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Patent code US10947215

Compile Data Set for Download or QSAR

Found 458 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298833
PNG
(US10125118, Example 239 | US10947215, Example 239)
Show SMILES CN1CCC(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C35H42N6O2/c1-40-16-14-25(15-17-40)18-24-6-10-27(11-7-24)28-12-8-26(9-13-28)23-43-33-5-3-4-32(33)39-35(42)31-19-29(20-37-34(31)36)30-21-38-41(2)22-30/h6-13,19-22,25,32-33H,3-5,14-18,23H2,1-2H3,(H2,36,37)(H,39,42)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298989
PNG
(US10125118, Example 395 | US10947215, Example 395)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccncc2)ccc1C |r|
Show InChI InChI=1S/C25H29N5O2/c1-3-18-10-17(5-4-16(18)2)15-32-23-14-28-13-22(23)30-25(31)21-11-20(12-29-24(21)26)19-6-8-27-9-7-19/h4-12,22-23,28H,3,13-15H2,1-2H3,(H2,26,29)(H,30,31)/t22-,23-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298995
PNG
(US10125118, Example 401 | US10947215, Example 401)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(NS(C)(=O)=O)cc2)ccc1C |r|
Show InChI InChI=1S/C27H33N5O4S/c1-4-19-11-18(6-5-17(19)2)16-36-25-15-29-14-24(25)31-27(33)23-12-21(13-30-26(23)28)20-7-9-22(10-8-20)32-37(3,34)35/h5-13,24-25,29,32H,4,14-16H2,1-3H3,(H2,28,30)(H,31,33)/t24-,25-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486780
PNG
(US10947215, Example 411)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(CC#N)cc2)ccc1C |r|
Show InChI InChI=1S/C28H31N5O2/c1-3-21-12-20(5-4-18(21)2)17-35-26-16-31-15-25(26)33-28(34)24-13-23(14-32-27(24)30)22-8-6-19(7-9-22)10-11-29/h4-9,12-14,25-26,31H,3,10,15-17H2,1-2H3,(H2,30,32)(H,33,34)/t25-,26-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298747
PNG
(US10125118, Example 153 | US10947215, Example 153)
Show SMILES CCc1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C30H33N5O2/c1-3-20-7-11-22(12-8-20)23-13-9-21(10-14-23)19-37-28-6-4-5-27(28)34-30(36)26-15-24(16-32-29(26)31)25-17-33-35(2)18-25/h7-18,27-28H,3-6,19H2,1-2H3,(H2,31,32)(H,34,36)/t27-,28-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298753
PNG
(US10125118, Example 159 | US10947215, Example 159)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2Cl)CC1 |r|
Show InChI InChI=1S/C34H40ClN7O2/c1-40-12-14-42(15-13-40)20-23-6-9-25(10-7-23)28-11-8-24(16-30(28)35)22-44-32-5-3-4-31(32)39-34(43)29-17-26(18-37-33(29)36)27-19-38-41(2)21-27/h6-11,16-19,21,31-32H,3-5,12-15,20,22H2,1-2H3,(H2,36,37)(H,39,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299039
PNG
(US10125118, Example 445 | US10947215, Example 445)
Show SMILES CN1C[C@H](NC(=O)c2cc(cnc2N)-c2cnn(C)c2)[C@H](C1)OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C36H43F3N8O3/c1-44-21-32(43-35(49)30-15-28(17-41-34(30)40)29-18-42-45(2)19-29)33(22-44)50-23-24-3-5-25(6-4-24)26-7-8-27(31(16-26)36(37,38)39)20-47-11-9-46(10-12-47)13-14-48/h3-8,15-19,32-33,48H,9-14,20-23H2,1-2H3,(H2,40,41)(H,43,49)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298779
PNG
(US10125118, Example 185 | US10947215, Example 185)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CCN1 |r|
