Found 943 hits of ic50 data for polymerid = 1570,50001605 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428590
(CHEMBL2337969)Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1 |t:15,30| Show InChI InChI=1S/C29H34N6O4/c1-4-21-18-25-23(11-14-28(38-3)35(25)32-21)24-12-13-27(37)34(33-24)15-5-6-16-39-22-9-7-20(8-10-22)29-19(2)17-26(36)30-31-29/h7-11,14,18-19H,4-6,12-13,15-17H2,1-3H3,(H,30,36) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM86219
(CAS_5537 | NSC_5537 | Trequinsin)Show SMILES COc1cc2CCn3c(cc(=Nc4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC |w:11.11| Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3 | PDB
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| PDB
Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.5 | 24 |
University of North Carolina
| Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate. |
J Biol Chem 287: 11788-97 (2012)
Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428577
(CHEMBL2337953)Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1C |t:15,30| Show InChI InChI=1S/C30H36N6O4/c1-5-22-18-25-24(12-13-28(39-4)36(25)33-22)30-20(3)17-27(38)35(34-30)14-6-7-15-40-23-10-8-21(9-11-23)29-19(2)16-26(37)31-32-29/h8-13,18-20H,5-7,14-17H2,1-4H3,(H,31,37) | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
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| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428588
(CHEMBL2337971)Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C1(C)C |t:15,30| Show InChI InChI=1S/C30H36N6O4/c1-6-21-18-24-23(13-14-26(39-5)36(24)33-21)28-30(3,4)29(38)35(34-28)15-7-8-16-40-22-11-9-20(10-12-22)27-19(2)17-25(37)31-32-27/h9-14,18-19H,6-8,15-17H2,1-5H3,(H,31,37) | PDB
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| CHEMBL
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UniChem
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| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559880
(CHEMBL4741180)Show SMILES Nc1nc2n(CCCOc3ccc(cc3)-c3nnn[nH]3)cnc2c(=O)[nH]1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559879
(CHEMBL4758355) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559883
(CHEMBL4783647)Show SMILES O=c1ccn(CCCCOc2ccc(cc2)-c2nnn[nH]2)c(=O)[nH]1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428589
(CHEMBL2337970)Show SMILES CCc1cc2c(ccc(OC)n2n1)-c1ccc(=O)n(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)n1 |t:33| Show InChI InChI=1S/C29H32N6O4/c1-4-21-18-25-23(11-14-28(38-3)35(25)32-21)24-12-13-27(37)34(33-24)15-5-6-16-39-22-9-7-20(8-10-22)29-19(2)17-26(36)30-31-29/h7-14,18-19H,4-6,15-17H2,1-3H3,(H,30,36) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50210628
(CHEMBL3946861)Show SMILES CCSc1ncc(-c2cc([nH]c(=N)c2C#N)-c2ccc(Br)cc2)n1Cc1ccccc1 Show InChI InChI=1S/C24H20BrN5S/c1-2-31-24-28-14-22(30(24)15-16-6-4-3-5-7-16)19-12-21(29-23(27)20(19)13-26)17-8-10-18(25)11-9-17/h3-12,14H,2,15H2,1H3,(H2,27,29) | PDB
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| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Hamdard University
Curated by ChEMBL
| Assay Description
Inhibition of human PDE3A using fluorescein-labelled cAMP as substrate measured after 60 mins by IMAP TR-FRET assay |
Eur J Med Chem 125: 143-189 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.023
BindingDB Entry DOI: 10.7270/Q23T9K6Z |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50210628
(CHEMBL3946861)Show SMILES CCSc1ncc(-c2cc([nH]c(=N)c2C#N)-c2ccc(Br)cc2)n1Cc1ccccc1 Show InChI InChI=1S/C24H20BrN5S/c1-2-31-24-28-14-22(30(24)15-16-6-4-3-5-7-16)19-12-21(29-23(27)20(19)13-26)17-8-10-18(25)11-9-17/h3-12,14H,2,15H2,1H3,(H2,27,29) | PDB
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UniChem
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| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N-terminal GST-tagged human PDE3A (484 to 1141 residues) expressed in Sf9 cells using cAMP as substrate after 60 mins by IM... |
Eur J Med Chem 150: 742-756 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.046
BindingDB Entry DOI: 10.7270/Q2JM2D83 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559886
