Found 7 hits of ec50 data for polymerid = 3594 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50228363
(CHEMBL257991 | N-(2-(3-(piperazin-1-ylmethyl)imida...)Show SMILES O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1 Show InChI InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Johns Hopkins UniversitySchool of Medicine
Curated by ChEMBL
| Assay Description Activation of human SirT2 protein fluorescence polarization assay |
Nat Chem Biol 4: 590-7 (2008)
Article DOI: 10.1038/nchembio.111 BindingDB Entry DOI: 10.7270/Q2JD4X1V |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50428988
(CHEMBL2333666)Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc3cc(ccc3c2)-c2ccccc2)c(O)c1Br Show InChI InChI=1S/C24H16Br2N2O3/c25-20-12-19(22(29)21(26)23(20)30)13-27-28-24(31)18-9-8-16-10-15(6-7-17(16)11-18)14-4-2-1-3-5-14/h1-13,29-30H,(H,28,31)/b27-13+ | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Activation of at N-terminal GST-tagged SIRT2 (34 to 356 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac... |
J Med Chem 56: 761-80 (2013)
Article DOI: 10.1021/jm301032j BindingDB Entry DOI: 10.7270/Q2XP768M |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM31963
(carbohydrazide derivative, 5f)Show SMILES Oc1c(Br)cc(C=NNC(=O)c2ccc-3c(Cc4ccccc-34)c2)c(O)c1Br |w:6.5| Show InChI InChI=1S/C21H14Br2N2O3/c22-17-9-14(19(26)18(23)20(17)27)10-24-25-21(28)12-5-6-16-13(8-12)7-11-3-1-2-4-15(11)16/h1-6,8-10,26-27H,7H2,(H,25,28) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.65E+4 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Activation of at N-terminal GST-tagged SIRT2 (34 to 356 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac... |
J Med Chem 56: 761-80 (2013)
Article DOI: 10.1021/jm301032j BindingDB Entry DOI: 10.7270/Q2XP768M |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50228363
(CHEMBL257991 | N-(2-(3-(piperazin-1-ylmethyl)imida...)Show SMILES O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1 Show InChI InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Activation of SIRT2 by mass spectrometry assay |
Nature 450: 712-716 (2007)
Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50228364
(3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1 Show InChI InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32) | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Activation of SIRT2 by mass spectrometry assay |
Nature 450: 712-716 (2007)
Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM50376978
(CHEMBL403308 | SRT-2183)Show SMILES O[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1 Show InChI InChI=1S/C27H24N4O2S/c32-22-11-12-30(15-22)14-21-17-34-27-29-25(16-31(21)27)23-7-3-4-8-24(23)28-26(33)20-10-9-18-5-1-2-6-19(18)13-20/h1-10,13,16-17,22,32H,11-12,14-15H2,(H,28,33)/t22-/m1/s1 | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Activation of SIRT2 by mass spectrometry assay |
Nature 450: 712-716 (2007)
Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human)) | BDBM23926
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ | PDB MMDB
NCI pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Activation of SIRT2 by mass spectrometry assay |
Nature 450: 712-716 (2007)
Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 |
More data for this Ligand-Target Pair | |