Show InChI InChI=1S/C34H41N7O2/c1-23-19-41(15-14-36-23)20-24-6-10-26(11-7-24)27-12-8-25(9-13-27)22-43-32-5-3-4-31(32)39-34(42)30-16-28(17-37-33(30)35)29-18-38-40(2)21-29/h6-13,16-18,21,23,31-32,36H,3-5,14-15,19-20,22H2,1-2H3,(H2,35,37)(H,39,42)/t23-,31+,32+/m1/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298799
PNG
(US10125118, Example 205 | US10947215, Example 205)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C36H42F3N7O3/c1-44-21-29(20-42-44)28-17-30(34(40)41-19-28)35(48)43-32-3-2-4-33(32)49-23-24-5-7-25(8-6-24)26-9-10-27(31(18-26)36(37,38)39)22-46-13-11-45(12-14-46)15-16-47/h5-10,17-21,32-33,47H,2-4,11-16,22-23H2,1H3,(H2,40,41)(H,43,48)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298800
PNG
(US10125118, Example 206 | US10947215, Example 206)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CCO)CC2)cc1Cl |r|
Show InChI InChI=1S/C35H42ClN7O3/c1-41-22-28(20-39-41)27-18-30(34(37)38-19-27)35(45)40-32-3-2-4-33(32)46-23-24-5-8-26(9-6-24)29-10-7-25(17-31(29)36)21-43-13-11-42(12-14-43)15-16-44/h5-10,17-20,22,32-33,44H,2-4,11-16,21,23H2,1H3,(H2,37,38)(H,40,45)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486573
PNG
(US10947215, Example 207)
Show SMILES CN1CCN(Cc2ccc(cc2C(C)(C)C)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cccnc3N)cc2)CC1 |r|
Show InChI InChI=1S/C34H45N5O2/c1-34(2,3)29-21-26(14-15-27(29)22-39-19-17-38(4)18-20-39)25-12-10-24(11-13-25)23-41-31-9-5-8-30(31)37-33(40)28-7-6-16-36-32(28)35/h6-7,10-16,21,30-31H,5,8-9,17-20,22-23H2,1-4H3,(H2,35,36)(H,37,40)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298803
PNG
(US10125118, Example 209 | US10947215, Example 209)
Show SMILES CC(N1C[C@H](C)N(C)[C@H](C)C1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C37H47N7O2/c1-24-20-44(21-25(2)43(24)5)26(3)28-13-15-30(16-14-28)29-11-9-27(10-12-29)23-46-35-8-6-7-34(35)41-37(45)33-17-31(18-39-36(33)38)32-19-40-42(4)22-32/h9-19,22,24-26,34-35H,6-8,20-21,23H2,1-5H3,(H2,38,39)(H,41,45)/t24-,25+,26?,34-,35-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298807
PNG
(US10125118, Example 213 | US10947215, Example 213)
Show SMILES C[C@@H](N1CCNCC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C34H41N7O2/c1-23(41-16-14-36-15-17-41)25-10-12-27(13-11-25)26-8-6-24(7-9-26)22-43-32-5-3-4-31(32)39-34(42)30-18-28(19-37-33(30)35)29-20-38-40(2)21-29/h6-13,18-21,23,31-32,36H,3-5,14-17,22H2,1-2H3,(H2,35,37)(H,39,42)/t23-,31+,32+/m1/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298808
PNG
(US10125118, Example 214 | US10947215, Example 214)
Show SMILES C[C@@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C35H43N7O2/c1-24(42-17-15-40(2)16-18-42)26-11-13-28(14-12-26)27-9-7-25(8-10-27)23-44-33-6-4-5-32(33)39-35(43)31-19-29(20-37-34(31)36)30-21-38-41(3)22-30/h7-14,19-22,24,32-33H,4-6,15-18,23H2,1-3H3,(H2,36,37)(H,39,43)/t24-,32+,33+/m1/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298825
PNG
(US10125118, Example 231 | US10947215, Example 231)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(Cl)cnc2N)cc1 |r|
