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Patent code US9434711

Compile Data Set for Download or QSAR

Found 709 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248702
PNG
(US9434711, 640)
Show SMILES Cc1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1nsc(=O)[nH]1
Show InChI InChI=1S/C22H20F3N3O3S3/c1-14-17-6-2-3-7-18(17)32-20(14)28(13-5-4-12-22(23,24)25)34(30,31)16-10-8-15(9-11-16)19-26-21(29)33-27-19/h2-3,6-11H,4-5,12-13H2,1H3,(H,26,27,29)
PDB

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US Patent
n/an/a 11n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248704
PNG
(US9434711, 642)
Show SMILES O=c1[nH]c(ns1)-c1ccc(cc1)S(=O)(=O)N(CCC1CC1)c1cc2ccccc2s1
Show InChI InChI=1S/C21H19N3O3S3/c25-21-22-20(23-29-21)15-7-9-17(10-8-15)30(26,27)24(12-11-14-5-6-14)19-13-16-3-1-2-4-18(16)28-19/h1-4,7-10,13-14H,5-6,11-12H2,(H,22,23,25)
PDB

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UniProtKB/TrEMBL

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n/an/a 41n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248712
PNG
(US9434711, 658)
Show SMILES CC(C)(O)c1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H24F3NO5S2/c1-22(2,30)19-17-7-3-4-8-18(17)33-20(19)27(14-6-5-13-23(24,25)26)34(31,32)16-11-9-15(10-12-16)21(28)29/h3-4,7-12,30H,5-6,13-14H2,1-2H3,(H,28,29)
PDB

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n/an/a 4.30n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248714
PNG
(US9434711, 660)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C23H17BrF4N2O4S3/c1-36(31,32)29-15-7-9-16(10-8-15)37(33,34)30(22-21(24)17-4-2-3-5-20(17)35-22)13-14-6-11-19(25)18(12-14)23(26,27)28/h2-12,29H,13H2,1H3
PDB

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n/an/a 11.2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248721
PNG
(US9434711, 671)
Show SMILES Cc1c(sc2ccccc12)N(CCC(F)(F)F)S(=O)(=O)CC(F)(F)F
Show InChI InChI=1S/C14H13F6NO2S2/c1-9-10-4-2-3-5-11(10)24-12(9)21(7-6-13(15,16)17)25(22,23)8-14(18,19)20/h2-5H,6-8H2,1H3
PDB

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n/an/a 34.5n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248735
PNG
(US9434711, 686)
Show SMILES OC(=O)c1ccc(c(F)c1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1cc2ccccc2s1
Show InChI InChI=1S/C23H14F5NO4S2/c24-17-7-5-13(9-16(17)23(26,27)28)12-29(21-11-14-3-1-2-4-19(14)34-21)35(32,33)20-8-6-15(22(30)31)10-18(20)25/h1-11H,12H2,(H,30,31)
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n/an/a 4.70n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248743
PNG
(US9434711, 695)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccc(NC(=O)C(F)(F)F)cc2)cc1C(F)(F)F
Show InChI InChI=1S/C24H14BrF7N2O3S2/c25-20-16-3-1-2-4-19(16)38-21(20)34(12-13-5-10-18(26)17(11-13)23(27,28)29)39(36,37)15-8-6-14(7-9-15)33-22(35)24(30,31)32/h1-11H,12H2,(H,33,35)
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n/an/a 17n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248749
PNG
(US9434711, 702)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)CC(F)(F)F)cc1C(F)(F)F
Show InChI InChI=1S/C18H11BrF7NO2S2/c19-15-11-3-1-2-4-14(11)30-16(15)27(31(28,29)9-17(21,22)23)8-10-5-6-13(20)12(7-10)18(24,25)26/h1-7H,8-9H2
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n/an/a 23n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248752
PNG
(US9434711, 705)
Show SMILES CNS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C17H13BrF4N2O2S2/c1-23-28(25,26)24(16-15(18)11-4-2-3-5-14(11)27-16)9-10-6-7-13(19)12(8-10)17(20,21)22/h2-8,23H,9H2,1H3
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n/an/a 19n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248766
PNG
(US9434711, 721)
Show SMILES Cc1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1cccc2nccnc12
Show InChI InChI=1S/C22H20F3N3O2S2/c1-15-16-7-2-3-9-18(16)31-21(15)28(14-5-4-11-22(23,24)25)32(29,30)19-10-6-8-17-20(19)27-13-12-26-17/h2-3,6-10,12-13H,4-5,11,14H2,1H3
PDB

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n/an/a 4.20n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248786
PNG
(US9434711, 750)
Show SMILES Cc1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C24H27F3N2O3S2/c1-18-21-6-2-3-7-22(21)33-23(18)29(13-5-4-12-24(25,26)27)34(30,31)20-10-8-19(9-11-20)28-14-16-32-17-15-28/h2-3,6-11H,4-5,12-17H2,1H3
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n/an/a 9.20n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248787
PNG
(US9434711, 753)
Show SMILES COC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1sc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H22F3NO5S2/c1-35-26(32)19-10-14-21(15-11-19)38(33,34)31(16-17-6-12-20(13-7-17)36-27(28,29)30)25-24(18-8-9-18)22-4-2-3-5-23(22)37-25/h2-7,10-15,18H,8-9,16H2,1H3
PDB

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n/an/a 27.2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248806
PNG
(US9434711, 772)
Show SMILES CC(=O)c1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H17F3N2O4S2/c1-16(31)23-21-4-2-3-5-22(21)35-24(23)30(36(32,33)20-12-8-17(14-29)9-13-20)15-18-6-10-19(11-7-18)34-25(26,27)28/h2-13H,15H2,1H3
PDB

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n/an/a 5.70n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248807
PNG
(US9434711, 773)
Show SMILES CC(=O)c1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C22H19F3N2O3S2/c1-15(28)20-18-6-2-3-7-19(18)31-21(20)27(13-5-4-12-22(23,24)25)32(29,30)17-10-8-16(14-26)9-11-17/h2-3,6-11H,4-5,12-13H2,1H3
PDB

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n/an/a 16.7n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248812
PNG
(US9434711, 779)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)CCCCn1ccnc1
Show InChI InChI=1S/C24H23F4N3O2S2/c1-17-19-6-2-3-7-22(19)34-23(17)31(15-18-8-9-21(25)20(14-18)24(26,27)28)35(32,33)13-5-4-11-30-12-10-29-16-30/h2-3,6-10,12,14,16H,4-5,11,13,15H2,1H3
PDB

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n/an/a 48.7n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248834
PNG
(US9434711, 804)
Show SMILES Cc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(nc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H20N6O2S2/c1-13-16-4-2-3-5-18(16)29-20(13)26(11-10-14-6-7-14)30(27,28)15-8-9-17(21-12-15)19-22-24-25-23-19/h2-5,8-9,12,14H,6-7,10-11H2,1H3,(H,22,23,24,25)
PDB

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n/an/a 11.1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248850
PNG
(US9434711, 822)
Show SMILES COC(C)c1c(sc2ccccc12)N(CCCF)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H22FNO3S2/c1-15(25-2)19-17-11-6-7-12-18(17)26-20(19)22(14-8-13-21)27(23,24)16-9-4-3-5-10-16/h3-7,9-12,15H,8,13-14H2,1-2H3
PDB

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n/an/a 49n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248854
PNG
(US9434711, 826)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)cc1)S(=O)(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H16F3NO2S2/c1-14-18-4-2-3-5-21(18)29-22(14)26(13-15-6-8-16(23)9-7-15)30(27,28)17-10-11-19(24)20(25)12-17/h2-12H,13H2,1H3
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n/an/a 24n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248867
PNG
(US9434711, 839)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C(C)OC
Show InChI InChI=1S/C21H21F4NO3S2/c1-4-31(27,28)26(12-14-9-10-17(22)16(11-14)21(23,24)25)20-19(13(2)29-3)15-7-5-6-8-18(15)30-20/h5-11,13H,4,12H2,1-3H3
PDB

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n/an/a 15.9n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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UniProtKB/SwissProt

DrugBank
antibodypedia
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US Patent
n/an/a 1.40n/an/an/an/an/a25



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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US Patent
n/an/a 0.183n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248174
PNG
(US9434711, 4)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Cl)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15ClFNO2S2/c22-20-18-8-4-5-9-19(18)27-21(20)24(14-15-10-12-16(23)13-11-15)28(25,26)17-6-2-1-3-7-17/h1-13H,14H2
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n/an/a 4n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248190
PNG
(US9434711, 21)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1cccc2cccnc12
Show InChI InChI=1S/C26H19F3N2O3S2/c1-17-21-8-2-3-9-22(21)35-25(17)31(16-18-11-13-20(14-12-18)34-26(27,28)29)36(32,33)23-10-4-6-19-7-5-15-30-24(19)23/h2-15H,16H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248194
PNG
(US9434711, 25)
Show SMILES COc1cccc(c1)S(=O)(=O)N(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C23H19F2NO3S2/c1-15-19-8-3-4-9-22(19)30-23(15)26(14-16-10-11-20(24)21(25)12-16)31(27,28)18-7-5-6-17(13-18)29-2/h3-13H,14H2,1-2H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248197
PNG
(US9434711, 28)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C26H19F3N2O3S2/c1-17-21-6-2-3-7-23(21)35-25(17)31(16-18-9-11-20(12-10-18)34-26(27,28)29)36(32,33)24-8-4-5-19-15-30-14-13-22(19)24/h2-15H,16H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248207
PNG
(US9434711, 38)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)F)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C21H15F4NO2S3/c1-13-15-5-2-3-6-18(15)30-20(13)26(31(27,28)19-7-4-10-29-19)12-14-8-9-16(17(22)11-14)21(23,24)25/h2-11H,12H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248214
PNG
(US9434711, 45)
Show SMILES CS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1cc2ccccc2s1
Show InChI InChI=1S/C17H13F4NO2S2/c1-26(23,24)22(16-9-12-4-2-3-5-15(12)25-16)10-11-6-7-14(18)13(8-11)17(19,20)21/h2-9H,10H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248217
PNG
(US9434711, 48)
Show SMILES COc1cccc(CN(c2cc3ccccc3s2)S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C22H19NO3S2/c1-26-19-10-7-8-17(14-19)16-23(28(24,25)20-11-3-2-4-12-20)22-15-18-9-5-6-13-21(18)27-22/h2-15H,16H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248230
PNG
(US9434711, 62)
Show SMILES Cc1ccccc1CN(c1cc2ccccc2s1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H19NO2S2/c1-17-9-5-6-11-19(17)16-23(27(24,25)20-12-3-2-4-13-20)22-15-18-10-7-8-14-21(18)26-22/h2-15H,16H2,1H3
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n/an/a 58.1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248253
PNG
(US9434711, 87)
Show SMILES CN(C)CCN(c1sc2ccccc2c1Cl)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19ClN2O2S2/c1-20(2)12-13-21(25(22,23)14-8-4-3-5-9-14)18-17(19)15-10-6-7-11-16(15)24-18/h3-11H,12-13H2,1-2H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248265
PNG
(US9434711, 100)
Show SMILES Cc1c(sc2ccccc12)N(CCOC(C)(C)C)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H25NO3S2/c1-16-18-12-8-9-13-19(18)26-20(16)22(14-15-25-21(2,3)4)27(23,24)17-10-6-5-7-11-17/h5-13H,14-15H2,1-4H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248285
PNG
(US9434711, 129)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C20H15F2NO2S3/c1-13-15-5-2-3-6-18(15)27-20(13)23(28(24,25)19-7-4-10-26-19)12-14-8-9-16(21)17(22)11-14/h2-11H,12H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248294
PNG
(US9434711, 146)
Show SMILES Fc1cc(CN(c2cc3ncccc3s2)S(=O)(=O)c2ccccc2)ccc1C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O2S2/c22-17-11-14(8-9-16(17)21(23,24)25)13-27(31(28,29)15-5-2-1-3-6-15)20-12-18-19(30-20)7-4-10-26-18/h1-12H,13H2
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248297
PNG
(US9434711, 149)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2cccnc2)cc1F
Show InChI InChI=1S/C20H13BrF2N2O2S2/c21-19-15-5-1-2-6-18(15)28-20(19)25(12-13-7-8-16(22)17(23)10-13)29(26,27)14-4-3-9-24-11-14/h1-11H,12H2
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248308
PNG
(US9434711, 161)
Show SMILES COc1ccc(Br)cc1CN(c1sc2ccccc2c1Br)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H17Br2NO3S2/c1-28-19-12-11-16(23)13-15(19)14-25(30(26,27)17-7-3-2-4-8-17)22-21(24)18-9-5-6-10-20(18)29-22/h2-13H,14H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248311
PNG
(US9434711, 164)
Show SMILES COc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C22H18BrNO3S2/c1-27-17-13-11-16(12-14-17)15-24(29(25,26)18-7-3-2-4-8-18)22-21(23)19-9-5-6-10-20(19)28-22/h2-14H,15H2,1H3
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n/an/a 31.9n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248312
PNG
(US9434711, 165)
Show SMILES COc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccccc2)cc1Br
Show InChI InChI=1S/C22H17Br2NO3S2/c1-28-19-12-11-15(13-18(19)23)14-25(30(26,27)16-7-3-2-4-8-16)22-21(24)17-9-5-6-10-20(17)29-22/h2-13H,14H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248316
PNG
(US9434711, 169)
Show SMILES Brc1c(sc2ccccc12)N(Cc1cccnc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H15BrN2O2S2/c21-19-17-10-4-5-11-18(17)26-20(19)23(14-15-7-6-12-22-13-15)27(24,25)16-8-2-1-3-9-16/h1-13H,14H2
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n/an/a 21.4n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248330
PNG
(US9434711, 183)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C18H14BrF4NO2S2/c1-2-28(25,26)24(17-16(19)12-5-3-4-6-15(12)27-17)10-11-7-8-14(20)13(9-11)18(21,22)23/h3-9H,2,10H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248337
PNG
(US9434711, 190)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C18H14ClF4NO2S2/c1-2-28(25,26)24(17-16(19)12-5-3-4-6-15(12)27-17)10-11-7-8-14(20)13(9-11)18(21,22)23/h3-9H,2,10H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248342
PNG
(US9434711, 196)
Show SMILES COC(=O)c1ccccc1S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C24H16ClF4NO4S2/c1-34-23(31)16-7-3-5-9-20(16)36(32,33)30(22-21(25)15-6-2-4-8-19(15)35-22)13-14-10-11-18(26)17(12-14)24(27,28)29/h2-12H,13H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248359
PNG
(US9434711, 216)
Show SMILES CS(=O)(=O)N(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1CO
Show InChI InChI=1S/C17H15F2NO3S2/c1-25(22,23)20(9-11-6-7-14(18)15(19)8-11)17-13(10-21)12-4-2-3-5-16(12)24-17/h2-8,21H,9-10H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248360
PNG
(US9434711, 217)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1CO
Show InChI InChI=1S/C19H17F4NO3S2/c1-2-29(26,27)24(10-12-7-8-16(20)15(9-12)19(21,22)23)18-14(11-25)13-5-3-4-6-17(13)28-18/h3-9,25H,2,10-11H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248362
PNG
(US9434711, 219)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1CO
Show InChI InChI=1S/C18H17F2NO3S2/c1-2-26(23,24)21(10-12-7-8-15(19)16(20)9-12)18-14(11-22)13-5-3-4-6-17(13)25-18/h3-9,22H,2,10-11H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248366
PNG
(US9434711, 223)
Show SMILES CC(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H19F4NO3S2/c1-15(30)22-18-9-5-6-10-21(18)33-23(22)29(34(31,32)17-7-3-2-4-8-17)14-16-11-12-20(25)19(13-16)24(26,27)28/h2-13,15,30H,14H2,1H3
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248376
PNG
(US9434711, 233)
Show SMILES Brc1c(sc2ccccc12)N(CCc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H18BrNO2S2/c23-21-19-13-7-8-14-20(19)27-22(21)24(16-15-17-9-3-1-4-10-17)28(25,26)18-11-5-2-6-12-18/h1-14H,15-16H2
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 22n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248378
PNG
(US9434711, 237)
Show SMILES Brc1c(sc2ccccc12)N(CCN1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H21BrN2O3S2/c21-19-17-8-4-5-9-18(17)27-20(19)23(11-10-22-12-14-26-15-13-22)28(24,25)16-6-2-1-3-7-16/h1-9H,10-15H2
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 24.8n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248387
PNG
(US9434711, 247)
Show SMILES CCN(c1sc2ccccc2c1Br)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H14BrNO2S2/c1-2-18(22(19,20)12-8-4-3-5-9-12)16-15(17)13-10-6-7-11-14(13)21-16/h3-11H,2H2,1H3
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 25.5n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248391
PNG
(US9434711, 251)
Show SMILES CC#CCCN(c1sc2ccccc2c1Br)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H16BrNO2S2/c1-2-3-9-14-21(25(22,23)15-10-5-4-6-11-15)19-18(20)16-12-7-8-13-17(16)24-19/h4-8,10-13H,9,14H2,1H3
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 38.7n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248398
PNG
(US9434711, 261)
Show SMILES CCCCN(c1sc2ccccc2c1Br)S(=O)(=O)CC
Show InChI InChI=1S/C14H18BrNO2S2/c1-3-5-10-16(20(17,18)4-2)14-13(15)11-8-6-7-9-12(11)19-14/h6-9H,3-5,10H2,1-2H3
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 12.6n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%