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Patent code US10016438

Compile Data Set for Download or QSAR

Found 200 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291235
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-16-7-14(10-29-12-16)18-8-17-15(11-30-18)13-32(25(34)26(17)5-6-26)24-22(27)19(35-2)9-20(36-3)23(24)28/h4,7-12H,1,5-6,13H2,2-3H3,(H,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291239
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)cnc2C)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-5-22(34)32-16-8-17(14(2)30-12-16)19-9-18-15(11-31-19)13-33(26(35)27(18)6-7-27)25-23(28)20(36-3)10-21(37-4)24(25)29/h5,8-12H,1,6-7,13H2,2-4H3,(H,32,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291245
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccc(CO)c(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C28H25F2N3O5/c1-4-23(35)32-20-9-15(5-6-16(20)14-34)19-10-18-17(12-31-19)13-33(27(36)28(18)7-8-28)26-24(29)21(37-2)11-22(38-3)25(26)30/h4-6,9-12,34H,1,7-8,13-14H2,2-3H3,(H,32,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM291236
PNG
(N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccnc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-20-9-14(5-8-29-20)17-10-16-15(12-30-17)13-32(25(34)26(16)6-7-26)24-22(27)18(35-2)11-19(36-3)23(24)28/h4-5,8-12H,1,6-7,13H2,2-3H3,(H,29,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291248
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES CCOCCn1ncc(NC(=O)C=C)c1-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C28H29F2N5O5/c1-5-22(36)33-19-14-32-35(9-10-40-6-2)25(19)18-11-17-16(13-31-18)15-34(27(37)28(17)7-8-28)26-23(29)20(38-3)12-21(39-4)24(26)30/h5,11-14H,1,6-10,15H2,2-4H3,(H,33,36)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291242
PNG
(N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)cc(c2)N2CCOCC2)c1F
Show InChI InChI=1S/C31H30F2N4O5/c1-4-26(38)35-20-11-18(12-21(13-20)36-7-9-42-10-8-36)23-14-22-19(16-34-23)17-37(30(39)31(22)5-6-31)29-27(32)24(40-2)15-25(41-3)28(29)33/h4,11-16H,1,5-10,17H2,2-3H3,(H,35,38)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291238
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)c(F)cc2C)c1F
Show InChI InChI=1S/C28H24F3N3O4/c1-5-23(35)33-20-9-16(14(2)8-18(20)29)19-10-17-15(12-32-19)13-34(27(36)28(17)6-7-28)26-24(30)21(37-3)11-22(38-4)25(26)31/h5,8-12H,1,6-7,13H2,2-4H3,(H,33,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM291236
PNG
(N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccnc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-20-9-14(5-8-29-20)17-10-16-15(12-30-17)13-32(25(34)26(16)6-7-26)24-22(27)18(35-2)11-19(36-3)23(24)28/h4-5,8-12H,1,6-7,13H2,2-3H3,(H,29,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291234
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)ccc2C)c1F
Show InChI InChI=1S/C28H25F2N3O4/c1-5-23(34)32-17-7-6-15(2)18(10-17)20-11-19-16(13-31-20)14-33(27(35)28(19)8-9-28)26-24(29)21(36-3)12-22(37-4)25(26)30/h5-7,10-13H,1,8-9,14H2,2-4H3,(H,32,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291264
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COCCn1cc(NC(=O)C=C)c(n1)-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C27H27F2N5O5/c1-5-21(35)31-18-14-33(8-9-37-2)32-24(18)17-10-16-15(12-30-17)13-34(26(36)27(16)6-7-27)25-22(28)19(38-3)11-20(39-4)23(25)29/h5,10-12,14H,1,6-9,13H2,2-4H3,(H,31,35)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291262
PNG
((R)-N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2C[C@H]2CCCO2)c1F |r|
