Compile Data Set for Download or QSAR

Found 71 hits of ph data with Target = 'Chymase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM134252 (US8846660, 3) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccn1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C29H30ClN5O6/c1-3-23(18-7-9-19(10-8-18)28(37)38)33-29(39)35-17-25(34-41-26-6-4-5-13-31-26)32-16-21(27(35)36)14-20-15-22(30)11-12-24(20)40-2/h4-13,15,21,23H,3,14,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t21?,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134281 (US8846660, 113) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2F)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C26H31ClFN5O5/c1-3-5-22(15-6-8-19(25(35)36)21(29)12-15)31-26(37)33-14-23(32-38-4-2)30-13-17(24(33)34)10-16-11-18(27)7-9-20(16)28/h6-9,11-12,17,22H,3-5,10,13-14,29H2,1-2H3,(H,30,32)(H,31,37)(H,35,36)/t17?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134254 (US8846660, 14) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\O)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C25H30ClN5O6/c1-3-4-20(14-5-7-18(24(33)34)19(27)11-14)29-25(35)31-13-22(30-36)28-12-16(23(31)32)9-15-10-17(26)6-8-21(15)37-2/h5-8,10-11,16,20,36H,3-4,9,12-13,27H2,1-2H3,(H,28,30)(H,29,35)(H,33,34)/t16?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134255 (US8846660, 15) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OC(C)C)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C28H36ClN5O6/c1-5-6-23(17-7-9-21(27(36)37)22(30)13-17)32-28(38)34-15-25(33-40-16(2)3)31-14-19(26(34)35)11-18-12-20(29)8-10-24(18)39-4/h7-10,12-13,16,19,23H,5-6,11,14-15,30H2,1-4H3,(H,31,33)(H,32,38)(H,36,37)/t19?,23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134256 (US8846660, 18) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCCO)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O7/c1-3-4-22(16-5-7-20(26(36)37)21(29)13-16)31-27(38)33-15-24(32-40-10-9-34)30-14-18(25(33)35)11-17-12-19(28)6-8-23(17)39-2/h5-8,12-13,18,22,34H,3-4,9-11,14-15,29H2,1-2H3,(H,30,32)(H,31,38)(H,36,37)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134257 (US8846660, 20) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCC(F)(F)F)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H31ClF3N5O6/c1-3-4-21(15-5-7-19(25(38)39)20(32)11-15)34-26(40)36-13-23(35-42-14-27(29,30)31)33-12-17(24(36)37)9-16-10-18(28)6-8-22(16)41-2/h5-8,10-11,17,21H,3-4,9,12-14,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t17?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134258 (US8846660, 22) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\N(C)C)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H35ClN6O5/c1-5-6-22(16-7-9-20(26(36)37)21(29)13-16)31-27(38)34-15-24(32-33(2)3)30-14-18(25(34)35)11-17-12-19(28)8-10-23(17)39-4/h7-10,12-13,18,22H,5-6,11,14-15,29H2,1-4H3,(H,30,32)(H,31,38)(H,36,37)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134259 (US8846660, 26) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(cc2)C(O)=O)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C29H28ClFN4O6/c1-17(18-3-5-19(6-4-18)28(37)38)33-29(39)35-16-26(34-41-24-10-8-23(31)9-11-24)32-15-21(27(35)36)13-20-14-22(30)7-12-25(20)40-2/h3-12,14,17,21H,13,15-16H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t17-,21?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134260 (US8846660, 27) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(cc2)C(O)=O)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C29H27ClF2N4O6/c1-16(17-3-5-18(6-4-17)28(38)39)34-29(40)36-15-26(35-42-24-12-22(31)11-23(32)13-24)33-14-20(27(36)37)9-19-10-21(30)7-8-25(19)41-2/h3-8,10-13,16,20H,9,14-15H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,20?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134261 (US8846660, 29) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C29H29ClFN5O6/c1-16(17-3-9-23(28(38)39)24(32)13-17)34-29(40)36-15-26(35-42-22-7-5-21(31)6-8-22)33-14-19(27(36)37)11-18-12-20(30)4-10-25(18)41-2/h3-10,12-13,16,19H,11,14-15,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t16-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134262 (US8846660, 30) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C29H28ClF2N5O6/c1-15(16-3-5-23(28(39)40)24(33)9-16)35-29(41)37-14-26(36-43-22-11-20(31)10-21(32)12-22)34-13-18(27(37)38)7-17-8-19(30)4-6-25(17)42-2/h3-6,8-12,15,18H,7,13-14,33H2,1-2H3,(H,34,36)(H,35,41)(H,39,40)/t15-,18?