4-6-26-23(10-21)7-8-32-28(26)30/h3-8,10-14,16-17H,9,15,18H2,1-2H3,(H2,30,32)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359618 (N-[(1-Aminoisoquinolin-6-yl)methyl]-6-oxo-1-({4-[(...) Show SMILES Nc1nccc2cc(CNC(=O)c3ccc(=O)n(Cc4ccc(Cn5ccccc5=O)cc4)c3)ccc12 Show InChI InChI=1S/C29H25N5O3/c30-28-25-10-8-22(15-23(25)12-13-31-28)16-32-29(37)24-9-11-27(36)34(19-24)18-21-6-4-20(5-7-21)17-33-14-2-1-3-26(33)35/h1-15,19H,16-18H2,(H2,30,31)(H,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.7	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359631 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(2-methylqu...) Show SMILES Cc1ccc2cc(Cc3cncc(c3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1 Show InChI InChI=1S/C27H23N5O/c1-17-2-5-22-11-18(4-7-25(22)32-17)10-20-13-23(16-29-14-20)27(33)31-15-19-3-6-24-21(12-19)8-9-30-26(24)28/h2-9,11-14,16H,10,15H2,1H3,(H2,28,30)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359623 (N-[(1-Aminoisoquinolin-6-yl)methyl]-6-({4-[(4-meth...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(n3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C27H25N7O/c1-18-12-32-34(16-18)17-20-4-2-19(3-5-20)11-23-14-29-15-25(33-23)27(35)31-13-21-6-7-24-22(10-21)8-9-30-26(24)28/h2-10,12,14-16H,11,13,17H2,1H3,(H2,28,30)(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.8	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359621 (N-((1-Aminoisoquinolin-6-yl)methyl)-5-(hydroxy(4-(...) Show SMILES Cc1cnn(Cc2ccc(cc2)C(O)c2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)c1 Show InChI InChI=1S/C28H26N6O2/c1-18-12-33-34(16-18)17-19-2-5-21(6-3-19)26(35)23-11-24(15-30-14-23)28(36)32-13-20-4-7-25-22(10-20)8-9-31-27(25)29/h2-12,14-16,26,35H,13,17H2,1H3,(H2,29,31)(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359695 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(pyrroli...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCCC4)c3)ccc12 Show InChI InChI=1S/C26H26N6O/c27-25-23-4-3-19(12-21(23)6-8-30-25)16-31-26(33)22-13-20(15-28-17-22)11-18-5-7-29-24(14-18)32-9-1-2-10-32/h3-8,12-15,17H,1-2,9-11,16H2,(H2,27,30)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.7	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359689 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({6-[isoprop...) Show SMILES CC(C)N(C)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C26H28N6O/c1-17(2)32(3)24-7-5-18(14-30-24)10-20-12-22(16-28-13-20)26(33)31-15-19-4-6-23-21(11-19)8-9-29-25(23)27/h4-9,11-14,16-17H,10,15H2,1-3H3,(H2,27,29)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51.1	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359681 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(diethyl...) Show SMILES CCN(CC)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C26H28N6O/c1-3-32(4-2)24-8-6-18(15-30-24)11-20-13-22(17-28-14-20)26(33)31-16-19-5-7-23-21(12-19)9-10-29-25(23)27/h5-10,12-15,17H,3-4,11,16H2,1-2H3,(H2,27,29)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52.7	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359635 (N-[(1-Aminoisoquinolin-6-yl)methyl]-6-(methylamino...) Show SMILES CNc1ncc(cc1Cc1ccc2nc(C)ccc2c1)C(=O)NCc1ccc2c(N)nccc2c1 Show InChI InChI=1S/C28H26N6O/c1-17-3-6-21-11-18(5-8-25(21)34-17)12-22-14-23(16-32-27(22)30-2)28(35)33-15-19-4-7-24-20(13-19)9-10-31-26(24)29/h3-11,13-14,16H,12,15H2,1-2H3,(H2,29,31)(H,30,32)(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53.3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359713 (N-{[4-(Aminomethyl)-2,6-dimethylphenyl]methyl}-6-(...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(n3)C(=O)NCc3c(C)cc(CN)cc3C)cc2)c1 Show InChI InChI=1S/C27H30N6O/c1-18-12-31-33(16-18)17-22-6-4-21(5-7-22)10-24-13-29-15-26(32-24)27(34)30-14-25-19(2)8-23(11-28)9-20(25)3/h4-9,12-13,15-16H,10-11,14,17,28H2,1-3H3,(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53.6	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359700 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(3-fluor...