(CHEMBL4792000) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50225508
(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)Show InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) | PDB
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MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559876
(CHEMBL4777633)Show SMILES O=c1ccn(CCCOc2ccc(cc2)-c2nnn[nH]2)c(=O)[nH]1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559888
(CHEMBL4783087)Show SMILES Cn1c2ncn(CCCCOc3ccc(cc3)-c3nnn[nH]3)c2c(=O)n(C)c1=O | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428587
(CHEMBL2337972)Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)C2(C)C)n2cc(nc12)C(F)(F)F |t:6,18| Show InChI InChI=1S/C28H27F5N6O4/c1-27(2)24(17-8-10-19(42-3)25-34-20(14-38(17)25)28(31,32)33)37-39(26(27)41)12-4-5-13-43-18-9-6-15(22(29)23(18)30)16-7-11-21(40)36-35-16/h6,8-10,14H,4-5,7,11-13H2,1-3H3,(H,36,40) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM15297
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23) | PDB
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CHEMBL
MCE
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 24 |
University of North Carolina
| Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate. |
J Biol Chem 287: 11788-97 (2012)
Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559877
(CHEMBL4796669)Show SMILES O=c1cnn(CCCOc2ccc(cc2)-c2nnn[nH]2)c(=O)[nH]1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559885
(CHEMBL4754536) | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428591
(CHEMBL2337968)Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)CC2C)c2cc(nn12)C(F)(F)F |t:6,18| Show InChI InChI=1S/C28H27F5N6O4/c1-15-13-23(41)38(37-27(15)17-6-10-24(42-2)39-19(17)14-21(36-39)28(31,32)33)11-3-4-12-43-20-8-5-16(25(29)26(20)30)18-7-9-22(40)35-34-18/h5-6,8,10,14-15H,3-4,7,9,11-13H2,1-2H3,(H,35,40) | PDB
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UniChem
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PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559881
(CHEMBL4757288)Show SMILES Cn1c2ncn(CCCOc3ccc(cc3)-c3nnn[nH]3)c2c(=O)n(C)c1=O | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568827
(US11427553, Example Intermediate 67)Show SMILES CC(C)(C)OC(=O)NCCNc1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |$;;;;;;;N;;;;;;;;;;;;;;;;;;;;$,t:22| | PDB
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| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568667
((6S)-6-Methyl-5-[4-(morpholin-4-yl)-3-(trifluorome...)Show SMILES C[C@@H]1OC(=O)NN=C1c1ccc(N2CCOCC2)c(C)c1 |r,c:6| | PDB
Reactome pathway
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50572927
(CHEMBL4862024)Show SMILES CCOc1ccc(cc1C(F)(F)F)C1=NNC(=O)O[C@H]1C |r,t:14| | PDB
Reactome pathway
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human full length PDE3A expressed in Sf9 cells measured after 60 mins by [3H]-cAMP Scintillation proximity assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00317
BindingDB Entry DOI: 10.7270/Q23J3HSQ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559878
(CHEMBL4748046) | PDB
Reactome pathway
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| Article
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| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559882
(CHEMBL4752339)Show SMILES Cn1cnc2n(C)c(=O)n(CCCOc3ccc(cc3)-c3nnn[nH]3)c(=O)c12 | PDB
Reactome pathway
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| Article
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| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559889
(CHEMBL4761400)Show SMILES Cn1cnc2n(C)c(=O)n(CCCCOc3ccc(cc3)-c3nnn[nH]3)c(=O)c12 | PDB
Reactome pathway
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| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559884
(CHEMBL4760080)Show SMILES O=c1cnn(CCCCOc2ccc(cc2)-c2nnn[nH]2)c(=O)[nH]1 | PDB
Reactome pathway
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| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428586
