Compile Data Set for Download or QSAR

Found 39 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 6164   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112737 (US8629141, 4) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:19.32,20.23,wD:10.10,1.0,(6.05,1.99,;4.57,2.39,;4.17,3.87,;2.68,4.27,;1.59,3.18,;1.99,1.7,;3.48,1.3,;.1,3.58,;-.99,2.49,;-2.47,2.89,;-.59,1.01,;.88,.53,;.88,-1.01,;2.37,-.7,;3.47,.45,;4.8,-.32,;4.64,-1.47,;3.31,-.7,;2.21,-1.78,;-.59,-1.49,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,)| Show InChI InChI=1S/C30H34Cl2FN3O3/c31-17-8-13-21-23(16-17)35-28(39)30(21)24(20-6-5-7-22(32)25(20)33)26(36-29(30)14-3-1-2-4-15-29)27(38)34-18-9-11-19(37)12-10-18/h5-8,13,16,18-19,24,26,36-37H,1-4,9-12,14-15H2,(H,34,38)(H,35,39)/t18?,19-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	15.6	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112736 (US8629141, 2) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,wD:10.10,1.0,(6.05,1.99,;4.57,2.39,;4.17,3.87,;2.68,4.27,;1.59,3.18,;1.99,1.7,;3.48,1.3,;.1,3.58,;-.99,2.49,;-2.47,2.89,;-.59,1.01,;.88,.53,;.88,-1.01,;2.21,-.24,;3.75,-.24,;3.75,-1.78,;2.21,-1.78,;-.59,-1.49,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c29-15-6-11-19-21(14-15)33-26(37)28(19)22(18-4-3-5-20(30)23(18)31)24(34-27(28)12-1-2-13-27)25(36)32-16-7-9-17(35)10-8-16/h3-6,11,14,16-17,22,24,34-35H,1-2,7-10,12-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41.8	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112754 (US8629141, 21) Show SMILES CNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C24H24Cl2FN3O2/c1-28-21(31)20-18(14-6-5-7-16(26)19(14)27)24(23(30-20)10-3-2-4-11-23)15-9-8-13(25)12-17(15)29-22(24)32/h5-9,12,18,20,30H,2-4,10-11H2,1H3,(H,28,31)(H,29,32)/t18-,20+,24+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112771 (US8629141, 41) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:18.31,19.22,1.0,wD:10.10,(3.02,6.52,;2.62,5.03,;3.71,3.94,;3.31,2.45,;1.82,2.06,;.73,3.14,;1.13,4.63,;1.42,.57,;-.06,.17,;-1.15,1.26,;.34,-1.32,;1.8,-1.79,;1.8,-3.33,;3.29,-3.71,;4.39,-4.79,;5.72,-4.02,;4.23,-3.71,;3.13,-2.56,;.31,-3.73,;-.57,-2.56,;-1.66,-1.47,;-1.26,.01,;-2.35,1.1,;-3.84,.7,;-4.24,-.78,;-5.72,-1.18,;-3.15,-1.87,;-3.54,-3.36,;1.22,-4.98,;2.76,-4.98,;.31,-6.22,;-1.15,-5.75,;-2.49,-6.52,;-3.82,-5.75,;-5.15,-6.52,;-3.82,-4.21,;-2.49,-3.44,;-1.15,-4.21,)| Show InChI InChI=1S/C29H32Cl2FN3O3/c30-16-7-12-20-22(15-16)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)13-2-1-3-14-28)26(37)33-17-8-10-18(36)11-9-17/h4-7,12,15,17-18,23,25,35-36H,1-3,8-11,13-14H2,(H,33,37)(H,34,38)/t17?,18-,23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112770 (US8629141, 40) Show SMILES