Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM225230 (EED226 | US11013745, Compound EED226) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 23.4 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis Institutes for BioMedical Research | Assay Description To assess the compounds potency in the H3K27me0 peptide (2144)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t... | Nat Chem Biol 13: 381-388 (2017) Article DOI: 10.1038/nchembio.2304 BindingDB Entry DOI: 10.7270/Q2S75F64 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM225230 (EED226 | US11013745, Compound EED226) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 53.5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis Institutes for BioMedical Research | Assay Description To assess the compounds potency in the H3K27me0 peptide (2144)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t... | Nat Chem Biol 13: 381-388 (2017) Article DOI: 10.1038/nchembio.2304 BindingDB Entry DOI: 10.7270/Q2S75F64 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |