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Patent code US9434711

Compile Data Set for Download or QSAR

Found 709 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
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US Patent
n/an/a 1.80n/an/an/an/an/a25



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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n/an/a 1.40n/an/an/an/an/a25



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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n/an/a 4n/an/an/an/an/a25



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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n/an/a 5n/an/an/an/an/a25



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248678
PNG
(US9434711, 613)
Show SMILES Cc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(cc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C22H21N3O4S2/c1-14-18-4-2-3-5-19(18)30-21(14)25(13-12-15-6-7-15)31(27,28)17-10-8-16(9-11-17)20-23-22(26)29-24-20/h2-5,8-11,15H,6-7,12-13H2,1H3,(H,23,24,26)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248680
PNG
(US9434711, 615)
Show SMILES Cc1c(sc2ccccc12)N(CCC(F)(F)F)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H16F3NO2S2/c1-13-15-9-5-6-10-16(15)25-17(13)22(12-11-18(19,20)21)26(23,24)14-7-3-2-4-8-14/h2-10H,11-12H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248693
PNG
(US9434711, 628)
Show SMILES COC(=O)c1ccc(cc1)S(=O)(=O)N(CCC1CC1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H23NO4S2/c1-15-19-5-3-4-6-20(19)28-21(15)23(14-13-16-7-8-16)29(25,26)18-11-9-17(10-12-18)22(24)27-2/h3-6,9-12,16H,7-8,13-14H2,1-2H3
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n/an/a 23.3n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248703
PNG
(US9434711, 641)
Show SMILES Cc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(cc1)-c1nsc(=O)[nH]1
Show InChI InChI=1S/C22H21N3O3S3/c1-14-18-4-2-3-5-19(18)29-21(14)25(13-12-15-6-7-15)31(27,28)17-10-8-16(9-11-17)20-23-22(26)30-24-20/h2-5,8-11,15H,6-7,12-13H2,1H3,(H,23,24,26)
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n/an/a 14n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248724
PNG
(US9434711, 674)
Show SMILES COC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C1CC1
Show InChI InChI=1S/C27H21F4NO4S2/c1-36-26(33)18-9-11-19(12-10-18)38(34,35)32(15-16-6-13-22(28)21(14-16)27(29,30)31)25-24(17-7-8-17)20-4-2-3-5-23(20)37-25/h2-6,9-14,17H,7-8,15H2,1H3
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n/an/a 77.6n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248729
PNG
(US9434711, 680)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)S(=O)(=O)N(CCCCC(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C20H20BrF3N2O4S3/c1-32(27,28)25-14-8-10-15(11-9-14)33(29,30)26(13-5-4-12-20(22,23)24)19-18(21)16-6-2-3-7-17(16)31-19/h2-3,6-11,25H,4-5,12-13H2,1H3
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n/an/a 56.1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248730
PNG
(US9434711, 681)
Show SMILES CS(=O)(=O)Nc1c(Cl)cc(cc1Cl)S(=O)(=O)N(CCC(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C18H14Cl3F3N2O4S3/c1-32(27,28)25-16-12(19)8-10(9-13(16)20)33(29,30)26(7-6-18(22,23)24)17-15(21)11-4-2-3-5-14(11)31-17/h2-5,8-9,25H,6-7H2,1H3
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n/an/a 67.4n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248736
PNG
(US9434711, 687)
Show SMILES FC(F)(F)CCCCN(c1cc2ccccc2s1)S(=O)(=O)c1ccc(cc1)-c1nsc(=O)[nH]1
Show InChI InChI=1S/C21H18F3N3O3S3/c22-21(23,24)11-3-4-12-27(18-13-15-5-1-2-6-17(15)31-18)33(29,30)16-9-7-14(8-10-16)19-25-20(28)32-26-19/h1-2,5-10,13H,3-4,11-12H2,(H,25,26,28)
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n/an/a 56.9n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248745
PNG
(US9434711, 697)
Show SMILES Fc1ccc(CN(c2cc3ccccc3s2)S(=O)(=O)CC(F)(F)F)cc1C(F)(F)F
Show InChI InChI=1S/C18H12F7NO2S2/c19-14-6-5-11(7-13(14)18(23,24)25)9-26(30(27,28)10-17(20,21)22)16-8-12-3-1-2-4-15(12)29-16/h1-8H,9-10H2
PDB