Show InChI InChI=1S/C29H29F2N5O5/c1-4-23(37)34-20-13-33-36(15-17-6-5-9-41-17)26(20)19-10-18-16(12-32-19)14-35(28(38)29(18)7-8-29)27-24(30)21(39-2)11-22(40-3)25(27)31/h4,10-13,17H,1,5-9,14-15H2,2-3H3,(H,34,37)/t17-/m1/s1
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291241
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cccc(c2)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C28H25F2N3O4/c1-5-23(34)32(2)18-8-6-7-16(11-18)20-12-19-17(14-31-20)15-33(27(35)28(19)9-10-28)26-24(29)21(36-3)13-22(37-4)25(26)30/h5-8,11-14H,1,9-10,15H2,2-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291244
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccc(CN3CCOCC3)c(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C32H32F2N4O5/c1-4-27(39)36-24-13-19(5-6-20(24)17-37-9-11-43-12-10-37)23-14-22-21(16-35-23)18-38(31(40)32(22)7-8-32)30-28(33)25(41-2)15-26(42-3)29(30)34/h4-6,13-16H,1,7-12,17-18H2,2-3H3,(H,36,39)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291233
PNG
(N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cccc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C27H23F2N3O4/c1-4-22(33)31-17-7-5-6-15(10-17)19-11-18-16(13-30-19)14-32(26(34)27(18)8-9-27)25-23(28)20(35-2)12-21(36-3)24(25)29/h4-7,10-13H,1,8-9,14H2,2-3H3,(H,31,33)
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Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291259
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2Cc2cnn(C)c2)c1F
Show InChI InChI=1S/C29H27F2N7O4/c1-5-23(39)35-20-12-34-38(14-16-10-33-36(2)13-16)26(20)19-8-18-17(11-32-19)15-37(28(40)29(18)6-7-29)27-24(30)21(41-3)9-22(42-4)25(27)31/h5,8-13H,1,6-7,14-15H2,2-4H3,(H,35,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291257
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2Cc2ccon2)c1F
Show InChI InChI=1S/C28H24F2N6O5/c1-4-22(37)33-19-12-32-36(14-16-5-8-41-34-16)25(19)18-9-17-15(11-31-18)13-35(27(38)28(17)6-7-28)26-23(29)20(39-2)10-21(40-3)24(26)30/h4-5,8-12H,1,6-7,13-14H2,2-3H3,(H,33,37)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291245
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccc(CO)c(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C28H25F2N3O5/c1-4-23(35)32-20-9-15(5-6-16(20)14-34)19-10-18-17(12-31-19)13-33(27(36)28(18)7-8-28)26-24(29)21(37-2)11-22(38-3)25(26)30/h4-6,9-12,34H,1,7-8,13-14H2,2-3H3,(H,32,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM400237
PNG
(N-(4-cyano-3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)ccc2[N+]#[C-])c1F |$;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$|
Show InChI InChI=1S/C28H22F2N4O4/c1-5-23(35)33-16-6-7-19(31-2)17(10-16)20-11-18-15(13-32-20)14-34(27(36)28(18)8-9-28)26-24(29)21(37-3)12-22(38-4)25(26)30/h5-7,10-13H,1,8-9,14H2,3-4H3,(H,33,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291261
PNG
((R)-N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2C[C@H]2CCOC2)c1F |r|
Show InChI InChI=1S/C29H29F2N5O5/c1-4-23(37)34-20-12-33-36(13-16-5-8-41-15-16)26(20)19-9-18-17(11-32-19)14-35(28(38)29(18)6-7-29)27-24(30)21(39-2)10-22(40-3)25(27)31/h4,9-12,16H,1,5-8,13-15H2,2-3H3,(H,34,37)/t16-/m1/s1
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291235
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cncc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-16-7-14(10-29-12-16)18-8-17-15(11-30-18)13-32(25(34)26(17)5-6-26)24-22(27)19(35-2)9-20(36-3)23(24)28/h4,7-12H,1,5-6,13H2,2-3H3,(H,31,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291241
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cccc(c2)N(C)C(=O)C=C)c1F
