| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily M member 8 |
|---|
| Ligand | BDBM248583 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Functional Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Branum, ST; Colburn, RW; Dax, SL; Flores, CM; Jetter, MC; Liu, Y; Ludovici, D; Macielag, MJ; Matthews, JM; McNally, JJ; Andraka, LM; Russell, RK; Qin, N; Teleha, C; Wells, KM; Youells, SC; Youngman, MA Sulfonamides as TRPM8 modulators US Patent US9434711 Publication Date 9/6/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily M member 8 |
|---|
| Name: | Transient receptor potential cation channel subfamily M member 8 |
|---|
| Synonyms: | Cmr1 | TRPM8_RAT | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential cation channel subfamily M member 8 | Trpm8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 127633.53 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q8R455 |
|---|
| Residue: | 1104 |
|---|
| Sequence: | MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRD
SKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRL
SCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQY
IMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIP
IVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVR
FLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDR
SSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
|
|
|
|---|
| BDBM248583 |
|---|
| n/a |
|---|
| Name | BDBM248583 |
|---|
| Synonyms: | US9434711, 496 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H18F3NO5S2 |
|---|
| Mol. Mass. | 521.529 |
|---|
| SMILES | Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
