Compile Data Set for Download or QSAR

Found 42 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339977 (5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-(5-chloro-1...) Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C19H21ClN6O/c20-11-5-6-13-10(7-11)8-15(24-13)17-18(19(22)27)23-9-16(26-17)25-14-4-2-1-3-12(14)21/h5-9,12,14,24H,1-4,21H2,(H2,22,27)(H,25,26)/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340000 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES CCc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340008 ((S)-5-((2-Aminopropyl)amino)-3-(5-(pyridin-3-yl)-1...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cccnc1 Show InChI InChI=1S/C21H21N7O/c1-12(22)9-25-18-11-26-20(21(23)29)19(28-18)17-8-15-7-13(4-5-16(15)27-17)14-3-2-6-24-10-14/h2-8,10-12,27H,9,22H2,1H3,(H2,23,29)(H,25,28)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339978 (5-{[(2S)-2- aminopropyl]amino}-3-(4- bromo-1H-indo...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(Br)cccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339999 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES COc1ccc2[nH]c(cc2c1OC)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50075732 (CHEMBL3414584 | US9775839, 2.1) Show SMILES N[C@H]1CCCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339998 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c3OCCOc3ccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339979 (5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...) Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339975 ((S)-5-((2-Aminopropyl)amino)-3-(5-(1-methyl-1H-pyr...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)-c1cnn(C)c1 Show InChI InChI=1S/C20H22N8O/c1-11(21)7-23-17-9-24-19(20(22)29)18(27-17)16-6-13-5-12(3-4-15(13)26-16)14-8-25-28(2)10-14/h3-6,8-11,26H,7,21H2,1-2H3,(H2,22,29)(H,23,27)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339981 (5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...) Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50075733 (CHEMBL3415610 | US9775839, 8.5) Show SMILES COc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339997 (5-(((3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(ccc2[nH]1)C(F)(F)F |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339974 ((S)-5-((2-aminopropyl)amino)-3-(5-bromo-1H-indol-2...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(Br)ccc2[nH]1 Show InChI InChI=1S/C16H17BrN6O/c1-8(18)6-20-13-7-21-15(16(19)24)14(23-13)12-5-9-4-10(17)2-3-11(9)22-12/h2-5,7-8,22H,6,18H2,1H3,(H2,19,24)(H,20,23)/t8-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339984 (5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES COc1ccc2[nH]c(cc2c1)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339994 (5-{[(2R)-2-amino-3- methoxypropyl]amino}-3- (4-met...) Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2c(OC)cccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339986 (5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(Cl)ccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339982 (5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccc(F)cc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339993 (5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339983 (5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339989 (5-{[(1R,2S)-2- aminocyclohexyl]amino}- 3-(4-methyl...) Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCCC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340003 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ncccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339991 (5-{[(3R,4R)-3- aminotetrahydro-2H- pyran-4-yl]amin...) Show SMILES Cc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340006 (5-(((3S,4S)-4-Amino-1,1-dioxidotetrahydro-2H-thiop...) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1[nH]c2ccccc2c1Cl Show InChI InChI=1S/C18H19ClN6O3S/c19-14-9-3-1-2-4-11(9)24-15(14)16-17(18(21)26)22-7-13(25-16)23-12-8-29(27,28)6-5-10(12)20/h1-4,7,10,12,24H,5-6,8,20H2,(H2,21,26)(H,23,25)/t10-,12+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50075944 (CHEMBL3415609 | US9775839, 3.1) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339996 (5-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)...) Show SMILES COc1cncc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O Show InChI InChI=1S/C18H21N7O3/c1-27-14-6-21-5-13-9(14)4-12(23-13)16-17(18(20)26)22-7-15(25-16)24-11-2-3-28-8-10(11)19/h4-7,10-11,23H,2-3,8,19H2,1H3,(H2,20,26)(H,24,25)/t10-,11+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339985 (5-{[(3S,4S)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES N[C@H]1CCS(=O)(=O)C[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339976 ((S)-5-((2-Aminopropyl)amino)-3-(5-(2-(2-oxopyrroli...