Show InChI InChI=1S/C28H25F2N3O4/c1-5-23(34)32(2)18-8-6-7-16(11-18)20-12-19-17(14-31-20)15-33(27(35)28(19)9-10-28)26-24(29)21(36-3)13-22(37-4)25(26)30/h5-8,11-14H,1,9-10,15H2,2-4H3
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291233
PNG
(N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cccc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C27H23F2N3O4/c1-4-22(33)31-17-7-5-6-15(10-17)19-11-18-16(13-30-19)14-32(26(34)27(18)8-9-27)25-23(28)20(35-2)12-21(36-3)24(25)29/h4-7,10-13H,1,8-9,14H2,2-3H3,(H,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291236
PNG
(N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccnc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-20-9-14(5-8-29-20)17-10-16-15(12-30-17)13-32(25(34)26(16)6-7-26)24-22(27)18(35-2)11-19(36-3)23(24)28/h4-5,8-12H,1,6-7,13H2,2-3H3,(H,29,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291267
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2nn(CC3CCOCC3)cc2NC(=O)C=C)c1F
Show InChI InChI=1S/C30H31F2N5O5/c1-4-24(38)34-21-16-36(14-17-5-9-42-10-6-17)35-27(21)20-11-19-18(13-33-20)15-37(29(39)30(19)7-8-30)28-25(31)22(40-2)12-23(41-3)26(28)32/h4,11-13,16-17H,1,5-10,14-15H2,2-3H3,(H,34,38)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291269
PNG
(N-(3-(6'-(2,6-difluoro-3,5-dimethoxyphenyl)-7'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(nc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)ccc2C)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-5-20(34)31-16-7-6-14(2)17(10-16)25-30-12-15-13-33(26(35)27(8-9-27)24(15)32-25)23-21(28)18(36-3)11-19(37-4)22(23)29/h5-7,10-12H,1,8-9,13H2,2-4H3,(H,31,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291242
PNG
(N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)cc(c2)N2CCOCC2)c1F
Show InChI InChI=1S/C31H30F2N4O5/c1-4-26(38)35-20-11-18(12-21(13-20)36-7-9-42-10-8-36)23-14-22-19(16-34-23)17-37(30(39)31(22)5-6-31)29-27(32)24(40-2)15-25(41-3)28(29)33/h4,11-16H,1,5-10,17H2,2-3H3,(H,35,38)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291243
PNG
(N-[3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(CN3CCOCC3)cc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C32H32F2N4O5/c1-4-27(39)36-22-12-19(17-37-7-9-43-10-8-37)11-20(13-22)24-14-23-21(16-35-24)18-38(31(40)32(23)5-6-32)30-28(33)25(41-2)15-26(42-3)29(30)34/h4,11-16H,1,5-10,17-18H2,2-3H3,(H,36,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291234
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)ccc2C)c1F
Show InChI InChI=1S/C28H25F2N3O4/c1-5-23(34)32-17-7-6-15(2)18(10-17)20-11-19-16(13-31-20)14-33(27(35)28(19)8-9-28)26-24(29)21(36-3)12-22(37-4)25(26)30/h5-7,10-13H,1,8-9,14H2,2-4H3,(H,32,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM400237
PNG
(N-(4-cyano-3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)ccc2[N+]#[C-])c1F |$;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$|
Show InChI InChI=1S/C28H22F2N4O4/c1-5-23(35)33-16-6-7-19(31-2)17(10-16)20-11-18-15(13-32-20)14-34(27(36)28(18)8-9-28)26-24(29)21(37-3)12-22(38-4)25(26)30/h5-7,10-13H,1,8-9,14H2,3-4H3,(H,33,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291253
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2Cc2ccncc2)c1F
Show InChI InChI=1S/C30H26F2N6O4/c1-4-24(39)36-21-14-35-38(15-17-5-9-33-10-6-17)27(21)20-11-19-18(13-34-20)16-37(29(40)30(19)7-8-30)28-25(31)22(41-2)12-23(42-3)26(28)32/h4-6,9-14H,1,7-8,15-16H2,2-3H3,(H,36,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291263
PNG
((S)-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2C[C@@H]2CCCO2)c1F |r|
Show InChI InChI=1S/C29H29F2N5O5/c1-4-23(37)34-20-13-33-36(15-17-6-5-9-41-17)26(20)19-10-18-16(12-32-19)14-35(28(38)29(18)7-8-29)27-24(30)21(39-2)11-22(40-3)25(27)31/h4,10-13,17H,1,5-9,14-15H2,2-3H3,(H,34,37)/t17-/m0/s1
