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Patent code US10709709

Compile Data Set for Download or QSAR

Found 212 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451167
PNG
(US10709709, Example 3)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H19F2N3O3/c1-9-11-4-5-24(19(11)23-8-22-9)15-7-12(17(26)18(15)27)16(25)10-2-3-13(20)14(21)6-10/h2-6,8,12,15-18,25-27H,7H2,1H3/t12-,15-,16-,17-,18+/m1/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 32n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451186
PNG
(US10709709, Example 12)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@@H](O)c2ccc(Cl)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20ClN3O3/c1-10-13-6-7-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-2-4-12(20)5-3-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16+,17-,18+/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 478n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451199
PNG
(US10709709, Example 25)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H]([C@H](O)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C18H18F2N4O3/c19-9-3-1-8(2-4-9)14(25)10-5-12(16(27)15(10)26)24-6-11(20)13-17(21)22-7-23-18(13)24/h1-4,6-7,10,12,14-16,25-27H,5H2,(H2,21,22,23)/t10-,12-,14-,15-,16+/m1/s1
PDB

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n/an/a 56n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451202
PNG
(US10709709, Example 28)
Show SMILES O[C@@H]([C@@H]1C[C@@H](Nc2ncnc3[nH]ccc23)[C@H](O)[C@@H]1O)c1ccc(F)c(F)c1 |r|
PDB

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n/an/a 5.77E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451217
PNG
(US10709709, Example 43)
Show SMILES CN([C@@H]1C[C@H]([C@@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1cc(N)ncn1 |r|
Show InChI InChI=1S/C17H20F2N4O3/c1-23(14-6-13(20)21-7-22-14)12-5-9(16(25)17(12)26)15(24)8-2-3-10(18)11(19)4-8/h2-4,6-7,9,12,15-17,24-26H,5H2,1H3,(H2,20,21,22)/t9-,12-,15+,16-,17+/m1/s1
PDB

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n/an/a 879n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451218
PNG
(US10709709, Example 44)
Show SMILES CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1cc(N)ncn1 |r|
Show InChI InChI=1S/C17H20F2N4O3/c1-23(14-6-13(20)21-7-22-14)12-5-9(16(25)17(12)26)15(24)8-2-3-10(18)11(19)4-8/h2-4,6-7,9,12,15-17,24-26H,5H2,1H3,(H2,20,21,22)/t9-,12+,15+,16+,17-/m0/s1
PDB

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n/an/a 1.70E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451241
PNG
(US10709709, Example 68)
Show SMILES Cc1cc(N[C@@H]2C[C@H](Oc3ccc(F)cc3C#N)[C@@H](O)[C@H]2O)ncn1 |r|
Show InChI InChI=1S/C17H17FN4O3/c1-9-4-15(21-8-20-9)22-12-6-14(17(24)16(12)23)25-13-3-2-11(18)5-10(13)7-19/h2-5,8,12,14,16-17,23-24H,6H2,1H3,(H,20,21,22)/t12-,14+,16+,17-/m1/s1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451253
PNG
(US10709709, Example 80)
Show SMILES Cc1ncnc2n(ccc12)C1C[C@H](Oc2cccc3CNCCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H24N4O3/c1-12-14-6-8-25(21(14)24-11-23-12)16-9-18(20(27)19(16)26)28-17-4-2-3-13-10-22-7-5-15(13)17/h2-4,6,8,11,16,18-20,22,26-27H,5,7,9-10H2,1H3/t16?,18-,19-,20+/m0/s1
PDB

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n/an/a 130n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451260
PNG
(US10709709, Example 87)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H23ClN4O3/c1-11-14-3-5-26(21(14)25-10-24-11)16-8-18(20(28)19(16)27)29-17-7-13(22)6-12-2-4-23-9-15(12)17/h3,5-7,10,16,18-20,23,27-28H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1
PDB

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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451266
PNG
(US10709709, Example 93)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451270
PNG
(US10709709, Example 97)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(C)(C)O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H30N4O4/c1-13-16-5-7-28(23(16)27-12-26-13)18-10-20(22(30)21(18)29)32-19-9-15(24(2,3)31)8-14-4-6-25-11-17(14)19/h5,7-9,12,18,20-22,25,29-31H,4,6,10-11H2,1-3H3/t18-,20+,21+,22-/m1/s1
PDB

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n/an/a 65n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451278
PNG
(US10709709, Example 105)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C21H24FN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451293
PNG
(US10709709, Example 120)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H21BrN6O3/c22-13-8-28(21-17(13)20(24)26-9-27-21)14-5-16(19(30)18(14)29)31-15-4-10(6-23)3-11-1-2-25-7-12(11)15/h3-4,8-9,14,16,18-19,25,29-30H,1-2,5,7H2,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451299
PNG
(US10709709, Example 126)
Show SMILES Cc1nc(N)c2c(F)cn([C@@H]3C[C@H](Oc4ccc(F)c5CCNCc45)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C21H23F2N5O3/c1-9-26-20(24)17-13(23)8-28(21(17)27-9)14-6-16(19(30)18(14)29)31-15-3-2-12(22)10-4-5-25-7-11(10)15/h2-3,8,14,16,18-19,25,29-30H,4-7H2,1H3,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451302
PNG
(US10709709, Example 129)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(Cl)c3c(N)ncnc23)c1 |r|
Show InChI InChI=1S/C21H24ClN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451315
PNG
(US10709709, Example 142)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cccc3CC[C@@H](N)c23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H24N4O3/c1-11-13-7-8-25(21(13)24-10-23-11)15-9-17(20(27)19(15)26)28-16-4-2-3-12-5-6-14(22)18(12)16/h2-4,7-8,10,14-15,17,19-20,26-27H,5-6,9,22H2,1H3/t14-,15-,17+,19+,20-/m1/s1
PDB

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n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451351
PNG
(US10709709, Example 181)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)n1 |r|
Show InChI InChI=1S/C21H25N5O3/c1-11-7-13-3-5-22-9-15(13)21(25-11)29-17-8-16(18(27)19(17)28)26-6-4-14-12(2)23-10-24-20(14)26/h4,6-7,10,16-19,22,27-28H,3,5,8-9H2,1-2H3/t16-,17+,18+,19-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM50523654
PNG
(CHEMBL4455651 | US10709709, Example 212)
Show SMILES CC1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cc(C(F)F)c(F)c12 |r|
Show InChI InChI=1S/C23H25F3N4O3/c1-10-7-27-8-14-16(5-13(22(25)26)19(24)18(10)14)33-17-6-15(20(31)21(17)32)30-4-3-12-11(2)28-9-29-23(12)30/h3-5,9-10,15,17,20-22,27,31-32H,6-8H2,1-2H3/t10?,15-,17+,20+,21-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451172
PNG
(US10709709, Example 5)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2ccc(F)c(Cl)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H19ClFN3O3/c1-9-11-4-5-24(19(11)23-8-22-9)15-7-12(17(26)18(15)27)16(25)10-2-3-14(21)13(20)6-10/h2-6,8,12,15-18,25-27H,7H2,1H3/t12-,15-,16-,17-,18+/m1/s1
PDB

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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451191
PNG
(US10709709, Example 17)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C1(O)CC1 |r|
Show InChI InChI=1S/C15H19N3O3/c1-8-9-2-5-18(14(9)17-7-16-8)11-6-10(12(19)13(11)20)15(21)3-4-15/h2,5,7,10-13,19-21H,3-4,6H2,1H3/t10-,11+,12+,13-/m0/s1
PDB

UniProtKB/SwissProt

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n/an/a 2.77E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451192
PNG
(US10709709, Example 18)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O |r|
Show InChI InChI=1S/C15H21N3O3/c1-8-9-4-5-18(14(9)17-7-16-8)11-6-10(15(2,3)21)12(19)13(11)20/h4-5,7,10-13,19-21H,6H2,1-3H3/t10-,11+,12+,13-/m0/s1
PDB

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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451203
PNG
(US10709709, Example 29)
Show SMILES OC([C@H]1C[C@@H](Nc2ncnc3c(cccc23)C#N)[C@H](O)[C@@H]1O)c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C21H18F2N4O3/c22-14-5-4-10(6-15(14)23)18(28)13-7-16(20(30)19(13)29)27-21-12-3-1-2-11(8-24)17(12)25-9-26-21/h1-6,9,13,16,18-20,28-30H,7H2,(H,25,26,27)/t13-,16-,18?,19-,20+/m1/s1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451204
PNG
(US10709709, Example 30)
Show SMILES OC([C@H]1C[C@H](Nc2ncnc3c(cccc23)C#N)[C@H](O)[C@@H]1O)c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C21H18F2N4O3/c22-14-5-4-10(6-15(14)23)18(28)13-7-16(20(30)19(13)29)27-21-12-3-1-2-11(8-24)17(12)25-9-26-21/h1-6,9,13,16,18-20,28-30H,7H2,(H,25,26,27)/t13-,16+,18?,19-,20+/m1/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451215
PNG
(US10709709, Example 41)
Show SMILES CN([C@@H]1C[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1nc(C)nc(N)n1 |r|
Show InChI InChI=1S/C17H21F2N5O3/c1-7-21-16(20)23-17(22-7)24(2)12-6-9(14(26)15(12)27)13(25)8-3-4-10(18)11(19)5-8/h3-5,9,12-15,25-27H,6H2,1-2H3,(H2,20,21,22,23)/t9-,12-,13-,14-,15+/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451224
PNG
(US10709709, Example 51)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@@H](CN)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H23FN4O2/c1-11-14-6-7-25(20(14)24-10-23-11)17-8-15(18(26)19(17)27)16(9-22)12-2-4-13(21)5-3-12/h2-7,10,15-19,26-27H,8-9,22H2,1H3/t15-,16+,17-,18-,19+/m1/s1
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n/an/a 676n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451228
PNG
(US10709709, Example 55)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Cc2ccc(Cl)cc2CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H23ClN4O2/c1-11-16-4-5-25(20(16)24-10-23-11)17-8-13(18(26)19(17)27)6-12-2-3-15(21)7-14(12)9-22/h2-5,7,10,13,17-19,26-27H,6,8-9,22H2,1H3/t13-,17+,18+,19-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451242
PNG
(US10709709, Example 69)
Show SMILES Cc1cc(N[C@H]2C[C@@H](Oc3ccc(F)cc3C#N)[C@H](O)[C@@H]2O)ncn1 |r|
Show InChI InChI=1S/C17H17FN4O3/c1-9-4-15(21-8-20-9)22-12-6-14(17(24)16(12)23)25-13-3-2-11(18)5-10(13)7-19/h2-5,8,12,14,16-17,23-24H,6H2,1H3,(H,20,21,22)/t12-,14+,16+,17-/m0/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451268
PNG
(US10709709, Example 95)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cncc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H23N5O3/c1-11-13-3-5-25(20(13)24-10-23-11)15-6-16(19(27)18(15)26)28-17-9-22-7-12-2-4-21-8-14(12)17/h3,5,7,9-10,15-16,18-19,21,26-27H,2,4,6,8H2,1H3/t15-,16+,18+,19-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451280
PNG
(US10709709, Example 107)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21F2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451297
PNG
(US10709709, Example 124)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(C)ncnc23)c1 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-5-13-3-4-24-8-14(13)17(6-11)30-18-7-16(20(28)21(18)29)27-9-15(23)19-12(2)25-10-26-22(19)27/h5-6,9-10,16,18,20-21,24,28-29H,3-4,7-8H2,1-2H3/t16-,18+,20+,21-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451300
PNG
(US10709709, Example 127)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3cnc(C)nc23)c1 |r|
Show InChI InChI=1S/C22H25FN4O3/c1-11-5-13-3-4-24-8-14(13)18(6-11)30-19-7-17(20(28)21(19)29)27-10-16(23)15-9-25-12(2)26-22(15)27/h5-6,9-10,17,19-21,24,28-29H,3-4,7-8H2,1-2H3/t17-,19+,20+,21-/m1/s1
PDB

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n/an/a 9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451303
PNG
(US10709709, Example 130)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H21Cl2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451322
PNG
(US10709709, Example 149)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccc(Cl)cc2C(O)CNC(=O)OC(C)(C)C)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C25H31ClN4O6/c1-13-15-7-8-30(23(15)29-12-28-13)17-10-20(22(33)21(17)32)35-19-6-5-14(26)9-16(19)18(31)11-27-24(34)36-25(2,3)4/h5-9,12,17-18,20-22,31-33H,10-11H2,1-4H3,(H,27,34)/t17-,18?,20+,21+,22-/m1/s1
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n/an/a 69n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451341
PNG
(US10709709, Example 170)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)-c2cnco2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C24H25N5O4/c1-13-16-3-5-29(24(16)28-11-27-13)18-8-20(23(31)22(18)30)33-19-7-15(21-10-26-12-32-21)6-14-2-4-25-9-17(14)19/h3,5-7,10-12,18,20,22-23,25,30-31H,2,4,8-9H2,1H3/t18-,20+,22+,23-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451345
PNG
(US10709709, Example 175)
Show SMILES Cc1ncc2c(F)cn([C@@H]3C[C@H](Oc4cc(Cl)cc5CCNCc45)[C@@H](O)[C@H]3O)c2n1 |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-25-8-14-15(23)9-27(21(14)26-10)16-6-18(20(29)19(16)28)30-17-5-12(22)4-11-2-3-24-7-13(11)17/h4-5,8-9,16,18-20,24,28-29H,2-3,6-7H2,1H3/t16-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451346
PNG
(US10709709, Example 176)
Show SMILES Cc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-18-14(23)8-27(21(18)26-9-25-10)15-6-17(20(29)19(15)28)30-16-5-12(22)4-11-2-3-24-7-13(11)16/h4-5,8-9,15,17,19-20,24,28-29H,2-3,6-7H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451349
PNG
(US10709709, Example 179)
Show SMILES Cc1cn([C@@H]2C[C@H](Oc3cc(F)c(F)c4CCNCc34)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12 |r|
Show InChI InChI=1S/C22H25F2N5O3/c1-9-8-29(22-17(9)21(25)27-10(2)28-22)14-6-16(20(31)19(14)30)32-15-5-13(23)18(24)11-3-4-26-7-12(11)15/h5,8,14,16,19-20,26,30-31H,3-4,6-7H2,1-2H3,(H2,25,27,28)/t14-,16+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451350
PNG
(US10709709, Example 180)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H22FN5O3/c21-13-1-2-15(12-8-23-5-3-10(12)13)29-16-7-14(17(27)18(16)28)26-6-4-11-19(22)24-9-25-20(11)26/h1-2,4,6,9,14,16-18,23,27-28H,3,5,7-8H2,(H2,22,24,25)/t14-,16+,17+,18-/m1/s1
PDB

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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451358
PNG
(US10709709, Example 188 | US10709709, Example 189)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cccc3OCC(N)Cc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H24N4O4/c1-11-13-5-6-25(21(13)24-10-23-11)15-8-18(20(27)19(15)26)29-17-4-2-3-16-14(17)7-12(22)9-28-16/h2-6,10,12,15,18-20,26-27H,7-9,22H2,1H3/t12?,15-,18+,19+,20-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451363
PNG
(US10709709, Example 193)
Show SMILES CC(C)Oc1nc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c2CNCCc2c1F |r|
Show InChI InChI=1S/C23H28FN5O4/c1-11(2)32-23-18(24)14-4-6-25-9-15(14)22(28-23)33-17-8-16(19(30)20(17)31)29-7-5-13-12(3)26-10-27-21(13)29/h5,7,10-11,16-17,19-20,25,30-31H,4,6,8-9H2,1-3H3/t16-,17+,19+,20-/m1/s1
PDB