OC(=O)[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:20.33,21.24,3.2,wD:12.12,(4.51,6.37,;3.02,5.97,;1.93,7.06,;2.62,4.49,;3.71,3.4,;3.31,1.91,;1.82,1.51,;.73,2.6,;1.13,4.09,;1.42,.02,;-.06,-.37,;-1.15,.71,;.34,-1.86,;1.8,-2.34,;1.8,-3.88,;3.29,-4.25,;4.39,-5.34,;5.72,-4.57,;4.23,-4.25,;3.13,-3.11,;.31,-4.28,;-.57,-3.11,;-1.66,-2.02,;-1.26,-.53,;-2.35,.56,;-3.84,.16,;-4.24,-1.33,;-5.72,-1.73,;-3.15,-2.42,;-3.54,-3.91,;1.22,-5.52,;2.76,-5.52,;.31,-6.77,;-1.15,-6.29,;-2.49,-7.06,;-3.82,-6.29,;-5.15,-7.06,;-3.82,-4.75,;-2.49,-3.98,;-1.15,-4.75,)| Show InChI InChI=1S/C30H32Cl2FN3O4/c31-17-9-12-20-22(15-17)35-28(40)30(20)23(19-5-4-6-21(32)24(19)33)25(36-29(30)13-2-1-3-14-29)26(37)34-18-10-7-16(8-11-18)27(38)39/h4-6,9,12,15-16,18,23,25,36H,1-3,7-8,10-11,13-14H2,(H,34,37)(H,35,40)(H,38,39)/t16-,18?,23-,25+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112769 (US8629141, 39) Show SMILES OC(=O)N1CC(C1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C27H27Cl2FN4O4/c28-14-7-8-17-19(11-14)32-24(36)27(17)20(16-5-4-6-18(29)21(16)30)22(33-26(27)9-2-1-3-10-26)23(35)31-15-12-34(13-15)25(37)38/h4-8,11,15,20,22,33H,1-3,9-10,12-13H2,(H,31,35)(H,32,36)(H,37,38)/t20-,22+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112768 (US8629141, 38) Show SMILES CC(=O)N1CC(C1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C28H29Cl2FN4O3/c1-15(36)35-13-17(14-35)32-25(37)24-22(18-6-5-7-20(30)23(18)31)28(27(34-24)10-3-2-4-11-27)19-9-8-16(29)12-21(19)33-26(28)38/h5-9,12,17,22,24,34H,2-4,10-11,13-14H2,1H3,(H,32,37)(H,33,38)/t22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112767 (US8629141, 37) Show SMILES OC(=O)CN1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C30H33Cl2FN4O4/c31-17-7-8-20-22(15-17)35-28(41)30(20)24(19-5-4-6-21(32)25(19)33)26(36-29(30)11-2-1-3-12-29)27(40)34-18-9-13-37(14-10-18)16-23(38)39/h4-8,15,18,24,26,36H,1-3,9-14,16H2,(H,34,40)(H,35,41)(H,38,39)/t24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112766 (US8629141, 36) Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)cn1 |r| Show InChI InChI=1S/C29H25Cl2FN4O4/c30-15-7-9-18-21(13-15)35-27(40)29(18)22(17-5-4-6-19(31)23(17)32)24(36-28(29)11-2-1-3-12-28)25(37)34-16-8-10-20(26(38)39)33-14-16/h4-10,13-14,22,24,36H,1-3,11-12H2,(H,34,37)(H,35,40)(H,38,39)/t22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112763 (US8629141, 33) Show SMILES