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291238
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)c(F)cc2C)c1F
Show InChI InChI=1S/C28H24F3N3O4/c1-5-23(35)33-20-9-16(14(2)8-18(20)29)19-10-17-15(12-32-19)13-34(27(36)28(17)6-7-28)26-24(30)21(37-3)11-22(38-4)25(26)31/h5,8-12H,1,6-7,13H2,2-4H3,(H,33,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291239
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(NC(=O)C=C)cnc2C)c1F
Show InChI InChI=1S/C27H24F2N4O4/c1-5-22(34)32-16-8-17(14(2)30-12-16)19-9-18-15(11-31-19)13-33(26(35)27(18)6-7-27)25-23(28)20(36-3)10-21(37-4)24(25)29/h5,8-12H,1,6-7,13H2,2-4H3,(H,32,34)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291246
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2[nH]ncc2NC(=O)C=C)c1F
Show InChI InChI=1S/C24H21F2N5O4/c1-4-18(32)29-15-10-28-30-21(15)14-7-13-12(9-27-14)11-31(23(33)24(13)5-6-24)22-19(25)16(34-2)8-17(35-3)20(22)26/h4,7-10H,1,5-6,11H2,2-3H3,(H,28,30)(H,29,32)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291249
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2CCO)c1F
Show InChI InChI=1S/C26H25F2N5O5/c1-4-20(35)31-17-12-30-33(7-8-34)23(17)16-9-15-14(11-29-16)13-32(25(36)26(15)5-6-26)24-21(27)18(37-2)10-19(38-3)22(24)28/h4,9-12,34H,1,5-8,13H2,2-3H3,(H,31,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291254
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2Cc2cccnc2)c1F
Show InChI InChI=1S/C30H26F2N6O4/c1-4-24(39)36-21-14-35-38(15-17-6-5-9-33-12-17)27(21)20-10-19-18(13-34-20)16-37(29(40)30(19)7-8-30)28-25(31)22(41-2)11-23(42-3)26(28)32/h4-6,9-14H,1,7-8,15-16H2,2-3H3,(H,36,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291255
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2Cc2ncn(C)n2)c1F
Show InChI InChI=1S/C28H26F2N8O4/c1-5-22(39)34-18-11-33-38(13-21-32-14-36(2)35-21)25(18)17-8-16-15(10-31-17)12-37(27(40)28(16)6-7-28)26-23(29)19(41-3)9-20(42-4)24(26)30/h5,8-11,14H,1,6-7,12-13H2,2-4H3,(H,34,39)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291268
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2nn(CC(=O)N(C)C)cc2NC(=O)C=C)c1F
Show InChI InChI=1S/C28H28F2N6O5/c1-6-21(37)32-18-13-35(14-22(38)34(2)3)33-25(18)17-9-16-15(11-31-17)12-36(27(39)28(16)7-8-28)26-23(29)19(40-4)10-20(41-5)24(26)30/h6,9-11,13H,1,7-8,12,14H2,2-5H3,(H,32,37)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291236
PNG
(N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccnc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C26H22F2N4O4/c1-4-21(33)31-20-9-14(5-8-29-20)17-10-16-15(12-30-17)13-32(25(34)26(16)6-7-26)24-22(27)18(35-2)11-19(36-3)23(24)28/h4-5,8-12H,1,6-7,13H2,2-3H3,(H,29,31,33)
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Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291243
PNG
(N-[3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cc(CN3CCOCC3)cc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C32H32F2N4O5/c1-4-27(39)36-22-12-19(17-37-7-9-43-10-8-37)11-20(13-22)24-14-23-21(16-35-24)18-38(31(40)32(23)5-6-32)30-28(33)25(41-2)15-26(42-3)29(30)34/h4,11-16H,1,5-10,17-18H2,2-3H3,(H,36,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291244
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccc(CN3CCOCC3)c(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C32H32F2N4O5/c1-4-27(39)36-24-13-19(5-6-20(24)17-37-9-11-43-12-10-37)23-14-22-21(16-35-23)18-38(31(40)32(22)7-8-32)30-28(33)25(41-2)15-26(42-3)29(30)34/h4-6,13-16H,1,7-12,17-18H2,2-3H3,(H,36,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291247
