Found 18 hits of ki data for polymerid = 3989 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM159183
(US9034866, 660)Show SMILES Cc1cnc(o1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |r,wU:6.8,wD:6.7,(8.21,.73,;6.88,-.04,;6.4,-1.51,;4.86,-1.51,;4.38,-.04,;5.63,.86,;3.05,.73,;4.38,1.5,;3.05,2.27,;1.72,-.04,;.38,-.81,;-.95,-1.58,;-.95,-3.12,;-2.28,-3.89,;-3.62,-3.12,;-4.82,-4.08,;-6.32,-3.74,;-6.99,-2.35,;-5.21,-2.35,;-6.32,-.98,;-7.23,.26,;-6.32,1.51,;-4.86,1.03,;-4.86,-.51,;-3.62,-1.58,;-2.28,-.81,;-6.72,3,;-5.63,4.08,;-8.21,3.39,)| Show InChI InChI=1S/C22H20N4O3/c1-12-10-24-21(29-12)22(2,28)6-5-13-3-4-16-14-8-15(9-14)26-11-18(19(23)27)25-20(26)17(16)7-13/h3-4,7,10-11,14-15,28H,8-9H2,1-2H3,(H2,23,27)/t14?,15?,22-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502741
(CHEMBL4517096)Show SMILES Cc1cnc(o1)C(C)(C)C#Cc1ccc2C3CC(C3)n3c(nc(C(N)=O)c3C3CC3)-c2c1 |(46.46,-35.32,;44.92,-35.41,;44.1,-36.7,;42.62,-36.32,;42.52,-34.79,;43.95,-34.23,;41.23,-33.97,;40.44,-32.67,;42.05,-32.66,;40.1,-35.02,;38.97,-36.07,;37.85,-37.12,;38.19,-38.63,;37.06,-39.68,;35.59,-39.22,;34.62,-40.41,;33.08,-40.4,;32.13,-39.18,;33.76,-38.96,;32.49,-37.68,;33.88,-37.04,;33.7,-35.52,;32.2,-35.22,;31.55,-33.82,;32.44,-32.56,;30.02,-33.68,;31.45,-36.55,;29.92,-36.74,;28.51,-36.13,;28.69,-37.66,;35.25,-37.72,;36.38,-36.67,)| Show InChI InChI=1S/C26H26N4O2/c1-14-13-28-25(32-14)26(2,3)9-8-15-4-7-19-17-11-18(12-17)30-22(16-5-6-16)21(23(27)31)29-24(30)20(19)10-15/h4,7,10,13,16-18H,5-6,11-12H2,1-3H3,(H2,27,31) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502745
(CHEMBL4444206)Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC(C)(C)c1ncc(C)o1)C(N)=O |(28.83,-24.05,;30.36,-23.87,;30.97,-22.45,;30.05,-21.22,;32.5,-22.27,;33.25,-20.94,;34.75,-21.24,;34.93,-22.75,;36.3,-23.44,;37.43,-22.39,;38.89,-22.84,;39.24,-24.35,;38.11,-25.4,;36.64,-24.94,;35.67,-26.13,;34.13,-26.12,;33.18,-24.9,;34.81,-24.68,;33.54,-23.39,;40.02,-21.79,;41.15,-20.74,;42.28,-19.69,;41.49,-18.39,;43.1,-18.38,;43.57,-20.51,;43.67,-22.04,;45.15,-22.42,;45.97,-21.13,;47.51,-21.04,;45,-19.95,;32.6,-19.54,;33.49,-18.28,;31.07,-19.4,)| Show InChI InChI=1S/C25H25N5O3/c1-13-12-28-24(33-13)25(2,3)8-7-14-5-6-17-15-10-16(11-15)30-20(23(32)27-4)19(21(26)31)29-22(30)18(17)9-14/h5-6,9,12,15-16H,10-11H2,1-4H3,(H2,26,31)(H,27,32) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158743
