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Patent code US9688615

Compile Data Set for Download or QSAR

Found 706 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164364
PNG
(US9688615, 175)
Show SMILES N[C@H]1CCCC[C@@H]1C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F |r|
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US Patent
n/an/a 4.40E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B


(Homo sapiens (Human))		BDBM164338
PNG
(US9688615, 149)
Show SMILES FC(F)(F)c1cc2nc(CN3CCNCC3=O)[nH]c2cc1C(F)(F)F
Show InChI InChI=1S/C14H12F6N4O/c15-13(16,17)7-3-9-10(4-8(7)14(18,19)20)23-11(22-9)6-24-2-1-21-5-12(24)25/h3-4,21H,1-2,5-6H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B


(Homo sapiens (Human))		BDBM164361
PNG
(US9688615, 172)
Show SMILES N[C@@H]1CCCC[C@@H]1C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F |r|
PDB

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n/an/a 6.20E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164199
PNG
(US9688615, 10)
Show SMILES FC(F)(F)c1cc2nc(CC3CNC3)[nH]c2cc1C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)7-2-9-10(3-8(7)13(17,18)19)22-11(21-9)1-6-4-20-5-6/h2-3,6,20H,1,4-5H2,(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164202
PNG
(US9688615, 13)
Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164203
PNG
(US9688615, 14)
Show SMILES CC(C)(N)CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H20F6N4O/c1-16(2,25)6-14(29)28-7-9(8-28)3-13-26-12-5-10(17(19,20)21)4-11(15(12)27-13)18(22,23)24/h4-5,9H,3,6-8,25H2,1-2H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164224
PNG
(US9688615, 35)
Show SMILES NCCCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c13-11(14,15)6-4-7(12(16,17)18)10-8(5-6)20-9(21-10)2-1-3-19/h4-5H,1-3,19H2,(H,20,21)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164225
PNG
(US9688615, 36)
Show SMILES CC(C)(N)C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H14F6N4O/c1-12(2,21)11(25)22-5-9-23-8-4-6(13(15,16)17)3-7(10(8)24-9)14(18,19)20/h3-4H,5,21H2,1-2H3,(H,22,25)(H,23,24)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164238
PNG
(US9688615, 49)
Show SMILES CN(C)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c1-21(2)5-9-19-8-4-6(11(13,14)15)3-7(10(8)20-9)12(16,17)18/h3-4H,5H2,1-2H3,(H,19,20)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164251
PNG
(US9688615, 62)
Show SMILES CC(C)(C)NC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F6N4O/c1-13(2,3)25-12(26)22-6-10-23-9-5-7(14(16,17)18)4-8(11(9)24-10)15(19,20)21/h4-5H,6H2,1-3H3,(H,23,24)(H2,22,25,26)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164300
PNG
(US9688615, 111)
Show SMILES CC1(C)NCCN(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1=O
Show InChI InChI=1S/C16H16F6N4O/c1-14(2)13(27)26(4-3-23-14)7-11-24-10-6-8(15(17,18)19)5-9(12(10)25-11)16(20,21)22/h5-6,23H,3-4,7H2,1-2H3,(H,24,25)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164342
PNG
(US9688615, 153)
Show SMILES FC(F)(F)c1cc(c2[nH]c(CN3CCNC(=O)C3)nc2c1)C(F)(F)F
Show InChI InChI=1S/C14H12F6N4O/c15-13(16,17)7-3-8(14(18,19)20)12-9(4-7)22-10(23-12)5-24-2-1-21-11(25)6-24/h3-4H,1-2,5-6H2,(H,21,25)(H,22,23)
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SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B


(Homo sapiens (Human))		BDBM164199
PNG
(US9688615, 10)
Show SMILES FC(F)(F)c1cc2nc(CC3CNC3)[nH]c2cc1C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)7-2-9-10(3-8(7)13(17,18)19)22-11(21-9)1-6-4-20-5-6/h2-3,6,20H,1,4-5H2,(H,21,22)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B


