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Patent code US10745410

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458729
PNG
((S)-2-(1-aminopropyl)-6- (3-fluoropyridin-4-yl) th...)
Show SMILES CC[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccncc1F |r|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458731
PNG
((S)-2-(amino(cyclopropyl) methyl)-6-(3-fluoropyrid...)
Show SMILES N[C@@H](C1CC1)c1nc2cc(sc2c(=O)[nH]1)-c1ccncc1F |r|
PDB

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n/an/a<100n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458726
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(2- methylpyridi...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(C)c1 |r|
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458723
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(2- chloropyridi...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(Cl)c1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458730
PNG
((S)-2-(1-aminoethyl)-6- (3-fluoropyridin-4-yl) thi...)
Show SMILES C[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccncc1F |r|
PDB

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US Patent
n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458722
PNG
((S)-2-(1-aminopropyl)-6- (2-fluoropyridin-4-yl) th...)
Show SMILES CC[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(F)c1 |r|
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458727
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(2,5- difluoropy...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1cc(F)ncc1F |r|
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458736
PNG
((S)-2-(1-amino-2- methylpropyl)-6- (pyrimidin-4-yl...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccncn1 |r|
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458738
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(1H- pyrrol-3-yl...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1cc[nH]c1 |r|
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458739
PNG
((R)-2-(1-amino-2- methylpropyl)-6-(3- fluoropyridi...)
Show SMILES CC(C)[C@@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccncc1F |r|
PDB

UniProtKB/SwissProt

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ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458733
PNG
(2-(2-aminopropan-2-yl)-6- (2-fluoropyridin-4- yl)t...)
Show SMILES CC(C)(N)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(F)c1
Show InChI InChI=1S/C14H13FN4OS/c1-14(2,16)13-18-8-6-9(21-11(8)12(20)19-13)7-3-4-17-10(15)5-7/h3-6H,16H2,1-2H3,(H,18,19,20)
PDB

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ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458737
PNG
((S)-2-(1-amino-2- methylpropyl)-6- (2H-1,2,3-triaz...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1cn[nH]n1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458735
PNG
((S)-2-(1-amino-2- methylpropyl)-6- (pyridazin-4-yl...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1ccnnc1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458725
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(1H- pyrazol-3-y...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1cc[nH]n1 |r|
PDB

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US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458724
PNG
((S)-2-(1-amino-2- methylpropyl)-6- (piperazin-1-yl...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)N1CCNCC1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458728
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(isoxazol- 4-yl)...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1cnoc1 |r|
PDB

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ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458732
PNG
((S)-6-(2-fluoropyridin-4- yl)-2-(2-methyl-1- (meth...)
Show SMILES CN[C@@H](C(C)C)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(F)c1 |r|
PDB

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n/an/a<1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
Cell division cycle 7-related protein kinase/Protein DBF4 homolog A


(Homo sapiens (Human))
BDBM458734
PNG
((S)-2-(1-amino-2- methylpropyl)-6-(1H- imidazol-4-...)
Show SMILES CC(C)[C@H](N)c1nc2cc(sc2c(=O)[nH]1)-c1c[nH]cn1 |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



ZENJI RESEARCH LABORATORIES

US Patent


Assay Description
Biochemical assay was tested in the U-shaped bottom 384 plate (corning, #4514) with a final volume of 20 ul at 27° C. The concentration of CDC7 was o...


US Patent US10745410 (2020)


BindingDB Entry DOI: 10.7270/Q28918X0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%