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCC(F)C4)c3)ccc12 Show InChI InChI=1S/C26H25FN6O/c27-22-5-8-33(16-22)24-12-17(3-6-30-24)9-19-11-21(15-29-13-19)26(34)32-14-18-1-2-23-20(10-18)4-7-31-25(23)28/h1-4,6-7,10-13,15,22H,5,8-9,14,16H2,(H2,28,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67.8	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359682 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({6-[2-(hydr...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCCC4CO)c3)ccc12 Show InChI InChI=1S/C27H28N6O2/c28-26-24-5-3-19(11-21(24)7-8-30-26)15-32-27(35)22-12-20(13-29-16-22)10-18-4-6-25(31-14-18)33-9-1-2-23(33)17-34/h3-8,11-14,16,23,34H,1-2,9-10,15,17H2,(H2,28,30)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	73.3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359625 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({4-[(4-meth...) Show SMILES Cc1cnn(Cc2ccc(Cc3cnnc(c3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C27H25N7O/c1-18-13-32-34(16-18)17-20-4-2-19(3-5-20)10-22-12-25(33-31-15-22)27(35)30-14-21-6-7-24-23(11-21)8-9-29-26(24)28/h2-9,11-13,15-16H,10,14,17H2,1H3,(H2,28,29)(H,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	82.3	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359692 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(3,3-dim...) Show SMILES CC1(C)CCN(C1)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C28H30N6O/c1-28(2)8-10-34(18-28)25-6-4-19(15-32-25)11-21-13-23(17-30-14-21)27(35)33-16-20-3-5-24-22(12-20)7-9-31-26(24)29/h3-7,9,12-15,17H,8,10-11,16,18H2,1-2H3,(H2,29,31)(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83.1	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359698 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(3,3-dif...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCC(F)(F)C4)c3)ccc12 Show InChI InChI=1S/C26H24F2N6O/c27-26(28)5-8-34(16-26)23-12-17(3-6-31-23)9-19-11-21(15-30-13-19)25(35)33-14-18-1-2-22-20(10-18)4-7-32-24(22)29/h1-4,6-7,10-13,15H,5,8-9,14,16H2,(H2,29,32)(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88.5	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359670 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(pyrroli...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCCC4)c3)ccc12 Show InChI InChI=1S/C26H26N6O/c27-25-23-5-3-19(12-21(23)7-8-29-25)16-31-26(33)22-13-20(14-28-17-22)11-18-4-6-24(30-15-18)32-9-1-2-10-32/h3-8,12-15,17H,1-2,9-11,16H2,(H2,27,29)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359707 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({2-[2-(hydr...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCCC4CO)c3)ccc12 Show InChI InChI=1S/C27H28N6O2/c28-26-24-4-3-19(11-21(24)6-8-31-26)15-32-27(35)22-12-20(14-29-16-22)10-18-5-7-30-25(13-18)33-9-1-2-23(33)17-34/h3-8,11-14,16,23,34H,1-2,9-10,15,17H2,(H2,28,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359637 (N-[(1-Aminoisoquinolin-6-yl)methyl]-2-methyl-5-[(2...) Show SMILES Cc1ccc2cc(Cc3cnc(C)c(c3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1 Show InChI InChI=1S/C28H25N5O/c1-17-3-6-23-12-19(5-8-26(23)33-17)11-21-14-25(18(2)31-16-21)28(34)32-15-20-4-7-24-22(13-20)9-10-30-27(24)29/h3-10,12-14,16H,11,15H2,1-2H3,(H2,29,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359701 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(3-methy...) Show SMILES CC1CCN(C1)c1cc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)ccn1 Show InChI InChI=1S/C27H28N6O/c1-18-6-9-33(17-18)25-13-19(4-7-30-25)10-21-12-23(16-29-14-21)27(34)32-15-20-2-3-24-22(11-20)5-8-31-26(24)28/h2-5,7-8,11-14,16,18H,6,9-10,15,17H2,1H3,(H2,28,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359653 