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134263 (US8846660, 31) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1ccccn1 |r| Show InChI InChI=1S/C28H29ClN6O6/c1-16(17-6-8-21(27(37)38)22(30)13-17)33-28(39)35-15-24(34-41-25-5-3-4-10-31-25)32-14-19(26(35)36)11-18-12-20(29)7-9-23(18)40-2/h3-10,12-13,16,19H,11,14-15,30H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t16-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134264 (US8846660, 34) Show SMILES CCC[C@@H](NC(=O)N1C\C(=N\OC)N(C)CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O6/c1-5-6-22(16-7-9-20(26(35)36)21(29)13-16)30-27(37)33-15-24(31-39-4)32(2)14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,5-6,11,14-15,29H2,1-4H3,(H,30,37)(H,35,36)/b31-24-/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134265 (US8846660, 37) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(s1)C(O)=O |r| Show InChI InChI=1S/C28H29ClN4O6S/c1-3-21(23-11-12-24(40-23)27(35)36)31-28(37)33-16-25(32-39-20-7-5-4-6-8-20)30-15-18(26(33)34)13-17-14-19(29)9-10-22(17)38-2/h4-12,14,18,21H,3,13,15-16H2,1-2H3,(H,30,32)(H,31,37)(H,35,36)/t18?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134266 (US8846660, 40) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C30H30ClFN4O6/c1-18(20-5-3-19(4-6-20)13-28(37)38)34-30(40)36-17-27(35-42-25-10-8-24(32)9-11-25)33-16-22(29(36)39)14-21-15-23(31)7-12-26(21)41-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t18-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134267 (US8846660, 41) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C30H29ClF2N4O6/c1-17(19-5-3-18(4-6-19)9-28(38)39)35-30(41)37-16-27(36-43-25-13-23(32)12-24(33)14-25)34-15-21(29(37)40)10-20-11-22(31)7-8-26(20)42-2/h3-8,11-14,17,21H,9-10,15-16H2,1-2H3,(H,34,36)(H,35,41)(H,38,39)/t17-,21?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134268 (US8846660, 42) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccccn1 |r| Show InChI InChI=1S/C29H30ClN5O6/c1-18(20-8-6-19(7-9-20)13-27(36)37)33-29(39)35-17-25(34-41-26-5-3-4-12-31-26)32-16-22(28(35)38)14-21-15-23(30)10-11-24(21)40-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,36,37)/t18-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134269 (US8846660, 44) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1cc(F)cc(F)c1)c1ccc(C(O)=O)c(O)c1 |r| Show InChI InChI=1S/C30H29ClF2N4O7/c1-3-24(16-4-6-23(29(40)41)25(38)10-16)35-30(42)37-15-27(36-44-22-12-20(32)11-21(33)13-22)34-14-18(28(37)39)8-17-9-19(31)5-7-26(17)43-2/h4-7,9-13,18,24,38H,3,8,14-15H2,1-2H3,(H,34,36)(H,35,42)(H,40,41)/t18?,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134270 (US8846660, 49) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1cncc(c1)C(O)=O |r| Show InChI InChI=1S/C29H30ClN5O6/c1-3-24(19-12-21(28(37)38)15-31-14-19)33-29(39)35-17-26(34-41-23-7-5-4-6-8-23)32-16-20(27(35)36)11-18-13-22(30)9-10-25(18)40-2/h4-10,12-15,20,24H,3,11,16-17H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t20?,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134271 (US8846660, 53) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)NCc2ccc(C(O)=O)c(N)c2)C1=O)=N/Oc1cc(F)cc(F)c1 Show InChI InChI=1S/C28H26ClF2N5O6/c1-41-24-5-3-18(29)8-16(24)7-17-13-33-25(35-42-21-10-19(30)9-20(31)11-21)14-36(26(17)37)28(40)34-12-15-2-4-22(27(38)39)23(32)6-15/h2-6,8-11,17H,7,12-14,32H2,1H3,(H,33,35)(H,34,40)(H,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134272 (US8846660, 58) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)C(=O)Nc1nnn[nH]1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134273 (US8846660, 64) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(CC(O)=O)cc1 |r| Show InChI InChI=1S/C31H33ClN4O6/c1-3-26(21-11-9-20(10-12-21)15-29(37)38)34-31(40)36-19-28(35-42-25-7-5-4-6-8-25)33-18-23(30(36)39)16-22-17-24(32)13-14-27(22)41-2/h4-14,17,23,26H,3,15-16,18-19H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t23?,26-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134274 (US8846660, 67) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1nc(cs1)C(O)=O |r| Show InChI InChI=1S/C27H28ClN5O6S/c1-3-20(24-30-21(15-40-24)26(35)36)31-27(37)33-14-23(32-39-19-7-5-4-6-8-19)29-13-17(25(33)34)11-16-12-18(28)9-10-22(16)38-2/h4-10,12,15,17,20H,3,11,13-14H2,1-2H3,(H,29,32)(H,31,37)(H,35,36)/t17?,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134275 (US8846660, 73) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1cccc(c1)C(O)=O |r| Show InChI InChI=1S/C30H31ClN4O6/c1-3-25(19-8-7-9-20(14-19)29(37)38)33-30(39)35-18-27(34-41-24-10-5-4-6-11-24)32-17-22(28(35)36)15-21-16-23(31)12-13-26(21)40-2/h4-14,16,22,25H,3,15,17-18H2,1-2H3,(H,32,34)(H,33,39)(H,37,38)/t22?