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Patent code US10709709

Compile Data Set for Download or QSAR

Found 212 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451181
PNG
(US10709709, Example 7)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2cccc(Cl)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20ClN3O3/c1-10-13-5-6-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-3-2-4-12(20)7-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

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n/an/a 120n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451185
PNG
(US10709709, Example 11)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2ccc(Cl)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20ClN3O3/c1-10-13-6-7-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-2-4-12(20)5-3-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

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n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451201
PNG
(US10709709, Example 27)
Show SMILES O[C@H]([C@H]1C[C@@H](Nc2ncnc3[nH]ccc23)[C@H](O)[C@@H]1O)c1ccc(F)c(F)c1 |r|
PDB

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n/an/a 449n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451203
PNG
(US10709709, Example 29)
Show SMILES OC([C@H]1C[C@@H](Nc2ncnc3c(cccc23)C#N)[C@H](O)[C@@H]1O)c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C21H18F2N4O3/c22-14-5-4-10(6-15(14)23)18(28)13-7-16(20(30)19(13)29)27-21-12-3-1-2-11(8-24)17(12)25-9-26-21/h1-6,9,13,16,18-20,28-30H,7H2,(H,25,26,27)/t13-,16-,18?,19-,20+/m1/s1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451205
PNG
(US10709709, Example 31)
Show SMILES CN([C@@H]1C[C@H]([C@@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ccncn1 |r|
Show InChI InChI=1S/C17H19F2N3O3/c1-22(14-4-5-20-8-21-14)13-7-10(16(24)17(13)25)15(23)9-2-3-11(18)12(19)6-9/h2-6,8,10,13,15-17,23-25H,7H2,1H3/t10-,13-,15+,16-,17+/m1/s1
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n/an/a 466n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451223
PNG
(US10709709, Example 50)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)[C@](F)(CN)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22F2N4O2/c1-11-14-6-7-26(19(14)25-10-24-11)16-8-15(17(27)18(16)28)20(22,9-23)12-2-4-13(21)5-3-12/h2-7,10,15-18,27-28H,8-9,23H2,1H3/t15-,16+,17+,18-,20-/m0/s1
PDB

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n/an/a 1.89E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451236
PNG
(US10709709, Example 63)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccccc2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H22N4O3/c1-11-13-6-7-23(19(13)22-10-21-11)14-8-16(18(25)17(14)24)26-15-5-3-2-4-12(15)9-20/h2-7,10,14,16-18,24-25H,8-9,20H2,1H3/t14-,16+,17+,18-/m1/s1
PDB

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n/an/a 1.06E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451238
PNG
(US10709709, Example 65)
Show SMILES Cc1cc(N[C@H]2C[C@@H](Oc3ccccc3C#N)[C@H](O)[C@@H]2O)ncn1 |r|
Show InChI InChI=1S/C17H18N4O3/c1-10-6-15(20-9-19-10)21-12-7-14(17(23)16(12)22)24-13-5-3-2-4-11(13)8-18/h2-6,9,12,14,16-17,22-23H,7H2,1H3,(H,19,20,21)/t12-,14+,16+,17-/m0/s1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451266
PNG
(US10709709, Example 93)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451267
PNG
(US10709709, Example 94)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22BrFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451270
PNG
(US10709709, Example 97)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(C)(C)O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H30N4O4/c1-13-16-5-7-28(23(16)27-12-26-13)18-10-20(22(30)21(18)29)32-19-9-15(24(2,3)31)8-14-4-6-25-11-17(14)19/h5,7-9,12,18,20-22,25,29-31H,4,6,10-11H2,1-3H3/t18-,20+,21+,22-/m1/s1
PDB

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n/an/a 65n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451274
PNG
(US10709709, Example 101)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21BrFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451278
PNG
(US10709709, Example 105)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C21H24FN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451279
PNG
(US10709709, Example 106)
Show SMILES CCc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C22H26FN5O3/c1-2-11-5-12-3-4-25-8-13(12)16(6-11)31-17-7-15(19(29)20(17)30)28-9-14(23)18-21(24)26-10-27-22(18)28/h5-6,9-10,15,17,19-20,25,29-30H,2-4,7-8H2,1H3,(H2,24,26,27)/t15-,17+,19+,20-/m1/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451283
PNG
(US10709709, Example 110 | US10709709, Example 111)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cccc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H22FN5O3/c21-12-8-26(20-16(12)19(22)24-9-25-20)13-6-15(18(28)17(13)27)29-14-3-1-2-10-4-5-23-7-11(10)14/h1-3,8-9,13,15,17-18,23,27-28H,4-7H2,(H2,22,24,25)/t13-,15+,17+,18-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451303
PNG
(US10709709, Example 130)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21Cl2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451320
PNG
(US10709709, Example 147)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)c(Cl)cc2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20Cl2N4O3/c1-9-11-2-3-25(19(11)24-8-23-9)14-6-16(18(27)17(14)26)28-15-5-13(21)12(20)4-10(15)7-22/h2-5,8,14,16-18,26-27H,6-7,22H2,1H3/t14-,16+,17+,18-/m1/s1
PDB

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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451321
PNG
(US10709709, Example 148)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)c(F)cc2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20F2N4O3/c1-9-11-2-3-25(19(11)24-8-23-9)14-6-16(18(27)17(14)26)28-15-5-13(21)12(20)4-10(15)7-22/h2-5,8,14,16-18,26-27H,6-7,22H2,1H3/t14-,16+,17+,18-/m1/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451323
PNG
(US10709709, Example 150)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccc(Cl)c(Cl)c2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20Cl2N4O3/c1-9-10-4-5-25(19(10)24-8-23-9)13-6-15(18(27)17(13)26)28-14-3-2-12(20)16(21)11(14)7-22/h2-5,8,13,15,17-18,26-27H,6-7,22H2,1H3/t13-,15+,17+,18-/m1/s1
PDB

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n/an/a 71n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451330
PNG
(US10709709, Example 157)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2nccc3CCN(Cc23)C(=O)OC(C)(C)C)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C25H31N5O5/c1-14-16-7-10-30(22(16)28-13-27-14)18-11-19(21(32)20(18)31)34-23-17-12-29(24(33)35-25(2,3)4)9-6-15(17)5-8-26-23/h5,7-8,10,13,18-21,31-32H,6,9,11-12H2,1-4H3/t18-,19+,20+,21-/m1/s1
PDB

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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451334
PNG
(US10709709, Example 161)
Show SMILES Cc1ncnc2n(ccc12)C1C[C@H]([C@@H](O)c2ccc(Cl)c(F)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H19ClFN3O3/c1-9-11-4-5-24(19(11)23-8-22-9)15-7-12(17(26)18(15)27)16(25)10-2-3-13(20)14(21)6-10/h2-6,8,12,15-18,25-27H,7H2,1H3/t12-,15?,16+,17-,18+/m1/s1
PDB

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n/an/a 201n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451346
PNG
(US10709709, Example 176)
Show SMILES Cc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-18-14(23)8-27(21(18)26-9-25-10)15-6-17(20(29)19(15)28)30-16-5-12(22)4-11-2-3-24-7-13(11)16/h4-5,8-9,15,17,19-20,24,28-29H,2-3,6-7H2,1H3/t15-,17+,19+,20-/m1/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451375
PNG
(US10709709, Example 205)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3OCCNCc23)C(F)F)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H24F2N4O4/c1-11-13-2-4-28(22(13)27-10-26-11)15-8-18(20(30)19(15)29)32-17-7-12(21(23)24)6-16-14(17)9-25-3-5-31-16/h2,4,6-7,10,15,18-21,25,29-30H,3,5,8-9H2,1H3/t15-,18+,19+,20-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523654
PNG
(CHEMBL4455651 | US10709709, Example 212)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C23H25F3N4O3/c1-10-7-27-8-14-16(5-13(22(25)26)19(24)18(10)14)33-17-6-15(20(31)21(17)32)30-4-3-12-11(2)28-9-29-23(12)30/h3-5,9-10,15,17,20-22,27,31-32H,6-8H2,1-2H3/t10?,15-,17+,20+,21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451193
PNG
(US10709709, Example 19)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1CC([C@@H](O)[C@H]1O)[C@@](C)(O)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H22FN3O3/c1-11-14-7-8-24(19(14)23-10-22-11)16-9-15(17(25)18(16)26)20(2,27)12-3-5-13(21)6-4-12/h3-8,10,15-18,25-27H,9H2,1-2H3/t15?,16-,17-,18+,20+/m1/s1
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n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451188
PNG
(US10709709, Example 14)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@@H](O)c2cc(F)c(F)c(F)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H18F3N3O3/c1-8-10-2-3-25(19(10)24-7-23-8)14-6-11(17(27)18(14)28)16(26)9-4-12(20)15(22)13(21)5-9/h2-5,7,11,14,16-18,26-28H,6H2,1H3/t11-,14-,16+,17-,18+/m1/s1
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n/an/a 719n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451189
PNG
(US10709709, Example 15 | US10709709, Example 16)
Show SMILES Cc1cccc(CC(O)[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)n1 |r|
Show InChI InChI=1S/C20H24N4O3/c1-11-4-3-5-13(23-11)8-17(25)15-9-16(19(27)18(15)26)24-7-6-14-12(2)21-10-22-20(14)24/h3-7,10,15-19,25-27H,8-9H2,1-2H3/t15-,16-,17?,18-,19+/m1/s1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451200
PNG
(US10709709, Example 26)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H]([C@@H](O)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H18F2N4O3/c19-9-3-1-8(2-4-9)14(25)10-5-12(16(27)15(10)26)24-6-11(20)13-17(21)22-7-23-18(13)24/h1-4,6-7,10,12,14-16,25-27H,5H2,(H2,21,22,23)/t10-,12-,14+,15-,16+/m1/s1
PDB

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n/an/a 704n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451208
PNG
(US10709709, Example 34)
Show SMILES Cc1cc(N[C@@H]2C[C@H]([C@@H](O)c3ccc(F)c(F)c3)[C@@H](O)[C@H]2O)ncn1 |r|
Show InChI InChI=1S/C17H19F2N3O3/c1-8-4-14(21-7-20-8)22-13-6-10(16(24)17(13)25)15(23)9-2-3-11(18)12(19)5-9/h2-5,7,10,13,15-17,23-25H,6H2,1H3,(H,20,21,22)/t10-,13-,15+,16-,17+/m1/s1
PDB

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n/an/a 5.95E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451210
PNG
(US10709709, Example 36)
Show SMILES Cc1nccc(N[C@@H]2C[C@H]([C@@H](O)c3ccc(F)c(F)c3)[C@@H](O)[C@H]2O)n1 |r|
Show InChI InChI=1S/C17H19F2N3O3/c1-8-20-5-4-14(21-8)22-13-7-10(16(24)17(13)25)15(23)9-2-3-11(18)12(19)6-9/h2-6,10,13,15-17,23-25H,7H2,1H3,(H,20,21,22)/t10-,13-,15+,16-,17+/m1/s1
PDB

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n/an/a 2.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451212
PNG
(US10709709, Example 38)
Show SMILES CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ncnc(N)n1 |r|
Show InChI InChI=1S/C16H19F2N5O3/c1-23(16-21-6-20-15(19)22-16)11-5-8(13(25)14(11)26)12(24)7-2-3-9(17)10(18)4-7/h2-4,6,8,11-14,24-26H,5H2,1H3,(H2,19,20,21,22)/t8-,11+,12+,13+,14-/m0/s1
PDB