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-[(4-methyl-2...) Show SMILES CN1CCOc2cc(Cc3cncc(c3)C(=O)NCc3ccc4c(N)nccc4c3)ccc12 Show InChI InChI=1S/C26H25N5O2/c1-31-8-9-33-24-13-17(3-5-23(24)31)10-19-12-21(16-28-14-19)26(32)30-15-18-2-4-22-20(11-18)6-7-29-25(22)27/h2-7,11-14,16H,8-10,15H2,1H3,(H2,27,29)(H,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359622 (N-[(1-Aminoisoquinolin-6-yl)methyl]-6-({4-[(4-meth...) Show SMILES Cc1cnn(Cc2ccc(Cc3cc(ncn3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C27H25N7O/c1-18-13-33-34(15-18)16-20-4-2-19(3-5-20)11-23-12-25(32-17-31-23)27(35)30-14-21-6-7-24-22(10-21)8-9-29-26(24)28/h2-10,12-13,15,17H,11,14,16H2,1H3,(H2,28,29)(H,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359655 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(4-methy...) Show SMILES Cc1cnn(CCOCc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)c1 Show InChI InChI=1S/C23H24N6O2/c1-16-10-28-29(14-16)6-7-31-15-18-9-20(13-25-11-18)23(30)27-12-17-2-3-21-19(8-17)4-5-26-22(21)24/h2-5,8-11,13-14H,6-7,12,15H2,1H3,(H2,24,26)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359680 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(2,2-dim...) Show SMILES CC1(C)CCCN1c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C28H30N6O/c1-28(2)9-3-11-34(28)25-7-5-19(16-32-25)12-21-14-23(18-30-15-21)27(35)33-17-20-4-6-24-22(13-20)8-10-31-26(24)29/h4-8,10,13-16,18H,3,9,11-12,17H2,1-2H3,(H2,29,31)(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359676 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(3-methy...) Show SMILES CC1CCN(C1)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C27H28N6O/c1-18-7-9-33(17-18)25-5-3-19(14-31-25)10-21-12-23(16-29-13-21)27(34)32-15-20-2-4-24-22(11-20)6-8-30-26(24)28/h2-6,8,11-14,16,18H,7,9-10,15,17H2,1H3,(H2,28,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359675 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(3-fluor...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCC(F)C4)c3)ccc12 Show InChI InChI=1S/C26H25FN6O/c27-22-6-8-33(16-22)24-4-2-17(13-31-24)9-19-11-21(15-29-12-19)26(34)32-14-18-1-3-23-20(10-18)5-7-30-25(23)28/h1-5,7,10-13,15,22H,6,8-9,14,16H2,(H2,28,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359646 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-(quinolin-6-...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc5ncccc5c4)c3)ccc12 Show InChI InChI=1S/C26H21N5O/c27-25-23-5-3-18(12-20(23)7-9-30-25)15-31-26(32)22-13-19(14-28-16-22)10-17-4-6-24-21(11-17)2-1-8-29-24/h1-9,11-14,16H,10,15H2,(H2,27,30)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359673 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(2-methy...) Show SMILES CC1CCCN1c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C27H28N6O/c1-18-3-2-10-33(18)25-7-5-19(15-31-25)11-21-13-23(17-29-14-21)27(34)32-16-20-4-6-24-22(12-20)8-9-30-26(24)28/h4-9,12-15,17-18H,2-3,10-11,16H2,1H3,(H2,28,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359697 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(2-methy...) Show SMILES CC1CCCN1c1cc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)ccn1 Show InChI InChI=1S/C27H28N6O/c1-18-3-2-10-33(18)25-14-19(6-8-30-25)11-21-13-23(17-29-15-21)27(34)32-16-20-4-5-24-22(12-20)7-9-31-26(24)28/h4-9,12-15,17-18H,2-3,10-11,16H2,1H3,(H2,28,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359629 (N-[(1-Aminoisoquinolin-6-yl)methyl]-1-({4-[(4-meth...) Show SMILES Cc1cnn(Cc2ccc(Cn3cc(ccc3=O)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-19-13-32-34(15-19)17-21-4-2-20(3-5-21)16-33-18-24(7-9-26(33)35)28(36)31-14-22-6-8-25-23(12-22)10-11-30-27(25)29/h2-13,15,18H,14,16-17H2,1H3,(H2,29,30)(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359616 (N-[(1-Aminoisoquinolin-6-yl)methyl]-4-({4-[(4-meth...) Show SMILES Cc1cnn(Cc2ccc(Cc3ccnc(c3)C(=O)NCc3ccc4c(N)nccc4c3)cc2)c1 Show InChI InChI=1S/C28H26N6O/c1-19-15-33-34(17-19)18-21-4-2-20(3-5-21)12-22-8-10-30-26(14-22)28(35)32-16-23-6-7-25-24(13-23)9-11-31-27(25)29/h2-11,13-15,17H,12,16,18H2,1H3,(H2,29,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359696 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(piperid...