(US9034866, 218)Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(C(N)=O)c(C4CC4)n3C3CC(C3)c2cc1F |r,wU:6.8,wD:6.9,(-9.15,-.72,;-7.82,-1.49,;-6.57,-.59,;-5.32,-1.49,;-5.8,-2.96,;-7.34,-2.96,;-3.99,-.72,;-3.22,-2.06,;-5.32,.05,;-2.66,.05,;-1.32,.82,;.01,1.59,;1.34,.82,;2.68,1.59,;3.88,.63,;3.74,-.91,;5.16,-1.51,;5.56,-3,;4.47,-4.09,;7.05,-3.4,;6.17,-.35,;7.66,-.75,;8.75,-1.84,;9.15,-.35,;5.38,.97,;6.05,2.36,;5.38,3.75,;3.88,4.09,;4.56,2.76,;2.68,3.13,;1.34,3.9,;.01,3.13,;-1.32,3.9,)| Show InChI InChI=1S/C25H23FN4O3/c1-12-7-20(29-33-12)25(2,32)6-5-14-10-18-17(11-19(14)26)15-8-16(9-15)30-22(13-3-4-13)21(23(27)31)28-24(18)30/h7,10-11,13,15-16,32H,3-4,8-9H2,1-2H3,(H2,27,31)/t15?,16?,25-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502746
(CHEMBL3941082)Show SMILES Cc1cc(no1)[C@@](C)(O)C#Cc1ccc2OCCn3c(C4CC4)c(nc3-c2c1)C(N)=O |r| Show InChI InChI=1S/C23H22N4O4/c1-13-11-18(26-31-13)23(2,29)8-7-14-3-6-17-16(12-14)22-25-19(21(24)28)20(15-4-5-15)27(22)9-10-30-17/h3,6,11-12,15,29H,4-5,9-10H2,1-2H3,(H2,24,28)/t23-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| <0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158675
(US9034866, 150)Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |r,wU:6.8,wD:6.7,(8.1,.72,;6.76,-.05,;5.52,.86,;4.27,-.05,;4.75,-1.51,;6.29,-1.51,;2.94,.72,;4.27,1.49,;2.94,2.26,;1.6,-.05,;.27,-.82,;-1.06,-1.59,;-1.06,-3.13,;-2.4,-3.9,;-3.73,-3.13,;-4.93,-4.09,;-6.44,-3.75,;-7.1,-2.36,;-5.49,-2.59,;-6.44,-.97,;-7.22,.35,;-6.21,1.51,;-4.8,.91,;-4.93,-.63,;-3.73,-1.59,;-2.4,-.82,;-6.61,3,;-5.52,4.09,;-8.1,3.4,)| Show InChI InChI=1S/C22H20N4O3/c1-12-7-19(25-29-12)22(2,28)6-5-13-3-4-16-14-9-15(10-14)26-11-18(20(23)27)24-21(26)17(16)8-13/h3-4,7-8,11,14-15,28H,9-10H2,1-2H3,(H2,23,27)/t14?,15?,22-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502744
(CHEMBL4524153)Show SMILES CCOc1nc2ccc(cc2n1-c1ccnc(N)n1)C#C[C@@](C)(O)c1ncc(C)o1 |r| Show InChI InChI=1S/C21H20N6O3/c1-4-29-20-25-15-6-5-14(7-9-21(3,28)18-24-12-13(2)30-18)11-16(15)27(20)17-8-10-23-19(22)26-17/h5-6,8,10-12,28H,4H2,1-3H3,(H2,22,23,26)/t21-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM159182
(US9034866, 659)Show SMILES Cc1cnc(o1)[C@@](C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |r,wU:6.7,wD:6.8,(8.21,.73,;6.88,-.04,;6.4,-1.51,;4.86,-1.51,;4.38,-.04,;5.63,.86,;3.05,.73,;4.38,1.5,;2.65,2.21,;1.72,-.04,;.38,-.81,;-.95,-1.58,;-.95,-3.12,;-2.28,-3.89,;-3.62,-3.12,;-4.82,-4.08,;-6.32,-3.74,;-6.99,-2.35,;-5.21,-2.35,;-6.32,-.98,;-7.23,.26,;-6.32,1.51,;-4.86,1.03,;-4.86,-.51,;-3.62,-1.58,;-2.28,-.81,;-6.72,3,;-5.63,4.08,;-8.21,3.39,)| Show InChI InChI=1S/C22H20N4O3/c1-12-10-24-21(29-12)22(2,28)6-5-13-3-4-16-14-8-15(9-14)26-11-18(19(23)27)25-20(26)17(16)7-13/h3-4,7,10-11,14-15,28H,8-9H2,1-2H3,(H2,23,27)/t14?,15?,22-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158533