(Homo sapiens (Human))		BDBM164251
PNG
(US9688615, 62)
Show SMILES CC(C)(C)NC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F6N4O/c1-13(2,3)25-12(26)22-6-10-23-9-5-7(14(16,17)18)4-8(11(9)24-10)15(19,20)21/h4-5H,6H2,1-3H3,(H,23,24)(H2,22,25,26)
PDB

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n/an/a 5.70E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164321
PNG
(US9688615, 132)
Show SMILES FC(F)(F)C(NC(=O)CC1CCNCC1)c1ccccn1
Show InChI InChI=1S/C14H18F3N3O/c15-14(16,17)13(11-3-1-2-6-19-11)20-12(21)9-10-4-7-18-8-5-10/h1-3,6,10,13,18H,4-5,7-9H2,(H,20,21)
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SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164203
PNG
(US9688615, 14)
Show SMILES CC(C)(N)CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H20F6N4O/c1-16(2,25)6-14(29)28-7-9(8-28)3-13-26-12-5-10(17(19,20)21)4-11(15(12)27-13)18(22,23)24/h4-5,9H,3,6-8,25H2,1-2H3,(H,26,27)
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SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164323
PNG
(US9688615, 134)
Show SMILES CC(C)(C)NC(=O)Cn1c(CN2CCNC(C)(C)C2=O)nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C20H27Cl2N5O2/c1-19(2,3)25-17(28)11-27-15-9-13(22)12(21)8-14(15)24-16(27)10-26-7-6-23-20(4,5)18(26)29/h8-9,23H,6-7,10-11H2,1-5H3,(H,25,28)
PDB

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SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164362
PNG
(US9688615, 173)
Show SMILES N[C@H]1CCCC[C@H]1C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F |r|
PDB

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SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164239
PNG
(US9688615, 50)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C12H10F6N4O/c1-22(10(19)23)4-8-20-7-3-5(11(13,14)15)2-6(9(7)21-8)12(16,17)18/h2-3H,4H2,1H3,(H2,19,23)(H,20,21)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164362
PNG
(US9688615, 173)
Show SMILES N[C@H]1CCCC[C@H]1C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F |r|
PDB

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n/an/a 7.20E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164212
PNG
(US9688615, 23)
Show SMILES NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C10H7F6N3/c11-9(12,13)4-1-5(10(14,15)16)8-6(2-4)18-7(3-17)19-8/h1-2H,3,17H2,(H,18,19)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164224
PNG
(US9688615, 35)
Show SMILES NCCCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c13-11(14,15)6-4-7(12(16,17)18)10-8(5-6)20-9(21-10)2-1-3-19/h4-5H,1-3,19H2,(H,20,21)
PDB

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n/an/a 4.39E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164261
PNG
(US9688615, 72)
Show SMILES FC(F)(F)c1cc(c2[nH]c(Cc3ccncc3)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9F6N3/c16-14(17,18)9-6-10(15(19,20)21)13-11(7-9)23-12(24-13)5-8-1-3-22-4-2-8/h1-4,6-7H,5H2,(H,23,24)
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n/an/a 2.40E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164312
PNG
(US9688615, 123)
Show SMILES CC(C)(O)Cn1c(CC2CCNCC2)nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C17H23Cl2N3O/c1-17(2,23)10-22-15-9-13(19)12(18)8-14(15)21-16(22)7-11-3-5-20-6-4-11/h8-9,11,20,23H,3-7,10H2,1-2H3
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164364
PNG
(US9688615, 175)
Show SMILES N[C@H]1CCCC[C@@H]1C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F |r|
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n/an/a 1.90E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C


