Compile Data Set for Download or QSAR

Found 163 hits of ec50 data for polymerid = 49000732   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (RAT)	BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258141 (CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)27-13)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127985 (CHEMBL3628113) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1 Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258224 (CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258142 (2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258185 (CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127965 (CHEMBL3628112) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1 Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50127993 (CHEMBL3628115) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1 Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	113	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1 Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	124	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258223 (CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12 Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	131	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258225 (2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...) Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1 Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258227 (4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	161	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258186 (4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...) Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12 Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	162	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	202	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258139 (CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...) Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1 Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258184 (CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...) Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1 Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	275	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258140 (CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	277	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50128021 (CHEMBL3628116) Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	356	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50258226 (CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...) Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1 Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	394	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology				Bioorg Med Chem Lett 19: 1666-9 (2009) Article DOI: 10.1016/j.bmcl.2009.01.108 BindingDB Entry DOI: 10.7270/Q20G3K12
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1c in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 1 (RAT)	BDBM55081 (ML182 | VU0400195-3 | cid_46869947) Show SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@]1([H])C2C(=O)N(C1=O)c1ccc(NC(=O)c2ccccn2)cc1Cl |c:5,TLB:10:9:2:5.6,THB:13:7:2:5.6| Show InChI InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,17-18H,9H2,(H,24,26)/t11-,12+,17-,18?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2HH6HG6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500949 (CHEMBL3797793) Show SMILES O=C(Nc1nc(cs1)C#N)C1c2ccccc2Oc2ccccc12 Show InChI InChI=1S/C18H11N3O2S/c19-9-11-10-24-18(20-11)21-17(22)16-12-5-1-3-7-14(12)23-15-8-4-2-6-13(15)16/h1-8,10,16H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500949 (CHEMBL3797793) Show SMILES O=C(Nc1nc(cs1)C#N)C1c2ccccc2Oc2ccccc12 Show InChI InChI=1S/C18H11N3O2S/c19-9-11-10-24-18(20-11)21-17(22)16-12-5-1-3-7-14(12)23-15-8-4-2-6-13(15)16/h1-8,10,16H,(H,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50293721 (CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...) Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	2.34E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2HH6HG6
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500951 (CHEMBL3799685) Show SMILES CC(C)c1csc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C20H18N2O2S/c1-12(2)15-11-25-20(21-15)22-19(23)18-13-7-3-5-9-16(13)24-17-10-6-4-8-14(17)18/h3-12,18H,1-2H3,(H,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500951 (CHEMBL3799685) Show SMILES CC(C)c1csc(NC(=O)C2c3ccccc3Oc3ccccc23)n1 Show InChI InChI=1S/C20H18N2O2S/c1-12(2)15-11-25-20(21-15)22-19(23)18-13-7-3-5-9-16(13)24-17-10-6-4-8-14(17)18/h3-12,18H,1-2H3,(H,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17660 ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...) Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1b in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Universit£ Ren£ Descartes Curated by ChEMBL					Assay Description Agonist activity in rat at Metabotropic glutamate receptor 1 expressed in HEK293 cells				Bioorg Med Chem Lett 11: 1569-72 (2001) BindingDB Entry DOI: 10.7270/Q2M61KRJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500948 (CHEMBL3800589) Show SMILES O=C(Nc1nccs1)C1c2ccccc2Oc2ccccc12 Show InChI InChI=1S/C17H12N2O2S/c20-16(19-17-18-9-10-22-17)15-11-5-1-3-7-13(11)21-14-8-4-2-6-12(14)15/h1-10,15H,(H,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50500948 (CHEMBL3800589) Show SMILES O=C(Nc1nccs1)C1c2ccccc2Oc2ccccc12 Show InChI InChI=1S/C17H12N2O2S/c20-16(19-17-18-9-10-22-17)15-11-5-1-3-7-13(11)21-14-8-4-2-6-12(14)15/h1-10,15H,(H,18,19,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilization				Bioorg Med Chem Lett 26: 2289-92 (2016) Article DOI: 10.1016/j.bmcl.2016.03.044 BindingDB Entry DOI: 10.7270/Q2GT5R7C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50034501 ((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...) Show SMILES N[C@H](C(O)=O)c1cc(=O)[nH]o1 Show InChI InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentration				Bioorg Med Chem 15: 3161-70 (2007) Article DOI: 10.1016/j.bmc.2007.02.040 BindingDB Entry DOI: 10.7270/Q2CN74RR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells				Bioorg Med Chem Lett 16: 196-9 (2005) Article DOI: 10.1016/j.bmcl.2005.09.014 BindingDB Entry DOI: 10.7270/Q2DZ0932
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM17657 ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) Show SMILES N[C@@H](CCC(O)=O)C(O)=O Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a
CNS Research Curated by ChEMBL					Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat				J Med Chem 38: 1417-26 (1995) BindingDB Entry DOI: 10.7270/Q20R9Q1R
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 163 total )  |  Next  |  Last  >>

Jump to: