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Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with all data for assayid = 2 entry = 50042592   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428279
PNG
(CHEMBL2337901)
Show SMILES Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccc(cc2)-c2ccc(Nc3cc(c(N)c4C(=O)c5ccccc5C(=O)c34)S([O-])(=O)=O)cc2)cc1S([O-])(=O)=O
Show InChI InChI=1S/C40H26N4O10S2/c41-35-29(55(49,50)51)17-27(31-33(35)39(47)25-7-3-1-5-23(25)37(31)45)43-21-13-9-19(10-14-21)20-11-15-22(16-12-20)44-28-18-30(56(52,53)54)36(42)34-32(28)38(46)24-6-2-4-8-26(24)40(34)48/h1-18,43-44H,41-42H2,(H,49,50,51)(H,52,53,54)/p-2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428281
PNG
(CHEMBL2337903)
Show SMILES COc1cc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)ccc1-c1ccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)cc1OC
Show InChI InChI=1S/C42H30N4O12S2/c1-57-29-15-19(45-27-17-31(59(51,52)53)37(43)35-33(27)39(47)23-7-3-5-9-25(23)41(35)49)11-13-21(29)22-14-12-20(16-30(22)58-2)46-28-18-32(60(54,55)56)38(44)36-34(28)40(48)24-8-4-6-10-26(24)42(36)50/h3-18,45-46H,43-44H2,1-2H3,(H,51,52,53)(H,54,55,56)/p-2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428283
PNG
(CHEMBL2337896)
Show SMILES Nc1c(cc(Nc2ccc(cc2)-c2ccc(Nc3ncccn3)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Show InChI InChI=1S/C30H21N5O5S/c31-27-24(41(38,39)40)16-23(25-26(27)29(37)22-5-2-1-4-21(22)28(25)36)34-19-10-6-17(7-11-19)18-8-12-20(13-9-18)35-30-32-14-3-15-33-30/h1-16,34H,31H2,(H,32,33,35)(H,38,39,40)/p-1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428280
PNG
(CHEMBL2337904)
Show SMILES Cc1cc(ccc1Nc1cc(c(N)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O)-c1ccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)c(C)c1
Show InChI InChI=1S/C42H30N4O10S2/c1-19-15-21(11-13-27(19)45-29-17-31(57(51,52)53)37(43)35-33(29)39(47)23-7-3-5-9-25(23)41(35)49)22-12-14-28(20(2)16-22)46-30-18-32(58(54,55)56)38(44)36-34(30)40(48)24-8-4-6-10-26(24)42(36)50/h3-18,45-46H,43-44H2,1-2H3,(H,51,52,53)(H,54,55,56)/p-2
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n/an/a 4.30E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428282
PNG
(CHEMBL2337902)
Show SMILES Cc1cc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)ccc1-c1ccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)cc1C
Show InChI InChI=1S/C42H30N4O10S2/c1-19-15-21(45-29-17-31(57(51,52)53)37(43)35-33(29)39(47)25-7-3-5-9-27(25)41(35)49)11-13-23(19)24-14-12-22(16-20(24)2)46-30-18-32(58(54,55)56)38(44)36-34(30)40(48)26-8-4-6-10-28(26)42(36)50/h3-18,45-46H,43-44H2,1-2H3,(H,51,52,53)(H,54,55,56)/p-2
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n/an/a 6.60E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428284
PNG
(CHEMBL2337891)
Show SMILES Cc1cc(ccc1N)-c1ccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)c(C)c1
Show InChI InChI=1S/C28H23N3O5S/c1-14-11-16(7-9-20(14)29)17-8-10-21(15(2)12-17)31-22-13-23(37(34,35)36)26(30)25-24(22)27(32)18-5-3-4-6-19(18)28(25)33/h3-13,31H,29-30H2,1-2H3,(H,34,35,36)/p-1
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n/an/a 8.40E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50428285
PNG
(CHEMBL2337890)
Show SMILES Nc1ccc(cc1)-c1ccc(Nc2cc(c(N)c3C(=O)c4ccccc4C(=O)c23)S([O-])(=O)=O)cc1
Show InChI InChI=1S/C26H19N3O5S/c27-16-9-5-14(6-10-16)15-7-11-17(12-8-15)29-20-13-21(35(32,33)34)24(28)23-22(20)25(30)18-3-1-2-4-19(18)26(23)31/h1-13,29H,27-28H2,(H,32,33,34)/p-1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using Poly(Glu,Tyr) at 4:1 ratio as substrate preincubated with substrate prior to enzyme addition measured afte...

ACS Med Chem Lett 4: 408-13 (2013)


Article DOI: 10.1021/ml4000047
BindingDB Entry DOI: 10.7270/Q23R0V7M
More data for this
Ligand-Target Pair