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134276 (US8846660, 76) Show SMILES CC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C30H32ClN5O6/c1-3-25(18-9-11-23(29(38)39)24(32)15-18)34-30(40)36-17-27(35-42-22-7-5-4-6-8-22)33-16-20(28(36)37)13-19-14-21(31)10-12-26(19)41-2/h4-12,14-15,20,25H,3,13,16-17,32H2,1-2H3,(H,33,35)(H,34,40)(H,38,39)/t20?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134277 (US8846660, 88) Show SMILES CC[C@@H](NC(=O)N1Cc2nnc(O)n2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C25H27ClN6O6/c1-3-19(13-4-6-17(23(34)35)18(27)10-13)28-24(36)32-12-21-29-30-25(37)31(21)11-15(22(32)33)8-14-9-16(26)5-7-20(14)38-2/h4-7,9-10,15,19H,3,8,11-12,27H2,1-2H3,(H,28,36)(H,30,37)(H,34,35)/t15?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134278 (US8846660, 96) Show SMILES CCC[C@@H](NC(=O)N1CC2=NOCC(=O)N2CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r,t:9| Show InChI InChI=1S/C27H30ClN5O7/c1-3-4-21(15-5-7-19(26(36)37)20(29)11-15)30-27(38)33-13-23-31-40-14-24(34)32(23)12-17(25(33)35)9-16-10-18(28)6-8-22(16)39-2/h5-8,10-11,17,21H,3-4,9,12-14,29H2,1-2H3,(H,30,38)(H,36,37)/t17?,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134280 (US8846660, 108) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(F)ccc2OC)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34FN5O6/c1-4-6-22(16-7-9-20(26(35)36)21(29)13-16)31-27(37)33-15-24(32-39-5-2)30-14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,4-6,11,14-15,29H2,1-3H3,(H,30,32)(H,31,37)(H,35,36)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM134253 (US8846660, 103 | US8846660, 12) Show SMILES CCC[C@@H](NC(=O)N1C\C(NCC(Cc2cc(Cl)ccc2OC)C1=O)=N\OCC)c1ccc(C(O)=O)c(N)c1 |r| Show InChI InChI=1S/C27H34ClN5O6/c1-4-6-22(16-7-9-20(26(35)36)21(29)13-16)31-27(37)33-15-24(32-39-5-2)30-14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,4-6,11,14-15,29H2,1-3H3,(H,30,32)(H,31,37)(H,35,36)/t18?,22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100306 (US8501749, 6) Show SMILES Cc1cccc2n(C)cc(Cn3c4cnccc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-4-3-5-15-18(12)13(9-22(15)2)10-23-16-8-21-7-6-14(16)19(27)24(20(23)28)11-17(25)26/h3-9H,10-11H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100307 (US8501749, 7) Show SMILES Cc1cccc2n(C)cc(Cn3c4ccncc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-4-3-5-16-18(12)13(9-22(16)2)10-23-15-6-7-21-8-14(15)19(27)24(20(23)28)11-17(25)26/h3-9H,10-11H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.60	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100308 (US8501749, 8) Show SMILES Cc1cccc2n(C)cc(Cn3c4cccnc4c(=O)n(CC(O)=O)c3=O)c12 Show InChI InChI=1S/C20H18N4O4/c1-12-5-3-6-14-17(12)13(9-22(14)2)10-23-15-7-4-8-21-18(15)19(27)24(20(23)28)11-16(25)26/h3-9H,10-11H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100312 (US8501749, 12) Show SMILES Cc1cccc2n(C)cc(Cn3c4ccncc4c(=O)n([C@H](C(O)=O)c4ccccc4)c3=O)c12 |r| Show InChI InChI=1S/C26H22N4O4/c1-16-7-6-10-21-22(16)18(14-28(21)2)15-29-20-11-12-27-13-19(20)24(31)30(26(29)34)23(25(32)33)17-8-4-3-5-9-17/h3-14,23H,15H2,1-2H3,(H,32,33)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100314 (US8501749, 14) Show SMILES CCCCC(Cn1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O)C(O)=O Show InChI InChI=1S/C25H28N4O4/c1-4-5-8-17(24(31)32)14-29-23(30)19-12-26-11-10-20(19)28(25(29)33)15-18-13-27(3)21-9-6-7-16(2)22(18)21/h6-7,9-13,17H,4-5,8,14-15H2,1-3H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100315 (US8501749, 15) Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(10-18(27)28)26-21(29)20-16(6-5-7-23-20)25(22(26)30)11-15-19-13(3)8-12(2)9-17(19)31-24-15/h5-9,14H,4,10-11H2,1-3H3,(H,27,28)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100316 (US8501749, 16) Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-10-23-6-5-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100317 (US8501749, 17) Show SMILES CC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C21H20N4O4S/c1-4-15(20(27)28)25-19(26)13-9-22-6-5-16(13)24(21(25)29)10-14-18-12(3)7-11(2)8-17(18)30-23-14/h5-9,15H,4,10H2,1-3H3,(H,27,28)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100318 (US8501749, 18) Show SMILES CCCC[C@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4S/c1-4-5-6-18(22(29)30)27-21(28)15-11-24-8-7-17(15)26(23(27)31)12-16-20-14(3)9-13(2)10-19(20)32-25-16/h7-11,18H,4-6,12H2,1-3H3,(H,29,30)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100319 (US8501749, 19) Show SMILES CCCC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4S/c1-4-5-6-18(22(29)30)27-21(28)15-11-24-8-7-17(15)26(23(27)31)12-16-20-14(3)9-13(2)10-19(20)32-25-16/h7-11,18H,4-6,12H2,1-3H3,(H,29,30)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100320 (US8501749, 20) Show SMILES CCC[C@@H](C(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-6-19(22(29)30)27-21(28)16-11-24-10-9-17(16)26(23(27)31)13-15-12-25(3)18-8-5-7-14(2)20(15)18/h5,7-12,19H,4,6,13H2,1-3H3,(H,29,30)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100321 (US8501749, 21) Show SMILES CCC[C@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-5-17(21(28)29)26-20(27)14-10-23-7-6-16(14)25(22(26)30)11-15-19-13(3)8-12(2)9-18(19)31-24-15/h6-10,17H,4-5,11H2,1-3H3,(H,28,29)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100322 (US8501749, 22) Show SMILES CCC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-5-17(21(28)29)26-20(27)14-10-23-7-6-16(14)25(22(26)30)11-15-19-13(3)8-12(2)9-18(19)31-24-15/h6-10,17H,4-5,11H2,1-3H3,(H,28,29)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100324 (US8501749, 24) Show SMILES CCCC[C@H](C(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C24H26N4O4/c1-4-5-8-20(23(30)31)28-22(29)17-12-25-11-10-18(17)27(24(28)32)14-16-13-26(3)19-9-6-7-15(2)21(16)19/h6-7,9-13,20H,4-5,8,14H2,1-3H3,(H,30,31)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100325 (US8501749, 25) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(10-20(28)29)27-22(30)17-11-24-9-8-18(17)26(23(27)31)13-15-12-25(3)19-7-5-6-14(2)21(15)19/h5-9,11-12,16H,4,10,13H2,1-3H3,(H,28,29)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100326 (US8501749, 26) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(10-20(28)29)27-22(30)17-8-9-24-11-19(17)26(23(27)31)13-15-12-25(3)18-7-5-6-14(2)21(15)18/h5-9,11-12,16H,4,10,13H2,1-3H3,(H,28,29)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100327 (US8501749, 27) Show SMILES CC[C@@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(11-19(28)29)27-22(30)21-18(9-6-10-24-21)26(23(27)31)13-15-12-25(3)17-8-5-7-14(2)20(15)17/h5-10,12,16H,4,11,13H2,1-3H3,(H,28,29)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100328 (US8501749, 28) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cnccc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-5-6-23-10-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100329 (US8501749, 29) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(9-19(27)28)26-21(29)15-10-23-6-5-17(15)25(22(26)30)11-16-20-13(3)7-12(2)8-18(20)31-24-16/h5-8,10,14H,4,9,11H2,1-3H3,(H,27,28)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.90	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100330 (US8501749, 30) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C23H24N4O4/c1-4-16(11-19(28)29)27-22(30)21-18(9-6-10-24-21)26(23(27)31)13-15-12-25(3)17-8-5-7-14(2)20(15)17/h5-10,12,16H,4,11,13H2,1-3H3,(H,28,29)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair
Chymase (Homo sapiens (Human))	BDBM100331 (US8501749, 31) Show SMILES CC[C@H](CC(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2cccnc2c1=O |r| Show InChI InChI=1S/C22H22N4O4S/c1-4-14(10-18(27)28)26-21(29)20-16(6-5-7-23-20)25(22(26)30)11-15-19-13(3)8-12(2)9-17(19)31-24-15/h5-9,14H,4,10-11H2,1-3H3,(H,27,28)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	8.0	28
Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition assay of Chymase.				US Patent US8501749 (2013) BindingDB Entry DOI: 10.7270/Q28G8JB2
					More data for this Ligand-Target Pair

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