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCCCC4)c3)ccc12 Show InChI InChI=1S/C27H28N6O/c28-26-24-5-4-20(13-22(24)7-9-31-26)17-32-27(34)23-14-21(16-29-18-23)12-19-6-8-30-25(15-19)33-10-2-1-3-11-33/h4-9,13-16,18H,1-3,10-12,17H2,(H2,28,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359630 (N-[(1-Aminoisoquinolin-6-yl)methyl]-1-[(2-methylqu...) Show SMILES Cc1ccc2cc(Cn3cc(ccc3=O)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1 Show InChI InChI=1S/C27H23N5O2/c1-17-2-5-21-13-19(4-8-24(21)31-17)15-32-16-22(6-9-25(32)33)27(34)30-14-18-3-7-23-20(12-18)10-11-29-26(23)28/h2-13,16H,14-15H2,1H3,(H2,28,29)(H,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359624 (N-[(1-Aminoisoquinolin-6-yl)methyl]-6-[(2-methylqu...) Show SMILES Cc1ccc2cc(Cc3cncc(n3)C(=O)NCc3ccc4c(N)nccc4c3)ccc2n1 Show InChI InChI=1S/C26H22N6O/c1-16-2-5-20-10-17(4-7-23(20)31-16)12-21-14-28-15-24(32-21)26(33)30-13-18-3-6-22-19(11-18)8-9-29-25(22)27/h2-11,14-15H,12-13H2,1H3,(H2,27,29)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359668 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(2-oxopy...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCCC4=O)c3)ccc12 Show InChI InChI=1S/C26H24N6O2/c27-25-22-5-3-18(11-20(22)7-8-29-25)15-31-26(34)21-12-19(13-28-16-21)10-17-4-6-23(30-14-17)32-9-1-2-24(32)33/h3-8,11-14,16H,1-2,9-10,15H2,(H2,27,29)(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359615 (5-({4-[(4-Methylpyrazol-1-yl)methyl]phenyl}methyl)...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3cnc4[nH]ccc4c3)cc2)c1 Show InChI InChI=1S/C26H24N6O/c1-18-11-31-32(16-18)17-20-4-2-19(3-5-20)8-21-9-24(15-27-12-21)26(33)30-14-22-10-23-6-7-28-25(23)29-13-22/h2-7,9-13,15-16H,8,14,17H2,1H3,(H,28,29)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	216	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359706 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(3-metho...) Show SMILES COC1CCN(C1)c1cc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)ccn1 Show InChI InChI=1S/C27H28N6O2/c1-35-23-6-9-33(17-23)25-13-18(4-7-30-25)10-20-12-22(16-29-14-20)27(34)32-15-19-2-3-24-21(11-19)5-8-31-26(24)28/h2-5,7-8,11-14,16,23H,6,9-10,15,17H2,1H3,(H2,28,31)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	234	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Kallikrein-1 (Homo sapiens (Human))	BDBM359627 (N-({2,4-Dimethyl-7H-pyrrolo[2,3-b]pyridin-3-yl}met...) Show SMILES Cc1nc2[nH]ccc(C)c2c1CNC(=O)c1cncc(Cc2ccc3nc(C)ccc3c2)c1 Show InChI InChI=1S/C27H25N5O/c1-16-8-9-29-26-25(16)23(18(3)32-26)15-30-27(33)22-12-20(13-28-14-22)10-19-5-7-24-21(11-19)6-4-17(2)31-24/h4-9,11-14H,10,15H2,1-3H3,(H,29,32)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	236	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359647 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[3-(pyrazol...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4cccc(Cn5cccn5)c4)c3)ccc12 Show InChI InChI=1S/C27H24N6O/c28-26-25-6-5-20(13-23(25)7-9-30-26)16-31-27(34)24-14-22(15-29-17-24)12-19-3-1-4-21(11-19)18-33-10-2-8-32-33/h1-11,13-15,17H,12,16,18H2,(H2,28,30)(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	237	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359672 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(3,3-dif...