PNG
(N-(5-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COCCn1ncc(NC(=O)C=C)c1-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C27H27F2N5O5/c1-5-21(35)32-18-13-31-34(8-9-37-2)24(18)17-10-16-15(12-30-17)14-33(26(36)27(16)6-7-27)25-22(28)19(38-3)11-20(39-4)23(25)29/h5,10-13H,1,6-9,14H2,2-4H3,(H,32,35)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291265
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2nn(CCOC(F)(F)F)cc2NC(=O)C=C)c1F
Show InChI InChI=1S/C27H24F5N5O5/c1-4-20(38)34-17-13-36(7-8-42-27(30,31)32)35-23(17)16-9-15-14(11-33-16)12-37(25(39)26(15)5-6-26)24-21(28)18(40-2)10-19(41-3)22(24)29/h4,9-11,13H,1,5-8,12H2,2-3H3,(H,34,38)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291266
PNG
(N-(3-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2nn(CCN3CCOCC3)cc2NC(=O)C=C)c1F
Show InChI InChI=1S/C30H32F2N6O5/c1-4-24(39)34-21-17-37(8-7-36-9-11-43-12-10-36)35-27(21)20-13-19-18(15-33-20)16-38(29(40)30(19)5-6-30)28-25(31)22(41-2)14-23(42-3)26(28)32/h4,13-15,17H,1,5-12,16H2,2-3H3,(H,34,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291260
PNG
((S)-N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2C[C@@H]2CCOC2)c1F |r|
Show InChI InChI=1S/C29H29F2N5O5/c1-4-23(37)34-20-12-33-36(13-16-5-8-41-15-16)26(20)19-9-18-17(11-32-19)14-35(28(38)29(18)6-7-29)27-24(30)21(39-2)10-22(40-3)25(27)31/h4,9-12,16H,1,5-8,13-15H2,2-3H3,(H,34,37)/t16-/m0/s1
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291250
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3',-o...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2C2CCOCC2)c1F
Show InChI InChI=1S/C29H29F2N5O5/c1-4-23(37)34-20-14-33-36(17-5-9-41-10-6-17)26(20)19-11-18-16(13-32-19)15-35(28(38)29(18)7-8-29)27-24(30)21(39-2)12-22(40-3)25(27)31/h4,11-14,17H,1,5-10,15H2,2-3H3,(H,34,37)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM291233
PNG
(N-{3-[2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cccc(NC(=O)C=C)c2)c1F
Show InChI InChI=1S/C27H23F2N3O4/c1-4-22(33)31-17-7-5-6-15(10-17)19-11-18-16(13-30-19)14-32(26(34)27(18)8-9-27)25-23(28)20(35-2)12-21(36-3)24(25)29/h4-7,10-13H,1,8-9,14H2,2-3H3,(H,31,33)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM350372
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES CNC(=O)Cn1ncc(NC(=O)C=C)c1-c1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1
Show InChI InChI=1S/C27H26F2N6O5/c1-5-20(36)33-17-11-32-35(13-21(37)30-2)24(17)16-8-15-14(10-31-16)12-34(26(38)27(15)6-7-27)25-22(28)18(39-3)9-19(40-4)23(25)29/h5,8-11H,1,6-7,12-13H2,2-4H3,(H,30,37)(H,33,36)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291251
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2CCN2CCOCC2)c1F
Show InChI InChI=1S/C30H32F2N6O5/c1-4-24(39)35-21-16-34-38(8-7-36-9-11-43-12-10-36)27(21)20-13-19-18(15-33-20)17-37(29(40)30(19)5-6-30)28-25(31)22(41-2)14-23(42-3)26(28)32/h4,13-16H,1,5-12,17H2,2-3H3,(H,35,39)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM291256
PNG
(N-(5-(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-3'-ox...)
Show SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2c(NC(=O)C=C)cnn2CC2CCOCC2)c1F
Show InChI InChI=1S/C30H31F2N5O5/c1-4-24(38)35-21-14-34-37(15-17-5-9-42-10-6-17)27(21)20-11-19-18(13-33-20)16-36(29(39)30(19)7-8-30)28-25(31)22(40-2)12-23(41-3)26(28)32/h4,11-14,17H,1,5-10,15-16H2,2-3H3,(H,35,38)
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US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...

US Patent US10016438 (2018)


BindingDB Entry DOI: 10.7270/Q2S46VB7
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%