(Homo sapiens (Human))		BDBM164312
PNG
(US9688615, 123)
Show SMILES CC(C)(O)Cn1c(CC2CCNCC2)nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C17H23Cl2N3O/c1-17(2,23)10-22-15-9-13(19)12(18)8-14(15)21-16(22)7-11-3-5-20-6-4-11/h8-9,11,20,23H,3-7,10H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164306
PNG
(US9688615, 117)
Show SMILES Cn1nc(cc1NC(=O)CN1CCNCC1=O)C(F)(F)F
Show InChI InChI=1S/C11H14F3N5O2/c1-18-8(4-7(17-18)11(12,13)14)16-9(20)6-19-3-2-15-5-10(19)21/h4,15H,2-3,5-6H2,1H3,(H,16,20)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164310
PNG
(US9688615, 121)
Show SMILES Clc1cc2nc(CCN3CCNCC3=O)[nH]c2cc1Cl
Show InChI InChI=1S/C13H14Cl2N4O/c14-8-5-10-11(6-9(8)15)18-12(17-10)1-3-19-4-2-16-7-13(19)20/h5-6,16H,1-4,7H2,(H,17,18)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164314
PNG
(US9688615, 125)
Show SMILES CC(C)(C)NC(=O)Cn1c(CN2CCNCC2=O)nc2c(cc(cc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H23F6N5O2/c1-18(2,3)29-15(32)10-31-13-7-11(19(21,22)23)6-12(20(24,25)26)17(13)28-14(31)9-30-5-4-27-8-16(30)33/h6-7,27H,4-5,8-10H2,1-3H3,(H,29,32)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164321
PNG
(US9688615, 132)
Show SMILES FC(F)(F)C(NC(=O)CC1CCNCC1)c1ccccn1
Show InChI InChI=1S/C14H18F3N3O/c15-14(16,17)13(11-3-1-2-6-19-11)20-12(21)9-10-4-7-18-8-5-10/h1-3,6,10,13,18H,4-5,7-9H2,(H,20,21)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164322
PNG
(US9688615, 133)
Show SMILES CC1(C)NCCN(CC(=O)Nc2ccc(cn2)C(F)(F)F)C1=O
Show InChI InChI=1S/C14H17F3N4O2/c1-13(2)12(23)21(6-5-19-13)8-11(22)20-10-4-3-9(7-18-10)14(15,16)17/h3-4,7,19H,5-6,8H2,1-2H3,(H,18,20,22)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164325
PNG
(US9688615, 136)
Show SMILES CC(C)(O)Cn1c(CC2CCNCC2)nc2c(cc(cc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H23F6N3O/c1-17(2,29)10-28-14-9-12(18(20,21)22)8-13(19(23,24)25)16(14)27-15(28)7-11-3-5-26-6-4-11/h8-9,11,26,29H,3-7,10H2,1-2H3
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G


(Homo sapiens (Human))		BDBM164331
PNG
(US9688615, 142)
Show SMILES FC(F)(F)c1cc2nc(CC3CCNCC3)[nH]c2cc1C(F)(F)F
Show InChI InChI=1S/C15H15F6N3/c16-14(17,18)9-6-11-12(7-10(9)15(19,20)21)24-13(23-11)5-8-1-3-22-4-2-8/h6-8,22H,1-5H2,(H,23,24)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164202
PNG
(US9688615, 13)
Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164203
PNG
(US9688615, 14)
Show SMILES CC(C)(N)CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H20F6N4O/c1-16(2,25)6-14(29)28-7-9(8-28)3-13-26-12-5-10(17(19,20)21)4-11(15(12)27-13)18(22,23)24/h4-5,9H,3,6-8,25H2,1-2H3,(H,26,27)
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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164212
PNG
(US9688615, 23)
Show SMILES NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C10H7F6N3/c11-9(12,13)4-1-5(10(14,15)16)8-6(2-4)18-7(3-17)19-8/h1-2H,3,17H2,(H,18,19)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164217
PNG
(US9688615, 28)
Show SMILES CC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H9F6N3O/c1-5(22)19-4-9-20-8-3-6(11(13,14)15)2-7(10(8)21-9)12(16,17)18/h2-3H,4H2,1H3,(H,19,22)(H,20,21)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164220
PNG
(US9688615, 31)
Show SMILES CC(C)C[C@H](CN)Cc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F |r|
PDB