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n/an/a 64n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248749
PNG
(US9434711, 702)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)CC(F)(F)F)cc1C(F)(F)F
Show InChI InChI=1S/C18H11BrF7NO2S2/c19-15-11-3-1-2-4-14(11)30-16(15)27(31(28,29)9-17(21,22)23)8-10-5-6-13(20)12(7-10)18(24,25)26/h1-7H,8-9H2
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248764
PNG
(US9434711, 718)
Show SMILES Clc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(NS(=O)(=O)C2CC2)cc1
Show InChI InChI=1S/C22H23ClN2O4S3/c23-21-19-3-1-2-4-20(19)30-22(21)25(14-13-15-5-6-15)32(28,29)18-9-7-16(8-10-18)24-31(26,27)17-11-12-17/h1-4,7-10,15,17,24H,5-6,11-14H2
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n/an/a 39n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248769
PNG
(US9434711, 725)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)CCC(C)(C)O
Show InChI InChI=1S/C22H23F4NO3S2/c1-14-16-6-4-5-7-19(16)31-20(14)27(32(29,30)11-10-21(2,3)28)13-15-8-9-18(23)17(12-15)22(24,25)26/h4-9,12,28H,10-11,13H2,1-3H3
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n/an/a 7.80n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248778
PNG
(US9434711, 736)
Show SMILES CC(C)(O)c1c(sc2ccccc12)N(Cc1ccccc1)S(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C24H22BrNO3S2/c1-24(2,27)22-20-10-6-7-11-21(20)30-23(22)26(16-17-8-4-3-5-9-17)31(28,29)19-14-12-18(25)13-15-19/h3-15,27H,16H2,1-2H3
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n/an/a 17.2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248780
PNG
(US9434711, 738)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)N(CCC1CC1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H26N2O2S2/c1-16-20-6-4-5-7-21(20)27-22(16)24(15-14-17-8-9-17)28(25,26)19-12-10-18(11-13-19)23(2)3/h4-7,10-13,17H,8-9,14-15H2,1-3H3
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n/an/a 8.90n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248783
PNG
(US9434711, 744)
Show SMILES COc1cc(NS(C)(=O)=O)ccc1S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C24H19ClF4N2O5S3/c1-36-19-12-15(30-38(2,32)33)8-10-21(19)39(34,35)31(23-22(25)16-5-3-4-6-20(16)37-23)13-14-7-9-18(26)17(11-14)24(27,28)29/h3-12,30H,13H2,1-2H3
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n/an/a 57.3n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248797
PNG
(US9434711, 763)
Show SMILES Cc1c(sc2ccccc12)N(Cc1cccc(OC(F)(F)F)c1)S(=O)(=O)CCC(C)(C)O
Show InChI InChI=1S/C22H24F3NO4S2/c1-15-18-9-4-5-10-19(18)31-20(15)26(32(28,29)12-11-21(2,3)27)14-16-7-6-8-17(13-16)30-22(23,24)25/h4-10,13,27H,11-12,14H2,1-3H3
PDB

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n/an/a 27.7n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248813
PNG
(US9434711, 780)
Show SMILES CS(=O)(=O)Nc1ccc(c(O)c1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C23H17ClF4N2O5S3/c1-37(32,33)29-14-7-9-20(18(31)11-14)38(34,35)30(22-21(24)15-4-2-3-5-19(15)36-22)12-13-6-8-17(25)16(10-13)23(26,27)28/h2-11,29,31H,12H2,1H3
PDB

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US Patent
n/an/a 145n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248816
PNG
(US9434711, 785)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C24H18F3N5O3S2/c1-15-20-4-2-3-5-21(20)36-23(15)32(14-16-6-10-18(11-7-16)35-24(25,26)27)37(33,34)19-12-8-17(9-13-19)22-28-30-31-29-22/h2-13H,14H2,1H3,(H,28,29,30,31)
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n/an/a 2.20n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248829
PNG
(US9434711, 799)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C25H23F3N2O3S2/c1-17-22-6-4-5-7-23(22)34-24(17)30(16-18-8-12-20(13-9-18)33-25(26,27)28)35(31,32)21-14-10-19(11-15-21)29(2)3/h4-15H,16H2,1-3H3
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n/an/a 3.90n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248834
PNG
(US9434711, 804)
Show SMILES Cc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(nc1)-c1nnn[nH]1
Show InChI InChI=1S/C20H20N6O2S2/c1-13-16-4-2-3-5-18(16)29-20(13)26(11-10-14-6-7-14)30(27,28)15-8-9-17(21-12-15)19-22-24-25-23-19/h2-5,8-9,12,14H,6-7,10-11H2,1H3,(H,22,23,24,25)
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n/an/a 11.1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248837
PNG
(US9434711, 807)
Show SMILES Cc1c(sc2ccccc12)N(CCC1CC1)S(=O)(=O)c1ccc(nc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C21H20N4O4S2/c1-13-16-4-2-3-5-18(16)30-20(13)25(11-10-14-6-7-14)31(27,28)15-8-9-17(22-12-15)19-23-21(26)29-24-19/h2-5,8-9,12,14H,6-7,10-11H2,1H3,(H,23,24,26)
PDB