(CHEMBL2337973)Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)C2(C)C)c2sc(nc12)C(F)(F)F |t:6,18| Show InChI InChI=1S/C28H26F5N5O4S/c1-27(2)24(15-7-10-18(41-3)22-23(15)43-25(34-22)28(31,32)33)37-38(26(27)40)12-4-5-13-42-17-9-6-14(20(29)21(17)30)16-8-11-19(39)36-35-16/h6-7,9-10H,4-5,8,11-13H2,1-3H3,(H,36,39) | PDB
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| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50572924
(CHEMBL4876937)Show SMILES C[C@@H]1OC(=O)NN=C1c1ccc(OCCC(F)(F)F)c(c1)C(F)(F)F |r,c:6| | PDB
Reactome pathway
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human full length PDE3A expressed in Sf9 cells measured after 60 mins by [3H]-cAMP Scintillation proximity assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00317
BindingDB Entry DOI: 10.7270/Q23J3HSQ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50559887
(CHEMBL4747854)Show SMILES Nc1nc2n(CCCCOc3ccc(cc3)-c3nnn[nH]3)cnc2c(=O)[nH]1 | PDB
Reactome pathway
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| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115540
BindingDB Entry DOI: 10.7270/Q2G164HZ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50615689
(CHEMBL5283715)Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(Cl)c(Cl)c1 |r,c:6| | PDB
Reactome pathway
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TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50572925
(CHEMBL4877229)Show SMILES CCCOc1ccc(cc1C(F)(F)F)C1=NNC(=O)O[C@H]1C |r,t:15| | PDB
Reactome pathway
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TBA
| Assay Description
Inhibition of human full length PDE3A expressed in Sf9 cells measured after 60 mins by [3H]-cAMP Scintillation proximity assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00317
BindingDB Entry DOI: 10.7270/Q23J3HSQ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50615690
(CHEMBL5286823)Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(C)=O)c(Cl)c1 |r,c:6| | PDB
Reactome pathway
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| | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50350802
(CHEMBL1819121)Show InChI InChI=1S/C21H23N3O2/c1-25-19-11-17-18(12-20(19)26-2)22-14-23-21(17)24-10-6-9-16(13-24)15-7-4-3-5-8-15/h3-5,7-8,11-12,14,16H,6,9-10,13H2,1-2H3 | PDB
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| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A |
J Med Chem 54: 4536-47 (2011)
Article DOI: 10.1021/jm2001508
BindingDB Entry DOI: 10.7270/Q2PN961Q |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50572926
(CHEMBL4853029)Show SMILES C[C@@H](F)COc1ccc(cc1C(F)(F)F)C1=NNC(=O)O[C@H]1C |r,t:16| | PDB
Reactome pathway
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human full length PDE3A expressed in Sf9 cells measured after 60 mins by [3H]-cAMP Scintillation proximity assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00317
BindingDB Entry DOI: 10.7270/Q23J3HSQ |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50615688
(CHEMBL5280568)Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(N2CCOCC2)c(F)c1 |r,c:6| | PDB
Reactome pathway
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| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568851
(5-[4-(3-methyl-1H-indazol-6-yl)-3-(trifluoromethyl...)Show SMILES Cc1n[nH]c2cc(ccc12)-c1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |t:23| | PDB
Reactome pathway
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TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428578
(CHEMBL2337954)Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1C |t:15,29| Show InChI InChI=1S/C29H34N6O4/c1-5-21-17-24-23(11-12-27(38-4)35(24)32-21)29-19(3)16-26(37)34(33-29)13-6-14-39-22-9-7-20(8-10-22)28-18(2)15-25(36)30-31-28/h7-12,17-19H,5-6,13-16H2,1-4H3,(H,30,36) | PDB
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568817
((6S)-5-[4-(3-Hydroxy-3-methylazetidin-1-yl)-3-(tri...)Show SMILES C[C@@H]1OC(=O)NN=C1c1ccc(N2CC(C)(O)C2)c(c1)C(F)(F)F |r,c:6| | PDB
Reactome pathway
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TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568669