(US9034866, 8)Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccc2OCCn3cc(nc3-c2c1)C(N)=O |r| Show InChI InChI=1S/C20H18N4O4/c1-12-9-17(23-28-12)20(2,26)6-5-13-3-4-16-14(10-13)19-22-15(18(21)25)11-24(19)7-8-27-16/h3-4,9-11,26H,7-8H2,1-2H3,(H2,21,25)/t20-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158654
(US9034866, 129)Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(cn3C3CC(C3)c2cc1F)C(N)=O |r,wU:6.7,wD:6.8,(3.31,5.03,;4.08,3.69,;3.61,2.23,;4.85,1.32,;6.1,2.23,;5.62,3.69,;4.85,-.22,;6.19,.55,;6.19,-.99,;3.52,-.99,;2.18,-1.76,;.85,-2.53,;-.48,-1.76,;-1.82,-2.53,;-3.02,-1.57,;-2.88,-.03,;-4.3,.57,;-5.31,-.59,;-4.52,-1.91,;-5.19,-3.3,;-4.52,-4.68,;-3.02,-5.03,;-3.58,-3.53,;-1.82,-4.07,;-.48,-4.84,;.85,-4.07,;2.18,-4.84,;-4.7,2.06,;-6.19,2.46,;-3.61,3.15,)| Show InChI InChI=1S/C22H19FN4O3/c1-11-5-19(26-30-11)22(2,29)4-3-12-8-16-15(9-17(12)23)13-6-14(7-13)27-10-18(20(24)28)25-21(16)27/h5,8-10,13-14,29H,6-7H2,1-2H3,(H2,24,28)/t13?,14?,22-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158645
(US9034866, 120)Show SMILES Cc1cc(no1)[C@@](C)(O)C#Cc1ccc2OCCn3cc(nc3-c2c1)C(N)=O |r| Show InChI InChI=1S/C20H18N4O4/c1-12-9-17(23-28-12)20(2,26)6-5-13-3-4-16-14(10-13)19-22-15(18(21)25)11-24(19)7-8-27-16/h3-4,9-11,26H,7-8H2,1-2H3,(H2,21,25)/t20-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM158562
(US9034866, 37)Show SMILES NC(=O)c1cn2C3CC(C3)c3ccc(cc3-c2n1)C#CC1(O)CCCC1 |(4.13,-4.09,;5.22,-3,;6.7,-3.4,;4.82,-1.51,;5.83,-.35,;5.04,.97,;5.71,2.36,;5.04,3.75,;3.54,4.09,;4.15,2.65,;2.34,3.13,;1,3.9,;-.33,3.13,;-.33,1.59,;1,.82,;2.34,1.59,;3.54,.63,;3.4,-.91,;-1.67,.82,;-3,.05,;-4.33,-.72,;-4.33,.82,;-5.8,-.25,;-6.7,-1.49,;-5.8,-2.74,;-4.33,-2.26,)| Show InChI InChI=1S/C21H21N3O2/c22-19(25)18-12-24-15-10-14(11-15)16-4-3-13(9-17(16)20(24)23-18)5-8-21(26)6-1-2-7-21/h3-4,9,12,14-15,26H,1-2,6-7,10-11H2,(H2,22,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502743
(CHEMBL4461552)Show SMILES NC(=O)c1cn2C3CC(C3)c3ccc(cc3-c2n1)C#CC1CCCC1 |(31.97,-3.51,;31.08,-4.77,;29.55,-4.63,;31.73,-6.17,;30.98,-7.5,;32.02,-8.62,;31.66,-10.13,;32.61,-11.35,;34.15,-11.36,;33.3,-9.91,;35.12,-10.17,;36.59,-10.62,;37.72,-9.58,;37.38,-8.07,;35.91,-7.62,;34.79,-8.67,;33.41,-7.98,;33.23,-6.46,;38.5,-7.02,;39.63,-5.97,;40.76,-4.91,;42.27,-5.21,;43.02,-3.86,;41.96,-2.73,;40.56,-3.39,)| Show InChI InChI=1S/C21H21N3O/c22-20(25)19-12-24-16-10-15(11-16)17-8-7-14(9-18(17)21(24)23-19)6-5-13-3-1-2-4-13/h7-9,12-13,15-16H,1-4,10-11H2,(H2,22,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502747