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n/an/a 7.58E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164223
PNG
(US9688615, 34)
Show SMILES CC(C)(N)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H13F6N3/c1-11(2,20)5-9-21-8-4-6(12(14,15)16)3-7(10(8)22-9)13(17,18)19/h3-4H,5,20H2,1-2H3,(H,21,22)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164231
PNG
(US9688615, 42)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)CN
Show InChI InChI=1S/C13H12F6N4O/c1-23(10(24)4-20)5-9-21-8-3-6(12(14,15)16)2-7(11(8)22-9)13(17,18)19/h2-3H,4-5,20H2,1H3,(H,21,22)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164238
PNG
(US9688615, 49)
Show SMILES CN(C)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c1-21(2)5-9-19-8-4-6(11(13,14)15)3-7(10(8)20-9)12(16,17)18/h3-4H,5H2,1-2H3,(H,19,20)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164297
PNG
(US9688615, 108)
Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl
Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164302
PNG
(US9688615, 113)
Show SMILES FC(F)(F)c1ccnc(NC(=O)CN2CCNCC2=O)c1
Show InChI InChI=1S/C12H13F3N4O2/c13-12(14,15)8-1-2-17-9(5-8)18-10(20)7-19-4-3-16-6-11(19)21/h1-2,5,16H,3-4,6-7H2,(H,17,18,20)
PDB

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SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164313
PNG
(US9688615, 124)
Show SMILES CC(C)(C)NC(=O)Cn1c(CN2CCNCC2=O)nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C18H23Cl2N5O2/c1-18(2,3)23-16(26)10-25-14-7-12(20)11(19)6-13(14)22-15(25)9-24-5-4-21-8-17(24)27/h6-7,21H,4-5,8-10H2,1-3H3,(H,23,26)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164315
PNG
(US9688615, 126)
Show SMILES FC(F)(F)c1cc(c2[nH]c(CCN3CCNCC3=O)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H14F6N4O/c16-14(17,18)8-5-9(15(19,20)21)13-10(6-8)23-11(24-13)1-3-25-4-2-22-7-12(25)26/h5-6,22H,1-4,7H2,(H,23,24)
PDB

UniProtKB/SwissProt

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164335
PNG
(US9688615, 146)
Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3
PDB

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164343
PNG
(US9688615, 154)
Show SMILES CC1(C)NCCN(Cc2nc3cc(Cl)c(Cl)cc3[nH]2)C1=O
Show InChI InChI=1S/C14H16Cl2N4O/c1-14(2)13(21)20(4-3-17-14)7-12-18-10-5-8(15)9(16)6-11(10)19-12/h5-6,17H,3-4,7H2,1-2H3,(H,18,19)
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM163526
PNG
(US9688615, 1)
Show SMILES FC(F)(F)c1cc(c2nc(CC3CNC3)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)7-2-8(13(17,18)19)11-9(3-7)21-10(22-11)1-6-4-20-5-6/h2-3,6,20H,1,4-5H2,(H,21,22)
PDB

UniProtKB/SwissProt

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n/an/a 1.98E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164203
PNG
(US9688615, 14)
Show SMILES CC(C)(N)CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H20F6N4O/c1-16(2,25)6-14(29)28-7-9(8-28)3-13-26-12-5-10(17(19,20)21)4-11(15(12)27-13)18(22,23)24/h4-5,9H,3,6-8,25H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.76E+3n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H


(Homo sapiens (Human))		BDBM164211
PNG
(US9688615, 22)
Show SMILES NCC(=O)NCc1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C10H10Cl2N4O/c11-5-1-7-8(2-6(5)12)16-9(15-7)4-14-10(17)3-13/h1-2H,3-4,13H2,(H,14,17)(H,15,16)
PDB

UniProtKB/SwissProt

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US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



SRMLSC

US Patent


Assay Description
Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...

US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%