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2cc(CCN3CCCC3=O)ccc2[nH]1 Show InChI InChI=1S/C22H27N7O2/c1-13(23)11-25-18-12-26-21(22(24)31)20(28-18)17-10-15-9-14(4-5-16(15)27-17)6-8-29-7-2-3-19(29)30/h4-5,9-10,12-13,27H,2-3,6-8,11,23H2,1H3,(H2,24,31)(H,25,28)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340002 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2cnccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340001 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES CCc1cccc2[nH]c(cc12)-c1nc(N[C@@H]2CCOC[C@@H]2N)cnc1C(N)=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50201711 (CHEMBL3951922 | US9775839, 2.2) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI InChI=1S/C16H18N6O/c1-9(17)7-19-13-8-20-15(16(18)23)14(22-13)12-6-10-4-2-3-5-11(10)21-12/h2-6,8-9,21H,7,17H2,1H3,(H2,18,23)(H,19,22)/t9-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340004 (5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...) Show SMILES N[C@H]1COCC[C@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccncc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339979 (5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- ...) Show SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339987 ((R)-5-((2-Amino-3-methoxypropyl)amino)-3-(1H-indol...) Show SMILES COC[C@H](N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C17H20N6O2/c1-25-9-11(18)7-20-14-8-21-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,20,23)/t11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339995 (5-[(2-Aminoethyl)amino]-3-(5-fluoro-1H-indol-2-yl)...) Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2cc(F)ccc2[nH]1 Show InChI InChI=1S/C15H15FN6O/c16-9-1-2-10-8(5-9)6-11(21-10)13-14(15(18)23)20-7-12(22-13)19-4-3-17/h1-2,5-7,21H,3-4,17H2,(H2,18,23)(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340009 (5-(2-Aminoethylamino)-3-(1H-indol-2-yl)pyrazine-2-...) Show SMILES NCCNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C15H16N6O/c16-5-6-18-12-8-19-14(15(17)22)13(21-12)11-7-9-3-1-2-4-10(9)20-11/h1-4,7-8,20H,5-6,16H2,(H2,17,22)(H,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340011 ((R)-5-((1-amino-3-methoxypropan-2-yl)amino)-3-(1H-...) Show SMILES COC[C@@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 Show InChI InChI=1S/C17H20N6O2/c1-25-9-11(7-18)21-14-8-20-16(17(19)24)15(23-14)13-6-10-4-2-3-5-12(10)22-13/h2-6,8,11,22H,7,9,18H2,1H3,(H2,19,24)(H,21,23)/t11-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340012 ((S)-5-((1-amino-3- methoxypropan-2- yl)amino)-3-(1...) Show SMILES COC[C@H](CN)Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340010 (5-{[2-Amino-3-(methylsulfonyl)propyl]amino}-3-(1H-...) Show SMILES CS(=O)(=O)CC(N)CNc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339988 (5-{[(3R,4R)-4-amino-1,1- dioxidotetrahydro-2H- thi...) Show SMILES N[C@@H]1CCS(=O)(=O)C[C@@H]1Nc1cnc(C(N)=O)c(n1)-c1cc2ccccc2[nH]1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM339970 ((R)-tert-butyl (1-((6-chloro-5-cyanopyrazin-2-yl)a...) Show SMILES COC[C@@H](CNc1cnc(C#N)c(Cl)n1)NC(=O)OC(C)(C)C Show InChI InChI=1S/C14H20ClN5O3/c1-14(2,3)23-13(21)19-9(8-22-4)6-18-11-7-17-10(5-16)12(15)20-11/h7,9H,6,8H2,1-4H3,(H,18,20)(H,19,21)/t9-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	528	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340005 ((S)-5-((2-Aminopropyl)amino)-3-(phenylethynyl)pyra...) Show SMILES C[C@H](N)CNc1cnc(C(N)=O)c(n1)C#Cc1ccccc1 Show InChI InChI=1S/C16H17N5O/c1-11(17)9-19-14-10-20-15(16(18)22)13(21-14)8-7-12-5-3-2-4-6-12/h2-6,10-11H,9,17H2,1H3,(H2,18,22)(H,19,21)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	992	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM340007 ((2-(6-(((3S,4S)-4-amino-1,1-dioxidotetrahydro-2H-t...) Show SMILES C[S+](C)c1c([nH]c2ccccc12)-c1nc(N[C@@H]2CS(=O)(=O)CC[C@@H]2N)cnc1C(N)=O Show InChI InChI=1S/C20H24N6O3S2/c1-30(2)19-11-5-3-4-6-13(11)25-17(19)16-18(20(22)27)23-9-15(26-16)24-14-10-31(28,29)8-7-12(14)21/h3-6,9,12,14H,7-8,10,21H2,1-2H3,(H3-,22,24,25,26,27)/p+1/t12-,14+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9775839 (2017) BindingDB Entry DOI: 10.7270/Q2MG7RN9
					More data for this Ligand-Target Pair