Show InChI InChI=1S/C31H38ClN5O2/c1-21(37-16-14-36(2)15-17-37)23-10-12-25(13-11-23)24-8-6-22(7-9-24)20-39-29-5-3-4-28(29)35-31(38)27-18-26(32)19-34-30(27)33/h6-13,18-19,21,28-29H,3-5,14-17,20H2,1-2H3,(H2,33,34)(H,35,38)/t21?,28-,29-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298958
PNG
(US10125118, Example 364 | US10947215, Example 364)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(F)c(F)c3)cc2)CC1 |r|
Show InChI InChI=1S/C36H39F2N5O2/c1-42-15-17-43(18-16-42)22-24-5-9-26(10-6-24)27-11-7-25(8-12-27)23-45-34-4-2-3-33(34)41-36(44)30-19-29(21-40-35(30)39)28-13-14-31(37)32(38)20-28/h5-14,19-21,33-34H,2-4,15-18,22-23H2,1H3,(H2,39,40)(H,41,44)/t33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298960
PNG
(US10125118, Example 366 | US10947215, Example 366)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(C)CC2)cc1 |r|
Show InChI InChI=1S/C39H50N8O2/c1-44-16-14-34(15-17-44)47-26-33(24-42-47)32-22-35(38(40)41-23-32)39(48)43-36-4-3-5-37(36)49-27-29-8-12-31(13-9-29)30-10-6-28(7-11-30)25-46-20-18-45(2)19-21-46/h6-13,22-24,26,34,36-37H,3-5,14-21,25,27H2,1-2H3,(H2,40,41)(H,43,48)/t36-,37-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298961
PNG
(US10125118, Example 367 | US10947215, Example 367)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(cc3)N3CCN(C)CC3)cc2)CC1 |r|
Show InChI InChI=1S/C41H51N7O2/c1-45-18-22-47(23-19-45)28-30-6-10-32(11-7-30)33-12-8-31(9-13-33)29-50-39-5-3-4-38(39)44-41(49)37-26-35(27-43-40(37)42)34-14-16-36(17-15-34)48-24-20-46(2)21-25-48/h6-17,26-27,38-39H,3-5,18-25,28-29H2,1-2H3,(H2,42,43)(H,44,49)/t38-,39-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298972
PNG
(US10125118, Example 378 | US10947215, Example 378)
Show SMILES CC1CCN(Cc2ccc(cc2)-c2cnc(N)c(c2)C(=O)N[C@H]2CCC[C@@H]2OCc2ccc(cc2)-c2ccc(CN3CCN(C)CC3)cc2)CC1 |r|
Show InChI InChI=1S/C43H54N6O2/c1-31-18-20-48(21-19-31)28-32-8-14-37(15-9-32)38-26-39(42(44)45-27-38)43(50)46-40-4-3-5-41(40)51-30-34-10-16-36(17-11-34)35-12-6-33(7-13-35)29-49-24-22-47(2)23-25-49/h6-17,26-27,31,40-41H,3-5,18-25,28-30H2,1-2H3,(H2,44,45)(H,46,50)/t40-,41-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298975
PNG
(US10125118, Example 381 | US10947215, Example 381)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(cc3)N3CCOCC3)cc2)CC1 |r|
Show InChI InChI=1S/C40H48N6O3/c1-44-17-19-45(20-18-44)27-29-5-9-31(10-6-29)32-11-7-30(8-12-32)28-49-38-4-2-3-37(38)43-40(47)36-25-34(26-42-39(36)41)33-13-15-35(16-14-33)46-21-23-48-24-22-46/h5-16,25-26,37-38H,2-4,17-24,27-28H2,1H3,(H2,41,42)(H,43,47)/t37-,38-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298978
PNG
(US10125118, Example 384 | US10947215, Example 384)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cc(F)nc(F)c3)cc2)CC1 |r|
Show InChI InChI=1S/C35H38F2N6O2/c1-42-13-15-43(16-14-42)21-23-5-9-25(10-6-23)26-11-7-24(8-12-26)22-45-31-4-2-3-30(31)40-35(44)29-17-28(20-39-34(29)38)27-18-32(36)41-33(37)19-27/h5-12,17-20,30-31H,2-4,13-16,21-22H2,1H3,(H2,38,39)(H,40,44)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486758
PNG
(US10947215, Example 389)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(CO)cc2)ccc1C |r|
