Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203368 (US9242981, 113) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203365 (US9242981, 110) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50094464 (CHEMBL3590107 | US10525036, Example SCH772984 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.0501 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50505988 (CHEMBL4482864) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 0.0501 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203378 (US9242981, 123) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50505988 (CHEMBL4482864) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50094464 (CHEMBL3590107 | US10525036, Example SCH772984 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203367 (US9242981, 112) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203349 (US9242981, 84) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203364 (US9242981, 109) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203339 (US9242981, 71) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203321 (US9242981, 53) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50265959 (CHEMBL4071576) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.158 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203326 (US9242981, 58) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203325 (US9242981, 57) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203337 (US9242981, 69) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50094465 (CHEMBL3590106 | US10525036, Example BVD-523 | US10...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.316 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203319 (US9242981, 48) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203355 (US9242981, 100) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203329 (US9242981, 61) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203322 (US9242981, 54) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203317 (US9242981, 46) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50265959 (CHEMBL4071576) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203328 (US9242981, 60) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.12 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203343 (US9242981, 75) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.36 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203327 (US9242981, 59) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.51 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203344 (US9242981, 76) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.55 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM120095 (US10525036, Example GDC-0994 | US10934304, Example...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM120095 (US10525036, Example GDC-0994 | US10934304, Example...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203330 (US9242981, 62) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM203308 (US9242981, 37) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluoresc... | US Patent US9242981 (2016) BindingDB Entry DOI: 10.7270/Q2GM864G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50094465 (CHEMBL3590106 | US10525036, Example BVD-523 | US10...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysis | J Med Chem 62: 11004-11018 (2019) Article DOI: 10.1021/acs.jmedchem.9b01295 BindingDB Entry DOI: 10.7270/Q24X5C3Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50254739 (CHEMBL4079223) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a |
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States. Curated by ChEMBL | Assay Description Binding affinity to full length wild type human ERK2 (M1 to P379 residues) expressed in bacterial expression system by KINOMEscan assay | ACS Med Chem Lett 8: 726-731 (2017) Article DOI: 10.1021/acsmedchemlett.7b00127 BindingDB Entry DOI: 10.7270/Q2ZW1PCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176676 (US9115122, 2.3.2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176678 (US9115122, SF-2-054) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM103302 (SCH772984 | US8546404, 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 233 | n/a | n/a | n/a | 7.5 | 15 |
George Washington University | Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250... | Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM103302 (SCH772984 | US8546404, 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | 7.5 | 30 |
George Washington University | Assay Description For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250... | Nat Chem Biol 10: 853-860 (2014) Article DOI: 10.1038/nchembio.1629 BindingDB Entry DOI: 10.7270/Q28G8JCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM482158 (BDBM50242742 | TAE684) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by ChEMBL | Assay Description Binding constant for ERK2 kinase domain | Nat Biotechnol 29: 1046-51 (2011) Article DOI: 10.1038/nbt.1990 BindingDB Entry DOI: 10.7270/Q25D8S70 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50601917 (CHEMBL5180873) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01244 BindingDB Entry DOI: 10.7270/Q2HT2TF2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176678 (US9115122, SF-2-054) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50254740 (CHEMBL4104378) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a |
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States. Curated by ChEMBL | Assay Description Binding affinity to C-terminal FLAG-tagged human ERK2 expressed in Escherichia coli (DE3) after 30 mins by fluorescence polarization assay | ACS Med Chem Lett 8: 726-731 (2017) Article DOI: 10.1021/acsmedchemlett.7b00127 BindingDB Entry DOI: 10.7270/Q2ZW1PCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50229978 (5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Binding affinity to ERK2 (unknown origin) by isothermal titration calorimetry | J Med Chem 56: 2155-9 (2013) Article DOI: 10.1021/jm301603n BindingDB Entry DOI: 10.7270/Q2PR7X98 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50030882 (CHEMBL3356114) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity to non-phosphorylated Erk2 (unknown origin) by TdF assay | Bioorg Med Chem Lett 25: 1627-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.049 BindingDB Entry DOI: 10.7270/Q2BK1F1S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176677 (US9115122, SF-2-062) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176678 (US9115122, SF-2-054) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50440018 (CHEMBL2425628) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a |
Roche Palo Alto Curated by ChEMBL | Assay Description Binding affinity to ERK2 (unknown origin) | Bioorg Med Chem Lett 23: 1486-92 (2013) Article DOI: 10.1016/j.bmcl.2012.12.047 BindingDB Entry DOI: 10.7270/Q20003HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176674 (US9115122, 76.3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50030882 (CHEMBL3356114) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity to activated Erk2 (unknown origin) by TdF assay | Bioorg Med Chem Lett 25: 1627-9 (2015) Article DOI: 10.1016/j.bmcl.2015.01.049 BindingDB Entry DOI: 10.7270/Q2BK1F1S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176675 (US9115122, 76.4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM176673 (US9115122, 76.2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF MARYLAND, BALTIMORE US Patent | Assay Description CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ... | US Patent US9115122 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JP7 | |||||||||||
More data for this Ligand-Target Pair |
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