((rac)-6-Methyl-5-(4-morpholino-3-(trifluoromethyl)...)Show SMILES CC1OC(=O)NN=C1c1ccc(N2CCOCC2)c(c1)C(F)(F)F |c:6| | PDB
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TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568680
((rac)-5-[4′-Hydroxy-2-(trifluoromethyl)-2...)Show SMILES OC1CCC(=CC1)c1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |c:4,t:19| | PDB
Reactome pathway
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TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568764
(5-[4-(4-Hydroxypiperidin-1-yl)-3-(trifluoromethyl)...)Show SMILES OC1CCN(CC1)c1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |t:19| | PDB
Reactome pathway
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50338586
(CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...)Show SMILES CC(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2NC(=O)C(C)(C)c2c1 |w:2.2| Show InChI InChI=1S/C19H21N3O3S/c1-12-5-8-15(9-6-12)26(24,25)22-21-13(2)14-7-10-17-16(11-14)19(3,4)18(23)20-17/h5-11,22H,1-4H3,(H,20,23) | PDB
Reactome pathway
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| n/a | n/a | 14.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE3A |
Bioorg Med Chem Lett 21: 1617-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.120
BindingDB Entry DOI: 10.7270/Q2WQ043X |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568743
((cis/trans)-5-[4-{[3-hydroxycyclobutyl]amino}-3-(t...)Show SMILES OC1CC(C1)Nc1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |t:18,(-6.94,1.47,;-5.61,.7,;-4.12,1.1,;-3.72,-.38,;-5.21,-.78,;-2.39,-1.15,;-1.06,-.38,;-1.06,1.15,;.28,1.93,;1.61,1.15,;1.61,-.38,;.28,-1.15,;.28,-2.69,;1.61,-3.47,;-1.06,-3.47,;.28,-4.23,;2.94,1.93,;4.28,1.16,;5.61,1.93,;5.61,3.47,;6.94,4.23,;4.28,4.23,;2.94,3.47,)| | PDB
Reactome pathway
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TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428592
(CHEMBL2337967)Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)C4(C)C)c(F)c3F)C(=O)CC2C)c2cc(nn12)C(F)(F)F |t:6,18| Show InChI InChI=1S/C29H29F5N6O4/c1-15-13-21(41)39(38-25(15)16-8-10-22(43-4)40-18(16)14-20(37-40)29(32,33)34)11-5-6-12-44-19-9-7-17(23(30)24(19)31)26-28(2,3)27(42)36-35-26/h7-10,14-15H,5-6,11-13H2,1-4H3,(H,36,42) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50428580
(CHEMBL2337958)Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(cc3)C3=NNC(=O)CC3C)C(=O)CC2C)c2cc(nn12)C(F)(F)F |t:6,21| Show InChI InChI=1S/C29H31F3N6O4/c1-17-14-24(39)33-34-27(17)19-6-8-20(9-7-19)42-13-5-4-12-37-25(40)15-18(2)28(36-37)21-10-11-26(41-3)38-22(21)16-23(35-38)29(30,31)32/h6-11,16-18H,4-5,12-15H2,1-3H3,(H,33,39) | PDB
Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay |
Bioorg Med Chem Lett 23: 375-81 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568692
(5-{4-[1-(Propan-2-yl)-1H-pyrazol-4-yl]-3-(trifluor...)Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |t:20| | PDB
Reactome pathway
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antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568850
(5-[4-(2-methyl-1H-benzimidazol-5-yl)-3-(trifluorom...)Show SMILES Cc1nc2cc(ccc2[nH]1)-c1ccc(cc1C(F)(F)F)C1=NNC(=O)OC1 |t:23| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM568581
((6S)-5-(3,5-Difluoro-4-morpholinophenyl)-6-methyl-...)Show SMILES C[C@@H]1OC(=O)NN=C1c1cc(F)c(N2CCOCC2)c(F)c1 |r,c:6| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2280BTW |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50042053
(CHEMBL3360172)Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)C1(CC1)C#N Show InChI InChI=1S/C23H23FN6O2S/c1-2-30-20(31)19-18(28-22(30)27-17-5-8-26-10-16(17)24)15(12-33-19)14-4-3-9-29(11-14)21(32)23(13-25)6-7-23/h5,8,10,12,14H,2-4,6-7,9,11H2,1H3,(H,26,27,28) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 607-8042
Curated by ChEMBL
| Assay Description
Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem Lett 25: 649-53 (2015)
Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P |
More data for this
Ligand-Target Pair | |
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