Show InChI InChI=1S/C27H32N4O3/c1-3-20-10-19(5-4-17(20)2)16-34-25-14-29-13-24(25)31-27(33)23-11-22(12-30-26(23)28)21-8-6-18(15-32)7-9-21/h4-12,24-25,29,32H,3,13-16H2,1-2H3,(H2,28,30)(H,31,33)/t24-,25-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299006
PNG
(US10125118, Example 412 | US10947215, Example 412)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(c2)C2CCNCC2)ccc1C |r|
Show InChI InChI=1S/C28H37N7O2/c1-3-20-10-19(5-4-18(20)2)17-37-26-15-31-14-25(26)34-28(36)24-11-21(12-32-27(24)29)22-13-33-35(16-22)23-6-8-30-9-7-23/h4-5,10-13,16,23,25-26,30-31H,3,6-9,14-15,17H2,1-2H3,(H2,29,32)(H,34,36)/t25-,26-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299007
PNG
(US10125118, Example 413 | US10947215, Example 413)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(c2)C2CCN(C)CC2)ccc1C |r|
Show InChI InChI=1S/C29H39N7O2/c1-4-21-11-20(6-5-19(21)2)18-38-27-16-31-15-26(27)34-29(37)25-12-22(13-32-28(25)30)23-14-33-36(17-23)24-7-9-35(3)10-8-24/h5-6,11-14,17,24,26-27,31H,4,7-10,15-16,18H2,1-3H3,(H2,30,32)(H,34,37)/t26-,27-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298738
PNG
(US10125118, Example 144 | US10947215, Example 144)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN)cc1 |r|
Show InChI InChI=1S/C29H32N6O2/c1-35-17-24(16-33-35)23-13-25(28(31)32-15-23)29(36)34-26-3-2-4-27(26)37-18-20-7-11-22(12-8-20)21-9-5-19(14-30)6-10-21/h5-13,15-17,26-27H,2-4,14,18,30H2,1H3,(H2,31,32)(H,34,36)/t26-,27-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299032
PNG
(US10125118, Example 438 | US10947215, Example 438)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C34H42N8O2/c1-23(42-14-12-40(2)13-15-42)25-8-10-27(11-9-25)26-6-4-24(5-7-26)22-44-32-20-36-19-31(32)39-34(43)30-16-28(17-37-33(30)35)29-18-38-41(3)21-29/h4-11,16-18,21,23,31-32,36H,12-15,19-20,22H2,1-3H3,(H2,35,37)(H,39,43)/t23?,31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299033
PNG
(US10125118, Example 439 | US10947215, Example 439)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CN(C)C[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C35H44N8O2/c1-24(43-15-13-40(2)14-16-43)26-9-11-28(12-10-26)27-7-5-25(6-8-27)23-45-33-22-41(3)21-32(33)39-35(44)31-17-29(18-37-34(31)36)30-19-38-42(4)20-30/h5-12,17-20,24,32-33H,13-16,21-23H2,1-4H3,(H2,36,37)(H,39,44)/t24?,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299048
PNG
(US10125118, Example 454 | US10947215, Example 454)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3COCC3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C33H39N7O3/c1-38-11-13-40(14-12-38)18-23-3-7-25(8-4-23)26-9-5-24(6-10-26)20-43-31-22-42-21-30(31)37-33(41)29-15-27(16-35-32(29)34)28-17-36-39(2)19-28/h3-10,15-17,19,30-31H,11-14,18,20-22H2,1-2H3,(H2,34,35)(H,37,41)/t30?,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298766
PNG
(2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C34H41N7O2/c1-39-14-16-41(17-15-39)21-24-6-10-26(11-7-24)27-12-8-25(9-13-27)23-43-32-5-3-4-31(32)38-34(42)30-18-28(19-36-33(30)35)29-20-37-40(2)22-29/h6-13,18-20,22,31-32H,3-5,14-17,21,23H2,1-2H3,(H2,35,36)(H,38,42)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298777
PNG
(US10125118, Example 183 | US10947215, Example 183)
