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Compile Data Set for Download or QSAR

Found 500 hits Enz. Inhib. hit(s) with Target = 'Insulin receptor-related protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 0.400n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Antagonist activity human P2Y14R expressed in African green monkey COS7 cells assessed as inhibition of UDPG-induced [3H]inositol phosphate accumulat...


J Med Chem 59: 6149-68 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00044
BindingDB Entry DOI: 10.7270/Q2DJ5K34
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 0.400n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 0.400n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Antagonist activity human P2Y14R expressed in African green monkey COS7 cells assessed as inhibition of UDPG-induced [3H]inositol phosphate accumulat...


J Med Chem 59: 6149-68 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00044
BindingDB Entry DOI: 10.7270/Q2DJ5K34
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515480
PNG
(CHEMBL4436879)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C1CCNCC1)C(O)=O
Show InChI InChI=1S/C26H26N2O3/c1-17-2-4-21(5-3-17)25(29)28-24-15-22(14-23(16-24)26(30)31)19-8-6-18(7-9-19)20-10-12-27-13-11-20/h2-9,14-16,20,27H,10-13H2,1H3,(H,28,29)(H,30,31)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515480
PNG
(CHEMBL4436879)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C1CCNCC1)C(O)=O
Show InChI InChI=1S/C26H26N2O3/c1-17-2-4-21(5-3-17)25(29)28-24-15-22(14-23(16-24)26(30)31)19-8-6-18(7-9-19)20-10-12-27-13-11-20/h2-9,14-16,20,27H,10-13H2,1H3,(H,28,29)(H,30,31)
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602122
PNG
(CHEMBL5208130)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(F)cc1)C(O)=O
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n/an/a 1.90n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596039
PNG
(CHEMBL5186555)
Show SMILES COc1ccc(CC(=O)Nc2cccc(c2)-c2nc3ccccc3o2)cc1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50569005
PNG
(CHEMBL4854775)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1ccoc1)C(O)=O
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50569007
PNG
(CHEMBL4858280)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1cc[nH]n1)C(O)=O
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n/an/a 2.60n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50569006
PNG
(CHEMBL4875670)
Show SMILES Cc1noc(C)c1-c1cc(NC(=O)c2ccc(C)cc2)cc(c1)C(O)=O
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50584891
PNG
(CHEMBL5085823)
Show SMILES [H][C@@]12C[C@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@@]([H])(CN1)C2 |r|
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n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50584891
PNG
(CHEMBL5085823)
Show SMILES [H][C@@]12C[C@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@@]([H])(CN1)C2 |r|
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n/an/a 3.11n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515476
PNG
(CHEMBL4577585)
Show SMILES OC(=O)c1cc(NC(=O)c2ccncc2)cc(c1)-c1ccc(cc1)C1CCNCC1
Show InChI InChI=1S/C24H23N3O3/c28-23(19-7-11-26-12-8-19)27-22-14-20(13-21(15-22)24(29)30)17-3-1-16(2-4-17)18-5-9-25-10-6-18/h1-4,7-8,11-15,18,25H,5-6,9-10H2,(H,27,28)(H,29,30)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602119
PNG
(CHEMBL5194881)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(cc1)C(F)(F)F)C(O)=O
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602131
PNG
(CHEMBL5203559)
Show SMILES CC(=O)c1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(F)cc1)C(O)=O
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602108
PNG
(CHEMBL5182459)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1cc(F)c(F)c(F)c1)C(O)=O
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n/an/a 4n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602109
PNG
(CHEMBL5175291)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(F)c(F)c1)C(O)=O
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515477
PNG
(CHEMBL4538561)
Show SMILES OC(=O)c1cc(NC(=O)c2cnccn2)cc(c1)-c1ccc(cc1)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3/c28-22(21-14-25-9-10-26-21)27-20-12-18(11-19(13-20)23(29)30)16-3-1-15(2-4-16)17-5-7-24-8-6-17/h1-4,9-14,17,24H,5-8H2,(H,27,28)(H,29,30)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515478
PNG
(CHEMBL4455311)
Show SMILES OC(=O)c1cc(NC(=O)c2ccc(cc2)C#N)cc(c1)-c1ccc(cc1)C1CCNCC1
Show InChI InChI=1S/C26H23N3O3/c27-16-17-1-3-21(4-2-17)25(30)29-24-14-22(13-23(15-24)26(31)32)19-7-5-18(6-8-19)20-9-11-28-12-10-20/h1-8,13-15,20,28H,9-12H2,(H,29,30)(H,31,32)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602115
PNG
(CHEMBL5192153)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(cc1)C#N)C(O)=O
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n/an/a 4.70n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602130
PNG
(CHEMBL5189241)
Show SMILES CCc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(F)cc1)C(O)=O
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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596040
PNG
(CHEMBL5193065)
Show SMILES FC(F)(F)Oc1ccc(CC(=O)Nc2cccc(c2)-c2nc3ccccc3o2)cc1
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Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602117
PNG
(CHEMBL5185002)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccccc1C(F)(F)F)C(O)=O
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n/an/a 4.80n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50569003
PNG
(CHEMBL4857372)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1ccccc1)C(O)=O
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515475
PNG
(CHEMBL4458922)
Show SMILES OC(=O)c1cc(NC(=O)c2ccccc2)cc(c1)-c1ccc(cc1)C1CCNCC1
Show InChI InChI=1S/C25H24N2O3/c28-24(20-4-2-1-3-5-20)27-23-15-21(14-22(16-23)25(29)30)18-8-6-17(7-9-18)19-10-12-26-13-11-19/h1-9,14-16,19,26H,10-13H2,(H,27,28)(H,29,30)
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n/an/a 5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602116
PNG
(CHEMBL5195243)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(cc1)[N+]([O-])=O)C(O)=O
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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50515479
PNG
(CHEMBL4526840)
Show SMILES OC(=O)c1cc(NC(=O)c2ccc(cc2)[N+]([O-])=O)cc(c1)-c1ccc(cc1)C1CCNCC1
Show InChI InChI=1S/C25H23N3O5/c29-24(19-5-7-23(8-6-19)28(32)33)27-22-14-20(13-21(15-22)25(30)31)17-3-1-16(2-4-17)18-9-11-26-12-10-18/h1-8,13-15,18,26H,9-12H2,(H,27,29)(H,30,31)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhib...


Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111564
BindingDB Entry DOI: 10.7270/Q20005D2
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602121
PNG
(CHEMBL5203936)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1cccc(F)c1)C(O)=O
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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602111
PNG
(CHEMBL5182261)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1cc(C)cc(C)c1)C(O)=O
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Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 6n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,...


J Med Chem 59: 6149-68 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00044
BindingDB Entry DOI: 10.7270/Q2DJ5K34
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 6n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,...


J Med Chem 59: 6149-68 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00044
BindingDB Entry DOI: 10.7270/Q2DJ5K34
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 6n/an/an/an/an/an/a



Saint Louis University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-...


ACS Med Chem Lett 11: 1281-1286 (2020)


Article DOI: 10.1021/acsmedchemlett.0c00115
BindingDB Entry DOI: 10.7270/Q2222Z99
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596035
PNG
(CHEMBL5189611)
Show SMILES FC(F)(F)c1ccc(CC(=O)Nc2cccc(c2)-c2nc3cc(Cl)ccc3o2)cc1
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n/an/a 6.10n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596034
PNG
(CHEMBL5175004)
Show SMILES Cc1ccc(CC(=O)Nc2cccc(c2)-c2nc3cc(Cl)ccc3o2)cc1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50602125
PNG
(CHEMBL5208342)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1Cc1ccc(Cl)cc1)C(O)=O
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.2c01632
BindingDB Entry DOI: 10.7270/Q26D5Z20
More data for this
Ligand-Target Pair
Insulin receptor-related protein


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 7.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human IRR using MBP as substrate by [gamma-33P]-ATP assay


Citation and Details

Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 8n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow...


J Med Chem 61: 4860-4882 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00168
BindingDB Entry DOI: 10.7270/Q2X069NH
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to human P2Y14 expressed in CHO cells incubated for 30 mins


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50584883
PNG
(CHEMBL5074765)
Show SMILES [H][C@]12C[C@@H](c3ccc(cc3)-c3cc(cc4cc(ccc34)-c3ccc(cc3)C(F)(F)F)C(O)=O)[C@]([H])(CN1)C2 |r|
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n/an/a 8.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596030
PNG
(CHEMBL5191983)
Show SMILES Cc1ccc(CC(=O)Nc2cccc(c2)-c2nc3ccccc3o2)cc1
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n/an/a 8.70n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596045
PNG
(CHEMBL5172530)
Show SMILES COc1ccc(CC(=O)Nc2cccc(c2)-c2nc3cc(Cl)ccc3o2)cc1
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n/an/a 9.20n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596031
PNG
(CHEMBL5204942)
Show SMILES Cc1ccccc1CC(=O)Nc1cccc(c1)-c1nc2ccccc2o1
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n/an/a 9.30n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50569004
PNG
(CHEMBL4871413)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(cc(c1)-c1ccsc1)C(O)=O
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TBA

Assay Description
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo ass...


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113313
BindingDB Entry DOI: 10.7270/Q2D50RQK
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596037
PNG
(CHEMBL5180780)
Show SMILES Cc1cccc(CC(=O)Nc2cc(C)cc(c2)-c2nc3cc(Cl)ccc3o2)c1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50456168
PNG
(CHEMBL1800685)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H24F3NO2/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20/h1-10,15-17,20,33H,11-14H2,(H,34,35)
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n/an/a 9.80n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 m...


J Med Chem 63: 9563-9589 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00745
BindingDB Entry DOI: 10.7270/Q20R9SZP
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50584896
PNG
(CHEMBL5087295)
Show SMILES [H][C@]12CN[C@]([H])(C1)[C@@H](C2)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
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TBA

Assay Description
Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01964
BindingDB Entry DOI: 10.7270/Q2611470
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Homo sapiens (Human))
BDBM50596048
PNG
(CHEMBL5186024)
Show SMILES FC(F)(F)Oc1ccc(CC(=O)Nc2cccc(c2)-c2nc3cc(Cl)ccc3o2)cc1
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113933
BindingDB Entry DOI: 10.7270/Q200063F
More data for this
Ligand-Target Pair
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