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n/an/a 6n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248840
PNG
(US9434711, 810)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)-c1nsc(=O)[nH]1
Show InChI InChI=1S/C25H18F3N3O4S3/c1-15-20-4-2-3-5-21(20)36-23(15)31(14-16-6-10-18(11-7-16)35-25(26,27)28)38(33,34)19-12-8-17(9-13-19)22-29-24(32)37-30-22/h2-13H,14H2,1H3,(H,29,30,32)
PDB

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n/an/a 1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248855
PNG
(US9434711, 827)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(OC)c1)c1sc2ccccc2c1C(C)O
Show InChI InChI=1S/C20H22FNO4S2/c1-4-28(24,25)22(12-14-9-10-16(21)17(11-14)26-3)20-19(13(2)23)15-7-5-6-8-18(15)27-20/h5-11,13,23H,4,12H2,1-3H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248857
PNG
(US9434711, 829)
Show SMILES CCS(=O)(=O)N(Cc1ccnc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C17H17FN2O2S2/c1-3-24(21,22)20(11-13-8-9-19-16(18)10-13)17-12(2)14-6-4-5-7-15(14)23-17/h4-10H,3,11H2,1-2H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248859
PNG
(US9434711, 831)
Show SMILES Cc1c(sc2ccccc12)N(CCCF)S(=O)(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H16F3NO2S2/c1-12-14-5-2-3-6-17(14)25-18(12)22(10-4-9-19)26(23,24)13-7-8-15(20)16(21)11-13/h2-3,5-8,11H,4,9-10H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248863
PNG
(US9434711, 835)
Show SMILES CCS(=O)(=O)N(Cc1ccnc(F)c1)c1sc2ccccc2c1C(C)O
Show InChI InChI=1S/C18H19FN2O3S2/c1-3-26(23,24)21(11-13-8-9-20-16(19)10-13)18-17(12(2)22)14-6-4-5-7-15(14)25-18/h4-10,12,22H,3,11H2,1-2H3
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n/an/a 55.1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248867
PNG
(US9434711, 839)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C(C)OC
Show InChI InChI=1S/C21H21F4NO3S2/c1-4-31(27,28)26(12-14-9-10-17(22)16(11-14)21(23,24)25)20-19(13(2)29-3)15-7-5-6-8-18(15)30-20/h5-11,13H,4,12H2,1-3H3
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n/an/a 15.9n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248177
PNG
(US9434711, 7)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Cl)S(=O)(=O)c2ccccc2)cc1C(F)(F)F
Show InChI InChI=1S/C22H14ClF4NO2S2/c23-20-16-8-4-5-9-19(16)31-21(20)28(32(29,30)15-6-2-1-3-7-15)13-14-10-11-18(24)17(12-14)22(25,26)27/h1-12H,13H2
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n/an/a 7.30n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248178
PNG
(US9434711, 8)
Show SMILES FC(F)(F)c1ccc(CN(c2sc3ccccc3c2Cl)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C22H15ClF3NO2S2/c23-20-18-8-4-5-9-19(18)30-21(20)27(31(28,29)17-6-2-1-3-7-17)14-15-10-12-16(13-11-15)22(24,25)26/h1-13H,14H2
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248185
PNG
(US9434711, 15)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1ccsc1
Show InChI InChI=1S/C20H15F2NO2S3/c1-13-16-4-2-3-5-19(16)27-20(13)23(28(24,25)15-8-9-26-12-15)11-14-6-7-17(21)18(22)10-14/h2-10,12H,11H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248188
PNG
(US9434711, 18)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C24H17F2NO2S3/c1-15-18-7-3-5-9-22(18)31-24(15)27(14-16-10-11-19(25)20(26)12-16)32(28,29)23-13-17-6-2-4-8-21(17)30-23/h2-13H,14H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248193
PNG
(US9434711, 24)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Cl)S(=O)(=O)c2ccccc2)cc1F
Show InChI InChI=1S/C21H14ClF2NO2S2/c22-20-16-8-4-5-9-19(16)28-21(20)25(13-14-10-11-17(23)18(24)12-14)29(26,27)15-6-2-1-3-7-15/h1-12H,13H2
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n/an/a 8.80n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248204
PNG
(US9434711, 35)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(F)c1)c1cc2ccccc2s1
Show InChI InChI=1S/C17H15F2NO2S2/c1-2-24(21,22)20(11-12-7-8-14(18)15(19)9-12)17-10-13-5-3-4-6-16(13)23-17/h3-10H,2,11H2,1H3
PDB