Show SMILES CCN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C35H43N7O2/c1-3-41-15-17-42(18-16-41)22-25-7-11-27(12-8-25)28-13-9-26(10-14-28)24-44-33-6-4-5-32(33)39-35(43)31-19-29(20-37-34(31)36)30-21-38-40(2)23-30/h7-14,19-21,23,32-33H,3-6,15-18,22,24H2,1-2H3,(H2,36,37)(H,39,43)/t32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486554
PNG
(US10947215, Example 191)
Show SMILES CC1CN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)C(C)CN1 |r|
Show InChI InChI=1S/C35H43N7O2/c1-23-19-42(24(2)16-37-23)20-25-7-11-27(12-8-25)28-13-9-26(10-14-28)22-44-33-6-4-5-32(33)40-35(43)31-15-29(17-38-34(31)36)30-18-39-41(3)21-30/h7-15,17-18,21,23-24,32-33,37H,4-6,16,19-20,22H2,1-3H3,(H2,36,38)(H,40,43)/t23?,24?,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298794
PNG
(US10125118, Example 200 | US10947215, Example 200)
Show SMILES CN1CCN(Cc2ccc(cc2[N+]([O-])=O)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C34H40N8O4/c1-39-12-14-41(15-13-39)21-26-11-10-25(17-31(26)42(44)45)24-8-6-23(7-9-24)22-46-32-5-3-4-30(32)38-34(43)29-16-27(18-36-33(29)35)28-19-37-40(2)20-28/h6-11,16-20,30,32H,3-5,12-15,21-22H2,1-2H3,(H2,35,36)(H,38,43)/t30-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298814
PNG
(US10125118, Example 220 | US10947215, Example 220)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(cc1)C1(CC1)N1CCN(CCO)CC1 |r|
Show InChI InChI=1S/C37H45N7O3/c1-42-24-30(23-40-42)29-21-32(35(38)39-22-29)36(46)41-33-3-2-4-34(33)47-25-26-5-7-27(8-6-26)28-9-11-31(12-10-28)37(13-14-37)44-17-15-43(16-18-44)19-20-45/h5-12,21-24,33-34,45H,2-4,13-20,25H2,1H3,(H2,38,39)(H,41,46)/t33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298824
PNG
(US10125118, Example 230 | US10947215, Example 230)
Show SMILES CC(N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cncc(F)c2)cc1 |r|
Show InChI InChI=1S/C36H41FN6O2/c1-24(43-16-14-42(2)15-17-43)26-10-12-28(13-11-26)27-8-6-25(7-9-27)23-45-34-5-3-4-33(34)41-36(44)32-19-30(21-40-35(32)38)29-18-31(37)22-39-20-29/h6-13,18-22,24,33-34H,3-5,14-17,23H2,1-2H3,(H2,38,40)(H,41,44)/t24?,33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298840
PNG
(US10125118, Example 246 | US10947215, Example 246)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C33H40N6O3/c1-38(2)16-5-17-41-28-14-12-25(13-15-28)24-10-8-23(9-11-24)22-42-31-7-4-6-30(31)37-33(40)29-18-26(19-35-32(29)34)27-20-36-39(3)21-27/h8-15,18-21,30-31H,4-7,16-17,22H2,1-3H3,(H2,34,35)(H,37,40)/t30-,31-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298973
PNG
(US10125118, Example 379 | US10947215, Example 379)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3ccc(CN4CCOCC4)cc3)cc2)CC1 |r|
Show InChI InChI=1S/C41H50N6O3/c1-45-17-19-46(20-18-45)27-30-5-11-33(12-6-30)34-15-9-32(10-16-34)29-50-39-4-2-3-38(39)44-41(48)37-25-36(26-43-40(37)42)35-13-7-31(8-14-35)28-47-21-23-49-24-22-47/h5-16,25-26,38-39H,2-4,17-24,27-29H2,1H3,(H2,42,43)(H,44,48)/t38-,39-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298990
PNG
(US10125118, Example 396 | US10947215, Example 396)
Show SMILES CCc1cc(CO[C@H]2CNC[C@@H]2NC(=O)c2cc(cnc2N)-c2cccnc2)ccc1C |r|