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCC(F)(F)C4)c3)ccc12 Show InChI InChI=1S/C26H24F2N6O/c27-26(28)6-8-34(16-26)23-4-2-17(13-32-23)9-19-11-21(15-30-12-19)25(35)33-14-18-1-3-22-20(10-18)5-7-31-24(22)29/h1-5,7,10-13,15H,6,8-9,14,16H2,(H2,29,31)(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359694 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(2-oxopy...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCCC4=O)c3)ccc12 Show InChI InChI=1S/C26H24N6O2/c27-25-22-4-3-18(11-20(22)6-8-30-25)15-31-26(34)21-12-19(14-28-16-21)10-17-5-7-29-23(13-17)32-9-1-2-24(32)33/h3-8,11-14,16H,1-2,9-10,15H2,(H2,27,30)(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	242	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359626 (N-({2,4-Dimethyl-7H-pyrrolo[2,3-b]pyridin-3-yl}met...) Show SMILES Cc1cnn(Cc2ccc(Cc3cncc(c3)C(=O)NCc3c(C)nc4[nH]ccc(C)c34)cc2)c1 Show InChI InChI=1S/C28H28N6O/c1-18-12-32-34(16-18)17-22-6-4-21(5-7-22)10-23-11-24(14-29-13-23)28(35)31-15-25-20(3)33-27-26(25)19(2)8-9-30-27/h4-9,11-14,16H,10,15,17H2,1-3H3,(H,30,33)(H,31,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359677 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(3-metho...) Show SMILES COC1CCN(C1)c1ccc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)cn1 Show InChI InChI=1S/C27H28N6O2/c1-35-23-7-9-33(17-23)25-5-3-18(14-31-25)10-20-12-22(16-29-13-20)27(34)32-15-19-2-4-24-21(11-19)6-8-30-26(24)28/h2-6,8,11-14,16,23H,7,9-10,15,17H2,1H3,(H2,28,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	255	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359645 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[3-(pyrazol...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4cccc(c4)-n4cccn4)c3)ccc12 Show InChI InChI=1S/C26H22N6O/c27-25-24-6-5-19(12-21(24)7-9-29-25)16-30-26(33)22-13-20(15-28-17-22)11-18-3-1-4-23(14-18)32-10-2-8-31-32/h1-10,12-15,17H,11,16H2,(H2,27,29)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359687 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({6-[3-(hydr...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCC(CO)C4)c3)ccc12 Show InChI InChI=1S/C27H28N6O2/c28-26-24-3-1-19(10-22(24)5-7-30-26)14-32-27(35)23-11-21(12-29-15-23)9-18-2-4-25(31-13-18)33-8-6-20(16-33)17-34/h1-5,7,10-13,15,20,34H,6,8-9,14,16-17H2,(H2,28,30)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	306	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359671 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[6-(piperid...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccc(nc4)N4CCCCC4)c3)ccc12 Show InChI InChI=1S/C27H28N6O/c28-26-24-6-4-20(13-22(24)8-9-30-26)17-32-27(34)23-14-21(15-29-18-23)12-19-5-7-25(31-16-19)33-10-2-1-3-11-33/h4-9,13-16,18H,1-3,10-12,17H2,(H2,28,30)(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	313	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359710 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-({2-[3-(hydr...) Show SMILES Nc1nccc2cc(CNC(=O)c3cncc(Cc4ccnc(c4)N4CCC(CO)C4)c3)ccc12 Show InChI InChI=1S/C27H28N6O2/c28-26-24-2-1-19(10-22(24)4-7-31-26)14-32-27(35)23-11-21(13-29-15-23)9-18-3-6-30-25(12-18)33-8-5-20(16-33)17-34/h1-4,6-7,10-13,15,20,34H,5,8-9,14,16-17H2,(H2,28,31)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM359705 (N-[(1-Aminoisoquinolin-6-yl)methyl]-5-{[2-(diethyl...) Show SMILES CCN(CC)c1cc(Cc2cncc(c2)C(=O)NCc2ccc3c(N)nccc3c2)ccn1 Show InChI InChI=1S/C26H28N6O/c1-3-32(4-2)24-14-18(7-9-29-24)11-20-13-22(17-28-15-20)26(33)31-16-19-5-6-23-21(12-19)8-10-30-25(23)27/h5-10,12-15,17H,3-4,11,16H2,1-2H3,(H2,27,30)(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	358	n/a	n/a	n/a	n/a	n/a	n/a
Kalvista Pharmaceuticals Limited US Patent					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				US Patent US10221161 (2019) BindingDB Entry DOI: 10.7270/Q23B62DG
					More data for this Ligand-Target Pair

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