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n/an/a 1.57E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451226
PNG
(US10709709, Example 53)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2ccc(Cl)cc2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H23ClN4O3/c1-10-13-4-5-25(20(13)24-9-23-10)16-7-15(18(27)19(16)28)17(26)14-3-2-12(21)6-11(14)8-22/h2-6,9,15-19,26-28H,7-8,22H2,1H3/t15-,16-,17-,18-,19+/m1/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451253
PNG
(US10709709, Example 80)
Show SMILES Cc1ncnc2n(ccc12)C1C[C@H](Oc2cccc3CNCCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H24N4O3/c1-12-14-6-8-25(21(14)24-11-23-12)16-9-18(20(27)19(16)26)28-17-4-2-3-13-10-22-7-5-15(13)17/h2-4,6,8,11,16,18-20,22,26-27H,5,7,9-10H2,1H3/t16?,18-,19-,20+/m0/s1
PDB

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n/an/a 130n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451265
PNG
(US10709709, Example 92)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22F2N4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451285
PNG
(US10709709, Example 112)
Show SMILES CC(F)(F)c1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C22H24F3N5O3/c1-22(24,25)11-4-10-2-3-27-7-12(10)15(5-11)33-16-6-14(18(31)19(16)32)30-8-13(23)17-20(26)28-9-29-21(17)30/h4-5,8-9,14,16,18-19,27,31-32H,2-3,6-7H2,1H3,(H2,26,28,29)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451291
PNG
(US10709709, Example 118)
Show SMILES O[C@@H]1[C@H](C[C@H]([C@@H]1O)n1ccc2cncnc12)Oc1cccc2CCNCc12 |r|
Show InChI InChI=1S/C20H22N4O3/c25-18-15(24-7-5-13-9-22-11-23-20(13)24)8-17(19(18)26)27-16-3-1-2-12-4-6-21-10-14(12)16/h1-3,5,7,9,11,15,17-19,21,25-26H,4,6,8,10H2/t15-,17+,18+,19-/m1/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451313
PNG
(US10709709, Example 140)
Show SMILES C[C@@H](N)c1cc(F)c(Cl)cc1O[C@H]1C[C@H]([C@H](O)[C@@H]1O)n1ccc2c(C)ncnc12 |r|
Show InChI InChI=1S/C20H22ClFN4O3/c1-9(23)12-5-14(22)13(21)6-16(12)29-17-7-15(18(27)19(17)28)26-4-3-11-10(2)24-8-25-20(11)26/h3-6,8-9,15,17-19,27-28H,7,23H2,1-2H3/t9-,15-,17+,18+,19-/m1/s1
PDB

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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451316
PNG
(US10709709, Example 143)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccc(Cl)c(F)c2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20ClFN4O3/c1-9-10-4-5-25(19(10)24-8-23-9)13-6-15(18(27)17(13)26)28-14-3-2-12(20)16(21)11(14)7-22/h2-5,8,13,15,17-18,26-27H,6-7,22H2,1H3/t13-,15+,17+,18-/m1/s1
PDB

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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451324
PNG
(US10709709, Example 151)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccc(Cl)c(Cl)c2OCCN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H22Cl2N4O4/c1-10-11-4-6-26(20(11)25-9-24-10)13-8-15(18(28)17(13)27)30-14-3-2-12(21)16(22)19(14)29-7-5-23/h2-4,6,9,13,15,17-18,27-28H,5,7-8,23H2,1H3/t13-,15+,17+,18-/m1/s1
PDB

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n/an/a 78n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451338
PNG
(US10709709, Example 165)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)-c2cn[nH]c2)[C@@H](O)[C@H]1O |r|
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451342
PNG
(US10709709, Example 171)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)-c2cc[nH]n2)[C@@H](O)[C@H]1O |r|
PDB