Show InChI InChI=1S/C25H29N5O2/c1-3-18-9-17(7-6-16(18)2)15-32-23-14-28-13-22(23)30-25(31)21-10-20(12-29-24(21)26)19-5-4-8-27-11-19/h4-12,22-23,28H,3,13-15H2,1-2H3,(H2,26,29)(H,30,31)/t22-,23-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486788
PNG
(US10947215, Example 419)
Show SMILES CCc1cc(CO[C@H]2CN(C[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(cc2)C(O)=O)C(=O)OC(C)(C)C)ccc1C |r|
Show InChI InChI=1S/C32H38N4O6/c1-6-21-13-20(8-7-19(21)2)18-41-27-17-36(31(40)42-32(3,4)5)16-26(27)35-29(37)25-14-24(15-34-28(25)33)22-9-11-23(12-10-22)30(38)39/h7-15,26-27H,6,16-18H2,1-5H3,(H2,33,34)(H,35,37)(H,38,39)/t26-,27-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298732
PNG
(US10125118, Example 138 | US10947215, Example 138)
Show SMILES CN(C)Cc1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C31H36N6O2/c1-36(2)18-21-7-11-23(12-8-21)24-13-9-22(10-14-24)20-39-29-6-4-5-28(29)35-31(38)27-15-25(16-33-30(27)32)26-17-34-37(3)19-26/h7-17,19,28-29H,4-6,18,20H2,1-3H3,(H2,32,33)(H,35,38)/t28-,29-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298741
PNG
(US10125118, Example 147 | US10947215, Example 147)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(nc1)N1CCNCC1 |r|
Show InChI InChI=1S/C31H36N8O2/c1-38-19-25(18-36-38)24-15-26(30(32)35-17-24)31(40)37-27-3-2-4-28(27)41-20-21-5-7-22(8-6-21)23-9-10-29(34-16-23)39-13-11-33-12-14-39/h5-10,15-19,27-28,33H,2-4,11-14,20H2,1H3,(H2,32,35)(H,37,40)/t27-,28-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM299029
PNG
(US10125118, Example 435 | US10947215, Example 435)
Show SMILES CN1C[C@H](NC(=O)c2cc(cnc2N)-c2cnn(C)c2)[C@H](C1)OCc1ccc(cc1)-c1ccc(CN2CCN(C)CC2)cc1 |r|
Show InChI InChI=1S/C34H42N8O2/c1-39-12-14-42(15-13-39)19-24-4-8-26(9-5-24)27-10-6-25(7-11-27)23-44-32-22-40(2)21-31(32)38-34(43)30-16-28(17-36-33(30)35)29-18-37-41(3)20-29/h4-11,16-18,20,31-32H,12-15,19,21-23H2,1-3H3,(H2,35,36)(H,38,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298773
PNG
(US10125118, Example 179 | US10947215, Example 179)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCC(CC2)N2CCCC2)cc1 |r|
Show InChI InChI=1S/C38H47N7O2/c1-43-25-32(23-41-43)31-21-34(37(39)40-22-31)38(46)42-35-5-4-6-36(35)47-26-28-9-13-30(14-10-28)29-11-7-27(8-12-29)24-44-19-15-33(16-20-44)45-17-2-3-18-45/h7-14,21-23,25,33,35-36H,2-6,15-20,24,26H2,1H3,(H2,39,40)(H,42,46)/t35-,36-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298776
PNG
(US10125118, Example 182 | US10947215, Example 182)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(CN2CCN(CC(C)(C)O)CC2)cc1 |r|
Show InChI InChI=1S/C37H47N7O3/c1-37(2,46)25-44-17-15-43(16-18-44)22-26-7-11-28(12-8-26)29-13-9-27(10-14-29)24-47-34-6-4-5-33(34)41-36(45)32-19-30(20-39-35(32)38)31-21-40-42(3)23-31/h7-14,19-21,23,33-34,46H,4-6,15-18,22,24-25H2,1-3H3,(H2,38,39)(H,41,45)/t33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM486555
PNG
(US10947215, Example 192)
Show SMILES CC1CN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)C(C)CN1C |r|
Show InChI InChI=1S/C36H45N7O2/c1-24-20-43(25(2)19-41(24)3)21-26-8-12-28(13-9-26)29-14-10-27(11-15-29)23-45-34-7-5-6-33(34)40-36(44)32-16-30(17-38-35(32)37)31-18-39-42(4)22-31/h8-18,22,24-25,33-34H,5-7,19-21,23H2,1-4H3,(H2,37,38)(H,40,44)/t24?,25?,33-,34-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298789