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n/an/a 60.8n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248212
PNG
(US9434711, 43)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1cc2ccccc2s1
Show InChI InChI=1S/C18H15F4NO2S2/c1-2-27(24,25)23(17-10-13-5-3-4-6-16(13)26-17)11-12-7-8-15(19)14(9-12)18(20,21)22/h3-10H,2,11H2,1H3
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248215
PNG
(US9434711, 46)
Show SMILES Clc1ccc(CN(c2cc3ccccc3s2)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H16ClNO2S2/c22-18-12-10-16(11-13-18)15-23(27(24,25)19-7-2-1-3-8-19)21-14-17-6-4-5-9-20(17)26-21/h1-14H,15H2
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248218
PNG
(US9434711, 49)
Show SMILES COc1ccc(CN(c2cc3ccccc3s2)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C22H19NO3S2/c1-26-19-13-11-17(12-14-19)16-23(28(24,25)20-8-3-2-4-9-20)22-15-18-7-5-6-10-21(18)27-22/h2-15H,16H2,1H3
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248220
PNG
(US9434711, 51)
Show SMILES [O-][N+](=O)c1cccc(CN(c2cc3ccccc3s2)S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H16N2O4S2/c24-23(25)18-9-6-7-16(13-18)15-22(29(26,27)19-10-2-1-3-11-19)21-14-17-8-4-5-12-20(17)28-21/h1-14H,15H2
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248247
PNG
(US9434711, 81)
Show SMILES CC(C)(C)OCCN(c1sc2ccccc2c1Cl)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H22ClNO3S2/c1-20(2,3)25-14-13-22(27(23,24)15-9-5-4-6-10-15)19-18(21)16-11-7-8-12-17(16)26-19/h4-12H,13-14H2,1-3H3
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248292
PNG
(US9434711, 140)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15BrFNO2S2/c22-20-18-8-4-5-9-19(18)27-21(20)24(14-15-10-12-16(23)13-11-15)28(25,26)17-6-2-1-3-7-17/h1-13H,14H2
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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248303
PNG
(US9434711, 155)
Show SMILES Fc1cccc(c1)S(=O)(=O)N(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1Br
Show InChI InChI=1S/C21H13BrF3NO2S2/c22-20-16-6-1-2-7-19(16)29-21(20)26(12-13-8-9-17(24)18(25)10-13)30(27,28)15-5-3-4-14(23)11-15/h1-11H,12H2
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 4n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248304
PNG
(US9434711, 157)
Show SMILES CS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C17H12BrF4NO2S2/c1-27(24,25)23(16-15(18)11-4-2-3-5-14(11)26-16)9-10-6-7-13(19)12(8-10)17(20,21)22/h2-8H,9H2,1H3
PDB

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UniProtKB/TrEMBL

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US Patent
n/an/a 14n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248323
PNG
(US9434711, 176)
Show SMILES COc1cc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccccc2)ccc1F
Show InChI InChI=1S/C22H17BrFNO3S2/c1-28-19-13-15(11-12-18(19)24)14-25(30(26,27)16-7-3-2-4-8-16)22-21(23)17-9-5-6-10-20(17)29-22/h2-13H,14H2,1H3
PDB

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UniProtKB/TrEMBL

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US Patent
n/an/a 2.80n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248333
PNG
(US9434711, 186)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccsc2)cc1C(F)(F)F
Show InChI InChI=1S/C20H12BrF4NO2S3/c21-18-14-3-1-2-4-17(14)30-19(18)26(31(27,28)13-7-8-29-11-13)10-12-5-6-16(22)15(9-12)20(23,24)25/h1-9,11H,10H2
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 3.70n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248345
PNG
(US9434711, 199)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1-c1cncnc1
Show InChI InChI=1S/C22H17F4N3O2S2/c1-2-33(30,31)29(12-14-7-8-18(23)17(9-14)22(24,25)26)21-20(15-10-27-13-28-11-15)16-5-3-4-6-19(16)32-21/h3-11,13H,2,12H2,1H3
PDB

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UniProtKB/TrEMBL

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US Patent
n/an/a 13n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248358
PNG
(US9434711, 215)
Show SMILES CS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1CO
Show InChI InChI=1S/C18H15F4NO3S2/c1-28(25,26)23(9-11-6-7-15(19)14(8-11)18(20,21)22)17-13(10-24)12-4-2-3-5-16(12)27-17/h2-8,24H,9-10H2,1H3
PDB

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UniProtKB/TrEMBL

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US Patent
n/an/a 6n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248368
PNG
(US9434711, 225)
Show SMILES CC(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C18H17F2NO3S2/c1-11(22)17-13-5-3-4-6-16(13)25-18(17)21(26(2,23)24)10-12-7-8-14(19)15(20)9-12/h3-9,11,22H,10H2,1-2H3
PDB

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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 4n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%