C[C@@]1(O)CC(C1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,1.1,wD:9.9,1.0,(3.48,5.68,;2.39,4.59,;1.99,6.08,;1.05,3.82,;1.82,2.49,;3.16,3.26,;1.42,1,;-.06,.61,;-1.15,1.69,;.34,-.88,;1.8,-1.36,;1.8,-2.9,;3.29,-3.27,;4.39,-4.35,;5.72,-3.59,;4.23,-3.27,;3.13,-2.13,;.31,-3.3,;-.57,-2.13,;-1.66,-1.04,;-1.26,.45,;-2.35,1.54,;-3.84,1.14,;-4.24,-.35,;-5.72,-.75,;-3.15,-1.44,;-3.54,-2.93,;1.22,-4.54,;2.76,-4.54,;.31,-5.79,;-1.15,-5.31,;-2.49,-6.08,;-3.82,-5.31,;-5.15,-6.08,;-3.82,-3.77,;-2.49,-3,;-1.15,-3.77,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c1-26(37)13-16(14-26)32-24(35)23-21(17-6-5-7-19(30)22(17)31)28(27(34-23)10-3-2-4-11-27)18-9-8-15(29)12-20(18)33-25(28)36/h5-9,12,16,21,23,34,37H,2-4,10-11,13-14H2,1H3,(H,32,35)(H,33,36)/t16?,21-,23+,26-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112762 (US8629141, 32) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCc1nnn[nH]1 |r| Show InChI InChI=1S/C25H24Cl2FN7O2/c26-13-7-8-15-17(11-13)30-23(37)25(15)19(14-5-4-6-16(27)20(14)28)21(31-24(25)9-2-1-3-10-24)22(36)29-12-18-32-34-35-33-18/h4-8,11,19,21,31H,1-3,9-10,12H2,(H,29,36)(H,30,37)(H,32,33,34,35)/t19-,21+,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112761 (US8629141, 31) Show SMILES COc1cc(ccc1NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(O)=O |r| Show InChI InChI=1S/C31H28Cl2FN3O5/c1-42-23-14-16(28(39)40)8-11-21(23)35-27(38)26-24(18-6-5-7-20(33)25(18)34)31(30(37-26)12-3-2-4-13-30)19-10-9-17(32)15-22(19)36-29(31)41/h5-11,14-15,24,26,37H,2-4,12-13H2,1H3,(H,35,38)(H,36,41)(H,39,40)/t24-,26+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112759 (US8629141, 29) Show SMILES OC(=O)c1ccc(CNC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)cc1 |r| Show InChI InChI=1S/C31H28Cl2FN3O4/c32-19-11-12-21-23(15-19)36-29(41)31(21)24(20-5-4-6-22(33)25(20)34)26(37-30(31)13-2-1-3-14-30)27(38)35-16-17-7-9-18(10-8-17)28(39)40/h4-12,15,24,26,37H,1-3,13-14,16H2,(H,35,38)(H,36,41)(H,39,40)/t24-,26+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112758 (US8629141, 28) Show SMILES OC(=O)[C@H]1CCC(CNC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)CC1 |r,wU:19.31,20.22,wD:11.10,3.2,(7.29,3.25,;6.2,4.34,;6.6,5.83,;4.72,3.94,;3.63,5.03,;2.14,4.63,;1.74,3.14,;.25,2.75,;-.15,1.26,;-1.63,.86,;-2.72,1.95,;-1.23,-.63,;.23,-1.1,;.23,-2.64,;1.72,-3.02,;2.82,-4.1,;4.15,-3.33,;2.66,-3.02,;1.56,-1.87,;-1.26,-3.04,;-2.14,-1.87,;-3.23,-.78,;-2.83,.7,;-3.92,1.79,;-5.41,1.39,;-5.8,-.09,;-7.29,-.49,;-4.72,-1.18,;-5.11,-2.67,;-.35,-4.29,;1.19,-4.29,;-1.26,-5.53,;-2.72,-5.06,;-4.06,-5.83,;-5.39,-5.06,;-6.72,-5.83,;-5.39,-3.52,;-4.06,-2.75,;-2.72,-3.52,;2.83,2.06,;4.32,2.45,)| Show InChI InChI=1S/C31H34Cl2FN3O4/c32-19-11-12-21-23(15-19)36-29(41)31(21)24(20-5-4-6-22(33)25(20)34)26(37-30(31)13-2-1-3-14-30)27(38)35-16-17-7-9-18(10-8-17)28(39)40/h4-6,11-12,15,17-18,24,26,37H,1-3,7-10,13-14,16H2,(H,35,38)(H,36,41)(H,39,40)/t17?,18-,24-,26+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112757 (US8629141, 27) Show SMILES