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UniChem
US Patent
n/an/a 180n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451373
PNG
(US10709709, Example 203)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)cc3OCCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C21H23FN4O4/c1-11-13-2-4-26(21(13)25-10-24-11)15-8-18(20(28)19(15)27)30-17-7-12(22)6-16-14(17)9-23-3-5-29-16/h2,4,6-7,10,15,18-20,23,27-28H,3,5,8-9H2,1H3/t15-,18+,19+,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451379
PNG
(US10709709, Example 209)
Show SMILES C[C@@H]1CNCc2c(O[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(C)ncnc34)cccc2O1 |r|
Show InChI InChI=1S/C22H26N4O4/c1-12-9-23-10-15-17(29-12)4-3-5-18(15)30-19-8-16(20(27)21(19)28)26-7-6-14-13(2)24-11-25-22(14)26/h3-7,11-12,16,19-21,23,27-28H,8-10H2,1-2H3/t12-,16-,19+,20+,21-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
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UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451195
PNG
(US10709709, Example 21)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](F)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H19F2N3O2/c1-10-13-6-7-24(19(13)23-9-22-10)15-8-14(17(25)18(15)26)16(21)11-2-4-12(20)5-3-11/h2-7,9,14-18,25-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/a 217n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451181
PNG
(US10709709, Example 7)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2cccc(Cl)c2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20ClN3O3/c1-10-13-5-6-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-3-2-4-12(20)7-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/a 120n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451183
PNG
(US10709709, Example 9)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H]([C@H](O)c2ccc(F)cc2)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C19H20FN3O3/c1-10-13-6-7-23(19(13)22-9-21-10)15-8-14(17(25)18(15)26)16(24)11-2-4-12(20)5-3-11/h2-7,9,14-18,24-26H,8H2,1H3/t14-,15-,16-,17-,18+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
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UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451210
PNG
(US10709709, Example 36)
Show SMILES Cc1nccc(N[C@@H]2C[C@H]([C@@H](O)c3ccc(F)c(F)c3)[C@@H](O)[C@H]2O)n1 |r|
Show InChI InChI=1S/C17H19F2N3O3/c1-8-20-5-4-14(21-8)22-13-7-10(16(24)17(13)25)15(23)9-2-3-11(18)12(19)6-9/h2-6,10,13,15-17,23-25H,7H2,1H3,(H,20,21,22)/t10-,13-,15+,16-,17+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem
US Patent
n/an/a 2.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451212
PNG
(US10709709, Example 38)
Show SMILES CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ncnc(N)n1 |r|
Show InChI InChI=1S/C16H19F2N5O3/c1-23(16-21-6-20-15(19)22-16)11-5-8(13(25)14(11)26)12(24)7-2-3-9(17)10(18)4-7/h2-4,6,8,11-14,24-26H,5H2,1H3,(H2,19,20,21,22)/t8-,11+,12+,13+,14-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 1.57E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451220
PNG
(US10709709, Example 47)
Show SMILES CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ncnc(C)n1 |r|
Show InChI InChI=1S/C17H20F2N4O3/c1-8-20-7-21-17(22-8)23(2)13-6-10(15(25)16(13)26)14(24)9-3-4-11(18)12(19)5-9/h3-5,7,10,13-16,24-26H,6H2,1-2H3/t10-,13+,14+,15+,16-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem
US Patent
n/an/a 2.95E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451281
PNG
(US10709709, Example 108)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451282
PNG
(US10709709, Example 109)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%