(CHEMBL4546659)Show SMILES CCOc1nc2ccc(cc2n1-c1ccnc(N)n1)C#C[C@](C)(O)c1ncc(C)o1 |r| Show InChI InChI=1S/C21H20N6O3/c1-4-29-20-25-15-6-5-14(7-9-21(3,28)18-24-12-13(2)30-18)11-16(15)27(20)17-8-10-23-19(22)26-17/h5-6,8,10-12,28H,4H2,1-3H3,(H2,22,23,26)/t21-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50502742
(CHEMBL3978002)Show SMILES [H]C12CC([H])(C1)n1cc(nc1-c1cc(ccc21)C#C[C@](C)(O)c1cc(C)on1)C(N)=O |r,wD:19.23,(1.78,4.35,;3.05,3.48,;4.57,3.77,;4.85,2.25,;6.13,1.38,;3.34,1.97,;5.31,.78,;5.08,-.74,;4.21,-2.01,;2.87,-2.78,;1.34,-2.9,;-.1,-2.33,;-1.14,-1.2,;-1.6,.27,;-1.36,1.79,;-.5,3.06,;.84,3.83,;-3.13,.15,;-4.67,.04,;-6.2,-.07,;-7.74,-.19,;-6.32,1.46,;-6.09,-1.61,;-4.78,-2.42,;-5.15,-3.92,;-4.15,-5.09,;-6.68,-4.03,;-7.26,-2.6,;5.25,-3.14,;4.8,-4.61,;6.76,-2.8,)| Show InChI InChI=1S/C22H20N4O3/c1-12-7-19(25-29-12)22(2,28)6-5-13-3-4-16-14-9-15(10-14)26-11-18(20(23)27)24-21(26)17(16)8-13/h3-4,7-8,11,14-15,28H,9-10H2,1-2H3,(H2,23,27)/t14?,15?,22-/m0/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of full length GST-tagged human PRKD1 expressed in Baculovirus expression system using ATP as substrate incubated for 1 to 2 hrs by transc... |
ACS Med Chem Lett 10: 1260-1265 (2019)
Article DOI: 10.1021/acsmedchemlett.8b00658
BindingDB Entry DOI: 10.7270/Q2GF0XRG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50463483
(CHEMBL4245242)Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of PRKD1 (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50463479
(CHEMBL4249925)Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description
Inhibition of PRKD1 (unknown origin) |
Bioorg Med Chem Lett 28: 2622-2626 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase D1
(Homo sapiens (Human)) | BDBM50427363
(CHEMBL2326002)Show SMILES CC(C)[C@@](C)(O)[C@@H]1CN(CCN1)c1nc(-c2n[nH]c3ncccc23)c(F)cc1Cl |r| Show InChI InChI=1S/C20H24ClFN6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-13(21)9-14(22)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1 | NCI pathway
Reactome pathway
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals (Europe) Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of PKC mu (unknown origin) |
J Med Chem 56: 1799-810 (2013)
Article DOI: 10.1021/jm301465a
BindingDB Entry DOI: 10.7270/Q2M046R2 |
More data for this
Ligand-Target Pair | |
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