OC(=O)CCCNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C27H28Cl2FN3O4/c28-15-9-10-17-19(14-15)32-25(37)27(17)21(16-6-4-7-18(29)22(16)30)23(24(36)31-13-5-8-20(34)35)33-26(27)11-2-1-3-12-26/h4,6-7,9-10,14,21,23,33H,1-3,5,8,11-13H2,(H,31,36)(H,32,37)(H,34,35)/t21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112755 (US8629141, 25) Show SMILES CS(=O)(=O)CCN1CCC(CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C31H37Cl2FN4O4S/c1-43(41,42)17-16-38-14-10-20(11-15-38)35-28(39)27-25(21-6-5-7-23(33)26(21)34)31(30(37-27)12-3-2-4-13-30)22-9-8-19(32)18-24(22)36-29(31)40/h5-9,18,20,25,27,37H,2-4,10-17H2,1H3,(H,35,39)(H,36,40)/t25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112773 (US8629141, 43) Show SMILES OC(=O)c1cccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)c1 |r| Show InChI InChI=1S/C30H26Cl2FN3O4/c31-17-10-11-20-22(15-17)35-28(40)30(20)23(19-8-5-9-21(32)24(19)33)25(36-29(30)12-2-1-3-13-29)26(37)34-18-7-4-6-16(14-18)27(38)39/h4-11,14-15,23,25,36H,1-3,12-13H2,(H,34,37)(H,35,40)(H,38,39)/t23-,25+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112753 (US8629141, 20) Show SMILES CS(=O)(=O)CCNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C26H28Cl2FN3O4S/c1-37(35,36)13-12-30-23(33)22-20(16-6-5-7-18(28)21(16)29)26(25(32-22)10-3-2-4-11-25)17-9-8-15(27)14-19(17)31-24(26)34/h5-9,14,20,22,32H,2-4,10-13H2,1H3,(H,30,33)(H,31,34)/t20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112748 (US8629141, 15) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112742 (US8629141, 9) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCC(F)(F)CC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:20.33,21.24,wD:10.10,1.0,(6.44,3.26,;4.9,3.26,;4.13,4.59,;2.59,4.59,;1.82,3.26,;2.59,1.93,;4.13,1.93,;.28,3.26,;-.81,2.17,;-1.58,3.51,;-.41,.68,;1.06,.21,;1.06,-1.33,;2.39,-.56,;3.48,-1.71,;4.98,-2.02,;6.47,-2.42,;5.38,-.53,;3.65,-2.79,;2.55,-1.71,;-.41,-1.81,;-1.31,-.56,;-2.4,.53,;-2,2.01,;-3.09,3.1,;-4.58,2.7,;-4.98,1.22,;-6.47,.82,;-3.89,.13,;-4.29,-1.36,;.5,-3.05,;2.04,-3.05,;-.41,-4.3,;-1.87,-3.82,;-3.21,-4.59,;-4.54,-3.82,;-5.87,-4.59,;-4.54,-2.28,;-3.21,-1.51,;-1.87,-2.28,)| Show InChI InChI=1S/C29H30Cl2F3N3O3/c30-15-4-9-19-21(14-15)36-26(40)29(19)22(18-2-1-3-20(31)23(18)32)24(25(39)35-16-5-7-17(38)8-6-16)37-27(29)10-12-28(33,34)13-11-27/h1-4,9,14,16-17,22,24,37-38H,5-8,10-13H2,(H,35,39)(H,36,40)/t16?,17-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112735 (US8629141, 1) Show SMILES CC1(C)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NC1CC[C@H](O)CC1 |r,wU:14.16,5.5,wD:4.28,31.35,(2.21,-1.78,;.88,-1.01,;2.36,-.61,;.88,.53,;-.59,1.01,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;-.59,-1.49,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,;-.99,2.49,;-2.47,2.89,;.1,3.58,;1.59,3.18,;2.68,4.27,;4.17,3.87,;4.57,2.39,;6.05,1.99,;3.48,1.3,;1.99,1.7,)| Show