PNG
(US10125118, Example 195 | US10947215, Example 195)
Show SMILES CN1CCN(Cc2ccc(cc2F)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C34H40FN7O2/c1-40-12-14-42(15-13-40)21-26-11-10-25(17-30(26)35)24-8-6-23(7-9-24)22-44-32-5-3-4-31(32)39-34(43)29-16-27(18-37-33(29)36)28-19-38-41(2)20-28/h6-11,16-20,31-32H,3-5,12-15,21-22H2,1-2H3,(H2,36,37)(H,39,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298790
PNG
(US10125118, Example 196 | US10947215, Example 196)
Show SMILES CN1CCN(Cc2c(F)cc(cc2F)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C34H39F2N7O2/c1-41-10-12-43(13-11-41)20-28-29(35)15-24(16-30(28)36)23-8-6-22(7-9-23)21-45-32-5-3-4-31(32)40-34(44)27-14-25(17-38-33(27)37)26-18-39-42(2)19-26/h6-9,14-19,31-32H,3-5,10-13,20-21H2,1-2H3,(H2,37,38)(H,40,44)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298796
PNG
(US10125118, Example 202 | US10947215, Example 202)
Show SMILES CN1CCN(Cc2ccc(c(Cl)c2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1 |r|
Show InChI InChI=1S/C34H40ClN7O2/c1-40-12-14-42(15-13-40)20-24-8-11-28(30(35)16-24)25-9-6-23(7-10-25)22-44-32-5-3-4-31(32)39-34(43)29-17-26(18-37-33(29)36)27-19-38-41(2)21-27/h6-11,16-19,21,31-32H,3-5,12-15,20,22H2,1-2H3,(H2,36,37)(H,39,43)/t31-,32-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298809
PNG
(US10125118, Example 215 | US10947215, Example 215)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2cnn(C)c2)cc1 |r|
Show InChI InChI=1S/C35H43N7O2/c1-24(42-17-15-40(2)16-18-42)26-11-13-28(14-12-26)27-9-7-25(8-10-27)23-44-33-6-4-5-32(33)39-35(43)31-19-29(20-37-34(31)36)30-21-38-41(3)22-30/h7-14,19-22,24,32-33H,4-6,15-18,23H2,1-3H3,(H2,36,37)(H,39,43)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298816
PNG
(US10125118, Example 222 | US10125118, Example 223 ...)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1 |r|
Show InChI InChI=1S/C36H41FN6O2/c1-24(43-18-16-42(2)17-19-43)26-10-12-28(13-11-26)27-8-6-25(7-9-27)23-45-33-5-3-4-32(33)41-36(44)31-20-30(22-40-35(31)38)29-14-15-34(37)39-21-29/h6-15,20-22,24,32-33H,3-5,16-19,23H2,1-2H3,(H2,38,40)(H,41,44)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer/receptor UFO


(Homo sapiens (Human))		BDBM298816
PNG
(US10125118, Example 222 | US10125118, Example 223 ...)
Show SMILES C[C@H](N1CCN(C)CC1)c1ccc(cc1)-c1ccc(CO[C@H]2CCC[C@@H]2NC(=O)c2cc(cnc2N)-c2ccc(F)nc2)cc1 |r|
Show InChI InChI=1S/C36H41FN6O2/c1-24(43-18-16-42(2)17-19-43)26-10-12-28(13-11-26)27-8-6-25(7-9-27)23-45-33-5-3-4-32(33)41-36(44)31-20-30(22-40-35(31)38)29-14-15-34(37)39-21-29/h6-15,20-22,24,32-33H,3-5,16-19,23H2,1-2H3,(H2,38,40)(H,41,44)/t24-,32-,33-/m0/s1
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Dong-A Socio Holdings Co., Ltd.

US Patent


Assay Description
For the SAR (structure-activity relationship) and compound screening, LanthaScreen™ TR-FRET (Time-Resolved fluorescence energy transfer) assay was em...

US Patent US10947215 (2021)


BindingDB Entry DOI: 10.7270/Q2862KKK
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 458 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%