| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
|---|
| Ligand | BDBM291236 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FGFR Enzymatic Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Lu, L; Wu, L; Shen, B; Yao, W Bicyclic heterocycles as FGFR4 inhibitors US Patent US10016438 Publication Date 7/10/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor receptor 4 |
|---|
| Name: | Fibroblast growth factor receptor 4 |
|---|
| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 87957.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22455 |
|---|
| Residue: | 802 |
|---|
| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
|
|
|
|---|
| BDBM291236 |
|---|
| n/a |
|---|
| Name | BDBM291236 |
|---|
| Synonyms: | N-(4-(2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-yl)pyridin-2-yl)acrylamide | US10016438, Example 4 | US9580423, Example 4 | US9801889, Example 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H22F2N4O4 |
|---|
| Mol. Mass. | 492.4741 |
|---|
| SMILES | COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2ccnc(NC(=O)C=C)c2)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