InChI InChI=1S/C26H28Cl2FN3O3/c1-25(2)26(17-11-6-13(27)12-19(17)31-24(26)35)20(16-4-3-5-18(28)21(16)29)22(32-25)23(34)30-14-7-9-15(33)10-8-14/h3-6,11-12,14-15,20,22,32-33H,7-10H2,1-2H3,(H,30,34)(H,31,35)/t14?,15-,20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112760 (US8629141, 30) Show SMILES CS(=O)(=O)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C24H24Cl2FN3O4S/c1-35(33,34)30-21(31)20-18(14-6-5-7-16(26)19(14)27)24(23(29-20)10-3-2-4-11-23)15-9-8-13(25)12-17(15)28-22(24)32/h5-9,12,18,20,29H,2-4,10-11H2,1H3,(H,28,32)(H,30,31)/t18-,20+,24+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112756 (US8629141, 26) Show SMILES OC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C23H21Cl2FN2O3/c24-12-7-8-14-16(11-12)27-21(31)23(14)17(13-5-4-6-15(25)18(13)26)19(20(29)30)28-22(23)9-2-1-3-10-22/h4-8,11,17,19,28H,1-3,9-10H2,(H,27,31)(H,29,30)/t17-,19+,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112740 (US8629141, 7) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC(F)(F)CC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C29H31Cl2F3N4O3/c30-17-4-5-19-21(16-17)36-26(40)29(19)22(18-2-1-3-20(31)23(18)32)24(37-27(29)6-8-28(33,34)9-7-27)25(39)35-10-11-38-12-14-41-15-13-38/h1-5,16,22,24,37H,6-15H2,(H,35,39)(H,36,40)/t22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112739 (US8629141, 6) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C28H33Cl2FN4O3/c1-3-27(4-2)28(19-9-8-17(29)16-21(19)33-26(28)37)22(18-6-5-7-20(30)23(18)31)24(34-27)25(36)32-10-11-35-12-14-38-15-13-35/h5-9,16,22,24,34H,3-4,10-15H2,1-2H3,(H,32,36)(H,33,37)/t22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112752 (US8629141, 19) Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112772 (US8629141, 42) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cncc(Cl)c1)C(=O)Nc1cc(Cl)ccc21 |r,wU:18.30,19.22,4.7,wD:10.10,1.0,(3.02,6.52,;2.62,5.03,;1.13,4.63,;.73,3.14,;1.82,2.06,;3.31,2.45,;3.71,3.94,;1.42,.57,;-.06,.17,;-1.15,1.26,;.34,-1.32,;1.8,-1.79,;1.8,-3.33,;3.29,-3.71,;4.39,-4.79,;5.72,-4.02,;4.23,-3.71,;3.13,-2.56,;.31,-3.73,;-.57,-2.56,;-1.66,-1.47,;-1.26,.01,;-2.35,1.1,;-3.84,.7,;-4.24,-.78,;-5.72,-1.18,;-3.15,-1.87,;1.22,-4.98,;2.76,-4.98,;.31,-6.22,;-1.15,-5.75,;-2.49,-6.52,;-3.82,-5.75,;-5.15,-6.52,;-3.82,-4.21,;-2.49,-3.44,;-1.15,-4.21,)| Show InChI InChI=1S/C28H32Cl2N4O3/c29-17-4-9-21-22(13-17)33-26(37)28(21)23(16-12-18(30)15-31-14-16)24(34-27(28)10-2-1-3-11-27)25(36)32-19-5-7-20(35)8-6-19/h4,9,12-15,19-20,23-24,34-35H,1-3,5-8,10-11H2,(H,32,36)(H,33,37)/t19-,20-,23-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112743 (US8629141, 10) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCOCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:19.22,wD:18.31,10.10,1.0,(6.78,3.13,;5.24,3.13,;4.47,4.46,;2.93,4.46,;2.16,3.13,;2.93,1.79,;4.47,1.79,;.62,3.13,;-.72,2.36,;-2.05,3.13,;-.72,.82,;.75,.34,;.75,-1.2,;2.29,-1.2,;3.62,-1.96,;4.71,-.87,;3.17,-.87,;1.84,-.11,;-.72,-1.67,;-1.62,-.43,;-2.71,.66,;-2.31,2.15,;-3.4,3.24,;-4.89,2.84,;-5.29,1.35,;-6.78,.95,;-4.2,.26,;-4.6,-1.23,;.19,-2.92,;1.73,-2.92,;-.72,-4.17,;-2.18,-3.69,;-3.52,-4.46,;-4.85,-3.69,;-6.18,-4.46,;-4.85,-2.15,;-3.52,-1.38,;-2.18,-2.15,)| Show InChI InChI=1S/C28H30Cl2FN3O4/c29-15-4-9-19-21(14-15)33-26(37)28(19)22(18-2-1-3-20(30)23(18)31)24(34-27(28)10-12-38-13-11-27)25(36)32-16-5-7-17(35)8-6-16/h1-4,9,14,16-17,22,24,34-35H,5-8,10-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112744 (US8629141, 11) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCOCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:18.31,19.22,wD:10.10,1.0,(6.78,3.13,;5.24,3.13,;4.47,4.46,;2.93,4.46,;2.16,3.13,;2.93,1.79,;4.47,1.79,;.62,3.13,;-.72,2.36,;-2.05,3.13,;-.72,.82,;.75,.34,;.75,-1.2,;2.29,-1.2,;3.62,-1.96,;4.71,-.87,;3.17,-.87,;1.84,-.11,;-.72,-1.67,;-1.62,-.43,;-2.71,.66,;-2.31,2.15,;-3.4,3.24,;-4.89,2.84,;-5.29,1.35,;-6.78,.95,;-4.2,.26,;-4.6,-1.23,;.19,-2.92,;1.73,-2.92,;-.72,-4.17,;-2.18,-3.69,;-3.52,-4.46,;-4.85,-3.69,;-6.18,-4.46,;-4.85,-2.15,;-3.52,-1.38,;-2.18,-2.15,)| Show InChI InChI=1S/C28H30Cl2FN3O4/c29-15-4-9-19-21(14-15)33-26(37)28(19)22(18-2-1-3-20(30)23(18)31)24(34-27(28)10-12-38-13-11-27)25(36)32-16-5-7-17(35)8-6-16/h1-4,9,14,16-17,22,24,34-35H,5-8,10-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112745 (US8629141, 12) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCOCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C28H31Cl2FN4O4/c29-17-4-5-19-21(16-17)33-26(37)28(19)22(18-2-1-3-20(30)23(18)31)24(34-27(28)6-12-38-13-7-27)25(36)32-8-9-35-10-14-39-15-11-35/h1-5,16,22,24,34H,6-15H2,(H,32,36)(H,33,37)/t22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112750 (US8629141, 17) Show SMILES CNC(=O)[C@@H]1NC2(CCN(C)CC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C24H25Cl2FN4O2/c1-28-21(32)20-18(14-4-3-5-16(26)19(14)27)24(23(30-20)8-10-31(2)11-9-23)15-7-6-13(25)12-17(15)29-22(24)33/h3-7,12,18,20,30H,8-11H2,1-2H3,(H,28,32)(H,29,33)/t18-,20+,24+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112751 (US8629141, 18) Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112741 (US8629141, 8) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC(F)(F)CC2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C29H31Cl2F3N4O3/c30-17-4-5-19-21(16-17)36-26(40)29(19)22(18-2-1-3-20(31)23(18)32)24(37-27(29)6-8-28(33,34)9-7-27)25(39)35-10-11-38-12-14-41-15-13-38/h1-5,16,22,24,37H,6-15H2,(H,35,39)(H,36,40)/t22-,24+,29-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112749 (US8629141, 16) Show SMILES CNC(=O)[C@@H]1NC2(CCN(C)CC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C24H25Cl2FN4O2/c1-28-21(32)20-18(14-4-3-5-16(26)19(14)27)24(23(30-20)8-10-31(2)11-9-23)15-7-6-13(25)12-17(15)29-22(24)33/h3-7,12,18,20,30H,8-11H2,1-2H3,(H,28,32)(H,29,33)/t18-,20+,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112738 (US8629141, 5) Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:13.25,14.16,wD:10.10,1.0,(6.05,1.99,;4.57,2.39,;4.17,3.87,;2.68,4.27,;1.59,3.18,;1.99,1.7,;3.48,1.3,;.1,3.58,;-.99,2.49,;-2.47,2.89,;-.59,1.01,;.88,.53,;.88,-1.01,;-.59,-1.49,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,)| Show InChI InChI=1S/C24H24Cl2FN3O3/c25-12-4-9-16-18(10-12)30-23(33)24(16)11-28-21(19(24)15-2-1-3-17(26)20(15)27)22(32)29-13-5-7-14(31)8-6-13/h1-4,9-10,13-14,19,21,28,31H,5-8,11H2,(H,29,32)(H,30,33)/t13?,14-,19-,21+,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112747 (US8629141, 14) Show SMILES CNC(=O)[C@@H]1NC2(CCNCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C23H23Cl2FN4O2/c1-27-20(31)19-17(13-3-2-4-15(25)18(13)26)23(22(30-19)7-9-28-10-8-22)14-6-5-12(24)11-16(14)29-21(23)32/h2-6,11,17,19,28,30H,7-10H2,1H3,(H,27,31)(H,29,32)/t17-,19+,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112764 (US8629141, 34) Show SMILES CNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cc(Cl)ccc1OC(C)(C)C(O)=O)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C28H31Cl2N3O5/c1-26(2,25(36)37)38-20-10-8-15(29)13-17(20)21-22(23(34)31-3)33-27(11-5-4-6-12-27)28(21)18-9-7-16(30)14-19(18)32-24(28)35/h7-10,13-14,21-22,33H,4-6,11-12H2,1-3H3,(H,31,34)(H,32,35)(H,36,37)/t21-,22+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112765 (US8629141, 35) Show SMILES CNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cc(Cl)cnc1OC(C)(C)C(O)=O)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C27H30Cl2N4O5/c1-25(2,24(36)37)38-22-16(11-15(29)13-31-22)19-20(21(34)30-3)33-26(9-5-4-6-10-26)27(19)17-8-7-14(28)12-18(17)32-23(27)35/h7-8,11-13,19-20,33H,4-6,9-10H2,1-3H3,(H,30,34)(H,32,35)(H,36,37)/t19-,20+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112746 (US8629141, 13) Show SMILES CNC(=O)[C@@H]1NC2(CCNCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C23H23Cl2FN4O2/c1-27-20(31)19-17(13-3-2-4-15(25)18(13)26)23(22(30-19)7-9-28-10-8-22)14-6-5-12(24)11-16(14)29-21(23)32/h2-6,11,17,19,28,30H,7-10H2,1H3,(H,27,31)(H,29,32)/t17-,19+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of Michigan; Sanofi US Patent					Assay Description The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...				US Patent US8629141 (2014) BindingDB Entry DOI: 10.7270/Q2W094KC
					More data for this Ligand-Target Pair