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UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451347
PNG
(US10709709, Example 177)
Show SMILES Cc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H21F3N4O3/c1-9-17-13(23)7-28(21(17)27-8-26-9)14-5-16(20(30)19(14)29)31-15-4-12(22)18(24)10-2-3-25-6-11(10)15/h4,7-8,14,16,19-20,25,29-30H,2-3,5-6H2,1H3/t14-,16+,19+,20-/m1/s1
PDB

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UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451352
PNG
(US10709709, Example 182)
Show SMILES C[C@H]1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)ccc(F)c12 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-8-24-9-14-17(4-3-15(23)19(11)14)30-18-7-16(20(28)21(18)29)27-6-5-13-12(2)25-10-26-22(13)27/h3-6,10-11,16,18,20-21,24,28-29H,7-9H2,1-2H3/t11-,16+,18-,20-,21+/m0/s1
PDB

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US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451353
PNG
(US10709709, Example 183)
Show SMILES C[C@@H]1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)ccc(F)c12 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-8-24-9-14-17(4-3-15(23)19(11)14)30-18-7-16(20(28)21(18)29)27-6-5-13-12(2)25-10-26-22(13)27/h3-6,10-11,16,18,20-21,24,28-29H,7-9H2,1-2H3/t11-,16-,18+,20+,21-/m1/s1
PDB

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US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451363
PNG
(US10709709, Example 193)
Show SMILES CC(C)Oc1nc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c2CNCCc2c1F |r|
Show InChI InChI=1S/C23H28FN5O4/c1-11(2)32-23-18(24)14-4-6-25-9-15(14)22(28-23)33-17-8-16(19(30)20(17)31)29-7-5-13-12(3)26-10-27-21(13)29/h5,7,10-11,16-17,19-20,25,30-31H,4,6,8-9H2,1-3H3/t16-,17+,19+,20-/m1/s1
PDB

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n/an/a 180n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451372
PNG
(US10709709, Example 202)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3OCCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C22H23N5O4/c1-12-14-2-4-27(22(14)26-11-25-12)16-8-19(21(29)20(16)28)31-18-7-13(9-23)6-17-15(18)10-24-3-5-30-17/h2,4,6-7,11,16,19-21,24,28-29H,3,5,8,10H2,1H3/t16-,19+,20+,21-/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451385
PNG
(US10709709, Example 215 | US10709709, Example 216)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3cc(F)c4c(N)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C22H23F4N5O3/c1-8-4-28-5-10-13(2-9(20(25)26)17(24)15(8)10)34-14-3-12(18(32)19(14)33)31-6-11(23)16-21(27)29-7-30-22(16)31/h2,6-8,12,14,18-20,28,32-33H,3-5H2,1H3,(H2,27,29,30)/t8?,12-,14+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451195
PNG
(US10709709, Example 21)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](F)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H19F2N3O2/c1-10-13-6-7-24(19(13)23-9-22-10)15-8-14(17(25)18(15)26)16(21)11-2-4-12(20)5-3-11/h2-7,9,14-18,25-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

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US Patent
n/an/a 217n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451184
PNG
(US10709709, Example 10 | US10709709, Example 58)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@@H](O)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20FN3O3/c1-10-13-6-7-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-2-4-12(20)5-3-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16+,17-,18+/m1/s1
PDB

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n/an/a 941n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451213
PNG
(US10709709, Example 39)
Show SMILES CN([C@@H]1C[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ccnc(N)n1 |r|
Show InChI InChI=1S/C17H20F2N4O3/c1-23(13-4-5-21-17(20)22-13)12-7-9(15(25)16(12)26)14(24)8-2-3-10(18)11(19)6-8/h2-6,9,12,14-16,24-26H,7H2,1H3,(H2,20,21,22)/t9-,12-,14-,15-,16+/m1/s1
PDB

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US Patent
n/an/a 114n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%